SUPERFAMILY 1.75 HMM library and genome assignments server

Protozoan pheromone proteins superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Protozoan pheromone-like [ 47013] (2)
Superfamily:   Protozoan pheromone proteins [ 47014]
Families:   Protozoan pheromone proteins [ 47015] (5)

Superfamily statistics
Genomes (0) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 0 6 5
Proteins 0 6 5

Functional annotation
General category Other
Detailed category Unknown function

Function annotation of SCOP domain superfamilies

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentSecreted0Moderately InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR009064 SSF47014 Protein matches

Protozoan pheromones are cell-type specific protein signals. Representatives of this family of proteins include Er-1, Er-2, Er-10, Er11 and Er22 from the ciliated protozoan Euplotes raikovi, which are constitutively secreted and bound back in an autocrine fashion with a positive effect on mitotic cell growth. The mitogenic activity induced by the Er pheromone autocrine signalling can be inhibited by cAMP [PubMed12681291]. The NMR structure reveals a closed up-and-down bundle of three helices with a left-handed twist [PubMed7833812]. In some cases, these pheromones can compete with each other in binding to their cell-surface receptors.

InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Protozoan pheromone proteins domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Protozoan pheromone proteins superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · UniProtKB KeyWords (KW) · Internal database links ]