SUPERFAMILY 1.75 HMM library and genome assignments server


Second domain of FERM superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Acyl-CoA binding protein-like [ 47026] (2)
Superfamily:   Second domain of FERM [ 47031]
Families:   Second domain of FERM [ 47032] (8)


Superfamily statistics
Genomes (232) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 6,356 0 21
Proteins 5,943 0 21


Functional annotation
General category Information
Detailed category Translation

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 2.935e-14 Least Informative Direct
Biological Process (BP) multicellular organismal process 3.874e-12 Least Informative Direct
Biological Process (BP) developmental process 7.784e-11 Least Informative Direct
Biological Process (BP) localization 5.716e-06 Least Informative Direct
Biological Process (BP) protein metabolic process 2.066e-05 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.001214 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.01562 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 3.783e-08 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 4.03e-08 Moderately Informative Direct
Biological Process (BP) organelle organization 1.033e-07 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 2.19e-07 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 5.256e-07 Moderately Informative Direct
Biological Process (BP) macromolecule localization 6.197e-07 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 5.699e-06 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0001099 Moderately Informative Direct
Biological Process (BP) tissue development 0.0001727 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.03331 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.1087 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.9319 Moderately Informative Inherited
Biological Process (BP) system process 0.1302 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1033 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.0409 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.8151 Moderately Informative Inherited
Biological Process (BP) reproduction 0.8192 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.2007 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.2483 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.387 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.004668 Moderately Informative Inherited
Biological Process (BP) organ development 0.1457 Moderately Informative Inherited
Biological Process (BP) immune system process 0.05306 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.1787 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.008203 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.4945 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.0574 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.04427 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.7409 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.0364 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.1629 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.8354 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.5964 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.04314 Moderately Informative Inherited
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) biological adhesion 2.706e-12 Informative Direct
Biological Process (BP) response to cytokine stimulus 1.901e-09 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 5.708e-09 Informative Direct
Biological Process (BP) locomotion 5.776e-08 Informative Direct
Biological Process (BP) cell projection organization 1.789e-07 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 3.114e-07 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 7.011e-07 Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 2.479e-06 Informative Direct
Biological Process (BP) tissue morphogenesis 1.376e-05 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 1.772e-05 Informative Direct
Biological Process (BP) glycosyl compound catabolic process 3.306e-05 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 4.543e-05 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 7.084e-05 Informative Direct
Biological Process (BP) cellular component movement 8.494e-05 Informative Direct
Biological Process (BP) organophosphate catabolic process 8.895e-05 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0.000143 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.0002585 Informative Direct
Biological Process (BP) intracellular signal transduction 0.0002842 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 0.0002912 Informative Direct
Biological Process (BP) organ morphogenesis 0.0003261 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0.0007843 Informative Direct
Biological Process (BP) positive regulation of protein modification process 0.3826 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.2334 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.4012 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.0993 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.09027 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.5122 Informative Inherited
Biological Process (BP) tube development 0.3463 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.03331 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.02222 Informative Inherited
Biological Process (BP) cell-cell signaling 0.01407 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.1623 Informative Inherited
Biological Process (BP) transmission of nerve impulse 0.001898 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.003138 Informative Inherited
Biological Process (BP) sexual reproduction 0.3963 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.5028 Informative Inherited
Biological Process (BP) single organism reproductive process 0.896 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.01636 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.3537 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.007064 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.00159 Informative Inherited
Biological Process (BP) regulation of locomotion 0.004229 Informative Inherited
Biological Process (BP) dephosphorylation 0.01891 Informative Inherited
Biological Process (BP) protein complex assembly 0.7335 Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0.00219 Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 0.002784 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.09364 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.002269 Informative Inherited
Biological Process (BP) generation of neurons 0.006777 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.03644 Informative Inherited
Biological Process (BP) central nervous system development 0.6123 Informative Inherited
Biological Process (BP) phosphorylation 0.02858 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.6139 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.002722 Informative Inherited
Biological Process (BP) regulation of growth 0.04234 Informative Inherited
Biological Process (BP) regulation of cell development 0.7548 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.001903 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.5456 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 1 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.3086 Informative Inherited
Biological Process (BP) response to wounding 0.1038 Informative Inherited
Biological Process (BP) muscle structure development 0.7279 Informative Inherited
Biological Process (BP) epithelium development 0.008983 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.9475 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) sensory organ development 0.04113 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.001998 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.04437 Informative Inherited
Biological Process (BP) localization of cell 0.002438 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.04226 Informative Inherited
Biological Process (BP) peptidyl-tyrosine modification 0 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0 Highly Informative Direct
Biological Process (BP) cell junction organization 7.281e-15 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 3.252e-11 Highly Informative Direct
Biological Process (BP) tissue homeostasis 3.033e-10 Highly Informative Direct
Biological Process (BP) maintenance of location 9.867e-10 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 3.444e-08 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 3.725e-08 Highly Informative Direct
Biological Process (BP) regulation of binding 6.174e-08 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 2.495e-07 Highly Informative Direct
Biological Process (BP) protein dephosphorylation 3.588e-07 Highly Informative Direct
Biological Process (BP) ATP metabolic process 4.52e-07 Highly Informative Direct
