SUPERFAMILY 1.75 HMM library and genome assignments server


4-helical cytokines superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   4-helical cytokines [ 47265]
Superfamily:   4-helical cytokines [ 47266] (3)
Families:   Long-chain cytokines [ 47267] (9)
  Short-chain cytokines [ 47286] (13)
  Interferons/interleukin-10 (IL-10) [ 47305] (8)


Superfamily statistics
Genomes (68) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,880 6,515 79
Proteins 2,860 6,496 77


Functional annotation
General category Processes_EC
Detailed category Immune response

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process00Least InformativeDirect
Biological Process (BP)developmental process1.53e-131.702e-13Least InformativeDirect
Biological Process (BP)single-organism cellular process1.511e-095.656e-08Least InformativeDirect
Biological Process (BP)response to stimulus00Least InformativeDirect
Biological Process (BP)regulation of cellular process0.0019190.02938Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.005461Least InformativeInherited
Biological Process (BP)biosynthetic process0.019270.74Least InformativeInherited
Biological Process (BP)regulation of metabolic process1.812e-080.009117Least InformativeInherited
Biological Process (BP)protein metabolic process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)localization11Least InformativeInherited
Biological Process (BP)immune system process00Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process00Moderately InformativeDirect
Biological Process (BP)response to organic substance3.324e-140Moderately InformativeDirect
Biological Process (BP)cell differentiation00Moderately InformativeDirect
Biological Process (BP)regulation of localization7.971e-077.774e-13Moderately InformativeDirect
Biological Process (BP)positive regulation of molecular function5.423e-061.058e-06Moderately InformativeDirect
Biological Process (BP)single-organism developmental process5.452e-062.971e-09Moderately InformativeDirect
Biological Process (BP)organ development5.424e-071.045e-11Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process00Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process3.809e-107.775e-06Moderately InformativeDirect
Biological Process (BP)regulation of developmental process3.748e-132.792e-13Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process00Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process00Moderately InformativeDirect
Biological Process (BP)multi-organism process00Moderately InformativeDirect
Biological Process (BP)regulation of signal transduction0.94431Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound10.272Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus11Moderately InformativeInherited
Biological Process (BP)tissue development0.93651Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.0075210.02854Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.00089021Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.41771Moderately InformativeInherited
Biological Process (BP)homeostatic process0.91890.4001Moderately InformativeInherited
Biological Process (BP)nervous system development11Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.00027131Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10Moderately InformativeInherited
Biological Process (BP)cellular response to stress11Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.087470.9174Moderately InformativeInherited
Biological Process (BP)cellular localization11Moderately InformativeInherited
Biological Process (BP)signal transduction0.030770.003198Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.085470.01141Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.96131Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process11Moderately InformativeInherited
Biological Process (BP)organic substance transport0.6040.06924Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.072852.003e-07Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process0.03730.4558Moderately InformativeInherited
Biological Process (BP)reproduction0.22120.04897Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.10381Moderately InformativeInherited
Biological Process (BP)regulation of cytokine production00InformativeDirect
Biological Process (BP)positive regulation of immune system process8.166e-063.706e-11InformativeDirect
Biological Process (BP)regulation of immune effector process4.844e-153.924e-10InformativeDirect
Biological Process (BP)apoptotic process00InformativeDirect
Biological Process (BP)defense response00InformativeDirect
Biological Process (BP)immune response1.04e-070InformativeDirect
Biological Process (BP)response to wounding4.798e-132.145e-12InformativeDirect
Biological Process (BP)positive regulation of signal transduction2.732e-058.015e-13InformativeDirect
Biological Process (BP)positive regulation of macromolecule biosynthetic process1.148e-131.751e-06InformativeDirect
Biological Process (BP)regulation of intracellular protein kinase cascade5.25e-082.575e-11InformativeDirect
Biological Process (BP)positive regulation of gene expression2.731e-101.519e-05InformativeDirect
