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Second domain of FERM superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Acyl-CoA binding protein-like [ 47026] (2)
Superfamily:   Second domain of FERM [ 47031]
Families:   Second domain of FERM [ 47032] (8)


Superfamily statistics
Genomes (239) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 6,721 6,912 21
Proteins 6,295 6,469 21


Functional annotation
General category Information
Detailed category Translation

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.000000000000009109 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.00000000002753 Least Informative Direct
Biological Process (BP) developmental process 0.0000000004456 Least Informative Direct
Biological Process (BP) localization 0.00001421 Least Informative Direct
Biological Process (BP) protein metabolic process 0.0000211 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.0008329 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.01819 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.000000000000001931 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.00000003864 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0.00000009239 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.0000001435 Moderately Informative Direct
Biological Process (BP) organelle organization 0.0000002364 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.0000004615 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0000007312 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.000005845 Moderately Informative Direct
Biological Process (BP) tissue development 0.000185 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0001865 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.02803 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.03228 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) system process 0.1322 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.05742 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.07684 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.8726 Moderately Informative Inherited
Biological Process (BP) reproduction 0.767 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.2409 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.2884 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.4416 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.008034 Moderately Informative Inherited
Biological Process (BP) organ development 0.1471 Moderately Informative Inherited
Biological Process (BP) immune system process 0.06863 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.1772 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.008321 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.6107 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.01898 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.02397 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.8109 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.04796 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound catabolic process 0.02038 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.1971 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.6641 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.04459 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.01131 Moderately Informative Inherited
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) biological adhesion 0.000000000001107 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.000000004313 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0000000085 Informative Direct
Biological Process (BP) response to cytokine stimulus 0.00000002649 Informative Direct
Biological Process (BP) locomotion 0.00000003373 Informative Direct
Biological Process (BP) cell projection organization 0.0000002713 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.0000008832 Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 0.000002985 Informative Direct
Biological Process (BP) tissue morphogenesis 0.00001534 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.00003178 Informative Direct
Biological Process (BP) glycosyl compound catabolic process 0.00004509 Informative Direct
Biological Process (BP) cellular component movement 0.00005097 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 0.00006338 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.0001252 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.0001264 Informative Direct
Biological Process (BP) intracellular signal transduction 0.0001919 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0.0002067 Informative Direct
Biological Process (BP) organ morphogenesis 0.0002939 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.0003529 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 0.0003878 Informative Direct
Biological Process (BP) positive regulation of protein modification process 0.398 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.03013 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.0874 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.5724 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.1779 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.1489 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.7225 Informative Inherited
Biological Process (BP) tube development 0.3369 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.04491 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.02242 Informative Inherited
Biological Process (BP) synaptic transmission 0.02119 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.004031 Informative Inherited
Biological Process (BP) sexual reproduction 0.2885 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.3972 Informative Inherited
Biological Process (BP) single organism reproductive process 0.8035 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.09954 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.1664 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.2797 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.01362 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.3745 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.007969 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.001647 Informative Inherited
Biological Process (BP) regulation of locomotion 0.005311 Informative Inherited
