SUPERFAMILY 1.75 HMM library and genome assignments server

  Home > SCOP hierarchy > Histidine-containing phosphotransfer domain, HPT domain superfamily


Histidine-containing phosphotransfer domain, HPT domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Four-helical up-and-down bundle [ 47161] (28)
Superfamily:   Histidine-containing phosphotransfer domain, HPT domain [ 47226] (6)
Families:   Aerobic respiration control sensor protein, ArcB [ 47227]
  Phosphorelay protein-like [ 47230] (3)
  Chemotaxis protein CheA P1 domain [ 63512]
  Sensor-like histidine kinase YojN, C-terminal domain [ 116868]
  Phosphorelay protein luxU [ 116871]
  SphA-like [ 158394]

 Superfamily statistics
Genomes (1,489) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 6,808 22,257 13
Proteins 6,087 20,314 13

 Functional annotation
General category Regulation
Detailed category Signal transduction

Document: Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus0.025297.148e-09Least InformativeInherited
Biological Process (BP)single-organism cellular process0.036340.08077Least InformativeInherited
Biological Process (BP)regulation of cellular process0.0026490.01502Least InformativeInherited
Biological Process (BP)signal transduction2.627e-063.863e-09Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus0.021780.8014Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.00055260.506Moderately InformativeInherited
Biological Process (BP)response to organic substance0.00074731Moderately InformativeInherited
Biological Process (BP)response to hormone stimulus4.371e-060.01967InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus1.309e-060.001635InformativeInherited
Biological Process (BP)hormone-mediated signaling pathway7.213e-060.0022Highly InformativeInherited
Molecular Function (MF)transferase activity3.05e-050Least InformativeDirect
Molecular Function (MF)binding0.48691Least InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups9.546e-090Moderately InformativeDirect
Molecular Function (MF)protein binding0.093170.4328Moderately InformativeInherited
Molecular Function (MF)enzyme binding4.881e-080.0006612InformativeDirect
Molecular Function (MF)molecular transducer activity3.163e-070InformativeDirect
Molecular Function (MF)kinase activity0.63120.2253InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 7.148e-09 Least Informative Direct
Biological Process (BP) protein metabolic process 0.4538 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.9219 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.08077 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.01502 Least Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 7.386e-05 Moderately Informative Direct
Biological Process (BP) signal transduction 3.863e-09 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.8014 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.506 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.1041 Moderately Informative Inherited
Biological Process (BP) locomotion 2.358e-08 Informative Direct
Biological Process (BP) protein phosphorylation 0.14 Informative Inherited
Biological Process (BP) response to external stimulus 0.001572 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.01967 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.001635 Informative Inherited
Biological Process (BP) chemotaxis 3.889e-06 Highly Informative Direct
Biological Process (BP) hormone-mediated signaling pathway 0.0022 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) protein binding 0.4328 Moderately Informative Inherited
Molecular Function (MF) receptor activity 3.322e-05 Informative Direct
Molecular Function (MF) enzyme binding 0.0006612 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) kinase activity 0.2253 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) protein kinase activity 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-histidine kinases0InformativeDirect

Document: EC annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processChemotaxis0InformativeDirect
Biological processVirulence2.231e-07InformativeDirect
Biological processTwo-component regulatory system0Highly InformativeDirect
Cellular componentMembrane0.001661Least InformativeInherited
Cellular componentCell membrane2.836e-05Moderately InformativeDirect
Cellular componentCell inner membrane5.852e-07InformativeDirect
DomainTransmembrane3.408e-07Least InformativeDirect
Molecular functionNucleotide-binding8.843e-10Least InformativeDirect
Post-translational modificationTransferase2.193e-11Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008207 SSF47226 Protein matches
Abstract This domain is present at the N terminus in proteins which undergo autophosphorylation. The group includes, the gliding motility regulatory protein from Myxococcus xanthus and a number of bacterial chemotaxis proteins.

InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 9 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Histidine-containing phosphotransfer domain, HPT domain domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 9 hidden Markov models representing the Histidine-containing phosphotransfer domain, HPT domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]
Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

Please send feedback, comments or questions to superfamily@cs.bris.ac.uk or use the feedback form.

© Copyright 2013 The SUPERFAMILY authors and Julian Gough.