SUPERFAMILY 1.75 HMM library and genome assignments server

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Homeodomain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DNA/RNA-binding 3-helical bundle [ 46688] (14)
Superfamily:   Homeodomain-like [ 46689] (19)
Families:   Homeodomain [ 46690] (40)
  Recombinase DNA-binding domain [ 46728] (5)
  Myb/SANT domain [ 46739] (15)
  SLIDE domain [ 100998]
  GARP response regulators [ 81683]
  DNA-binding domain of telomeric protein [ 46745] (2)
  Paired domain [ 46748] (3)
  DNA-binding domain of rap1 [ 46753]
  Centromere-binding [ 46756] (2)
  FIS-like [ 100918] (4)
  AraC type transcriptional activator [ 46759] (2)
  Tetracyclin repressor-like, N-terminal domain [ 46764] (34)
  Middle operon regulator, Mor [ 109659]
  Psq domain [ 140213]
  Alr1493-like [ 140216]
  Nanomeric phage protein-like [ 140219]
  SWIRM domain [ 140222] (3)
  Cgl2762-like [ 158260]
  RpiR-like [ 158263]


Superfamily statistics
Genomes (2,980) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 216,597 919,205 207
Proteins 188,053 784,857 197


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.000000000011730Least InformativeDirect
Biological Process (BP)developmental process0.00000000020120Least InformativeDirect
Biological Process (BP)multicellular organismal process0.0000000014920Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.00078370Least InformativeDirect
Biological Process (BP)single-organism cellular process0.0015430.0000002274Least InformativeInherited
Biological Process (BP)response to stimulus0.90840.8822Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.44240.4145Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.62840.000006753Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.63510.000007142Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.75290.001976Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.76620.01768Least InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process00Moderately InformativeDirect
Biological Process (BP)regulation of cellular biosynthetic process00Moderately InformativeDirect
Biological Process (BP)regulation of gene expression00Moderately InformativeDirect
Biological Process (BP)cell differentiation0.00000000000099060.00000000004067Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.0000068760Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.00002820.00003563Moderately InformativeDirect
Biological Process (BP)anatomical structure morphogenesis0.011620Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.25060.00000000000006071Moderately InformativeInherited
Biological Process (BP)signal transduction11Moderately InformativeInherited
Biological Process (BP)nervous system development0.95060.00001037Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.017721Moderately InformativeInherited
Biological Process (BP)tissue development0.004520.000009448Moderately InformativeInherited
Biological Process (BP)organ development0.0034450Moderately InformativeInherited
Biological Process (BP)embryonic morphogenesis0.000004690InformativeDirect
Biological Process (BP)negative regulation of developmental process0.000022330.000009278InformativeDirect
Biological Process (BP)sensory organ development0.00018590InformativeDirect
Biological Process (BP)generation of neurons0.26880.00000008218InformativeInherited
Biological Process (BP)positive regulation of developmental process0.037520.01443InformativeInherited
Biological Process (BP)regulation of nervous system development0.47880.00007659InformativeInherited
Biological Process (BP)regulation of cell development10.2312InformativeInherited
Biological Process (BP)enzyme linked receptor protein signaling pathway0.0034530.2403InformativeInherited
Biological Process (BP)central nervous system development0.60090InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.71621InformativeInherited
Biological Process (BP)epithelium development0.099440.2294InformativeInherited
Biological Process (BP)DNA metabolic process0.0053510.02053InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching0.022450.4253InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.0043680.0009337InformativeInherited
Biological Process (BP)pattern specification process0.000000000020290Highly InformativeDirect
Biological Process (BP)cell fate commitment0.0000041180Highly InformativeDirect
Biological Process (BP)regulation of epithelial cell differentiation0.000069790.00001222Highly InformativeDirect
Biological Process (BP)retina development in camera-type eye0.0002080.000000000007545Highly InformativeDirect
Biological Process (BP)diencephalon development0.0005990Highly InformativeDirect
Biological Process (BP)neural tube development0.00085470.00000001285Highly InformativeDirect
Biological Process (BP)epidermal cell differentiation0.0010840.01531Highly InformativeInherited
Biological Process (BP)DNA recombination0.0000057950.9891Highly InformativeInherited
Molecular Function (MF)binding0.019340Least InformativeInherited
Molecular Function (MF)nucleic acid binding0.000000069360Moderately InformativeDirect
Molecular Function (MF)nucleic acid binding transcription factor activity00InformativeDirect
Molecular Function (MF)DNA binding0.000000000052010InformativeDirect
Molecular Function (MF)chromatin binding0.0000000055470InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.052430Least InformativeInherited
Cellular Component (CC)intracellular organelle part10.005093Least InformativeInherited
Cellular Component (CC)protein complex0.62710.00000000000003985Least InformativeInherited
Cellular Component (CC)intracellular organelle lumen0.11580Moderately InformativeInherited
Cellular Component (CC)nuclear part0.81670.00000000002706Moderately InformativeInherited
Cellular Component (CC)nucleoplasm part0.00043740InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0000002274 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.000006753 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0.000007142 Least Informative Direct
Biological Process (BP) biosynthetic process 0.00003175 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.01768 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.001976 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.8822 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.4145 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.1333 Least Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.00000000004067 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.00003563 Moderately Informative Direct