Biological Process (BP) protein phosphorylation 4.785e-07 Highly Informative Direct
Biological Process (BP) cell adhesion 5.716e-07 Highly Informative Direct
Biological Process (BP) regulation of Rho GTPase activity 1.079e-06 Highly Informative Direct
Biological Process (BP) phagocytosis 3.309e-06 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate catabolic process 1.096e-05 Highly Informative Direct
Biological Process (BP) negative regulation of growth 1.122e-05 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 1.803e-05 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 1.85e-05 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 2.185e-05 Highly Informative Direct
Biological Process (BP) regulation of neural precursor cell proliferation 0.0001435 Highly Informative Direct
Biological Process (BP) cellular response to peptide 0.0002553 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 0.0003277 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0.000676 Highly Informative Direct
Biological Process (BP) hemostasis 0.0009097 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 0.001513 Highly Informative Inherited
Biological Process (BP) regulation of proteolysis 0.003165 Highly Informative Inherited
Biological Process (BP) regulation of protein ubiquitination 0.02764 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 0.06077 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.309 Highly Informative Inherited
Biological Process (BP) response to peptide hormone stimulus 0.001463 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 1 Highly Informative Inherited
Biological Process (BP) sensory perception 0.4228 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.003167 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.2293 Highly Informative Inherited
Biological Process (BP) positive regulation of Ras GTPase activity 0.01509 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.01378 Highly Informative Inherited
Biological Process (BP) telencephalon development 0.002959 Highly Informative Inherited
Biological Process (BP) histone modification 0.9962 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.4443 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.5592 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.1154 Highly Informative Inherited
Biological Process (BP) coagulation 0.03026 Highly Informative Inherited
Biological Process (BP) wound healing 0.05012 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.06968 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.007607 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.518 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.01587 Highly Informative Inherited
Biological Process (BP) photoreceptor cell differentiation 0.03717 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.1035 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.04901 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 5.685e-08 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0005263 Moderately Informative Direct
Molecular Function (MF) structural molecule activity 0.0008579 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.09344 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.009593 Moderately Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 7.516e-11 Informative Direct
Molecular Function (MF) kinase activity 1.129e-09 Informative Direct
Molecular Function (MF) phosphoric ester hydrolase activity 5.073e-07 Informative Direct
Molecular Function (MF) tetrapyrrole binding 3.498e-05 Informative Direct
Molecular Function (MF) GTPase regulator activity 5.529e-05 Informative Direct
Molecular Function (MF) lipid binding 0.01756 Informative Inherited
Molecular Function (MF) receptor binding 0.03836 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 0.002951 Informative Inherited
Molecular Function (MF) protein kinase activity 4.078e-14 Highly Informative Direct
Molecular Function (MF) phosphoprotein phosphatase activity 2.58e-13 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol binding 3.988e-11 Highly Informative Direct
Molecular Function (MF) small GTPase regulator activity 1.135e-06 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 2.471e-06 Highly Informative Direct
Molecular Function (MF) protein complex binding 2.096e-05 Highly Informative Direct
Molecular Function (MF) heme binding 2.591e-05 Highly Informative Direct
Molecular Function (MF) actin binding 0.0003237 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.09194 Highly Informative Inherited
Molecular Function (MF) cytokine receptor binding 0.03451 Highly Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) membrane 7.345e-09 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.1991 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.02394 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 2.64e-14 Moderately Informative Direct
Cellular Component (CC) plasma membrane 2.036e-09 Moderately Informative Direct
Cellular Component (CC) cell leading edge 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 0 Informative Direct
Cellular Component (CC) cell cortex 0 Informative Direct
Cellular Component (CC) synapse part 7.259e-05 Informative Direct
Cellular Component (CC) cell-cell junction 1 Informative Inherited
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) adherens junction 0 Highly Informative Direct
Cellular Component (CC) microvillus 3.762e-14 Highly Informative Direct
Cellular Component (CC) ruffle 6.128e-10 Highly Informative Direct
Cellular Component (CC) actin filament 4.165e-09 Highly Informative Direct
Cellular Component (CC) cell-substrate junction 6.861e-09 Highly Informative Direct
Cellular Component (CC) cell division site part 7.376e-08 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 1.099e-06 Highly Informative Direct
Cellular Component (CC) myosin complex 1.806e-05 Highly Informative Direct
Cellular Component (CC) internal side of plasma membrane 8.633e-05 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 0.0001789 Highly Informative Direct
Cellular Component (CC) apical junction complex 0.0002985 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 0.0007523 Highly Informative Direct
Cellular Component (CC) cilium part 0.003149 Highly Informative Inherited
Cellular Component (CC) extrinsic to plasma membrane 0.002232 Highly Informative Inherited
Cellular Component (CC) cell-cell contact zone 0.0602 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds2.725e-08Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases7.826e-15Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.922Least InformativeInherited
Disease Ontology (DO)nervous system cancer0.04443Moderately InformativeInherited
Disease Ontology (DO)meningioma0.0001563InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the ear0.17InformativeInherited
Phenotypic Abnormality (PA)Functional abnormality of the inner ear0.03113Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.1523Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.6136Least InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.6496Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.6973Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hair cell morphology0.01904InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear sensory epithelium morphology0.01904InformativeInherited
Mammalian Phenotype (MP)abnormal membranous labyrinth morphology0.04212InformativeInherited
Mammalian Phenotype (MP)short cochlear hair cell stereocilia2.274e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal outer hair cell stereociliary bundle morphology0.0006021Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cochlear inner hair cell morphology0.00579Highly InformativeInherited
Mammalian Phenotype (MP)abnormal erythrocyte morphology0.0723Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell migration variant6.718e-05InformativeDirect
Worm Phenotype (WP)distal tip cell migration variant4.994e-06Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)anatomical group0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)head0Moderately InformativeDirect
Fly Anatomy (FA)acellular anatomical structure0.0003325Moderately InformativeDirect
Fly Anatomy (FA)tagmatic subdivision of integument0.009968Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.04522Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.08439Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.1986Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.3862Moderately InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval digestive system0.01197InformativeInherited
Fly Anatomy (FA)chaeta0.06199InformativeInherited
Fly Anatomy (FA)adult external head0.06739InformativeInherited
Fly Anatomy (FA)head bristle0.0002857Highly InformativeDirect
Fly Anatomy (FA)embryonic foregut0.0005725Highly InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0.07651Least InformativeInherited