Biological Process (BP)positive regulation of cellular biosynthetic process7.065e-100.0002122InformativeDirect
Biological Process (BP)regulation of defense response0.00025764.144e-07InformativeDirect
Biological Process (BP)positive regulation of protein modification process3.025e-080InformativeDirect
Biological Process (BP)response to nutrient levels3.511e-081.617e-05InformativeDirect
Biological Process (BP)response to lipid1.243e-078.183e-10InformativeDirect
Biological Process (BP)response to cytokine stimulus1.47e-071.593e-10InformativeDirect
Biological Process (BP)regulation of cell proliferation00InformativeDirect
Biological Process (BP)leukocyte activation1.165e-071.936e-15InformativeDirect
Biological Process (BP)positive regulation of phosphate metabolic process2.661e-110InformativeDirect
Biological Process (BP)hematopoietic or lymphoid organ development00InformativeDirect
Biological Process (BP)regulation of immune response5.341e-101.826e-12InformativeDirect
Biological Process (BP)regulation of body fluid levels1.326e-065.156e-05InformativeDirect
Biological Process (BP)regulation of secretion00InformativeDirect
Biological Process (BP)positive regulation of transport1.553e-082.28e-08InformativeDirect
Biological Process (BP)negative regulation of transport3.859e-099.136e-15InformativeDirect
Biological Process (BP)positive regulation of developmental process9.713e-061.925e-11InformativeDirect
Biological Process (BP)positive regulation of nitrogen compound metabolic process5.211e-118.631e-06InformativeDirect
Biological Process (BP)positive regulation of multicellular organismal process4.716e-054.109e-07InformativeDirect
Biological Process (BP)response to other organism2.6e-123.215e-07InformativeDirect
Biological Process (BP)negative regulation of cell communication0.99491InformativeInherited
Biological Process (BP)negative regulation of signaling0.92051InformativeInherited
Biological Process (BP)regulation of apoptotic process0.019030.004691InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.35150.07036InformativeInherited
Biological Process (BP)response to organic cyclic compound0.00056630.01704InformativeInherited
Biological Process (BP)regulation of establishment of protein localization0.016120.02088InformativeInherited
Biological Process (BP)regulation of lipid metabolic process0.75890.4543InformativeInherited
Biological Process (BP)generation of neurons2.847e-060.007267InformativeInherited
Biological Process (BP)regulation of cell development11InformativeInherited
Biological Process (BP)response to hormone stimulus0.071340.008864InformativeInherited
Biological Process (BP)negative regulation of cell death0.01112.611e-06InformativeInherited
Biological Process (BP)regulation of cell cycle process0.33560.5046InformativeInherited
Biological Process (BP)regulation of growth0.062230.002045InformativeInherited
Biological Process (BP)negative regulation of protein metabolic process0.23860.009689InformativeInherited
Biological Process (BP)negative regulation of biosynthetic process11InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.00068260.2738InformativeInherited
Biological Process (BP)regulation of response to external stimulus0.072610.01026InformativeInherited
Biological Process (BP)regulation of nervous system development11InformativeInherited
Biological Process (BP)regulation of system process11InformativeInherited
Biological Process (BP)regulation of cellular catabolic process0.023160.01806InformativeInherited
Biological Process (BP)cellular component movement0.10340.8949InformativeInherited
Biological Process (BP)locomotion0.00083180.3163InformativeInherited
Biological Process (BP)localization of cell2.392e-050.003527InformativeInherited
Biological Process (BP)secretion by cell0.45990.2262InformativeInherited
Biological Process (BP)peptidyl-amino acid modification0.030430.1563InformativeInherited
Biological Process (BP)phosphorylation0.28790.8343InformativeInherited
Biological Process (BP)regulation of hormone levels0.97280.2057InformativeInherited
Biological Process (BP)single-organism behavior0.52311InformativeInherited
Biological Process (BP)alcohol metabolic process0.0027570.1306InformativeInherited
Biological Process (BP)single organism reproductive process0.18260.6052InformativeInherited
Biological Process (BP)multi-multicellular organism process0.19657.973e-07InformativeInherited
Biological Process (BP)intracellular signal transduction10.9504InformativeInherited
Biological Process (BP)nitrogen compound transport0.43720.1119InformativeInherited
Biological Process (BP)immune effector process0.0016992.215e-11InformativeInherited
Biological Process (BP)regulation of protein phosphorylation0.012532.539e-05InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching0.01710.3821InformativeInherited
Biological Process (BP)embryonic organ development0.010720.3148InformativeInherited
Biological Process (BP)negative regulation of immune system process00Highly InformativeDirect
Biological Process (BP)regulation of production of molecular mediator of immune response3.084e-090Highly InformativeDirect
Biological Process (BP)regulation of lymphocyte mediated immunity00Highly InformativeDirect
