SUPERFAMILY 1.75 HMM library and genome assignments server


Histone-fold superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Histone-fold [ 47112]
Superfamily:   Histone-fold [ 47113] (4)
Families:   Nucleosome core histones [ 47114] (5)
  Archaeal histone [ 47129]
  TBP-associated factors, TAFs [ 47134] (13)
  Bacterial histone-fold protein [ 101318] (2)


Superfamily statistics
Genomes (573) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 24,546 30,395 82
Proteins 24,174 30,004 81


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process4.513e-090Least InformativeDirect
Biological Process (BP)nitrogen compound metabolic process7.74e-065.957e-13Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process1.001e-084.36e-11Least InformativeDirect
Biological Process (BP)heterocycle metabolic process2.886e-090Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis8.84e-108.126e-09Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process9.152e-080Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.1430.0001396Least InformativeInherited
Biological Process (BP)localization0.9531Least InformativeInherited
Biological Process (BP)response to stimulus0.40951Least InformativeInherited
Biological Process (BP)regulation of cellular process0.85680.4385Least InformativeInherited
Biological Process (BP)protein metabolic process11Least InformativeInherited
Biological Process (BP)biosynthetic process10.0001371Least InformativeInherited
Biological Process (BP)single-organism cellular process1.12e-050.07886Least InformativeInherited
Biological Process (BP)organelle organization3.099e-150Moderately InformativeDirect
Biological Process (BP)regulation of biosynthetic process0.00040939.202e-07Moderately InformativeDirect
Biological Process (BP)macromolecular complex subunit organization1.609e-073.495e-13Moderately InformativeDirect
Biological Process (BP)cellular component biogenesis0.00018672.303e-06Moderately InformativeDirect
Biological Process (BP)regulation of nitrogen compound metabolic process0.00065761.085e-09Moderately InformativeDirect
Biological Process (BP)macromolecule localization0.52091Moderately InformativeInherited
Biological Process (BP)cellular localization11Moderately InformativeInherited
Biological Process (BP)cellular response to stress4.479e-050.01243Moderately InformativeInherited
Biological Process (BP)regulation of cellular metabolic process0.019517.386e-06Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.53710.8819Moderately InformativeInherited
Biological Process (BP)RNA metabolic process0.88312.856e-06Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.89543.867e-09Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.70232.868e-09Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.91398.332e-09Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.95261.889e-07Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process0.10755.317e-13Moderately InformativeInherited
Biological Process (BP)gene expression0.90691.941e-05Moderately InformativeInherited
Biological Process (BP)reproduction0.007770.01892Moderately InformativeInherited
Biological Process (BP)DNA metabolic process04.305e-11InformativeDirect
Biological Process (BP)transcription, DNA-dependent0.00032620InformativeDirect
Biological Process (BP)response to DNA damage stimulus2.026e-111.764e-07InformativeDirect
Biological Process (BP)cellular macromolecular complex assembly00InformativeDirect
Biological Process (BP)chromosome organization00InformativeDirect
Biological Process (BP)protein localization to organelle0.056140.2208InformativeInherited
Biological Process (BP)peptidyl-amino acid modification0.018830.0001066InformativeInherited
Biological Process (BP)cell cycle process0.12120.06542InformativeInherited
Biological Process (BP)cellular process involved in reproduction0.00013560.02243InformativeInherited
Biological Process (BP)DNA packaging00Highly InformativeDirect
Biological Process (BP)chromatin assembly or disassembly3.111e-120Highly InformativeDirect
Biological Process (BP)internal protein amino acid acetylation2.827e-072.081e-14Highly InformativeDirect
Biological Process (BP)chromosome segregation1.75e-061.656e-12Highly InformativeDirect
Biological Process (BP)histone modification1.607e-052.667e-08Highly InformativeDirect
Biological Process (BP)peptidyl-lysine modification1.636e-056.862e-12Highly InformativeDirect
Biological Process (BP)organelle assembly0.030015.665e-05Highly InformativeInherited
Biological Process (BP)DNA replication0.12650.4261Highly InformativeInherited
