SUPERFAMILY 1.75 HMM library and genome assignments server


4-helical cytokines superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   4-helical cytokines [ 47265]
Superfamily:   4-helical cytokines [ 47266] (3)
Families:   Long-chain cytokines [ 47267] (9)
  Short-chain cytokines [ 47286] (13)
  Interferons/interleukin-10 (IL-10) [ 47305] (8)


Superfamily statistics
Genomes (63) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,635 0 79
Proteins 2,615 0 77


Functional annotation
General category Processes_EC
Detailed category Immune response

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process00Least InformativeDirect
Biological Process (BP)developmental process4.664e-142.271e-14Least InformativeDirect
Biological Process (BP)single-organism cellular process1.435e-083.929e-07Least InformativeDirect
Biological Process (BP)response to stimulus00Least InformativeDirect
Biological Process (BP)regulation of cellular process0.0033950.03507Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.0037681Least InformativeInherited
Biological Process (BP)biosynthetic process0.011360.6228Least InformativeInherited
Biological Process (BP)regulation of metabolic process3.037e-080.008977Least InformativeInherited
Biological Process (BP)protein metabolic process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)localization11Least InformativeInherited
Biological Process (BP)immune system process00Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process00Moderately InformativeDirect
Biological Process (BP)response to organic substance5.952e-140Moderately InformativeDirect
Biological Process (BP)cell differentiation00Moderately InformativeDirect
Biological Process (BP)regulation of localization8.747e-075.067e-13Moderately InformativeDirect
Biological Process (BP)positive regulation of molecular function5.28e-068.814e-07Moderately InformativeDirect
Biological Process (BP)single-organism developmental process5.558e-061.754e-09Moderately InformativeDirect
Biological Process (BP)organ development4.874e-073.089e-12Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process00Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process5.869e-105.868e-06Moderately InformativeDirect
Biological Process (BP)regulation of developmental process9.126e-135.067e-13Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process00Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process00Moderately InformativeDirect
Biological Process (BP)multi-organism process00Moderately InformativeDirect
Biological Process (BP)regulation of signal transduction0.97031Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound10.3826Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus11Moderately InformativeInherited
Biological Process (BP)tissue development0.93011Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.0059670.02106Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.38111Moderately InformativeInherited
Biological Process (BP)homeostatic process0.91620.3987Moderately InformativeInherited
Biological Process (BP)nervous system development11Moderately InformativeInherited
Biological Process (BP)regulation of biosynthetic process1.352e-070.6373Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10Moderately InformativeInherited
Biological Process (BP)cellular response to stress11Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.094040.9074Moderately InformativeInherited
Biological Process (BP)cellular localization11Moderately InformativeInherited
Biological Process (BP)signal transduction0.030210.002678Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.1520.02069Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.95321Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process11Moderately InformativeInherited
Biological Process (BP)organic substance transport0.5820.05413Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.07912.959e-07Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process0.030950.4086Moderately InformativeInherited
Biological Process (BP)reproduction0.19650.03227Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.10221Moderately InformativeInherited
Biological Process (BP)regulation of cytokine production00InformativeDirect
Biological Process (BP)positive regulation of immune system process1.384e-053.897e-11InformativeDirect
Biological Process (BP)regulation of immune effector process9.589e-155.462e-10InformativeDirect
Biological Process (BP)defense response00InformativeDirect
Biological Process (BP)immune response1.41e-070InformativeDirect
Biological Process (BP)response to wounding8.358e-143.911e-13InformativeDirect
Biological Process (BP)positive regulation of signal transduction1.881e-052.707e-13InformativeDirect
Biological Process (BP)positive regulation of macromolecule biosynthetic process1.431e-131.498e-06InformativeDirect
Biological Process (BP)regulation of intracellular protein kinase cascade3.018e-081.652e-11InformativeDirect
Biological Process (BP)positive regulation of gene expression1.834e-101.213e-05InformativeDirect
Biological Process (BP)programmed cell death00InformativeDirect