Biological Process (BP)regulation of adaptive immune response based on somatic recombination of immune receptors built from00Highly InformativeDirect
Biological Process (BP)inflammatory response4.157e-061.611e-06Highly InformativeDirect
Biological Process (BP)hemostasis00.0009779Highly InformativeDirect
Biological Process (BP)negative regulation of cell proliferation3.164e-102.688e-08Highly InformativeDirect
Biological Process (BP)response to virus1.879e-091.2e-07Highly InformativeDirect
Biological Process (BP)hormone transport0.00028827.975e-07Highly InformativeDirect
Biological Process (BP)peptidyl-tyrosine modification0.00021910.0006725Highly InformativeDirect
Biological Process (BP)cytokine-mediated signaling pathway8.107e-113.827e-13Highly InformativeDirect
Biological Process (BP)regulation of proteolysis0.00021093.605e-05Highly InformativeDirect
Biological Process (BP)negative regulation of cellular catabolic process00Highly InformativeDirect
Biological Process (BP)regulation of cell killing0.00017080.0005099Highly InformativeDirect
Biological Process (BP)negative regulation of response to external stimulus3.574e-083.55e-10Highly InformativeDirect
Biological Process (BP)response to lipopolysaccharide4.202e-069.596e-10Highly InformativeDirect
Biological Process (BP)regulation of interleukin-1 beta production2.074e-071.132e-06Highly InformativeDirect
Biological Process (BP)regulation of cytokine biosynthetic process4.886e-083.159e-10Highly InformativeDirect
Biological Process (BP)regulation of protein catabolic process1.163e-073.312e-06Highly InformativeDirect
Biological Process (BP)amide transport0.00054391.232e-05Highly InformativeDirect
Biological Process (BP)regulation of multi-organism process8.949e-070.0002162Highly InformativeDirect
Biological Process (BP)regulation of nitric oxide biosynthetic process1.08e-052.748e-10Highly InformativeDirect
Biological Process (BP)regulation of myeloid cell differentiation1.348e-060Highly InformativeDirect
Biological Process (BP)positive regulation of transcription, DNA-dependent3.256e-157.41e-12Highly InformativeDirect
Biological Process (BP)alpha-beta T cell activation0.0005150Highly InformativeDirect
Biological Process (BP)regulation of cytokine secretion4.46e-062.715e-06Highly InformativeDirect
Biological Process (BP)positive regulation of protein secretion00Highly InformativeDirect
Biological Process (BP)positive regulation of peptidyl-tyrosine phosphorylation00Highly InformativeDirect
Biological Process (BP)regulation of steroid biosynthetic process9.386e-061.045e-05Highly InformativeDirect
Biological Process (BP)coagulation3.593e-081.845e-06Highly InformativeDirect
Biological Process (BP)negative regulation of cell activation00Highly InformativeDirect
Biological Process (BP)positive regulation of cell activation00Highly InformativeDirect
Biological Process (BP)negative regulation of secretion9.973e-089.772e-10Highly InformativeDirect
Biological Process (BP)regulation of DNA metabolic process2.731e-118.637e-11Highly InformativeDirect
Biological Process (BP)positive regulation of sequence-specific DNA binding transcription factor activity02.094e-12Highly InformativeDirect
Biological Process (BP)negative regulation of protein transport3.288e-050.0001734Highly InformativeDirect
Biological Process (BP)negative regulation of multicellular organismal process6.385e-151.073e-12Highly InformativeDirect
Biological Process (BP)response to glucocorticoid stimulus00Highly InformativeDirect
Biological Process (BP)leukocyte proliferation2.594e-059.643e-07Highly InformativeDirect
Biological Process (BP)positive regulation of leukocyte proliferation1.165e-063.217e-11Highly InformativeDirect
Biological Process (BP)cellular response to biotic stimulus3.256e-061.733e-07Highly InformativeDirect
Biological Process (BP)extrinsic apoptotic signaling pathway6.496e-117.341e-15Highly InformativeDirect
Biological Process (BP)regulation of leukocyte differentiation2.14e-110Highly InformativeDirect
Biological Process (BP)negative regulation of apoptotic signaling pathway0.00084370.0001344Highly InformativeDirect
Biological Process (BP)regulation of T cell activation11Highly InformativeInherited
Biological Process (BP)connective tissue development0.011742.145e-06Highly InformativeInherited
Biological Process (BP)regulation of innate immune response0.73121Highly InformativeInherited
Biological Process (BP)regulation of mononuclear cell proliferation0.98861Highly InformativeInherited
Biological Process (BP)positive regulation of neurogenesis0.24090.001275Highly InformativeInherited
Biological Process (BP)regulation of reproductive process0.52570.7265Highly InformativeInherited
Biological Process (BP)T cell differentiation0.18950.002032Highly InformativeInherited
Biological Process (BP)cell fate commitment0.17838.356e-08Highly InformativeInherited
Biological Process (BP)response to topologically incorrect protein0.14990.4267Highly InformativeInherited
Biological Process (BP)innate immune response11Highly InformativeInherited
Biological Process (BP)regulation of toll-like receptor signaling pathway0.0030630.009977Highly InformativeInherited
