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Histidine-containing phosphotransfer domain, HPT domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Four-helical up-and-down bundle [ 47161] (28)
Superfamily:   Histidine-containing phosphotransfer domain, HPT domain [ 47226] (6)
Families:   Aerobic respiration control sensor protein, ArcB [ 47227]
  Phosphorelay protein-like [ 47230] (3)
  Chemotaxis protein CheA P1 domain [ 63512]
  Sensor-like histidine kinase YojN, C-terminal domain [ 116868]
  Phosphorelay protein luxU [ 116871]
  SphA-like [ 158394]


Superfamily statistics
Genomes (1,899) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 8,941 44,306 13
Proteins 7,965 38,844 13


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.00055290.0006247Least InformativeDirect
Biological Process (BP)response to stimulus0.011450.0000001453Least InformativeInherited
Biological Process (BP)single-organism cellular process0.032140.02128Least InformativeInherited
Biological Process (BP)signal transduction0.000023390.000000000388Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus0.058930.7602Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.0015230.4425Moderately InformativeInherited
Biological Process (BP)response to organic substance0.0016211Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.0015450.000000002962Moderately InformativeInherited
Biological Process (BP)phosphorylation0.00000087030InformativeDirect
Biological Process (BP)response to hormone stimulus0.0000096150.01624InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus0.0000030630.001546InformativeInherited
Biological Process (BP)response to cytokinin stimulus0.0000000000074450.000000001195Highly InformativeDirect
Biological Process (BP)hormone-mediated signaling pathway0.000016220.002135Highly InformativeInherited
Molecular Function (MF)transferase activity0.0000028130Least InformativeDirect
Molecular Function (MF)binding0.60271Least InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups0.00000000007490Moderately InformativeDirect
Molecular Function (MF)enzyme binding0.00000019950.0006714InformativeDirect
Molecular Function (MF)molecular transducer activity0.00000000074080InformativeDirect
Molecular Function (MF)kinase activity0.51380.1223InformativeInherited
Molecular Function (MF)kinase binding0.0000000003620.000002346Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0.0006247 Least Informative Direct
Biological Process (BP) response to stimulus 0.0000001453 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.02128 Least Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.000000002962 Moderately Informative Direct
Biological Process (BP) signal transduction 0.000000000388 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.7602 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.4425 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) locomotion 0.0000354 Informative Direct
Biological Process (BP) response to hormone stimulus 0.01624 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.001546 Informative Inherited
Biological Process (BP) chemotaxis 0.0006099 Highly Informative Direct
Biological Process (BP) response to cytokinin stimulus 0.000000001195 Highly Informative Direct
Biological Process (BP) hormone-mediated signaling pathway 0.002135 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) receptor activity 0.00001207 Informative Direct
Molecular Function (MF) enzyme binding 0.0006714 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) kinase activity 0.1223 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) kinase binding 0.000002346 Highly Informative Direct
Molecular Function (MF) protein kinase activity 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-histidine kinases0InformativeDirect

Document: EC annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)flower0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processChemotaxis0InformativeDirect
Biological processVirulence0.0000004341InformativeDirect
Biological processTwo-component regulatory system0Highly InformativeDirect
Cellular componentMembrane0.002156Least InformativeInherited
Cellular componentCell membrane0.00001758Moderately InformativeDirect
Cellular componentCell inner membrane0.0000007961InformativeDirect
DomainTransmembrane0.0000007214Least InformativeDirect
Molecular functionNucleotide-binding0.0000000005843Least InformativeDirect
Molecular functionATP-binding0.000000000006302Moderately InformativeDirect
Post-translational modificationTransferase0.00000000002061Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008207 SSF47226 Protein matches
Abstract This domain is present at the N terminus in proteins which undergo autophosphorylation. The group includes, the gliding motility regulatory protein from Myxococcus xanthus and a number of bacterial chemotaxis proteins.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 9 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Histidine-containing phosphotransfer domain, HPT domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 9 hidden Markov models representing the Histidine-containing phosphotransfer domain, HPT domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]