SUPERFAMILY 1.75 HMM library and genome assignments server

Second domain of FERM superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Acyl-CoA binding protein-like [ 47026] (2)
Superfamily:   Second domain of FERM [ 47031]
Families:   Second domain of FERM [ 47032] (8)


Superfamily statistics
Genomes (239) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 6,718 6,912 21
Proteins 6,289 6,469 21


Functional annotation
General category Information
Detailed category Translation

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00000000000001086 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.00000000002884 Least Informative Direct
Biological Process (BP) developmental process 0.0000000004516 Least Informative Direct
Biological Process (BP) localization 0.00001655 Least Informative Direct
Biological Process (BP) protein metabolic process 0.00002274 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.0009431 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.01858 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.000000000000001938 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0.00000000005141 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.00000003284 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.00000004052 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.00000004462 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.000000145 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0000001965 Moderately Informative Direct
Biological Process (BP) organelle organization 0.0000002368 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0000006495 Moderately Informative Direct
Biological Process (BP) tissue development 0.0001914 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.02657 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.0334 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.05631 Moderately Informative Inherited
Biological Process (BP) system process 0.1369 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.5604 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.8659 Moderately Informative Inherited
Biological Process (BP) reproduction 0.7705 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.2444 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.5878 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.4857 Moderately Informative Inherited
Biological Process (BP) organ development 0.147 Moderately Informative Inherited
Biological Process (BP) immune system process 0.06883 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.09113 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.1685 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.008677 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.6218 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.02079 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.02501 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.7708 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.04838 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.199 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.8959 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.6675 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.04562 Moderately Informative Inherited
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) biological adhesion 0.000000000001111 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.000000003943 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.000000007324 Informative Direct
Biological Process (BP) response to cytokine stimulus 0.000000027 Informative Direct
Biological Process (BP) locomotion 0.0000000327 Informative Direct
Biological Process (BP) cell projection organization 0.00000009581 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.0000009513 Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 0.000002644 Informative Direct
Biological Process (BP) tissue morphogenesis 0.00001447 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.00003206 Informative Direct
Biological Process (BP) cellular component movement 0.0000475 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 0.00006469 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 0.000101 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.0001287 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 0.0001377 Informative Direct
Biological Process (BP) intracellular signal transduction 0.0002034 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0.0002099 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 0.0002196 Informative Direct
Biological Process (BP) organ morphogenesis 0.0002972 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.0003607 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 0.0003963 Informative Direct
Biological Process (BP) negative regulation of signaling 0.000444 Informative Direct
Biological Process (BP) localization of cell 0.0009781 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 0.05728 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.001344 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.03114 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.001283 Informative Inherited
Biological Process (BP) regulation of protein localization 0.003742 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.08929 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.5796 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.1749 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.1526 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.7216 Informative Inherited
Biological Process (BP) tube development 0.3356 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.04698 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.02199 Informative Inherited
Biological Process (BP) synaptic transmission 0.02168 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.01118 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.00356 Informative Inherited
Biological Process (BP) sexual reproduction 0.2961 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.3974 Informative Inherited
Biological Process (BP) single organism reproductive process 0.8102 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.001476 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.8123 Informative Inherited
Biological Process (BP) regulation of locomotion 0.004834 Informative Inherited
Biological Process (BP) dephosphorylation 0.01306 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.1253 Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0.008209 Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 0.009851 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.001103 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.003411 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.2016 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.7471 Informative Inherited
Biological Process (BP) generation of neurons 0.006637 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.03762 Informative Inherited
Biological Process (BP) central nervous system development 0.6351 Informative Inherited
Biological Process (BP) phosphorylation 0.03034 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.9005 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.004186 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.003471 Informative Inherited
Biological Process (BP) regulation of growth 0.0489 Informative Inherited
Biological Process (BP) regulation of cell development 0.764 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.001095 Informative Inherited
Biological Process (BP) response to wounding 0.1213 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.325 Informative Inherited
Biological Process (BP) muscle structure development 0.7424 Informative Inherited
Biological Process (BP) epithelium development 0.008135 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.8429 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.01146 Informative Inherited
Biological Process (BP) sensory organ development 0.0396 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.002003 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.05095 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.0521 Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0 Highly Informative Direct
Biological Process (BP) cell junction organization 0.000000000000007347 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0.00000000003437 Highly Informative Direct
Biological Process (BP) maintenance of location 0.000000001577 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.00000006271 Highly Informative Direct
Biological Process (BP) protein dephosphorylation 0.0000001157 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.0000001413 Highly Informative Direct
Biological Process (BP) cell adhesion 0.0000002512 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 0.0000002606 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0.0000007781 Highly Informative Direct