Biological Process (BP)negative regulation of apoptotic process10.9895Highly InformativeInherited
Biological Process (BP)positive regulation of cytokine production0.0290.0009476Highly InformativeInherited
Biological Process (BP)regulation of response to nutrient levels11Highly InformativeInherited
Biological Process (BP)regulation of ion homeostasis11Highly InformativeInherited
Biological Process (BP)ER-nucleus signaling pathway0.0082110.125Highly InformativeInherited
Biological Process (BP)response to endoplasmic reticulum stress7.589e-050.008639Highly InformativeInherited
Biological Process (BP)chemotaxis0.45981Highly InformativeInherited
Biological Process (BP)leukocyte migration0.28380.4116Highly InformativeInherited
Biological Process (BP)signal release0.0020030.0001357Highly InformativeInherited
Biological Process (BP)protein phosphorylation0.080820.5128Highly InformativeInherited
Biological Process (BP)regulation of cellular carbohydrate metabolic process0.28780.08478Highly InformativeInherited
Biological Process (BP)adult behavior0.00065280.03495Highly InformativeInherited
Biological Process (BP)sterol metabolic process0.00031380.008173Highly InformativeInherited
Biological Process (BP)wound healing0.72881Highly InformativeInherited
Biological Process (BP)female pregnancy1.001e-070.004129Highly InformativeInherited
Biological Process (BP)cell-type specific apoptotic process0.025940.007168Highly InformativeInherited
Biological Process (BP)positive regulation of programmed cell death4.173e-050.001266Highly InformativeInherited
Biological Process (BP)leukocyte activation involved in immune response0.041551.657e-10Highly InformativeInherited
Biological Process (BP)placenta development2.232e-050.002865Highly InformativeInherited
Biological Process (BP)leukocyte homeostasis0.01460.02927Highly InformativeInherited
Molecular Function (MF)binding00Least InformativeDirect
Molecular Function (MF)receptor binding00InformativeDirect
Molecular Function (MF)cytokine activity5.356e-080Highly InformativeDirect
Molecular Function (MF)cytokine receptor binding2.373e-060Highly InformativeDirect
Molecular Function (MF)growth factor receptor binding0.0002280.0001292Highly InformativeDirect
Cellular Component (CC)membrane11Least InformativeInherited
Cellular Component (CC)extracellular region part00Moderately InformativeDirect
Cellular Component (CC)plasma membrane0.26561Moderately InformativeInherited
Cellular Component (CC)extracellular space00InformativeDirect
Cellular Component (CC)cell surface5.537e-128.004e-06InformativeDirect
Cellular Component (CC)external side of plasma membrane2.011e-104.959e-09Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 1.702e-13 Least Informative Direct
Biological Process (BP) single-organism cellular process 5.656e-08 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.02938 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.74 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.009117 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) response to organic substance 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 7.774e-13 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 1.058e-06 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 2.971e-09 Moderately Informative Direct
Biological Process (BP) organ development 1.045e-11 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 7.775e-06 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 2.003e-07 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 2.792e-13 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.272 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.04897 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.02854 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.4001 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.003198 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.8266 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.9174 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.01141 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.06924 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.4558 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cytokine production 0 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 2.539e-05 Informative Direct
Biological Process (BP) immune effector process 2.215e-11 Informative Direct
Biological Process (BP) positive regulation of immune system process 3.706e-11 Informative Direct
Biological Process (BP) regulation of immune effector process 3.924e-10 Informative Direct
Biological Process (BP) apoptotic process 0 Informative Direct
Biological Process (BP) defense response 0 Informative Direct
Biological Process (BP) immune response 0 Informative Direct
Biological Process (BP) response to wounding 2.145e-12 Informative Direct
Biological Process (BP) positive regulation of signal transduction 8.015e-13 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1.751e-06 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 2.575e-11 Informative Direct
Biological Process (BP) positive regulation of gene expression 1.519e-05 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.0002122 Informative Direct
