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Acyl-CoA binding protein superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Acyl-CoA binding protein-like [ 47026] (2)
Superfamily:   Acyl-CoA binding protein [ 47027]
Families:   Acyl-CoA binding protein [ 47028]


Superfamily statistics
Genomes (648) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,492 2,945 2
Proteins 2,479 2,926 2


Functional annotation
General category Metabolism
Detailed category Lipid metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)developmental process0.00034230.452Least InformativeInherited
Biological Process (BP)multicellular organismal process0.0051640.6434Least InformativeInherited
Biological Process (BP)localization0.01690.04877Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.0010680.000147Least InformativeInherited
Biological Process (BP)cellular lipid metabolic process0.0000020040.00000000001112Moderately InformativeDirect
Biological Process (BP)macromolecule localization0.013820.0002556Moderately InformativeInherited
Biological Process (BP)tissue development0.017990.1855Moderately InformativeInherited
Biological Process (BP)organ development0.048350.3712Moderately InformativeInherited
Biological Process (BP)lipid localization0.00000013440.0000000000002274InformativeDirect
Biological Process (BP)glycerolipid metabolic process0.0026490.1328InformativeInherited
Biological Process (BP)hair follicle development0.00000000021480.00000001816Highly InformativeDirect
Biological Process (BP)acylglycerol metabolic process0.0097230.0005309Highly InformativeInherited
Molecular Function (MF)binding0.017050.419Least InformativeInherited
Molecular Function (MF)anion binding0.0000000085170.0000000000007223Moderately InformativeDirect
Molecular Function (MF)cofactor binding0.0000000000000026230InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.000147 Least Informative Direct
Biological Process (BP) developmental process 0.452 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.6434 Least Informative Inherited
Biological Process (BP) localization 0.04877 Least Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.0009402 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0002556 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 0.00000000001112 Moderately Informative Direct
Biological Process (BP) tissue development 0.1855 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.01879 Moderately Informative Inherited
Biological Process (BP) organ development 0.3712 Moderately Informative Inherited
Biological Process (BP) lipid localization 0.0000000000002274 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0.1328 Informative Inherited
Biological Process (BP) hair follicle development 0.00000001816 Highly Informative Direct
Biological Process (BP) acylglycerol metabolic process 0.0005309 Highly Informative Direct
Molecular Function (MF) binding 0.419 Least Informative Inherited
Molecular Function (MF) anion binding 0.0000000000007223 Moderately Informative Direct
Molecular Function (MF) cofactor binding 0 Informative Direct
Cellular Component (CC) cytoplasmic part 0.000005066 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.00758 Least Informative Inherited
Cellular Component (CC) microbody 0.0000005201 Informative Direct

Document: GO annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)fruit0.000003341InformativeDirect
Plant ANatomical entity (PAN)gamete0.001904InformativeInherited
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0InformativeDirect
Enzyme Commission (EC)Transposing C==C bonds0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.0000000000008489Moderately InformativeDirect
Cellular componentPeroxisome0InformativeDirect
DomainCoiled coil0.00000000003053Moderately InformativeDirect
DomainANK repeat0.00000000000006546InformativeDirect
Molecular functionLipid-binding0InformativeDirect
Post-translational modificationAcetylation0.0000000001027Least InformativeDirect
Post-translational modificationPhosphoprotein0.0000001677Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000582 SSF47027 Protein matches
Abstract

Acyl-CoA-binding protein (ACBP) is a small (10 Kd) protein that binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters [PubMed1454809]. ACBP is also known as diazepam binding inhibitor (DBI) or endozepine (EP) because of its ability to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor [PubMed1649940].

ACBP is a highly conserved protein of about 90 residues that is found in all four eukaryotic kingdoms, Animalia, Plantae, Fungi and Protista, and in some eubacterial species [PubMed16018771].

Although ACBP occurs as a completely independent protein, intact ACB domains have been identified in a number of large, multifunctional proteins in a variety of eukaryotic species. These include large membrane-associated proteins with N-terminal ACB domains, multifunctional enzymes with both ACB and peroxisomal enoyl-CoA Delta(3), Delta(2)-enoyl-CoA isomerase domains, and proteins with both an ACB domain and ankyrin repeats [PubMed16018771].

The ACB domain consists of four alpha-helices arranged in a bowl shape with a highly exposed acyl-CoA-binding site. The ligand is bound through specific interactions with residues on the protein, most notably several conserved positive charges that interact with the phosphate group on the adenosine-3'phosphate moiety, and the acyl chain is sandwiched between the hydrophobic surfaces of CoA and the protein [PubMed11491287].

Other proteins containing an ACB domain include:

  • Endozepine-like peptide (ELP) (gene DBIL5) from mouse [PubMed8898349]. ELP is a testis- specific ACBP homolog that may be involved in the energy metabolism of the mature sperm.
  • MA-DBI, a transmembrane protein of unknown function which has been found in mammals. MA-DBI contains a N-terminal ACB domain.
  • DRS-1 [PubMed10354522], a human protein of unknown function that contains a N-terminal ACB domain and a C-terminal enoyl-CoA isomerase/hydratase domain.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Acyl-CoA binding protein domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Acyl-CoA binding protein superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]