Biological Process (BP)positive regulation of cellular biosynthetic process6.556e-100.0001844InformativeDirect
Biological Process (BP)positive regulation of protein modification process3.198e-080InformativeDirect
Biological Process (BP)response to nutrient levels2.317e-088.495e-06InformativeDirect
Biological Process (BP)response to lipid6.415e-074.434e-09InformativeDirect
Biological Process (BP)response to cytokine stimulus4.996e-087.468e-11InformativeDirect
Biological Process (BP)regulation of cell proliferation00InformativeDirect
Biological Process (BP)leukocyte activation1.343e-071.922e-15InformativeDirect
Biological Process (BP)positive regulation of phosphate metabolic process2.612e-110InformativeDirect
Biological Process (BP)hematopoietic or lymphoid organ development00InformativeDirect
Biological Process (BP)regulation of immune response3.242e-101.222e-12InformativeDirect
Biological Process (BP)regulation of body fluid levels1.305e-064.718e-05InformativeDirect
Biological Process (BP)regulation of secretion00InformativeDirect
Biological Process (BP)positive regulation of transport1.588e-081.822e-08InformativeDirect
Biological Process (BP)positive regulation of developmental process1.406e-057.658e-11InformativeDirect
Biological Process (BP)positive regulation of nitrogen compound metabolic process5.772e-117.768e-06InformativeDirect
Biological Process (BP)positive regulation of multicellular organismal process5.416e-054.205e-07InformativeDirect
Biological Process (BP)response to other organism2.543e-123.791e-07InformativeDirect
Biological Process (BP)negative regulation of cell communication0.99541InformativeInherited
Biological Process (BP)negative regulation of signaling0.92941InformativeInherited
Biological Process (BP)regulation of apoptotic process0.017820.00451InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.5230.1318InformativeInherited
Biological Process (BP)response to organic cyclic compound0.00039080.01272InformativeInherited
Biological Process (BP)regulation of establishment of protein localization0.015010.01707InformativeInherited
Biological Process (BP)regulation of lipid metabolic process0.74290.4332InformativeInherited
Biological Process (BP)generation of neurons1.964e-060.009107InformativeInherited
Biological Process (BP)regulation of cell development11InformativeInherited
Biological Process (BP)response to hormone stimulus0.040170.004261InformativeInherited
Biological Process (BP)negative regulation of cell death0.00912.366e-06InformativeInherited
Biological Process (BP)regulation of cell cycle process0.32310.5028InformativeInherited
Biological Process (BP)regulation of growth0.035340.001829InformativeInherited
Biological Process (BP)negative regulation of protein metabolic process0.25080.009828InformativeInherited
Biological Process (BP)negative regulation of biosynthetic process11InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.00060090.2492InformativeInherited
Biological Process (BP)regulation of response to external stimulus0.080230.01731InformativeInherited
Biological Process (BP)regulation of nervous system development11InformativeInherited
Biological Process (BP)regulation of system process11InformativeInherited
Biological Process (BP)regulation of response to stress0.025230.3363InformativeInherited
Biological Process (BP)regulation of cellular catabolic process0.022720.01667InformativeInherited
Biological Process (BP)cellular component movement0.10160.872InformativeInherited
Biological Process (BP)locomotion0.00071040.2659InformativeInherited
Biological Process (BP)localization of cell2.281e-050.002504InformativeInherited
Biological Process (BP)cell-cell signaling0.062740.68InformativeInherited
Biological Process (BP)secretion by cell0.44010.2119InformativeInherited
Biological Process (BP)peptidyl-amino acid modification0.033650.1355InformativeInherited
Biological Process (BP)phosphorylation0.27040.8009InformativeInherited
Biological Process (BP)regulation of hormone levels0.98410.2127InformativeInherited
Biological Process (BP)single-organism behavior0.50581InformativeInherited
Biological Process (BP)alcohol metabolic process0.0021660.1115InformativeInherited
Biological Process (BP)single organism reproductive process0.18180.5939InformativeInherited
Biological Process (BP)intracellular signal transduction10.9589InformativeInherited
Biological Process (BP)nitrogen compound transport0.4230.09697InformativeInherited
Biological Process (BP)immune effector process0.0018172.548e-11InformativeInherited
Biological Process (BP)regulation of protein phosphorylation0.0132.358e-05InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching0.018850.3436InformativeInherited
Biological Process (BP)embryonic organ development0.010510.3185InformativeInherited
Biological Process (BP)negative regulation of immune system process00Highly InformativeDirect
Biological Process (BP)regulation of production of molecular mediator of immune response3.986e-090Highly InformativeDirect
Biological Process (BP)regulation of lymphocyte mediated immunity00Highly InformativeDirect
Biological Process (BP)regulation of adaptive immune response based on somatic recombination of immune receptors built from00Highly InformativeDirect