Biological Process (BP) regulation of defense response 4.144e-07 Informative Direct
Biological Process (BP) positive regulation of protein modification process 0 Informative Direct
Biological Process (BP) response to nutrient levels 1.617e-05 Informative Direct
Biological Process (BP) response to lipid 8.183e-10 Informative Direct
Biological Process (BP) response to cytokine stimulus 1.593e-10 Informative Direct
Biological Process (BP) regulation of cell proliferation 0 Informative Direct
Biological Process (BP) multi-multicellular organism process 7.973e-07 Informative Direct
Biological Process (BP) leukocyte activation 1.936e-15 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0 Informative Direct
Biological Process (BP) gland development 0.0006823 Informative Direct
Biological Process (BP) regulation of immune response 1.826e-12 Informative Direct
Biological Process (BP) regulation of body fluid levels 5.156e-05 Informative Direct
Biological Process (BP) regulation of secretion 0 Informative Direct
Biological Process (BP) positive regulation of transport 2.28e-08 Informative Direct
Biological Process (BP) negative regulation of transport 9.136e-15 Informative Direct
Biological Process (BP) positive regulation of developmental process 1.925e-11 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 8.631e-06 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 4.109e-07 Informative Direct
Biological Process (BP) response to other organism 3.215e-07 Informative Direct
Biological Process (BP) negative regulation of cell death 2.611e-06 Informative Direct
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.004691 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.07036 Informative Inherited
Biological Process (BP) growth 0.7555 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.215 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.9041 Informative Inherited
Biological Process (BP) epithelium development 0.7019 Informative Inherited
Biological Process (BP) tube development 0.3966 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.01704 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.03695 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.4543 Informative Inherited
Biological Process (BP) generation of neurons 0.007267 Informative Inherited
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.008864 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.5046 Informative Inherited
Biological Process (BP) regulation of growth 0.002045 Informative Inherited
Biological Process (BP) regulation of locomotion 0.04456 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.04529 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.1563 Informative Inherited
Biological Process (BP) phosphorylation 0.8343 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.9504 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.009689 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) protein localization to organelle 0.006432 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.2738 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.01026 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.01806 Informative Inherited
Biological Process (BP) cellular component movement 0.8949 Informative Inherited
Biological Process (BP) locomotion 0.3163 Informative Inherited
Biological Process (BP) localization of cell 0.003527 Informative Inherited
Biological Process (BP) secretion by cell 0.2262 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.2057 Informative Inherited
Biological Process (BP) single-organism behavior 1 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.1306 Informative Inherited
Biological Process (BP) single organism reproductive process 0.6052 Informative Inherited
Biological Process (BP) protein transport 0.3721 Informative Inherited
Biological Process (BP) nitrogen compound transport 0.1119 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.02088 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.3821 Informative Inherited
Biological Process (BP) embryonic organ development 0.3148 Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.0009476 Highly Informative Direct
Biological Process (BP) leukocyte activation involved in immune response 1.657e-10 Highly Informative Direct
Biological Process (BP) negative regulation of immune system process 0 Highly Informative Direct
Biological Process (BP) regulation of production of molecular mediator of immune response 0 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte mediated immunity 0 Highly Informative Direct
Biological Process (BP) regulation of adaptive immune response based on somatic recombination of immune receptors built from 0 Highly Informative Direct
Biological Process (BP) inflammatory response 1.611e-06 Highly Informative Direct
Biological Process (BP) hemostasis 0.0009779 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 2.688e-08 Highly Informative Direct
Biological Process (BP) response to virus 1.2e-07 Highly Informative Direct
Biological Process (BP) hormone transport 7.975e-07 Highly Informative Direct
Biological Process (BP) protein import 6.352e-06 Highly Informative Direct