Biological Process (BP) organ development 0 Moderately Informative Direct
Biological Process (BP) tissue development 0.000009448 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0 Moderately Informative Direct
Biological Process (BP) reproduction 0.000000002644 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.000000007416 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.0000001086 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.00000000000006071 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) nervous system development 0.00001037 Moderately Informative Direct
Biological Process (BP) gene expression 0 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.001871 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.006529 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.5809 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.004744 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.2753 Moderately Informative Inherited
Biological Process (BP) embryonic morphogenesis 0 Informative Direct
Biological Process (BP) negative regulation of developmental process 0.000009278 Informative Direct
Biological Process (BP) sensory organ development 0 Informative Direct
Biological Process (BP) embryonic organ development 0 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.0009337 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.000000001086 Informative Direct
Biological Process (BP) organ morphogenesis 0 Informative Direct
Biological Process (BP) tissue morphogenesis 0.0001769 Informative Direct
Biological Process (BP) tube development 0.00001202 Informative Direct
Biological Process (BP) generation of neurons 0.00000008218 Informative Direct
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.00000000000001435 Informative Direct
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.000000001169 Informative Direct
Biological Process (BP) regulation of nervous system development 0.00007659 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.00001147 Informative Direct
Biological Process (BP) central nervous system development 0 Informative Direct
Biological Process (BP) response to hormone stimulus 0 Informative Direct
Biological Process (BP) response to lipid 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) chromosome organization 0 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) transcription, DNA-dependent 0 Informative Direct
Biological Process (BP) gland development 0.000000000000001938 Informative Direct
Biological Process (BP) cellular component movement 0.0000000001978 Informative Direct
Biological Process (BP) cell projection organization 0.00000017 Informative Direct
Biological Process (BP) leukocyte activation 0.0009247 Informative Direct
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of apoptotic signaling pathway 0.7587 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.3095 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) regulation of secretion 0.185 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.9292 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 1 Informative Inherited
Biological Process (BP) regulation of peptidase activity 0.3098 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) epithelium development 0.2294 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) synaptic transmission 1 Informative Inherited
Biological Process (BP) reproductive system development 0.983 Informative Inherited
Biological Process (BP) organelle localization 1 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) microtubule-based process 1 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.01443 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of cell development 0.2312 Informative Inherited
Biological Process (BP) cardiovascular system development 1 Informative Inherited
Biological Process (BP) response to light stimulus 0.1957 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.7542 Informative Inherited
Biological Process (BP) response to inorganic substance 0.6871 Informative Inherited
Biological Process (BP) membrane lipid metabolic process 0.01476 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) single-organism behavior 1 Informative Inherited
Biological Process (BP) muscle tissue development 1 Informative Inherited
Biological Process (BP) muscle structure development 0.03995 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.5564 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 1 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) transmembrane transport 1 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.2403 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 1 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.4253 Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 1 Informative Inherited
Biological Process (BP) secretion by cell 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.8355 Informative Inherited
Biological Process (BP) DNA metabolic process 0.02053 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.5214 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.14 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.001686 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 1 Informative Inherited
Biological Process (BP) isoprenoid metabolic process 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 1 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) apoptotic process 1 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.2795 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.01112 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.008284 Informative Inherited
Biological Process (BP) protein localization to organelle 0.4481 Informative Inherited
Biological Process (BP) protein transport 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) pattern specification process 0 Highly Informative Direct
Biological Process (BP) cell fate commitment 0 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell differentiation 0.00001222 Highly Informative Direct
Biological Process (BP) retina development in camera-type eye 0.000000000007545 Highly Informative Direct
Biological Process (BP) diencephalon development 0 Highly Informative Direct
Biological Process (BP) neural tube development 0.00000001285 Highly Informative Direct