Biological Process (BP)inflammatory response2.508e-068.213e-07Highly InformativeDirect
Biological Process (BP)hemostasis00.0009172Highly InformativeDirect
Biological Process (BP)negative regulation of cell proliferation3.5e-103.392e-08Highly InformativeDirect
Biological Process (BP)response to virus6.803e-092.347e-07Highly InformativeDirect
Biological Process (BP)hormone transport0.00028846.013e-07Highly InformativeDirect
Biological Process (BP)peptidyl-tyrosine modification0.0001620.0004339Highly InformativeDirect
Biological Process (BP)cytokine-mediated signaling pathway2.243e-113.151e-13Highly InformativeDirect
Biological Process (BP)regulation of proteolysis0.00018982.805e-05Highly InformativeDirect
Biological Process (BP)negative regulation of cellular catabolic process00Highly InformativeDirect
Biological Process (BP)regulation of cell killing0.0001910.0004684Highly InformativeDirect
Biological Process (BP)response to corticosteroid stimulus1.59e-061.622e-08Highly InformativeDirect
Biological Process (BP)negative regulation of response to external stimulus4.295e-082.549e-10Highly InformativeDirect
Biological Process (BP)response to lipopolysaccharide3.617e-051.124e-08Highly InformativeDirect
Biological Process (BP)regulation of interleukin-1 beta production1.863e-079.045e-07Highly InformativeDirect
Biological Process (BP)regulation of cytokine biosynthetic process5.504e-083.324e-10Highly InformativeDirect
Biological Process (BP)regulation of protein catabolic process5.319e-082.345e-06Highly InformativeDirect
Biological Process (BP)amide transport0.00050759.531e-06Highly InformativeDirect
Biological Process (BP)regulation of multi-organism process1.154e-060.0002186Highly InformativeDirect
Biological Process (BP)regulation of nitric oxide biosynthetic process1.198e-052.662e-10Highly InformativeDirect
Biological Process (BP)positive regulation of cell differentiation4.294e-080Highly InformativeDirect
Biological Process (BP)regulation of myeloid cell differentiation1.768e-060Highly InformativeDirect
Biological Process (BP)positive regulation of transcription, DNA-dependent3.3e-156.006e-12Highly InformativeDirect
Biological Process (BP)alpha-beta T cell activation0.00051590Highly InformativeDirect
Biological Process (BP)regulation of cytokine secretion5.248e-061.598e-06Highly InformativeDirect
Biological Process (BP)positive regulation of protein secretion00Highly InformativeDirect
Biological Process (BP)positive regulation of peptidyl-tyrosine phosphorylation00Highly InformativeDirect
Biological Process (BP)regulation of steroid biosynthetic process8.611e-069.054e-06Highly InformativeDirect
Biological Process (BP)coagulation3.04e-081.573e-06Highly InformativeDirect
Biological Process (BP)positive regulation of cell activation00Highly InformativeDirect
Biological Process (BP)negative regulation of secretion1.93e-071.661e-09Highly InformativeDirect
Biological Process (BP)regulation of DNA metabolic process3.711e-119.375e-11Highly InformativeDirect
Biological Process (BP)positive regulation of sequence-specific DNA binding transcription factor activity02.263e-12Highly InformativeDirect
Biological Process (BP)negative regulation of protein transport3.482e-050.0002094Highly InformativeDirect
Biological Process (BP)negative regulation of multicellular organismal process1.707e-152.336e-13Highly InformativeDirect
Biological Process (BP)leukocyte proliferation2.613e-058.009e-07Highly InformativeDirect
Biological Process (BP)positive regulation of leukocyte proliferation1.23e-064.632e-11Highly InformativeDirect
Biological Process (BP)cellular response to biotic stimulus7.811e-054.217e-06Highly InformativeDirect
Biological Process (BP)extrinsic apoptotic signaling pathway8.719e-111.077e-14Highly InformativeDirect
Biological Process (BP)regulation of leukocyte differentiation3.196e-110Highly InformativeDirect
Biological Process (BP)negative regulation of apoptotic signaling pathway0.0009060.0001318Highly InformativeDirect
Biological Process (BP)regulation of T cell activation11Highly InformativeInherited
Biological Process (BP)connective tissue development0.011471.925e-06Highly InformativeInherited
Biological Process (BP)regulation of innate immune response0.76581Highly InformativeInherited
Biological Process (BP)regulation of mononuclear cell proliferation0.98981Highly InformativeInherited
Biological Process (BP)regulation of reproductive process0.53610.7213Highly InformativeInherited
Biological Process (BP)negative regulation of growth0.69390.63Highly InformativeInherited
Biological Process (BP)T cell differentiation0.18960.001607Highly InformativeInherited
Biological Process (BP)cell fate commitment0.18397.366e-08Highly InformativeInherited
Biological Process (BP)response to topologically incorrect protein0.16260.4418Highly InformativeInherited
Biological Process (BP)innate immune response11Highly InformativeInherited
Biological Process (BP)regulation of toll-like receptor signaling pathway0.003330.01062Highly InformativeInherited
Biological Process (BP)negative regulation of apoptotic process10.9937Highly InformativeInherited