Biological Process (BP) peptidyl-tyrosine modification 0.0006725 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 3.827e-13 Highly Informative Direct
Biological Process (BP) signal release 0.0001357 Highly Informative Direct
Biological Process (BP) regulation of proteolysis 3.605e-05 Highly Informative Direct
Biological Process (BP) negative regulation of cellular catabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of cell killing 0.0005099 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 3.55e-10 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 9.596e-10 Highly Informative Direct
Biological Process (BP) regulation of interleukin-1 beta production 1.132e-06 Highly Informative Direct
Biological Process (BP) protein localization to nucleus 2.76e-06 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 3.159e-10 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 3.312e-06 Highly Informative Direct
Biological Process (BP) amide transport 1.232e-05 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 0.0002162 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 3.744e-07 Highly Informative Direct
Biological Process (BP) cell fate commitment 8.356e-08 Highly Informative Direct
Biological Process (BP) regulation of nitric oxide biosynthetic process 2.748e-10 Highly Informative Direct
Biological Process (BP) regulation of myeloid cell differentiation 0 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 7.41e-12 Highly Informative Direct
Biological Process (BP) alpha-beta T cell activation 0 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 0.0008886 Highly Informative Direct
Biological Process (BP) regulation of cytokine secretion 2.715e-06 Highly Informative Direct
Biological Process (BP) positive regulation of protein secretion 0 Highly Informative Direct
Biological Process (BP) positive regulation of peptidyl-tyrosine phosphorylation 0 Highly Informative Direct
Biological Process (BP) regulation of steroid biosynthetic process 1.045e-05 Highly Informative Direct
Biological Process (BP) coagulation 1.845e-06 Highly Informative Direct
Biological Process (BP) negative regulation of cell activation 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 0 Highly Informative Direct
Biological Process (BP) negative regulation of secretion 9.772e-10 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 8.637e-11 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 2.094e-12 Highly Informative Direct
Biological Process (BP) nuclear import 4.699e-07 Highly Informative Direct
Biological Process (BP) negative regulation of protein transport 0.0001734 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 1.073e-12 Highly Informative Direct
Biological Process (BP) response to glucocorticoid stimulus 0 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 3.054e-05 Highly Informative Direct
Biological Process (BP) connective tissue development 2.145e-06 Highly Informative Direct
Biological Process (BP) leukocyte proliferation 9.643e-07 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 3.217e-11 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 1.733e-07 Highly Informative Direct
Biological Process (BP) extrinsic apoptotic signaling pathway 7.341e-15 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 0 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic signaling pathway 0.0001344 Highly Informative Direct
Biological Process (BP) regulation of T cell activation 1 Highly Informative Inherited
Biological Process (BP) developmental growth 0.7646 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 0.2808 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 1 Highly Informative Inherited
Biological Process (BP) regulation of mononuclear cell proliferation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of neurogenesis 0.001275 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.7265 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.002032 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 0.5128 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.4972 Highly Informative Inherited
Biological Process (BP) response to topologically incorrect protein 0.4267 Highly Informative Inherited
Biological Process (BP) innate immune response 1 Highly Informative Inherited
Biological Process (BP) regulation of toll-like receptor signaling pathway 0.009977 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.9895 Highly Informative Inherited
Biological Process (BP) regulation of response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 1 Highly Informative Inherited
Biological Process (BP) ER-nucleus signaling pathway 0.125 Highly Informative Inherited
Biological Process (BP) response to endoplasmic reticulum stress 0.008639 Highly Informative Inherited
Biological Process (BP) chemotaxis 1 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.4116 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.08478 Highly Informative Inherited
Biological Process (BP) adult behavior 0.03495 Highly Informative Inherited
Biological Process (BP) sterol metabolic process 0.008173 Highly Informative Inherited
