SUPERFAMILY 1.75 HMM library and genome assignments server

Smac/diablo superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Spectrin repeat-like [ 46965] (16)
Superfamily:   Smac/diablo [ 46984]
Families:   Smac/diablo [ 46985]


Superfamily statistics
Genomes (87) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 131 155 2
Proteins 130 155 2


Functional annotation
General category coiled coil
Detailed category This is a complex coiled arrangement. The details of which will appear on this page shortly (some coiled coil details are being checked before they are included on the site). If you want to see examples of the states please click here here. If you require further details urgently please contact Owen Rackham

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Cellular Component (CC)intracellular membrane-bounded organelle00Least InformativeDirect
Cellular Component (CC)cytoplasmic part00Least InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0.0000001976 Least Informative Direct
Biological Process (BP) positive regulation of biological process 0.000001149 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.000005832 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.0003427 Least Informative Direct
Biological Process (BP) response to stimulus 0.005748 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.007024 Least Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.000000000002291 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.000000000023 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.00000000006054 Moderately Informative Direct
Biological Process (BP) gene expression 0.0000000002522 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.00000001326 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0.0000001669 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0000003301 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.000305 Moderately Informative Direct
Biological Process (BP) signal transduction 0.001157 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.001067 Moderately Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0 Informative Direct
Biological Process (BP) regulation of peptidase activity 0 Informative Direct
Biological Process (BP) protein maturation 0 Informative Direct
Biological Process (BP) positive regulation of cell death 0 Informative Direct
Biological Process (BP) apoptotic process 0.000000000000001913 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.00000000000005349 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.0000000000006576 Informative Direct
Biological Process (BP) positive regulation of gene expression 0.00000000007871 Informative Direct
Biological Process (BP) response to oxidative stress 0.0000000009987 Informative Direct
Biological Process (BP) intracellular signal transduction 0.000000002924 Informative Direct
Biological Process (BP) zymogen activation 0 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 0 Highly Informative Direct
Biological Process (BP) intrinsic apoptotic signaling pathway 0 Highly Informative Direct
Biological Process (BP) positive regulation of endopeptidase activity 0 Highly Informative Direct
Biological Process (BP) cell-type specific apoptotic process 0.0003007 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
DomainTransit peptide0Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR009062 SSF46984 Protein matches
Abstract

Smac/DIABLO (second mitochondria-derived activator of caspase/direct IAP-binding protein with low PI) is a 29 kDa mitochondrial precursor protein. Apoptosis, or programmed cell death, is an essential process in metazoan development and homeostasis. Apoptosis is carried out by caspases, which are under tight regulatory control. Inhibitor-of-apoptosis proteins (IAP) suppress apoptosis by inhibiting caspases, while the mitochondrial protein Smac/Diablo promotes apoptosis by suppressing IAPs. The N-terminal four sequences in Smac/Diablo are responsible for the protein's interaction with IAPs [PubMed11140638]. The crystal structure of Smac/Diablo reveals a closed, three-helical bundle structure with a left-handed twist, and that the protein homodimerises through an extensive hydrophobic interface [PubMed10972280].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Smac/diablo domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Smac/diablo superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]