SUPERFAMILY 1.75 HMM library and genome assignments server

Second domain of FERM superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Acyl-CoA binding protein-like [ 47026] (2)
Superfamily:   Second domain of FERM [ 47031]
Families:   Second domain of FERM [ 47032] (8)


Superfamily statistics
Genomes (239) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 6,721 6,912 21
Proteins 6,295 6,469 21


Functional annotation
General category Information
Detailed category Translation

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) developmental process 0.0000000004347 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.00000001779 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0000001235 Least Informative Direct
Biological Process (BP) localization 0.00001713 Least Informative Direct
Biological Process (BP) protein metabolic process 0.00002503 Least Informative Direct
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.0179 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.001529 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.000000000000003707 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.000000000000003707 Moderately Informative Direct
Biological Process (BP) single-organism organelle organization 0.000000000001129 Moderately Informative Direct
Biological Process (BP) regulation of phosphorus metabolic process 0.000000003004 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.00000002105 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.00000002436 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.00000003965 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0000001203 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.000001831 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.000004841 Moderately Informative Direct
Biological Process (BP) tissue development 0.0001948 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.03846 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.4212 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.8309 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.008467 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.005568 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.01568 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.6398 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.1292 Moderately Informative Inherited
Biological Process (BP) immune system process 0.06796 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.5485 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.005594 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.05399 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.5912 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.1784 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.008134 Moderately Informative Inherited
Biological Process (BP) organ development 0.1661 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.5841 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.3112 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.254 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.2491 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.633 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.7541 Moderately Informative Inherited
Biological Process (BP) reproductive process 0.7484 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.8186 Moderately Informative Inherited
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) biological adhesion 0.0000000000006182 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.000000002225 Informative Direct
Biological Process (BP) cell projection organization 0.000000002586 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0000000182 Informative Direct
Biological Process (BP) locomotion 0.00000003213 Informative Direct
Biological Process (BP) response to cytokine 0.0000001224 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.0000009297 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 0.00000111 Informative Direct
Biological Process (BP) multicellular organismal homeostasis 0.000002061 Informative Direct
Biological Process (BP) cellular component movement 0.00000251 Informative Direct
Biological Process (BP) tissue morphogenesis 0.000004318 Informative Direct
Biological Process (BP) regulation of transferase activity 0.000009682 Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 0.0000121 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.00003627 Informative Direct
Biological Process (BP) organ morphogenesis 0.00006565 Informative Direct
Biological Process (BP) negative regulation of catalytic activity 0.00008395 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.000148 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 0.0001932 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.0003399 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.0004287 Informative Direct
Biological Process (BP) intracellular signal transduction 0.0005116 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0.0005447 Informative Direct
Biological Process (BP) positive regulation of catabolic process 0.0005503 Informative Direct
Biological Process (BP) embryonic morphogenesis 0.0007244 Informative Direct
Biological Process (BP) negative regulation of cellular protein metabolic process 0.0009032 Informative Direct
Biological Process (BP) localization of cell 0.0009465 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 0.0009576 Informative Direct
Biological Process (BP) synaptic transmission 0.0009868 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.004073 Informative Inherited
Biological Process (BP) regulation of locomotion 0.005704 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.001742 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.08029 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.8993 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.2028 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.507 Informative Inherited
Biological Process (BP) regulation of protein localization 0.003977 Informative Inherited
Biological Process (BP) tube development 0.494 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.4268 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.2442 Informative Inherited
Biological Process (BP) neurological system process 0.1754 Informative Inherited
Biological Process (BP) regulation of growth 0.04715 Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.2569 Informative Inherited
Biological Process (BP) positive regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.08938 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.02436 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.005295 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.003339 Informative Inherited
Biological Process (BP) regulation of MAPK cascade 0.01732 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.001195 Informative Inherited
Biological Process (BP) dephosphorylation 0.008816 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 0.01277 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.1347 Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0.0108 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.001254 Informative Inherited
Biological Process (BP) epithelium development 0.04863 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.04847 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.765 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.2965 Informative Inherited
Biological Process (BP) generation of neurons 0.006842 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.02029 Informative Inherited
Biological Process (BP) central nervous system development 0.6403 Informative Inherited
Biological Process (BP) phosphorylation 0.09369 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) muscle structure development 0.5056 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.003929 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.001354 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.3265 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 1 Informative Inherited
Biological Process (BP) sexual reproduction 0.382 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.3172 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.004231 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.01296 Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.002435 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.05293 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.1427 Informative Inherited
Biological Process (BP) cell junction organization 0 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0 Highly Informative Direct
Biological Process (BP) cell adhesion 0.000000000000153 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0.00000000003248 Highly Informative Direct
Biological Process (BP) maintenance of location 0.00000007968 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.0000000837 Highly Informative Direct
Biological Process (BP) protein dephosphorylation 0.0000001093 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.0000001873 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0.0000002024 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 0.000000306 Highly Informative Direct