Biological Process (BP)positive regulation of cytokine production0.031860.001072Highly InformativeInherited
Biological Process (BP)regulation of response to nutrient levels11Highly InformativeInherited
Biological Process (BP)regulation of ion homeostasis11Highly InformativeInherited
Biological Process (BP)ER-nucleus signaling pathway0.009320.1288Highly InformativeInherited
Biological Process (BP)response to endoplasmic reticulum stress7.154e-050.007294Highly InformativeInherited
Biological Process (BP)chemotaxis0.45041Highly InformativeInherited
Biological Process (BP)leukocyte migration0.28490.4149Highly InformativeInherited
Biological Process (BP)signal release0.0018080.0001075Highly InformativeInherited
Biological Process (BP)protein phosphorylation0.077490.4797Highly InformativeInherited
Biological Process (BP)regulation of cellular carbohydrate metabolic process0.28480.08557Highly InformativeInherited
Biological Process (BP)adult behavior0.00068870.035Highly InformativeInherited
Biological Process (BP)sterol metabolic process0.00026510.007887Highly InformativeInherited
Biological Process (BP)wound healing0.74411Highly InformativeInherited
Biological Process (BP)female pregnancy8.667e-080.00428Highly InformativeInherited
Biological Process (BP)cell-type specific apoptotic process0.029370.007209Highly InformativeInherited
Biological Process (BP)positive regulation of programmed cell death5.501e-050.001219Highly InformativeInherited
Biological Process (BP)leukocyte activation involved in immune response0.041641.231e-10Highly InformativeInherited
Biological Process (BP)placenta development2.387e-050.003Highly InformativeInherited
Biological Process (BP)leukocyte homeostasis0.014860.027Highly InformativeInherited
Molecular Function (MF)binding00Least InformativeDirect
Molecular Function (MF)receptor binding00InformativeDirect
Molecular Function (MF)cytokine activity4.888e-080Highly InformativeDirect
Molecular Function (MF)cytokine receptor binding2.188e-060Highly InformativeDirect
Molecular Function (MF)growth factor receptor binding0.00022080.0001198Highly InformativeDirect
Cellular Component (CC)membrane11Least InformativeInherited
Cellular Component (CC)extracellular region part00Moderately InformativeDirect
Cellular Component (CC)plasma membrane0.1450.9037Moderately InformativeInherited
Cellular Component (CC)cell surface4.479e-124.329e-06InformativeDirect
Cellular Component (CC)external side of plasma membrane1.996e-103.05e-09Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 2.271e-14 Least Informative Direct
Biological Process (BP) single-organism cellular process 3.929e-07 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.03507 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.6228 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.008977 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) response to organic substance 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 5.067e-13 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 8.814e-07 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 1.754e-09 Moderately Informative Direct
Biological Process (BP) organ development 3.089e-12 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 5.868e-06 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 2.959e-07 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 5.067e-13 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.3826 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.03227 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.02106 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.3987 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.6373 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.002678 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.7652 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.9074 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.02069 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.05413 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.4086 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cytokine production 0 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 2.358e-05 Informative Direct
Biological Process (BP) immune effector process 2.548e-11 Informative Direct
Biological Process (BP) positive regulation of immune system process 3.897e-11 Informative Direct
Biological Process (BP) regulation of immune effector process 5.462e-10 Informative Direct
Biological Process (BP) defense response 0 Informative Direct
Biological Process (BP) immune response 0 Informative Direct
Biological Process (BP) response to wounding 3.911e-13 Informative Direct
Biological Process (BP) positive regulation of signal transduction 2.707e-13 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1.498e-06 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 1.652e-11 Informative Direct
Biological Process (BP) positive regulation of gene expression 1.213e-05 Informative Direct
Biological Process (BP) programmed cell death 0 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.0001844 Informative Direct
Biological Process (BP) positive regulation of protein modification process 0 Informative Direct
