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VHP, Villin headpiece domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   VHP, Villin headpiece domain [ 47049]
Superfamily:   VHP, Villin headpiece domain [ 47050]
Families:   VHP, Villin headpiece domain [ 47051] (4)


Superfamily statistics
Genomes (236) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,403 1,342 8
Proteins 1,403 1,341 8


Functional annotation
General category Processes_IC
Detailed category Cell motility

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of metabolic process 0.0009075 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.0000001293 Least Informative Direct
Biological Process (BP) developmental process 0.0000000022 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.000002095 Least Informative Direct
Biological Process (BP) response to stimulus 0.000005867 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.0467 Least Informative Inherited
Biological Process (BP) nervous system development 0.00006047 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.00004232 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.00007934 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.000000000000009109 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0.0000004877 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.00000000001348 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.06801 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.7602 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.06516 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.03804 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.06252 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.007689 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.8291 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.005341 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.7763 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.2246 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.07787 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.9616 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.02153 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.1475 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.01084 Moderately Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0 Informative Direct
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0.00001308 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.0009808 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0 Informative Direct
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) actin filament-based process 0.000000001071 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.000000000000003741 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.000000000003735 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) regulation of locomotion 0.0002702 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0000245 Informative Direct
Biological Process (BP) generation of neurons 0 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.000001075 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.000000000000001931 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.0002589 Informative Direct
Biological Process (BP) regulation of cell development 0.00057 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0.00001998 Informative Direct
Biological Process (BP) cellular macromolecular complex assembly 0.3513 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.001296 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.00269 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.02021 Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.0001725 Highly Informative Direct
Biological Process (BP) chemotaxis 0.0000000000337 Highly Informative Direct
Biological Process (BP) actin filament organization 0 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.0001141 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.00004723 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.0000000007889 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 0.0000000006916 Highly Informative Direct
Biological Process (BP) cell part morphogenesis 0.00001722 Highly Informative Direct
Biological Process (BP) regulation of protein complex disassembly 0.000004172 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 0 Highly Informative Direct
Biological Process (BP) protein polymerization 0.000000005757 Highly Informative Direct
Biological Process (BP) regulation of wound healing 0.00000000000007974 Highly Informative Direct
Biological Process (BP) neuron projection development 0.01792 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.004455 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.004427 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.03337 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.007823 Highly Informative Inherited
Molecular Function (MF) binding 0.000001166 Least Informative Direct
Molecular Function (MF) enzyme regulator activity 0.002403 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.01376 Moderately Informative Inherited
Molecular Function (MF) cation binding 0.007458 Moderately Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.000001502 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) carboxylic acid binding 0.0000005781 Informative Direct
Molecular Function (MF) peptidase regulator activity 0.000000205 Informative Direct
Molecular Function (MF) lipid binding 0.00309 Informative Inherited
Molecular Function (MF) protein dimerization activity 0.1966 Informative Inherited
Molecular Function (MF) cysteine-type endopeptidase inhibitor activity 0.0000000001783 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0.000004613 Highly Informative Direct
Molecular Function (MF) monocarboxylic acid binding 0.000000001872 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol binding 0.0000004093 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 0.0005594 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 0.00000000008687 Highly Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.7794 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.0000002504 Moderately Informative Direct
Cellular Component (CC) cell projection 0.000003511 Moderately Informative Direct
Cellular Component (CC) actin cytoskeleton 0.000000000000003092 Informative Direct
Cellular Component (CC) cell leading edge 0.00000101 Informative Direct

Document: GO annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)intestine0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentCytoplasm0.000000000007558Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Coding sequence diversityAlternative splicing0Least InformativeDirect
DomainRepeat0.000000000000001527Least InformativeDirect
DomainLIM domain0.0000000000004639Highly InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionActin-binding0InformativeDirect
Post-translational modificationActin capping0Highly InformativeDirect
Post-translational modificationPhosphoprotein0.000000000001484Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR003128 SSF47050 Protein matches
Abstract

Villin is an F-actin bundling protein involved in the maintenance of the microvilli of the absorptive epithelia. The villin-type "headpiece" domain is a modular motif found at the extreme C-terminus of larger "core" domains in over 25 cytoskeletal proteins in plants and animals, often in assocation with the Gelsolin repeat. Although the headpiece is classified as an F-actin-binding domain, it has been shown that not all headpiece domains are intrinsically F-actin-binding motifs, surface charge distribution may be an important element for F-actin recognition [PubMed11977079]. An autonomously folding, 35 residue, thermostable subdomain (HP36) of the full-length 76 amino acid residue villin headpiece, is the smallest known example of a cooperatively folded domain of a naturally occurring protein. The structure of HP36, as determined by NMR spectroscopy, consists of three short helices surrounding a tightly packed hydrophobic core [PubMed12095260].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a VHP, Villin headpiece domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the VHP, Villin headpiece domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]