SUPERFAMILY 1.75 HMM library and genome assignments server

Histidine-containing phosphotransfer domain, HPT domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Four-helical up-and-down bundle [ 47161] (28)
Superfamily:   Histidine-containing phosphotransfer domain, HPT domain [ 47226] (6)
Families:   Aerobic respiration control sensor protein, ArcB [ 47227]
  Phosphorelay protein-like [ 47230] (3)
  Chemotaxis protein CheA P1 domain [ 63512]
  Sensor-like histidine kinase YojN, C-terminal domain [ 116868]
  Phosphorelay protein luxU [ 116871]
  SphA-like [ 158394]


Superfamily statistics
Genomes (1,900) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 8,943 44,306 13
Proteins 7,967 38,844 13


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.00058980.0006699Least InformativeDirect
Biological Process (BP)response to stimulus0.011670.000000153Least InformativeInherited
Biological Process (BP)single-organism cellular process0.032340.02174Least InformativeInherited
Biological Process (BP)signal transduction0.000021970.0000000003498Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus0.059920.7693Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.0015310.4445Moderately InformativeInherited
Biological Process (BP)response to organic substance0.0016791Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.00160.0000000029Moderately InformativeInherited
Biological Process (BP)phosphorylation0.00000088330InformativeDirect
Biological Process (BP)response to hormone stimulus0.0000099150.0162InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus0.0000031180.001595InformativeInherited
Biological Process (BP)response to cytokinin stimulus0.0000000000074230.000000001187Highly InformativeDirect
Biological Process (BP)hormone-mediated signaling pathway0.000016280.002202Highly InformativeInherited
Molecular Function (MF)transferase activity0.0000028220Least InformativeDirect
Molecular Function (MF)binding0.60361Least InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups0.000000000074030Moderately InformativeDirect
Molecular Function (MF)enzyme binding0.00000020160.0006908InformativeDirect
Molecular Function (MF)molecular transducer activity0.00000000076960InformativeDirect
Molecular Function (MF)kinase activity0.51330.1207InformativeInherited
Molecular Function (MF)kinase binding0.00000000035930.000002395Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0.0006699 Least Informative Direct
Biological Process (BP) response to stimulus 0.000000153 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.02174 Least Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.0000000029 Moderately Informative Direct
Biological Process (BP) signal transduction 0.0000000003498 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.7693 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.4445 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) locomotion 0.00003504 Informative Direct
Biological Process (BP) response to hormone stimulus 0.0162 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.001595 Informative Inherited
Biological Process (BP) chemotaxis 0.0005788 Highly Informative Direct
Biological Process (BP) response to cytokinin stimulus 0.000000001187 Highly Informative Direct
Biological Process (BP) hormone-mediated signaling pathway 0.002202 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) receptor activity 0.000012 Informative Direct
Molecular Function (MF) enzyme binding 0.0006908 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) kinase activity 0.1207 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) kinase binding 0.000002395 Highly Informative Direct
Molecular Function (MF) protein kinase activity 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-histidine kinases0InformativeDirect

Document: EC annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)flower0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processChemotaxis0InformativeDirect
Biological processVirulence0.0000004345InformativeDirect
Biological processTwo-component regulatory system0Highly InformativeDirect
Cellular componentMembrane0.00219Least InformativeInherited
Cellular componentCell membrane0.00001825Moderately InformativeDirect
Cellular componentCell inner membrane0.0000008285InformativeDirect
DomainTransmembrane0.0000007207Least InformativeDirect
Molecular functionNucleotide-binding0.0000000005801Least InformativeDirect
Molecular functionATP-binding0.000000000006268Moderately InformativeDirect
Post-translational modificationTransferase0.00000000002065Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008207 SSF47226 Protein matches
Abstract This domain is present at the N terminus in proteins which undergo autophosphorylation. The group includes, the gliding motility regulatory protein from Myxococcus xanthus and a number of bacterial chemotaxis proteins.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 9 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Histidine-containing phosphotransfer domain, HPT domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 9 hidden Markov models representing the Histidine-containing phosphotransfer domain, HPT domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]