Biological Process (BP) response to nutrient levels 8.495e-06 Informative Direct
Biological Process (BP) response to lipid 4.434e-09 Informative Direct
Biological Process (BP) response to cytokine stimulus 7.468e-11 Informative Direct
Biological Process (BP) regulation of cell proliferation 0 Informative Direct
Biological Process (BP) leukocyte activation 1.922e-15 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0 Informative Direct
Biological Process (BP) gland development 0.0007359 Informative Direct
Biological Process (BP) regulation of immune response 1.222e-12 Informative Direct
Biological Process (BP) regulation of body fluid levels 4.718e-05 Informative Direct
Biological Process (BP) regulation of secretion 0 Informative Direct
Biological Process (BP) positive regulation of transport 1.822e-08 Informative Direct
Biological Process (BP) positive regulation of developmental process 7.658e-11 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 7.768e-06 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 4.205e-07 Informative Direct
Biological Process (BP) response to other organism 3.791e-07 Informative Direct
Biological Process (BP) negative regulation of cell death 2.366e-06 Informative Direct
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.00451 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.1318 Informative Inherited
Biological Process (BP) growth 0.5149 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.2159 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.907 Informative Inherited
Biological Process (BP) epithelium development 0.719 Informative Inherited
Biological Process (BP) tube development 0.3917 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.01272 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.02992 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.4332 Informative Inherited
Biological Process (BP) generation of neurons 0.009107 Informative Inherited
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.004261 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.5028 Informative Inherited
Biological Process (BP) regulation of growth 0.001829 Informative Inherited
Biological Process (BP) regulation of locomotion 0.0429 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.04325 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.1355 Informative Inherited
Biological Process (BP) phosphorylation 0.8009 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.9589 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.009828 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) protein localization to organelle 0.00511 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.2492 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.01731 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) regulation of response to stress 0.3363 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.01667 Informative Inherited
Biological Process (BP) cellular component movement 0.872 Informative Inherited
Biological Process (BP) locomotion 0.2659 Informative Inherited
Biological Process (BP) localization of cell 0.002504 Informative Inherited
Biological Process (BP) cell-cell signaling 0.68 Informative Inherited
Biological Process (BP) secretion by cell 0.2119 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.2127 Informative Inherited
Biological Process (BP) single-organism behavior 1 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.1115 Informative Inherited
Biological Process (BP) single organism reproductive process 0.5939 Informative Inherited
Biological Process (BP) protein transport 0.3658 Informative Inherited
Biological Process (BP) nitrogen compound transport 0.09697 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.01707 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.3436 Informative Inherited
Biological Process (BP) embryonic organ development 0.3185 Informative Inherited
Biological Process (BP) leukocyte activation involved in immune response 1.231e-10 Highly Informative Direct
Biological Process (BP) negative regulation of immune system process 0 Highly Informative Direct
Biological Process (BP) regulation of production of molecular mediator of immune response 0 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte mediated immunity 0 Highly Informative Direct
Biological Process (BP) regulation of adaptive immune response based on somatic recombination of immune receptors built from 0 Highly Informative Direct
Biological Process (BP) inflammatory response 8.213e-07 Highly Informative Direct
Biological Process (BP) hemostasis 0.0009172 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 3.392e-08 Highly Informative Direct
Biological Process (BP) response to virus 2.347e-07 Highly Informative Direct
Biological Process (BP) hormone transport 6.013e-07 Highly Informative Direct
Biological Process (BP) protein import 4.678e-06 Highly Informative Direct
Biological Process (BP) peptidyl-tyrosine modification 0.0004339 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 3.151e-13 Highly Informative Direct
Biological Process (BP) signal release 0.0001075 Highly Informative Direct
