SUPERFAMILY 1.73 HMM library and genome assignments server


Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (258)
Fold:   Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex [ 47004]
  3 helices; bundle, closed, right-handed twist; up-and-down
Superfamily:   Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex [ 47005]
Families:   Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex [ 47006] (3)


Superfamily statistics
Genomes (1,019) UniProt 15.0 PDB chains (SCOP 1.73)
Domains 2,509 2,622 7
Proteins 2,432 2,534 7


Functional annotation
General category General
Detailed category General

Function annotation of SCOP domain superfamilies
InterPro annotation
Cross references IPR004167 SSF47005 Protein matches
Abstract A small domain of the E2 subunit of 2-oxo-acid dehydrogenases that is responsible for the binding of the E3 subunit. Proteins containing this domain include the branched-chain alpha-keto acid dehydrogenase complex of bacteria, which catalyses the overall conversion of alpha-keto acids to acyl-CoA and carbon dioxide; and the E-3 binding protein of eukaryotic pyruvate dehydrogenase.

InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Internal database links ]