Biological Process (BP) wound healing 1 Highly Informative Inherited
Biological Process (BP) female pregnancy 0.004129 Highly Informative Inherited
Biological Process (BP) cell-type specific apoptotic process 0.007168 Highly Informative Inherited
Biological Process (BP) positive regulation of programmed cell death 0.001266 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.119 Highly Informative Inherited
Biological Process (BP) placenta development 0.002865 Highly Informative Inherited
Biological Process (BP) leukocyte homeostasis 0.02927 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) cytokine activity 0 Highly Informative Direct
Molecular Function (MF) cytokine receptor binding 0 Highly Informative Direct
Molecular Function (MF) growth factor receptor binding 0.0001292 Highly Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0.4543 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) extracellular space 0 Informative Direct
Cellular Component (CC) cell surface 8.004e-06 Informative Direct
Cellular Component (CC) secretory granule 3.911e-07 Informative Direct
Cellular Component (CC) external side of plasma membrane 4.959e-09 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease6.229e-07Least InformativeDirect
Disease Ontology (DO)organ system cancer0.0002081Least InformativeDirect
Disease Ontology (DO)nervous system disease0.21Least InformativeInherited
Disease Ontology (DO)lung disease8.734e-12Moderately InformativeDirect
Disease Ontology (DO)skin disease3.089e-08Moderately InformativeDirect
Disease Ontology (DO)syndrome0.0001879Moderately InformativeDirect
Disease Ontology (DO)disease of metabolism0.0005544Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0.0009336Moderately InformativeDirect
Disease Ontology (DO)mouth disease0.0022Moderately InformativeInherited
Disease Ontology (DO)bacterial infectious disease0.01937Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.0389Moderately InformativeInherited
Disease Ontology (DO)bone disease0.07909Moderately InformativeInherited
Disease Ontology (DO)disease of mental health0.1837Moderately InformativeInherited
Disease Ontology (DO)muscular disease0.3437Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.3881Moderately InformativeInherited
Disease Ontology (DO)sensory system disease0.709Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.8321Moderately InformativeInherited
Disease Ontology (DO)inflammatory bowel disease1.986e-07InformativeDirect
Disease Ontology (DO)multiple sclerosis2.074e-07InformativeDirect
Disease Ontology (DO)hemorrhagic disease3.209e-07InformativeDirect
Disease Ontology (DO)allergic rhinitis1.975e-06InformativeDirect
Disease Ontology (DO)opportunistic mycosis3.385e-06InformativeDirect
Disease Ontology (DO)myositis9.845e-05InformativeDirect
Disease Ontology (DO)connective tissue cancer0.02226InformativeInherited
Disease Ontology (DO)auditory system disease0.06163InformativeInherited
Disease Ontology (DO)schizophrenia0.06443InformativeInherited
Disease Ontology (DO)lymphoma0.1223InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type IV disease0.1241InformativeInherited
Disease Ontology (DO)kidney failure0.1256InformativeInherited
Disease Ontology (DO)developmental disorder of mental health0.1278InformativeInherited
Disease Ontology (DO)parasitic helminthiasis infectious disease0.1365InformativeInherited
Disease Ontology (DO)primary immunodeficiency disease0.309InformativeInherited
Disease Ontology (DO)viral infectious disease0.37InformativeInherited
Disease Ontology (DO)esophageal disease0.4382InformativeInherited
Disease Ontology (DO)arthritis0.8896InformativeInherited
Disease Ontology (DO)glucose metabolism disease1InformativeInherited
Disease Ontology (DO)rheumatoid arthritis1.34e-07Highly InformativeDirect
Disease Ontology (DO)agammaglobulinemia5.456e-05Highly InformativeDirect
Disease Ontology (DO)otitis media0.0001068Highly InformativeDirect
Disease Ontology (DO)sarcoidosis0.0001181Highly InformativeDirect
Disease Ontology (DO)aggressive systemic mastocytosis0.0004925Highly InformativeDirect
Disease Ontology (DO)pertussis0.0008527Highly InformativeDirect
Disease Ontology (DO)eating disorder0.004593Highly InformativeInherited

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype3.976e-05Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.0001584Least InformativeDirect
Mammalian Phenotype (MP)abnormal homeostasis0.2718Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.3214Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body phenotype0.42Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.8057Least InformativeInherited