Biological Process (BP)transcription from RNA polymerase II promoter0.019747.398e-10Highly InformativeInherited
Biological Process (BP)meiosis0.0015120.006212Highly InformativeInherited
Biological Process (BP)DNA recombination0.98251Highly InformativeInherited
Molecular Function (MF)binding1.077e-105.662e-10Least InformativeDirect
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)organic cyclic compound binding1.314e-153.4e-12Moderately InformativeDirect
Molecular Function (MF)heterocyclic compound binding01.135e-12Moderately InformativeDirect
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups0.84831Moderately InformativeInherited
Molecular Function (MF)nucleic acid binding transcription factor activity00InformativeDirect
Molecular Function (MF)DNA binding00InformativeDirect
Molecular Function (MF)nucleotidyltransferase activity0.017970.03067InformativeInherited
Molecular Function (MF)transcription factor binding transcription factor activity8.558e-055.971e-10Highly InformativeDirect
Molecular Function (MF)sequence-specific DNA binding transcription factor activity00Highly InformativeDirect
Molecular Function (MF)DNA polymerase activity3.501e-050.0001053Highly InformativeDirect
Cellular Component (CC)intracellular non-membrane-bounded organelle1.812e-129.353e-08Least InformativeDirect
Cellular Component (CC)intracellular organelle part00Least InformativeDirect
Cellular Component (CC)protein complex10.8653Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)nuclear part00Moderately InformativeDirect
Cellular Component (CC)intracellular organelle lumen00Moderately InformativeDirect
Cellular Component (CC)DNA-directed RNA polymerase complex4.58e-050InformativeDirect
Cellular Component (CC)chromosome00InformativeDirect
Cellular Component (CC)nucleoplasm part4.326e-090InformativeDirect
Cellular Component (CC)chromatin2.471e-068.124e-05Highly InformativeDirect
Cellular Component (CC)transcription factor complex0.00010170Highly InformativeDirect
Cellular Component (CC)lipid particle00Highly InformativeDirect
Cellular Component (CC)DNA polymerase complex1.035e-082.285e-12Highly InformativeDirect
Cellular Component (CC)nuclear chromosome part4.782e-070.001298Highly InformativeInherited
Cellular Component (CC)replisome0.010230.001174Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 5.957e-13 Least Informative Direct
Biological Process (BP) biosynthetic process 0.0001371 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.0001396 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 4.36e-11 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 8.126e-09 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.4385 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.07886 Least Informative Inherited
Biological Process (BP) organelle organization 0 Moderately Informative Direct
Biological Process (BP) regulation of biosynthetic process 9.202e-07 Moderately Informative Direct
Biological Process (BP) gene expression 1.941e-05 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 1.692e-05 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 2.856e-06 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 3.867e-09 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 2.868e-09 Moderately Informative Direct
Biological Process (BP) regulation of cellular metabolic process 7.386e-06 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 5.317e-13 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 3.495e-13 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 2.303e-06 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 8.332e-09 Moderately Informative Direct
Biological Process (BP) regulation of nitrogen compound metabolic process 1.085e-09 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 1.889e-07 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.2514 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.01243 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.8819 Moderately Informative Inherited
Biological Process (BP) reproduction 0.01892 Moderately Informative Inherited
Biological Process (BP) DNA metabolic process 4.305e-11 Informative Direct
Biological Process (BP) transcription, DNA-dependent 0 Informative Direct
Biological Process (BP) response to DNA damage stimulus 1.764e-07 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.0001066 Informative Direct
Biological Process (BP) cellular macromolecular complex assembly 0 Informative Direct
Biological Process (BP) chromosome organization 0 Informative Direct
Biological Process (BP) protein localization to organelle 0.2208 Informative Inherited