Biological Process (BP) regulation of proteolysis 2.805e-05 Highly Informative Direct
Biological Process (BP) negative regulation of cellular catabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of cell killing 0.0004684 Highly Informative Direct
Biological Process (BP) response to corticosteroid stimulus 1.622e-08 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 2.549e-10 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 1.124e-08 Highly Informative Direct
Biological Process (BP) regulation of interleukin-1 beta production 9.045e-07 Highly Informative Direct
Biological Process (BP) protein localization to nucleus 2.047e-06 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 3.324e-10 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 2.345e-06 Highly Informative Direct
Biological Process (BP) amide transport 9.531e-06 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 0.0002186 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 2.83e-07 Highly Informative Direct
Biological Process (BP) cell fate commitment 7.366e-08 Highly Informative Direct
Biological Process (BP) regulation of nitric oxide biosynthetic process 2.662e-10 Highly Informative Direct
Biological Process (BP) positive regulation of cell differentiation 0 Highly Informative Direct
Biological Process (BP) regulation of myeloid cell differentiation 0 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 6.006e-12 Highly Informative Direct
Biological Process (BP) alpha-beta T cell activation 0 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 0.000855 Highly Informative Direct
Biological Process (BP) regulation of cytokine secretion 1.598e-06 Highly Informative Direct
Biological Process (BP) positive regulation of protein secretion 0 Highly Informative Direct
Biological Process (BP) positive regulation of peptidyl-tyrosine phosphorylation 0 Highly Informative Direct
Biological Process (BP) regulation of steroid biosynthetic process 9.054e-06 Highly Informative Direct
Biological Process (BP) coagulation 1.573e-06 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 0 Highly Informative Direct
Biological Process (BP) negative regulation of secretion 1.661e-09 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 9.375e-11 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 2.263e-12 Highly Informative Direct
Biological Process (BP) nuclear import 3.554e-07 Highly Informative Direct
Biological Process (BP) negative regulation of protein transport 0.0002094 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 2.336e-13 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 3.116e-05 Highly Informative Direct
Biological Process (BP) connective tissue development 1.925e-06 Highly Informative Direct
Biological Process (BP) leukocyte proliferation 8.009e-07 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 4.632e-11 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 4.217e-06 Highly Informative Direct
Biological Process (BP) extrinsic apoptotic signaling pathway 1.077e-14 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 0 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic signaling pathway 0.0001318 Highly Informative Direct
Biological Process (BP) regulation of T cell activation 1 Highly Informative Inherited
Biological Process (BP) developmental growth 0.7789 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 0.2815 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 1 Highly Informative Inherited
Biological Process (BP) regulation of mononuclear cell proliferation 1 Highly Informative Inherited
Biological Process (BP) tissue homeostasis 0.0393 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.7213 Highly Informative Inherited
Biological Process (BP) negative regulation of growth 0.63 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.001607 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 0.4797 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.3471 Highly Informative Inherited
Biological Process (BP) response to topologically incorrect protein 0.4418 Highly Informative Inherited
Biological Process (BP) innate immune response 1 Highly Informative Inherited
Biological Process (BP) regulation of toll-like receptor signaling pathway 0.01062 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.9937 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.001072 Highly Informative Inherited
Biological Process (BP) regulation of response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 1 Highly Informative Inherited
Biological Process (BP) ER-nucleus signaling pathway 0.1288 Highly Informative Inherited
Biological Process (BP) response to endoplasmic reticulum stress 0.007294 Highly Informative Inherited
Biological Process (BP) chemotaxis 1 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.4149 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.08557 Highly Informative Inherited
Biological Process (BP) adult behavior 0.035 Highly Informative Inherited
Biological Process (BP) sterol metabolic process 0.007887 Highly Informative Inherited
Biological Process (BP) wound healing 1 Highly Informative Inherited
Biological Process (BP) female pregnancy 0.00428 Highly Informative Inherited