Biological Process (BP) dephosphorylation 0.01498 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.1033 Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0.003367 Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 0.004139 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.001092 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.003342 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.21 Informative Inherited
Biological Process (BP) generation of neurons 0.006372 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.03763 Informative Inherited
Biological Process (BP) central nervous system development 0.6278 Informative Inherited
Biological Process (BP) phosphorylation 0.02997 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.613 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.003449 Informative Inherited
Biological Process (BP) regulation of growth 0.05113 Informative Inherited
Biological Process (BP) regulation of cell development 0.7466 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.001226 Informative Inherited
Biological Process (BP) response to wounding 0.1202 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.3281 Informative Inherited
Biological Process (BP) muscle structure development 0.7375 Informative Inherited
Biological Process (BP) epithelium development 0.007825 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.8416 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) sensory organ development 0.03915 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.002063 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.04818 Informative Inherited
Biological Process (BP) localization of cell 0.001026 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.05322 Informative Inherited
Biological Process (BP) peptidyl-tyrosine modification 0 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0 Highly Informative Direct
Biological Process (BP) cell junction organization 0.000000000000007318 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0.00000000003769 Highly Informative Direct
Biological Process (BP) maintenance of location 0.000000001703 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.00000006798 Highly Informative Direct
Biological Process (BP) protein dephosphorylation 0.0000001095 Highly Informative Direct
Biological Process (BP) regulation of binding 0.0000001151 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.0000001521 Highly Informative Direct
Biological Process (BP) cell adhesion 0.0000002741 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 0.0000003 Highly Informative Direct
Biological Process (BP) ATP metabolic process 0.0000005449 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0.0000008138 Highly Informative Direct
Biological Process (BP) regulation of Rho GTPase activity 0.000001456 Highly Informative Direct
Biological Process (BP) phagocytosis 0.00000487 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 0.00001436 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate catabolic process 0.00001467 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 0.00002482 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 0.00002941 Highly Informative Direct
Biological Process (BP) regulation of neural precursor cell proliferation 0.000163 Highly Informative Direct
Biological Process (BP) cellular response to peptide 0.0003014 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 0.0003895 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0.0008692 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 0.001705 Highly Informative Inherited
Biological Process (BP) regulation of proteolysis 0.003415 Highly Informative Inherited
Biological Process (BP) regulation of protein ubiquitination 0.02726 Highly Informative Inherited
Biological Process (BP) regulation of protein complex disassembly 0.002673 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 0.05915 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.2977 Highly Informative Inherited
Biological Process (BP) response to peptide hormone stimulus 0.001716 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 1 Highly Informative Inherited
Biological Process (BP) sensory perception 0.4171 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.001114 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.2083 Highly Informative Inherited
Biological Process (BP) positive regulation of Ras GTPase activity 0.01653 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.04362 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.05338 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.01587 Highly Informative Inherited
Biological Process (BP) telencephalon development 0.003099 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.473 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.5033 Highly Informative Inherited
Biological Process (BP) hemostasis 0.001137 Highly Informative Inherited
Biological Process (BP) coagulation 0.03165 Highly Informative Inherited
Biological Process (BP) wound healing 0.05237 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.07613 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.007378 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.4958 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.006704 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.09772 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 0.009751 Least Informative Inherited
Molecular Function (MF) hydrolase activity 0.07012 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.0000001171 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0008179 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.1128 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.01092 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.007316 Moderately Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.0000000001499 Informative Direct
Molecular Function (MF) kinase activity 0.000000002315 Informative Direct
Molecular Function (MF) phosphoric ester hydrolase activity 0.000001035 Informative Direct
Molecular Function (MF) tetrapyrrole binding 0.00004951 Informative Direct
Molecular Function (MF) GTPase regulator activity 0.00007467 Informative Direct
Molecular Function (MF) lipid binding 0.01757 Informative Inherited
Molecular Function (MF) receptor binding 0.03943 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 0.003687 Informative Inherited
Molecular Function (MF) protein kinase activity 0.00000000000008797 Highly Informative Direct
