SUPERFAMILY 1.75 HMM library and genome assignments server

Acyl-CoA binding protein superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Acyl-CoA binding protein-like [ 47026] (2)
Superfamily:   Acyl-CoA binding protein [ 47027]
Families:   Acyl-CoA binding protein [ 47028]


Superfamily statistics
Genomes (649) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,500 2,945 2
Proteins 2,487 2,926 2


Functional annotation
General category Metabolism
Detailed category Lipid metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)positive regulation of biological process0.016460.8941Least InformativeInherited
Biological Process (BP)regulation of cellular process0.046541Least InformativeInherited
Biological Process (BP)response to stimulus0.051860.5902Least InformativeInherited
Biological Process (BP)multicellular organismal process0.0043720.5759Least InformativeInherited
Biological Process (BP)localization0.019870.05925Least InformativeInherited
Biological Process (BP)developmental process0.00035010.456Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.020780.0005155Least InformativeInherited
Biological Process (BP)single-organism cellular process0.026950.2352Least InformativeInherited
Biological Process (BP)lipid metabolic process0.0000002060.000000000002464Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process0.008020.7309Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.000028330.0155Moderately InformativeInherited
Biological Process (BP)organ development0.045960.3621Moderately InformativeInherited
Biological Process (BP)nervous system development0.000052390.1451Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.011670.0001794Moderately InformativeInherited
Biological Process (BP)tissue development0.015360.1885Moderately InformativeInherited
Biological Process (BP)defense response0.038510.02393Moderately InformativeInherited
Biological Process (BP)lipid localization0.00000015830.0000000000002522InformativeDirect
Biological Process (BP)single-organism behavior0.000031350.0007657InformativeDirect
Biological Process (BP)central nervous system development0.0000002290.001339InformativeInherited
Biological Process (BP)epithelium development0.000024980.02928InformativeInherited
Biological Process (BP)neurological system process0.21020.1257InformativeInherited
Biological Process (BP)glycerolipid metabolic process0.00260.134InformativeInherited
Biological Process (BP)behavioral fear response0.000000000029490.00000000004779Highly InformativeDirect
Biological Process (BP)learning or memory0.000000025960.00001048Highly InformativeDirect
Biological Process (BP)epidermis development0.000000053570.00003143Highly InformativeDirect
Biological Process (BP)telencephalon development0.00000067020.000002022Highly InformativeDirect
Biological Process (BP)hair cycle process0.00000000014450.00000001178Highly InformativeDirect
Biological Process (BP)regulation of synaptic transmission0.000000016230.0000004824Highly InformativeDirect
Biological Process (BP)acylglycerol metabolic process0.0096830.0005177Highly InformativeInherited
Molecular Function (MF)binding0.017890.4429Least InformativeInherited
Molecular Function (MF)anion binding0.0000000085480.0000000000007946Moderately InformativeDirect
Molecular Function (MF)cofactor binding0.0000000000000026380InformativeDirect
Molecular Function (MF)sulfur compound binding00InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.0005155 Least Informative Direct
Biological Process (BP) positive regulation of biological process 0.8941 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.5902 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.5759 Least Informative Inherited
Biological Process (BP) localization 0.05925 Least Informative Inherited
Biological Process (BP) developmental process 0.456 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.2352 Least Informative Inherited
Biological Process (BP) lipid metabolic process 0.000000000002464 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0001794 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.7309 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.0155 Moderately Informative Inherited
Biological Process (BP) organ development 0.3621 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.1451 Moderately Informative Inherited
Biological Process (BP) tissue development 0.1885 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.01555 Moderately Informative Inherited
Biological Process (BP) defense response 0.02393 Moderately Informative Inherited
Biological Process (BP) lipid localization 0.0000000000002522 Informative Direct
Biological Process (BP) single-organism behavior 0.0007657 Informative Direct
Biological Process (BP) central nervous system development 0.001339 Informative Inherited
Biological Process (BP) epithelium development 0.02928 Informative Inherited
Biological Process (BP) neurological system process 0.1257 Informative Inherited
Biological Process (BP) glycerolipid metabolic process 0.134 Informative Inherited
Biological Process (BP) behavioral fear response 0.00000000004779 Highly Informative Direct
Biological Process (BP) acylglycerol metabolic process 0.0005177 Highly Informative Direct
Biological Process (BP) learning or memory 0.00001048 Highly Informative Direct
Biological Process (BP) epidermis development 0.00003143 Highly Informative Direct
Biological Process (BP) telencephalon development 0.000002022 Highly Informative Direct
Biological Process (BP) hair cycle process 0.00000001178 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 0.0000004824 Highly Informative Direct
Molecular Function (MF) binding 0.4429 Least Informative Inherited
Molecular Function (MF) anion binding 0.0000000000007946 Moderately Informative Direct
Molecular Function (MF) cofactor binding 0 Informative Direct
Molecular Function (MF) sulfur compound binding 0 Informative Direct
Cellular Component (CC) cytoplasmic part 0.000005541 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.005173 Least Informative Inherited
Cellular Component (CC) microbody 0.0000005824 Informative Direct

Document: GO annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)fruit0.000003341InformativeDirect
Plant ANatomical entity (PAN)gamete0.001904InformativeInherited
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0InformativeDirect
Enzyme Commission (EC)Transposing C==C bonds0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processAutophagy0Highly InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.000000000001297Moderately InformativeDirect
Cellular componentPeroxisome0InformativeDirect
DomainCoiled coil0.00000000006599Moderately InformativeDirect
DomainANK repeat0.00000000000009962InformativeDirect
Molecular functionLipid-binding0InformativeDirect
Post-translational modificationAcetylation0.000000000326Least InformativeDirect
Post-translational modificationPhosphoprotein0.00000007237Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000582 SSF47027 Protein matches
Abstract

Acyl-CoA-binding protein (ACBP) is a small (10 Kd) protein that binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters [PubMed1454809]. ACBP is also known as diazepam binding inhibitor (DBI) or endozepine (EP) because of its ability to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor [PubMed1649940].

ACBP is a highly conserved protein of about 90 residues that is found in all four eukaryotic kingdoms, Animalia, Plantae, Fungi and Protista, and in some eubacterial species [PubMed16018771].

Although ACBP occurs as a completely independent protein, intact ACB domains have been identified in a number of large, multifunctional proteins in a variety of eukaryotic species. These include large membrane-associated proteins with N-terminal ACB domains, multifunctional enzymes with both ACB and peroxisomal enoyl-CoA Delta(3), Delta(2)-enoyl-CoA isomerase domains, and proteins with both an ACB domain and ankyrin repeats [PubMed16018771].

The ACB domain consists of four alpha-helices arranged in a bowl shape with a highly exposed acyl-CoA-binding site. The ligand is bound through specific interactions with residues on the protein, most notably several conserved positive charges that interact with the phosphate group on the adenosine-3'phosphate moiety, and the acyl chain is sandwiched between the hydrophobic surfaces of CoA and the protein [PubMed11491287].

Other proteins containing an ACB domain include:

  • Endozepine-like peptide (ELP) (gene DBIL5) from mouse [PubMed8898349]. ELP is a testis- specific ACBP homolog that may be involved in the energy metabolism of the mature sperm.
  • MA-DBI, a transmembrane protein of unknown function which has been found in mammals. MA-DBI contains a N-terminal ACB domain.
  • DRS-1 [PubMed10354522], a human protein of unknown function that contains a N-terminal ACB domain and a C-terminal enoyl-CoA isomerase/hydratase domain.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Acyl-CoA binding protein domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Acyl-CoA binding protein superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]