Biological Process (BP) regulation of binding 0.00000112 Highly Informative Direct
Biological Process (BP) purine ribonucleoside monophosphate metabolic process 0.000001351 Highly Informative Direct
Biological Process (BP) phagocytosis 0.00000509 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 0.00001244 Highly Informative Direct
Biological Process (BP) ribonucleoside triphosphate catabolic process 0.00001508 Highly Informative Direct
Biological Process (BP) purine nucleoside triphosphate catabolic process 0.00001694 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 0.00002542 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 0.00003013 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate metabolic process 0.00003236 Highly Informative Direct
Biological Process (BP) regulation of Rho protein signal transduction 0.00003593 Highly Informative Direct
Biological Process (BP) regulation of striated muscle cell differentiation 0.0001062 Highly Informative Direct
Biological Process (BP) regulation of neural precursor cell proliferation 0.0002297 Highly Informative Direct
Biological Process (BP) regulation of Ras GTPase activity 0.0002548 Highly Informative Direct
Biological Process (BP) cellular response to peptide 0.0003304 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 0.0005271 Highly Informative Direct
Biological Process (BP) negative regulation of phosphorylation 0.0005896 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0.0008344 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 0.005836 Highly Informative Inherited
Biological Process (BP) regulation of proteolysis 0.01561 Highly Informative Inherited
Biological Process (BP) regulation of protein ubiquitination 0.09533 Highly Informative Inherited
Biological Process (BP) regulation of protein complex disassembly 0.002533 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 0.05899 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.2978 Highly Informative Inherited
Biological Process (BP) response to peptide hormone stimulus 0.00184 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 1 Highly Informative Inherited
Biological Process (BP) sensory perception 0.4072 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.001223 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.7906 Highly Informative Inherited
Biological Process (BP) regulation of peptidyl-tyrosine phosphorylation 0.3164 Highly Informative Inherited
Biological Process (BP) positive regulation of GTPase activity 0.3875 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.04357 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.05168 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.01929 Highly Informative Inherited
Biological Process (BP) telencephalon development 0.00332 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.4811 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.4955 Highly Informative Inherited
Biological Process (BP) hemostasis 0.001127 Highly Informative Inherited
Biological Process (BP) coagulation 0.03137 Highly Informative Inherited
Biological Process (BP) wound healing 0.05341 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.07539 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.007309 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.4874 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.007358 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.00142 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.1004 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 0.009739 Least Informative Inherited
Molecular Function (MF) hydrolase activity 0.06968 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.0000001113 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0003483 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.1156 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.01043 Moderately Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.0000000001395 Informative Direct
Molecular Function (MF) kinase activity 0.000000002156 Informative Direct
Molecular Function (MF) phosphoric ester hydrolase activity 0.0000009189 Informative Direct
Molecular Function (MF) tetrapyrrole binding 0.00005059 Informative Direct
Molecular Function (MF) GTPase regulator activity 0.00007474 Informative Direct
Molecular Function (MF) lipid binding 0.008403 Informative Inherited
Molecular Function (MF) receptor binding 0.04111 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 0.003651 Informative Inherited
Molecular Function (MF) protein kinase activity 0.00000000000007911 Highly Informative Direct
Molecular Function (MF) phosphoprotein phosphatase activity 0.0000000000004227 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol binding 0.000000000005777 Highly Informative Direct
Molecular Function (MF) small GTPase regulator activity 0.00000171 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.000002868 Highly Informative Direct
Molecular Function (MF) protein complex binding 0.00002703 Highly Informative Direct
Molecular Function (MF) heme binding 0.00003868 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.08927 Highly Informative Inherited
Molecular Function (MF) cytokine receptor binding 0.03233 Highly Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) membrane 0.0000004734 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.1629 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.03581 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.00000000000001474 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.000000009788 Moderately Informative Direct
Cellular Component (CC) cell leading edge 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 0 Informative Direct
Cellular Component (CC) cell cortex 0 Informative Direct
Cellular Component (CC) cell junction 0 Informative Direct
Cellular Component (CC) synapse part 0.000211 Informative Direct
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) adherens junction 0 Highly Informative Direct
Cellular Component (CC) cell division site part 0.000000000001614 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 0.000001014 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 0.0002645 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 0.000306 Highly Informative Direct
Cellular Component (CC) cilium part 0.003469 Highly Informative Inherited
Cellular Component (CC) extrinsic to plasma membrane 0.002437 Highly Informative Inherited
Cellular Component (CC) cell-cell contact zone 0.09503 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.00000002725Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000000000000007826Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.9317Least InformativeInherited
Disease Ontology (DO)nervous system cancer0.04878Moderately InformativeInherited
Disease Ontology (DO)meningioma0.0001722InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the ear0.1697InformativeInherited
Phenotypic Abnormality (PA)Functional abnormality of the inner ear0.0325Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.1167Least InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.6641Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.7087Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hair cell morphology0.02251InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear sensory epithelium morphology0.02251InformativeInherited
Mammalian Phenotype (MP)abnormal membranous labyrinth morphology0.04646InformativeInherited
Mammalian Phenotype (MP)short cochlear hair cell stereocilia0.00002573Highly InformativeDirect
Mammalian Phenotype (MP)abnormal outer hair cell stereociliary bundle morphology0.0008469Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cochlear inner hair cell morphology0.007041Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell migration variant0.00006718InformativeDirect
Worm Phenotype (WP)distal tip cell migration variant0.000004994Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)anatomical group0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)adult head0Moderately InformativeDirect
Fly Anatomy (FA)acellular anatomical structure0.0002828Moderately InformativeDirect
Fly Anatomy (FA)tagmatic subdivision of integument0.007877Moderately InformativeInherited
Fly Anatomy (FA)external sensory organ0.02647Moderately InformativeInherited
Fly Anatomy (FA)adult sense organ0.09855Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.1686Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.3653Moderately InformativeInherited
Fly Anatomy (FA)sensillum0.519Moderately InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval digestive system0.01008InformativeInherited
Fly Anatomy (FA)chaeta0.05068InformativeInherited
Fly Anatomy (FA)adult external head0.05838InformativeInherited
Fly Anatomy (FA)head bristle0.0002911Highly InformativeDirect
Fly Anatomy (FA)embryonic foregut0.0005169Highly InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0.07639Least InformativeInherited