Biological Process (BP) regulation of binding 0.000002003 Highly Informative Direct
Biological Process (BP) phagocytosis 0.000006327 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 0.00000984 Highly Informative Direct
Biological Process (BP) ribonucleoside triphosphate catabolic process 0.00001754 Highly Informative Direct
Biological Process (BP) purine nucleoside triphosphate catabolic process 0.00001968 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 0.00002951 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 0.00003493 Highly Informative Direct
Biological Process (BP) regulation of Rho protein signal transduction 0.00003968 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 0.0001216 Highly Informative Direct
Biological Process (BP) negative regulation of protein phosphorylation 0.0001729 Highly Informative Direct
Biological Process (BP) regulation of neural precursor cell proliferation 0.0002239 Highly Informative Direct
Biological Process (BP) regulation of Ras GTPase activity 0.00028 Highly Informative Direct
Biological Process (BP) negative regulation of transferase activity 0.0003045 Highly Informative Direct
Biological Process (BP) cellular response to peptide 0.000363 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular signal transduction 0.0005488 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0.0009452 Highly Informative Direct
Biological Process (BP) regulation of proteolysis involved in cellular protein catabolic process 0.02109 Highly Informative Inherited
Biological Process (BP) positive regulation of protein modification by small protein conjugation or removal 0.005028 Highly Informative Inherited
Biological Process (BP) regulation of protein complex disassembly 0.002616 Highly Informative Inherited
Biological Process (BP) response to peptide hormone 0.003488 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 1 Highly Informative Inherited
Biological Process (BP) negative regulation of nervous system development 0.002286 Highly Informative Inherited
Biological Process (BP) sensory perception 0.001074 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.501 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.7995 Highly Informative Inherited
Biological Process (BP) regulation of peptidyl-tyrosine phosphorylation 0.3775 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.294 Highly Informative Inherited
Biological Process (BP) positive regulation of GTPase activity 0.3588 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.03929 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.04796 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.01767 Highly Informative Inherited
Biological Process (BP) telencephalon development 0.003884 Highly Informative Inherited
Biological Process (BP) histone modification 0.4793 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.1599 Highly Informative Inherited
Biological Process (BP) hemostasis 0.001204 Highly Informative Inherited
Biological Process (BP) coagulation 0.02321 Highly Informative Inherited
Biological Process (BP) wound healing 0.3376 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.00359 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 0.05948 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.485 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.001348 Highly Informative Inherited
Biological Process (BP) germ cell development 0.3015 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.001508 Highly Informative Inherited
Biological Process (BP) columnar/cuboidal epithelial cell differentiation 1 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.05003 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 0.01274 Least Informative Inherited
Molecular Function (MF) hydrolase activity 0.08259 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.0000001644 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0004229 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.01167 Moderately Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.000000000219 Informative Direct
Molecular Function (MF) kinase activity 0.000000003157 Informative Direct
Molecular Function (MF) phosphatase activity 0.00000003256 Informative Direct
Molecular Function (MF) tetrapyrrole binding 0.00005548 Informative Direct
Molecular Function (MF) protein complex binding 0.0001717 Informative Direct
Molecular Function (MF) lipid binding 0.00832 Informative Inherited
Molecular Function (MF) receptor binding 0.04022 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 0.004153 Informative Inherited
Molecular Function (MF) protein kinase activity 0.0000000000001228 Highly Informative Direct
Molecular Function (MF) phosphoprotein phosphatase activity 0.0000000000006094 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol binding 0.000000000007103 Highly Informative Direct
Molecular Function (MF) cell adhesion molecule binding 0.0000000001508 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.000003018 Highly Informative Direct
Molecular Function (MF) heme binding 0.00004242 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.0002673 Highly Informative Direct
Molecular Function (MF) cytokine receptor binding 0.03266 Highly Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) membrane 0.000001785 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.01213 Least Informative Inherited
Cellular Component (CC) protein complex 0.04021 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 0.000000003007 Moderately Informative Direct
Cellular Component (CC) membrane region 0.000001108 Moderately Informative Direct
Cellular Component (CC) cell cortex 0 Informative Direct
Cellular Component (CC) cell leading edge 0 Informative Direct
Cellular Component (CC) cell junction 0 Informative Direct
Cellular Component (CC) synapse 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 0.0000000000005934 Informative Direct
Cellular Component (CC) plasma membrane region 0.000000000001823 Informative Direct
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) cell surface 0.01594 Informative Inherited
Cellular Component (CC) adherens junction 0 Highly Informative Direct
Cellular Component (CC) cell division site part 0.000000000003411 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 0.00000001051 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 0.0000004923 Highly Informative Direct
Cellular Component (CC) extrinsic component of cytoplasmic side of plasma membrane 0.000001107 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 0.000008127 Highly Informative Direct
Cellular Component (CC) cell-cell contact zone 0.09476 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.00000002725Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000000000000007826Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.9317Least InformativeInherited
Disease Ontology (DO)nervous system cancer0.04878Moderately InformativeInherited
Disease Ontology (DO)meningioma0.0001722InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the ear0.1697InformativeInherited
Phenotypic Abnormality (PA)Functional abnormality of the inner ear0.0325Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.1167Least InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.6641Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.7087Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hair cell morphology0.02251InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear sensory epithelium morphology0.02251InformativeInherited
Mammalian Phenotype (MP)abnormal membranous labyrinth morphology0.04646InformativeInherited
Mammalian Phenotype (MP)short cochlear hair cell stereocilia0.00002573Highly InformativeDirect
Mammalian Phenotype (MP)abnormal outer hair cell stereociliary bundle morphology0.0008469Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cochlear inner hair cell morphology0.007041Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell migration variant0.00006718InformativeDirect
Worm Phenotype (WP)distal tip cell migration variant0.000004994Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)anatomical group0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)adult head0Moderately InformativeDirect
Fly Anatomy (FA)acellular anatomical structure0.0002828Moderately InformativeDirect
Fly Anatomy (FA)tagmatic subdivision of integument0.007877Moderately InformativeInherited
Fly Anatomy (FA)external sensory organ0.02647Moderately InformativeInherited
Fly Anatomy (FA)adult sense organ0.09855Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.1686Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.3653Moderately InformativeInherited
Fly Anatomy (FA)sensillum0.519Moderately InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval digestive system0.01008InformativeInherited
Fly Anatomy (FA)chaeta0.05068InformativeInherited
Fly Anatomy (FA)adult external head0.05838InformativeInherited
Fly Anatomy (FA)head bristle0.0002911Highly InformativeDirect
Fly Anatomy (FA)embryonic foregut0.0005169Highly InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0.07639Least InformativeInherited