Molecular Function (MF) phosphoprotein phosphatase activity 0.000000000000416 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol binding 0.00000000005953 Highly Informative Direct
Molecular Function (MF) small GTPase regulator activity 0.000001716 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.000002542 Highly Informative Direct
Molecular Function (MF) protein complex binding 0.00002487 Highly Informative Direct
Molecular Function (MF) heme binding 0.00003781 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.08929 Highly Informative Inherited
Molecular Function (MF) cytokine receptor binding 0.03313 Highly Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) membrane 0.0000007741 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.1638 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.03666 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.00000000000001332 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.00000002083 Moderately Informative Direct
Cellular Component (CC) cell leading edge 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 0 Informative Direct
Cellular Component (CC) cell cortex 0 Informative Direct
Cellular Component (CC) cell junction 0 Informative Direct
Cellular Component (CC) synapse part 0.000157 Informative Direct
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) adherens junction 0 Highly Informative Direct
Cellular Component (CC) cell division site part 0.00000000002475 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 0.000001071 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 0.0002429 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 0.0007615 Highly Informative Direct
Cellular Component (CC) cilium part 0.003247 Highly Informative Inherited
Cellular Component (CC) extrinsic to plasma membrane 0.002153 Highly Informative Inherited
Cellular Component (CC) cell-cell contact zone 0.09379 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.00000002725Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000000000000007826Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.9266Least InformativeInherited
Disease Ontology (DO)nervous system cancer0.04521Moderately InformativeInherited
Disease Ontology (DO)meningioma0.0001728InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the ear0.1691InformativeInherited
Phenotypic Abnormality (PA)Functional abnormality of the inner ear0.03258Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.1505Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.6165Least InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.6518Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.7009Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear sensory epithelium morphology0.0199InformativeInherited
Mammalian Phenotype (MP)abnormal hair cell morphology0.0203InformativeInherited
Mammalian Phenotype (MP)abnormal membranous labyrinth morphology0.04321InformativeInherited
Mammalian Phenotype (MP)short cochlear hair cell stereocilia0.00002235Highly InformativeDirect
Mammalian Phenotype (MP)abnormal outer hair cell stereociliary bundle morphology0.0007435Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cochlear inner hair cell morphology0.00626Highly InformativeInherited
Mammalian Phenotype (MP)abnormal erythrocyte morphology0.03307Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell migration variant0.00006718InformativeDirect
Worm Phenotype (WP)distal tip cell migration variant0.000004994Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)anatomical group0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)adult head0Moderately InformativeDirect
Fly Anatomy (FA)acellular anatomical structure0.0002835Moderately InformativeDirect
Fly Anatomy (FA)tagmatic subdivision of integument0.007833Moderately InformativeInherited
Fly Anatomy (FA)external sensory organ0.02655Moderately InformativeInherited
Fly Anatomy (FA)adult sense organ0.09881Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.1682Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.3653Moderately InformativeInherited
Fly Anatomy (FA)sensillum0.5186Moderately InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval digestive system0.0101InformativeInherited
Fly Anatomy (FA)chaeta0.0508InformativeInherited
Fly Anatomy (FA)adult external head0.05853InformativeInherited
Fly Anatomy (FA)head bristle0.0002913Highly InformativeDirect
Fly Anatomy (FA)embryonic foregut0.0005178Highly InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0.07638Least InformativeInherited

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0.0000000003675Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.01531Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000000000000008015Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAngiogenesis0InformativeDirect
Biological processCell adhesion0.00000000008083InformativeDirect
Biological processCell shape0.0005538InformativeDirect
Biological processAdaptive immunity0.0000000000001331Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm3.239e-16Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentCell membrane0.000000000001779Moderately InformativeDirect
Cellular componentSynapse1InformativeInherited
Cellular componentSynaptosome0.000225Highly InformativeDirect
Coding sequence diversityAlternative promoter usage0.0001171Moderately InformativeDirect
DiseaseTumor suppressor0.000944Moderately InformativeDirect
DiseaseDeafness0.000002706InformativeDirect
DomainRepeat0.00000000002501Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainSH2 domain0InformativeDirect
DomainSH3 domain0.00000000001599InformativeDirect
Molecular functionActin-binding0InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Molecular functionLipid-binding0.0001954InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0.00000000009661Moderately InformativeDirect
Post-translational modificationKinase0.00008584Moderately InformativeDirect
Post-translational modificationProtein phosphatase0.0000000000000175InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0.000000000183InformativeDirect
Post-translational modificationChromatin regulator0.00003503InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationActin capping0.0000000001983Highly InformativeDirect
Post-translational modificationMyosin0.0000176Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Second domain of FERM domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the Second domain of FERM superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]