SUPERFAMILY 1.75 HMM library and genome assignments server


Acyl-CoA binding protein superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Acyl-CoA binding protein-like [ 47026] (2)
Superfamily:   Acyl-CoA binding protein [ 47027]
Families:   Acyl-CoA binding protein [ 47028]


Superfamily statistics
Genomes (648) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,492 2,945 2
Proteins 2,479 2,926 2


Functional annotation
General category Metabolism
Detailed category Lipid metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.0421Least InformativeInherited
Biological Process (BP)developmental process0.00034850.4527Least InformativeInherited
Biological Process (BP)localization0.017170.05046Least InformativeInherited
Biological Process (BP)multicellular organismal process0.0052210.6452Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.0010620.0001438Least InformativeInherited
Biological Process (BP)response to stimulus0.052840.5849Least InformativeInherited
Biological Process (BP)lipid metabolic process2.452e-072.522e-12Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process0.0059990.6389Moderately InformativeInherited
Biological Process (BP)system process0.00058370.02897Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.00034070.1742Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.00025510.09223Moderately InformativeInherited
Biological Process (BP)nervous system development5.064e-050.1432Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.013530.0002462Moderately InformativeInherited
Biological Process (BP)tissue development0.018020.1867Moderately InformativeInherited
Biological Process (BP)organ development0.048920.3719Moderately InformativeInherited
Biological Process (BP)lipid localization1.34e-072.252e-13InformativeDirect
Biological Process (BP)regulation of system process1.148e-070.0001151InformativeDirect
Biological Process (BP)positive regulation of multicellular organismal process2.529e-050.000629InformativeDirect
Biological Process (BP)central nervous system development2.174e-070.001286InformativeInherited
Biological Process (BP)single-organism behavior5.298e-060.001303InformativeInherited
Biological Process (BP)glycerolipid metabolic process0.0026410.1332InformativeInherited
Biological Process (BP)defense response0.039920.02905InformativeInherited
Biological Process (BP)behavioral fear response2.969e-114.864e-11Highly InformativeDirect
Biological Process (BP)hair follicle development1.459e-101.064e-08Highly InformativeDirect
Biological Process (BP)learning or memory2.286e-089.799e-06Highly InformativeDirect
Biological Process (BP)telencephalon development5.656e-071.747e-06Highly InformativeDirect
Biological Process (BP)regulation of synaptic transmission5.814e-104.688e-07Highly InformativeDirect
Biological Process (BP)acylglycerol metabolic process0.0097340.0005255Highly InformativeInherited
Molecular Function (MF)binding0.017220.4266Least InformativeInherited
Molecular Function (MF)anion binding8.495e-097.915e-13Moderately InformativeDirect
Molecular Function (MF)cofactor binding2.62e-150InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.0001438 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) developmental process 0.4527 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.6452 Least Informative Inherited
Biological Process (BP) localization 0.05046 Least Informative Inherited
Biological Process (BP) response to stimulus 0.5849 Least Informative Inherited
Biological Process (BP) lipid metabolic process 2.522e-12 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0.0009198 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0002462 Moderately Informative Direct
Biological Process (BP) system process 0.02897 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.6389 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.1742 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.09223 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.1432 Moderately Informative Inherited
Biological Process (BP) tissue development 0.1867 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.01805 Moderately Informative Inherited
Biological Process (BP) organ development 0.3719 Moderately Informative Inherited
Biological Process (BP) lipid localization 2.252e-13 Informative Direct
Biological Process (BP) regulation of system process 0.0001151 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.000629 Informative Direct
Biological Process (BP) central nervous system development 0.001286 Informative Inherited
Biological Process (BP) single-organism behavior 0.001303 Informative Inherited
Biological Process (BP) glycerolipid metabolic process 0.1332 Informative Inherited
Biological Process (BP) defense response 0.02905 Informative Inherited
Biological Process (BP) behavioral fear response 4.864e-11 Highly Informative Direct
Biological Process (BP) hair follicle development 1.064e-08 Highly Informative Direct
Biological Process (BP) acylglycerol metabolic process 0.0005255 Highly Informative Direct
Biological Process (BP) learning or memory 9.799e-06 Highly Informative Direct
Biological Process (BP) telencephalon development 1.747e-06 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 4.688e-07 Highly Informative Direct
Molecular Function (MF) binding 0.4266 Least Informative Inherited
Molecular Function (MF) anion binding 7.915e-13 Moderately Informative Direct
Molecular Function (MF) cofactor binding 0 Informative Direct
Cellular Component (CC) cytoplasmic part 5.287e-06 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.007804 Least Informative Inherited
Cellular Component (CC) microbody 5.154e-07 Informative Direct

Document: GO annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)fruit3.341e-06InformativeDirect
Plant ANatomical entity (PAN)gamete0.001904InformativeInherited
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0InformativeDirect
Enzyme Commission (EC)Transposing C==C bonds0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processAutophagy0Highly InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum1.297e-12Moderately InformativeDirect
Cellular componentPeroxisome0InformativeDirect
DomainCoiled coil6.599e-11Moderately InformativeDirect
DomainANK repeat9.962e-14InformativeDirect
Molecular functionLipid-binding0InformativeDirect
Post-translational modificationAcetylation3.26e-10Least InformativeDirect
Post-translational modificationPhosphoprotein7.237e-08Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000582 SSF47027 Protein matches
Abstract

Acyl-CoA-binding protein (ACBP) is a small (10 Kd) protein that binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters [PubMed1454809]. ACBP is also known as diazepam binding inhibitor (DBI) or endozepine (EP) because of its ability to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor [PubMed1649940].

ACBP is a highly conserved protein of about 90 residues that is found in all four eukaryotic kingdoms, Animalia, Plantae, Fungi and Protista, and in some eubacterial species [PubMed16018771].

Although ACBP occurs as a completely independent protein, intact ACB domains have been identified in a number of large, multifunctional proteins in a variety of eukaryotic species. These include large membrane-associated proteins with N-terminal ACB domains, multifunctional enzymes with both ACB and peroxisomal enoyl-CoA Delta(3), Delta(2)-enoyl-CoA isomerase domains, and proteins with both an ACB domain and ankyrin repeats [PubMed16018771].

The ACB domain consists of four alpha-helices arranged in a bowl shape with a highly exposed acyl-CoA-binding site. The ligand is bound through specific interactions with residues on the protein, most notably several conserved positive charges that interact with the phosphate group on the adenosine-3'phosphate moiety, and the acyl chain is sandwiched between the hydrophobic surfaces of CoA and the protein [PubMed11491287].

Other proteins containing an ACB domain include:

  • Endozepine-like peptide (ELP) (gene DBIL5) from mouse [PubMed8898349]. ELP is a testis- specific ACBP homolog that may be involved in the energy metabolism of the mature sperm.
  • MA-DBI, a transmembrane protein of unknown function which has been found in mammals. MA-DBI contains a N-terminal ACB domain.
  • DRS-1 [PubMed10354522], a human protein of unknown function that contains a N-terminal ACB domain and a C-terminal enoyl-CoA isomerase/hydratase domain.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Acyl-CoA binding protein domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Acyl-CoA binding protein superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]