Biological Process (BP) cell-type specific apoptotic process 0.007209 Highly Informative Inherited
Biological Process (BP) positive regulation of programmed cell death 0.001219 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.1069 Highly Informative Inherited
Biological Process (BP) placenta development 0.003 Highly Informative Inherited
Biological Process (BP) leukocyte homeostasis 0.027 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) cytokine activity 0 Highly Informative Direct
Molecular Function (MF) cytokine receptor binding 0 Highly Informative Direct
Molecular Function (MF) growth factor receptor binding 0.0001198 Highly Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0.3394 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.9037 Moderately Informative Inherited
Cellular Component (CC) cell surface 4.329e-06 Informative Direct
Cellular Component (CC) secretory granule 2.842e-07 Informative Direct
Cellular Component (CC) external side of plasma membrane 3.05e-09 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease1.63e-06Least InformativeDirect
Disease Ontology (DO)organ system cancer0.0002058Least InformativeDirect
Disease Ontology (DO)nervous system disease0.1919Least InformativeInherited
Disease Ontology (DO)lung disease3.825e-12Moderately InformativeDirect
Disease Ontology (DO)skin disease1.638e-07Moderately InformativeDirect
Disease Ontology (DO)hematologic cancer3.92e-07Moderately InformativeDirect
Disease Ontology (DO)gastrointestinal system disease7.999e-06Moderately InformativeDirect
Disease Ontology (DO)syndrome0.000123Moderately InformativeDirect
Disease Ontology (DO)disease of metabolism0.0004026Moderately InformativeDirect
Disease Ontology (DO)musculoskeletal system disease0.001143Moderately InformativeInherited
Disease Ontology (DO)urinary system disease0.002241Moderately InformativeInherited
Disease Ontology (DO)bacterial infectious disease0.02027Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.02581Moderately InformativeInherited
Disease Ontology (DO)disease of mental health0.151Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.3644Moderately InformativeInherited
Disease Ontology (DO)sensory system disease0.6734Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.857Moderately InformativeInherited
Disease Ontology (DO)multiple sclerosis1.201e-07InformativeDirect
Disease Ontology (DO)inflammatory bowel disease1.253e-07InformativeDirect
Disease Ontology (DO)hemorrhagic disease2.189e-07InformativeDirect
Disease Ontology (DO)allergic rhinitis1.418e-06InformativeDirect
Disease Ontology (DO)opportunistic mycosis2.028e-06InformativeDirect
Disease Ontology (DO)familial hyperlipidemia0.0009779InformativeDirect
Disease Ontology (DO)connective tissue cancer0.01916InformativeInherited
Disease Ontology (DO)schizophrenia0.05565InformativeInherited
Disease Ontology (DO)auditory system disease0.05825InformativeInherited
Disease Ontology (DO)muscular disease0.05889InformativeInherited
Disease Ontology (DO)kidney failure0.08704InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type IV disease0.1016InformativeInherited
Disease Ontology (DO)lymphoma0.1189InformativeInherited
Disease Ontology (DO)developmental disorder of mental health0.1292InformativeInherited
Disease Ontology (DO)parasitic helminthiasis infectious disease0.1421InformativeInherited
Disease Ontology (DO)primary immunodeficiency disease0.2676InformativeInherited
Disease Ontology (DO)viral infectious disease0.3542InformativeInherited
Disease Ontology (DO)esophageal disease0.4428InformativeInherited
Disease Ontology (DO)arthritis0.9133InformativeInherited
Disease Ontology (DO)glucose metabolism disease1InformativeInherited
Disease Ontology (DO)rheumatoid arthritis8.04e-07Highly InformativeDirect
Disease Ontology (DO)agammaglobulinemia4.774e-05Highly InformativeDirect
Disease Ontology (DO)sarcoidosis0.0001021Highly InformativeDirect
Disease Ontology (DO)otitis media0.0001174Highly InformativeDirect
Disease Ontology (DO)aggressive systemic mastocytosis0.0003438Highly InformativeDirect
Disease Ontology (DO)pertussis0.0007509Highly InformativeDirect
Disease Ontology (DO)eating disorder0.003504Highly InformativeInherited

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype3.937e-05Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.0001611Least InformativeDirect
Mammalian Phenotype (MP)abnormal homeostasis0.2727Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.3244Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body phenotype0.4235Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.8062Least InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection1.605e-08Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level2.194e-05Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.0001277Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.0005077Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype0.001895Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.004202Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.005357Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.006684Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.01115Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.01439Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.03124Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.1407Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.1443Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.1673Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.172Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.1812Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.201Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.4014Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.5337Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.6414Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)increased susceptibility to infection1.004e-09InformativeDirect