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0.0000000003576Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.01524Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000000000000008035Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)selective immunosuppressants0.000001484InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAngiogenesis0InformativeDirect
Biological processCell adhesion0.00000000008159InformativeDirect
Biological processCell shape0.0005539InformativeDirect
Biological processAdaptive immunity0.0000000000001319Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm3.244e-16Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentCell membrane0.000000000002048Moderately InformativeDirect
Cellular componentSynapse1InformativeInherited
Cellular componentSynaptosome0.0002222Highly InformativeDirect
Coding sequence diversityAlternative promoter usage0.0001202Moderately InformativeDirect
DiseaseTumor suppressor0.0009284Moderately InformativeDirect
DiseaseDeafness0.000002796InformativeDirect
DomainRepeat0.00000000002623Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainSH2 domain0InformativeDirect
DomainSH3 domain0.00000000001571InformativeDirect
Molecular functionActin-binding0InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Molecular functionLipid-binding0.0001956InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0.00000000009458Moderately InformativeDirect
Post-translational modificationKinase0.00008648Moderately InformativeDirect
Post-translational modificationProtein phosphatase0.00000000000001731InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0.0000000001817InformativeDirect
Post-translational modificationChromatin regulator0.00003684InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationActin capping0.0000000001974Highly InformativeDirect
Post-translational modificationMyosin0.00001761Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Second domain of FERM domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the Second domain of FERM superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


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