Mammalian Phenotype (MP)abnormal protein level2.241e-05Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.0001247Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.0004953Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype0.001838Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.004132Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.005252Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.00676Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.01173Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.01446Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.03089Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.138Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.1467Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.166Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.1717Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.1808Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.2021Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.4047Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.53Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.6385Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)increased susceptibility to infection9.539e-10InformativeDirect
Mammalian Phenotype (MP)autoimmune response1.332e-07InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland morphology3.521e-05InformativeDirect
Mammalian Phenotype (MP)abnormal liver physiology5.898e-05InformativeDirect
Mammalian Phenotype (MP)abnormal female reproductive system physiology0.0007747InformativeDirect
Mammalian Phenotype (MP)abnormal circulating cytokine level0.001167InformativeInherited
Mammalian Phenotype (MP)abnormal antigen presentation0.001546InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system physiology0.003445InformativeInherited
Mammalian Phenotype (MP)abnormal intestine morphology0.02146InformativeInherited
Mammalian Phenotype (MP)abnormal humoral immune response0.05904InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.09072InformativeInherited
Mammalian Phenotype (MP)abnormal lymph node morphology0.1162InformativeInherited
Mammalian Phenotype (MP)abnormal cranium morphology0.1492InformativeInherited
Mammalian Phenotype (MP)abnormal circulating amino acid level0.153InformativeInherited
Mammalian Phenotype (MP)abnormal B cell physiology0.2299InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin level0.4419InformativeInherited
Mammalian Phenotype (MP)abnormal respiration0.8676InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to autoimmune disorder1.06e-08Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland development3.4e-07Highly InformativeDirect
Mammalian Phenotype (MP)decreased interleukin-10 secretion4.441e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal alveolar process morphology4.62e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal intestinal mucosa morphology5.233e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal glial cell physiology6.697e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal airway responsiveness8.579e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal level of surface class II molecules0.0001377Highly InformativeDirect
Mammalian Phenotype (MP)colitis0.0007257Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mesenteric lymph node morphology0.00125Highly InformativeInherited
Mammalian Phenotype (MP)respiratory system inflammation0.005419Highly InformativeInherited
Mammalian Phenotype (MP)abnormal circulating interleukin-17 level0.03357Highly InformativeInherited
Mammalian Phenotype (MP)abnormal ovulation cycle0.07402Highly InformativeInherited
Mammalian Phenotype (MP)abnormal dendritic cell number0.1075Highly InformativeInherited
Mammalian Phenotype (MP)abnormal immunoglobulin level0.1969Highly InformativeInherited

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processHost-virus interaction0.6135Moderately InformativeInherited
Biological processInflammatory response1.981e-07InformativeDirect
Biological processCell adhesion5.264e-06InformativeDirect
Biological processViral immunoevasion0.008888InformativeInherited
Biological processAcute phase0Highly InformativeDirect
Biological processAntiviral defense0Highly InformativeDirect
Biological processGrowth regulation0Highly InformativeDirect
Biological processAdaptive immunity0Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Coding sequence diversityPolymorphism0.0001013Moderately InformativeDirect
DiseaseObesity0InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionZinc2.66e-07Least InformativeDirect
Post-translational modificationGrowth factor0InformativeDirect
Post-translational modificationCytokine0Highly InformativeDirect
Post-translational modificationHormone0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR009079 SSF47266 Protein matches
Abstract

These domains display a core structure consisting of a closed bundle of four helices in a left-handed twist, with two crossover connections. Proteins containing such domains include long-chain cytokines, such as leukaemia inhibitory factor (LIF) [PubMed14511776], the growth hormone somatotropin [PubMed14507421], interleukin-6 [PubMed9118960] and leptin [PubMed9144295]; short-chain cytokines, such as erythropoietin [PubMed9783743], stem cell factor (SCF) [PubMed10880433], macrophage colony-stimulating factor (M-CSF) and interleukin-2, -3, -4, -5 and -13; and interferons/interleukin-10.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 43 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a 4-helical cytokines domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 43 hidden Markov models representing the 4-helical cytokines superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]