Biological Process (BP) cell cycle process 0.06542 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.02243 Informative Inherited
Biological Process (BP) nuclear division 0.0007633 Highly Informative Direct
Biological Process (BP) DNA packaging 0 Highly Informative Direct
Biological Process (BP) chromatin assembly or disassembly 0 Highly Informative Direct
Biological Process (BP) transcription from RNA polymerase II promoter 7.398e-10 Highly Informative Direct
Biological Process (BP) internal protein amino acid acetylation 2.081e-14 Highly Informative Direct
Biological Process (BP) chromosome segregation 1.656e-12 Highly Informative Direct
Biological Process (BP) histone modification 2.667e-08 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 6.862e-12 Highly Informative Direct
Biological Process (BP) multi-organism cellular process 0.0001828 Highly Informative Direct
Biological Process (BP) organelle assembly 5.665e-05 Highly Informative Direct
Biological Process (BP) DNA replication 0.4261 Highly Informative Inherited
Biological Process (BP) meiosis 0.006212 Highly Informative Inherited
Biological Process (BP) DNA recombination 1 Highly Informative Inherited
Molecular Function (MF) binding 5.662e-10 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) organic cyclic compound binding 3.4e-12 Moderately Informative Direct
Molecular Function (MF) heterocyclic compound binding 1.135e-12 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) protein binding 1 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.5963 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0.07675 Informative Inherited
Molecular Function (MF) GTPase regulator activity 0.02154 Informative Inherited
Molecular Function (MF) nucleotidyltransferase activity 0.03067 Informative Inherited
Molecular Function (MF) transcription factor binding transcription factor activity 5.971e-10 Highly Informative Direct
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.0003364 Highly Informative Direct
Molecular Function (MF) transcription factor binding 2.659e-10 Highly Informative Direct
Molecular Function (MF) acetyltransferase activity 0.0009588 Highly Informative Direct
Molecular Function (MF) DNA polymerase activity 0.0001053 Highly Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 9.353e-08 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0 Least Informative Direct
Cellular Component (CC) protein complex 0.8653 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) nuclear part 0 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0 Moderately Informative Direct
Cellular Component (CC) DNA-directed RNA polymerase complex 0 Informative Direct
Cellular Component (CC) chromosome 0 Informative Direct
Cellular Component (CC) nucleoplasm part 0 Informative Direct
Cellular Component (CC) kinetochore 3.743e-05 Highly Informative Direct
Cellular Component (CC) chromatin 8.124e-05 Highly Informative Direct
Cellular Component (CC) transcription factor complex 0 Highly Informative Direct
Cellular Component (CC) lipid particle 0 Highly Informative Direct
Cellular Component (CC) DNA polymerase complex 2.285e-12 Highly Informative Direct
Cellular Component (CC) nuclear chromosome part 0.001298 Highly Informative Inherited
Cellular Component (CC) replisome 0.001174 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Nucleotidyltransferases0Least InformativeDirect
Enzyme Commission (EC)DNA-directed DNA polymerase0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.5346Least InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant3.072e-11Moderately InformativeDirect
Worm Phenotype (WP)gametogenesis variant5.892e-05Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0.0002031Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.012Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.01602Moderately InformativeInherited
Worm Phenotype (WP)cell death variant0.4618Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0InformativeDirect
Worm Phenotype (WP)chromosome segregation variant0InformativeDirect
Worm Phenotype (WP)meiotic chromosome organization variant7.995e-13InformativeDirect
Worm Phenotype (WP)alimentary system development variant2.643e-07InformativeDirect
Worm Phenotype (WP)protruding vulva3.745e-05InformativeDirect
Worm Phenotype (WP)cell corpse number variant0.005489InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.01066InformativeInherited
Worm Phenotype (WP)organism stress response variant0.08471InformativeInherited
Worm Phenotype (WP)body width variant0.2544InformativeInherited
Worm Phenotype (WP)diplotene progression during oogenesis variant0.2832InformativeInherited