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups3.682e-10Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.01481Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases8.003e-15Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAngiogenesis0InformativeDirect
Biological processCell adhesion8.222e-11InformativeDirect
Biological processCell shape0.0005565InformativeDirect
Biological processAdaptive immunity1.348e-13Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm3.235e-16Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentCell membrane1.531e-12Moderately InformativeDirect
Cellular componentSynapse1InformativeInherited
Cellular componentSynaptosome0.0002251Highly InformativeDirect
Coding sequence diversityAlternative promoter usage0.0001139Moderately InformativeDirect
DiseaseTumor suppressor0.000944Moderately InformativeDirect
DiseaseDeafness2.706e-06InformativeDirect
DomainRepeat2.57e-11Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainSH2 domain0InformativeDirect
DomainSH3 domain1.63e-11InformativeDirect
Molecular functionActin-binding0InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Molecular functionLipid-binding0.0001964InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein9.908e-11Moderately InformativeDirect
Post-translational modificationKinase8.607e-05Moderately InformativeDirect
Post-translational modificationProtein phosphatase1.729e-14InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor1.852e-10InformativeDirect
Post-translational modificationChromatin regulator3.537e-05InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationActin capping2e-10Highly InformativeDirect
Post-translational modificationMyosin1.757e-05Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Second domain of FERM domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the Second domain of FERM superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


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