Mammalian Phenotype (MP)autoimmune response1.278e-07InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland morphology3.435e-05InformativeDirect
Mammalian Phenotype (MP)abnormal female reproductive system physiology0.0007722InformativeDirect
Mammalian Phenotype (MP)abnormal circulating cytokine level0.001117InformativeInherited
Mammalian Phenotype (MP)abnormal antigen presentation0.001564InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system physiology0.003491InformativeInherited
Mammalian Phenotype (MP)abnormal intestine morphology0.02138InformativeInherited
Mammalian Phenotype (MP)abnormal humoral immune response0.05763InformativeInherited
Mammalian Phenotype (MP)abnormal hepatobiliary system physiology0.06468InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.0886InformativeInherited
Mammalian Phenotype (MP)abnormal lymph node morphology0.1141InformativeInherited
Mammalian Phenotype (MP)abnormal cranium morphology0.1508InformativeInherited
Mammalian Phenotype (MP)abnormal circulating amino acid level0.1538InformativeInherited
Mammalian Phenotype (MP)abnormal B cell physiology0.2262InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin level0.4457InformativeInherited
Mammalian Phenotype (MP)abnormal respiration0.8696InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to autoimmune disorder9.92e-09Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland development3.323e-07Highly InformativeDirect
Mammalian Phenotype (MP)decreased interleukin-10 secretion4.06e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal alveolar process morphology4.722e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal intestinal mucosa morphology5.043e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal glial cell physiology6.883e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal airway responsiveness8.796e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal level of surface class II molecules0.0001406Highly InformativeDirect
Mammalian Phenotype (MP)colitis0.0007433Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mesenteric lymph node morphology0.00128Highly InformativeInherited
Mammalian Phenotype (MP)respiratory system inflammation0.005267Highly InformativeInherited
Mammalian Phenotype (MP)abnormal circulating interleukin-17 level0.03015Highly InformativeInherited
Mammalian Phenotype (MP)abnormal ovulation cycle0.0725Highly InformativeInherited
Mammalian Phenotype (MP)abnormal dendritic cell number0.1092Highly InformativeInherited

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processHost-virus interaction0.6147Moderately InformativeInherited
Biological processInflammatory response2.007e-07InformativeDirect
Biological processCell adhesion5.355e-06InformativeDirect
Biological processViral immunoevasion0.008953InformativeInherited
Biological processAcute phase0Highly InformativeDirect
Biological processAntiviral defense0Highly InformativeDirect
Biological processGrowth regulation0Highly InformativeDirect
Biological processAdaptive immunity0Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Coding sequence diversityPolymorphism0.0001014Moderately InformativeDirect
DiseaseObesity0InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionZinc2.748e-07Least InformativeDirect
Post-translational modificationGrowth factor0InformativeDirect
Post-translational modificationCytokine0Highly InformativeDirect
Post-translational modificationHormone0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR009079 SSF47266 Protein matches
Abstract

These domains display a core structure consisting of a closed bundle of four helices in a left-handed twist, with two crossover connections. Proteins containing such domains include long-chain cytokines, such as leukaemia inhibitory factor (LIF) [PubMed14511776], the growth hormone somatotropin [PubMed14507421], interleukin-6 [PubMed9118960] and leptin [PubMed9144295]; short-chain cytokines, such as erythropoietin [PubMed9783743], stem cell factor (SCF) [PubMed10880433], macrophage colony-stimulating factor (M-CSF) and interleukin-2, -3, -4, -5 and -13; and interferons/interleukin-10.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 43 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a 4-helical cytokines domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 43 hidden Markov models representing the 4-helical cytokines superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]