SUPERFAMILY 1.75 HMM library and genome assignments server

VHP, Villin headpiece domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   VHP, Villin headpiece domain [ 47049]
Superfamily:   VHP, Villin headpiece domain [ 47050]
Families:   VHP, Villin headpiece domain [ 47051] (4)


Superfamily statistics
Genomes (237) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,406 1,342 8
Proteins 1,406 1,341 8


Functional annotation
General category Processes_IC
Detailed category Cell motility

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) developmental process 0.000000002324 Least Informative Direct
Biological Process (BP) positive regulation of biological process 0.000000008578 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.00000005343 Least Informative Direct
Biological Process (BP) response to stimulus 0.000006489 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00005269 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.001634 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.05891 Least Informative Inherited
Biological Process (BP) cell differentiation 0.00000000000001246 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.00000000003391 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0000000001088 Moderately Informative Direct
Biological Process (BP) single-organism organelle organization 0.00003163 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.00004295 Moderately Informative Direct
Biological Process (BP) nervous system development 0.00007834 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0.1623 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.1344 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.7701 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.06943 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.07264 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.4413 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.01123 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.746 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.002054 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.2682 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.122 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.9205 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.9565 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.8178 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.08071 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.1691 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.9561 Moderately Informative Inherited
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0 Informative Direct
Biological Process (BP) positive regulation of RNA metabolic process 0 Informative Direct
Biological Process (BP) generation of neurons 0 Informative Direct
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.000000000000001913 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.000000000000005526 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.00000000002274 Informative Direct
Biological Process (BP) actin filament-based process 0.0000000001984 Informative Direct
Biological Process (BP) regulation of response to wounding 0.000000003473 Informative Direct
Biological Process (BP) positive regulation of gene expression 0.000001244 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.000001509 Informative Direct
Biological Process (BP) cytoskeleton organization 0.000007477 Informative Direct
Biological Process (BP) negative regulation of cellular protein metabolic process 0.00000802 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0000318 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.0002458 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.0002549 Informative Direct
Biological Process (BP) regulation of locomotion 0.0002699 Informative Direct
Biological Process (BP) regulation of cell development 0.0003809 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.0009937 Informative Direct
Biological Process (BP) cellular macromolecular complex assembly 0.3275 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.004154 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.001374 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.3416 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.02776 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.01807 Informative Inherited
Biological Process (BP) actin filament organization 0 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-templated 0 Highly Informative Direct
Biological Process (BP) regulation of wound healing 0.00000000000007575 Highly Informative Direct
Biological Process (BP) chemotaxis 0.00000000002852 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 0.0000000006755 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.0000000007939 Highly Informative Direct
Biological Process (BP) protein polymerization 0.00000002297 Highly Informative Direct
Biological Process (BP) regulation of protein complex disassembly 0.000003874 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.00002129 Highly Informative Direct
Biological Process (BP) cell projection morphogenesis 0.00002259 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.0001145 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.0002671 Highly Informative Direct
Biological Process (BP) neuron projection development 0.01631 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.004541 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.003843 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular component biogenesis 0.01468 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.04159 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.006921 Highly Informative Inherited
Molecular Function (MF) binding 0.000001566 Least Informative Direct
Molecular Function (MF) enzyme regulator activity 0.0008423 Moderately Informative Direct
Molecular Function (MF) anion binding 0.01416 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.05219 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.08626 Moderately Informative Inherited
Molecular Function (MF) cation binding 0.007616 Moderately Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) peptidase regulator activity 0.000000205 Informative Direct
Molecular Function (MF) carboxylic acid binding 0.0000006227 Informative Direct
Molecular Function (MF) enzyme inhibitor activity 0.000001537 Informative Direct
Molecular Function (MF) protein complex binding 0.0002695 Informative Direct
Molecular Function (MF) protein dimerization activity 0.1957 Informative Inherited
Molecular Function (MF) lipid binding 0.003134 Informative Inherited
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 0.00000000008693 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase inhibitor activity 0.0000000001793 Highly Informative Direct
Molecular Function (MF) monocarboxylic acid binding 0.000000001876 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol binding 0.0000004535 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0.000004781 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 0.0005718 Highly Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.0005632 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.7688 Least Informative Inherited
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.0000002369 Moderately Informative Direct
Cellular Component (CC) actin cytoskeleton 0 Informative Direct
Cellular Component (CC) synapse 0.0000000000000118 Informative Direct
Cellular Component (CC) cell leading edge 0.0000009804 Informative Direct

Document: GO annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)intestine0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentCytoplasm0.000000000007562Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Coding sequence diversityAlternative splicing0.000000000000002276Least InformativeDirect
DomainRepeat0.000000000000001525Least InformativeDirect
DomainLIM domain0.0000000000004563Highly InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionActin-binding0InformativeDirect
Post-translational modificationActin capping0Highly InformativeDirect
Post-translational modificationPhosphoprotein0.000000000001537Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR003128 SSF47050 Protein matches
Abstract

Villin is an F-actin bundling protein involved in the maintenance of the microvilli of the absorptive epithelia. The villin-type "headpiece" domain is a modular motif found at the extreme C-terminus of larger "core" domains in over 25 cytoskeletal proteins in plants and animals, often in assocation with the Gelsolin repeat. Although the headpiece is classified as an F-actin-binding domain, it has been shown that not all headpiece domains are intrinsically F-actin-binding motifs, surface charge distribution may be an important element for F-actin recognition [PubMed11977079]. An autonomously folding, 35 residue, thermostable subdomain (HP36) of the full-length 76 amino acid residue villin headpiece, is the smallest known example of a cooperatively folded domain of a naturally occurring protein. The structure of HP36, as determined by NMR spectroscopy, consists of three short helices surrounding a tightly packed hydrophobic core [PubMed12095260].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a VHP, Villin headpiece domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the VHP, Villin headpiece domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]