Worm Phenotype (WP)body elongation variant0Highly InformativeDirect
Worm Phenotype (WP)pharyngeal development variant1.717e-14Highly InformativeDirect
Worm Phenotype (WP)embryonic arrest2.499e-13Highly InformativeDirect
Worm Phenotype (WP)stress induced lethality increased1.048e-07Highly InformativeDirect
Worm Phenotype (WP)organism osmotic stress response variant2.574e-06Highly InformativeDirect
Worm Phenotype (WP)chromosome condensation variant1.192e-05Highly InformativeDirect
Worm Phenotype (WP)pathogen susceptibility increased6.252e-05Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)cell cycle progression0.00207InformativeInherited
Yeast Phenotype (YP)development0.05098InformativeInherited
Yeast Phenotype (YP)budding index3.348e-07Highly InformativeDirect
Yeast Phenotype (YP)cell cycle progression in G2 phase0.0001074Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root0.2598Least InformativeInherited
Plant ANatomical entity (PAN)shoot apex0.6127Least InformativeInherited
Plant ANatomical entity (PAN)portion of meristem tissue0.7009Least InformativeInherited
Plant ANatomical entity (PAN)primordium0.0009161InformativeDirect
Plant ANatomical entity (PAN)root tip0.01257InformativeInherited
Plant ANatomical entity (PAN)lateral root primordium6.142e-06Highly InformativeDirect
Plant ANatomical entity (PAN)lateral root1.433e-05Highly InformativeDirect
Plant ANatomical entity (PAN)reproductive shoot apex7.418e-05Highly InformativeDirect
Plant ANatomical entity (PAN)root meristem0.0001055Highly InformativeDirect
Plant ANatomical entity (PAN)shoot apical meristem0.0005518Highly InformativeDirect
Plant structure DEvelopment stage (PDE)seedling development stage2.727e-07InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)DNA-directed DNA polymerase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDNA damage4.522e-15Moderately InformativeDirect
Biological processTranscription regulation3.734e-11Moderately InformativeDirect
Biological processCell cycle0.3691Moderately InformativeInherited
Biological processMitosis2.78e-08InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentChromosome0InformativeDirect
Cellular componentCentromere0Highly InformativeDirect
Cellular componentKinetochore0Highly InformativeDirect
Molecular functionDNA-binding0Moderately InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationNucleotidyltransferase0.4107Moderately InformativeInherited
Post-translational modificationDNA-directed DNA polymerase0InformativeDirect
Post-translational modificationAntimicrobial1.368e-09InformativeDirect
Post-translational modificationChromatin regulator1.443e-09InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0.0006335InformativeDirect
Post-translational modificationAntibiotic2.084e-12Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0Moderately InformativeDirect
Post-translational modificationMethylation0Moderately InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR009072 SSF47113 Protein matches
Abstract

Histones mediate DNA organisation and plays a dominant role in regulating eukaryotic transcription. The histone-fold consists of a core of three helices, where the long middle helix is flanked at each end by shorter ones. Proteins displaying this structure include the nucleosome core histones, which form octomers composed of two copies of each of the four histones, H2A, H2B, H3 and H4; archaeal histone, which possesses only the core domain part of eukaryotic histone; and the TATA-box binding protein (TBP)-associated factors (TAF), where the histone fold is a common motif for mediating TAF-TAF interactions. TAF proteins include TAF(II)18 and TAF(II)28, which form a heterodimer, TAF(II)42 and TAF(II)62, which form a heterotetramer similar to (H3-H4)2, and the negative cofactor 2 (NC2) alpha and beta chains, which form a heterodimer. The TAF proteins are a component of transcription factor IID (TFIID), along with the TBP protein. TFIID forms part of the pre-initiation complex on core promoter elements required for RNA polymerase II-dependent transcription. The TAF subunits of TFIID mediate transcriptional activation of subsets of eukaryotic genes. The NC2 complex mediates the inhibition of TATA-dependent transcription through interactions with TBP.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 32 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Histone-fold domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 32 hidden Markov models representing the Histone-fold superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]