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0.0000000003576Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.01524Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000000000000008035Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)selective immunosuppressants0.000001484InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAngiogenesis0InformativeDirect
Biological processCell adhesion0.00000000008159InformativeDirect
Biological processCell shape0.0005539InformativeDirect
Biological processAdaptive immunity0.0000000000001319Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm3.244e-16Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentCell membrane0.000000000002048Moderately InformativeDirect
Cellular componentSynapse1InformativeInherited
Cellular componentSynaptosome0.0002222Highly InformativeDirect
Coding sequence diversityAlternative promoter usage0.0001202Moderately InformativeDirect
DiseaseTumor suppressor0.0009284Moderately InformativeDirect
DiseaseDeafness0.000002796InformativeDirect
DomainRepeat0.00000000002623Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainSH2 domain0InformativeDirect
DomainSH3 domain0.00000000001571InformativeDirect
Molecular functionActin-binding0InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Molecular functionLipid-binding0.0001956InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0.00000000009458Moderately InformativeDirect
Post-translational modificationKinase0.00008648Moderately InformativeDirect
Post-translational modificationProtein phosphatase0.00000000000001731InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0.0000000001817InformativeDirect
Post-translational modificationChromatin regulator0.00003684InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationActin capping0.0000000001974Highly InformativeDirect
Post-translational modificationMyosin0.00001761Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Second domain of FERM domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the Second domain of FERM superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]