Biological Process (BP) endocrine system development 0 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 0.00000000008275 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0.00002767 Highly Informative Direct
Biological Process (BP) skeletal system development 0.0000000000001766 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.0001297 Highly Informative Direct
Biological Process (BP) hormone-mediated signaling pathway 0.0000000000008876 Highly Informative Direct
Biological Process (BP) alpha-beta T cell activation 0.00000000000371 Highly Informative Direct
Biological Process (BP) limb morphogenesis 0.000000000226 Highly Informative Direct
Biological Process (BP) response to alcohol 0.0000000005503 Highly Informative Direct
Biological Process (BP) sphingolipid biosynthetic process 0.000000000595 Highly Informative Direct
Biological Process (BP) regulation of neural precursor cell proliferation 0.00000000109 Highly Informative Direct
Biological Process (BP) response to cadmium ion 0.00000002701 Highly Informative Direct
Biological Process (BP) histone modification 0.00000002861 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.00000003281 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 0.00000008105 Highly Informative Direct
Biological Process (BP) chemotaxis 0.0000001232 Highly Informative Direct
Biological Process (BP) regulation of binding 0.0000002756 Highly Informative Direct
Biological Process (BP) response to salt stress 0.0000005782 Highly Informative Direct
Biological Process (BP) protein deacylation 0.000001126 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.000003433 Highly Informative Direct
Biological Process (BP) epithelial tube formation 0.000005274 Highly Informative Direct
Biological Process (BP) artery morphogenesis 0.000008717 Highly Informative Direct
Biological Process (BP) regulation of intrinsic apoptotic signaling pathway 0.00003289 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 0.0000527 Highly Informative Direct
Biological Process (BP) renal system development 0.00007971 Highly Informative Direct
Biological Process (BP) response to water deprivation 0.0001088 Highly Informative Direct
Biological Process (BP) neural precursor cell proliferation 0.0001997 Highly Informative Direct
Biological Process (BP) circadian rhythm 0.00022 Highly Informative Direct
Biological Process (BP) stem cell development 0.0003765 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0.0004374 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic signaling pathway 0.06254 Highly Informative Inherited
Biological Process (BP) positive regulation of programmed cell death 1 Highly Informative Inherited
Biological Process (BP) regulation of peptide transport 0.007079 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.006754 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.00628 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.009825 Highly Informative Inherited
Biological Process (BP) positive regulation of endopeptidase activity 0.02054 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 1 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 1 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Highly Informative Inherited
Biological Process (BP) response to cytokinin stimulus 0.07341 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 1 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.5961 Highly Informative Inherited
Biological Process (BP) respiratory tube development 0.6143 Highly Informative Inherited
Biological Process (BP) erythrocyte differentiation 0.04027 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.8586 Highly Informative Inherited
Biological Process (BP) cardiocyte differentiation 0.6531 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 1 Highly Informative Inherited
Biological Process (BP) cardiac muscle tissue development 1 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.7911 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of neurogenesis 1 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.09572 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.3068 Highly Informative Inherited
Biological Process (BP) ceramide metabolic process 0.006775 Highly Informative Inherited
Biological Process (BP) regulation of cellular amine metabolic process 0.7331 Highly Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 1 Highly Informative Inherited
Biological Process (BP) meiosis 1 Highly Informative Inherited
Biological Process (BP) respiratory system development 1 Highly Informative Inherited
Biological Process (BP) ear development 0.09823 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.3957 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 0.4453 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 1 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.006854 Highly Informative Inherited
Biological Process (BP) hormone transport 0.1269 Highly Informative Inherited
Biological Process (BP) amide transport 0.1951 Highly Informative Inherited
Biological Process (BP) signal release 0.9246 Highly Informative Inherited
Biological Process (BP) telencephalon development 0.002346 Highly Informative Inherited
Biological Process (BP) glial cell differentiation 0.2724 Highly Informative Inherited
Biological Process (BP) mesenchyme development 0.006053 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 1 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 1 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.01531 Highly Informative Inherited
Biological Process (BP) regulation of cell division 0.06452 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.0757 Highly Informative Inherited
Biological Process (BP) isoprenoid biosynthetic process 0.9677 Highly Informative Inherited
Biological Process (BP) learning or memory 1 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.1138 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.6185 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.716 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.2279 Highly Informative Inherited
Biological Process (BP) DNA recombination 0.9891 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.5362 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.02896 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.9747 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 0.3917 Highly Informative Inherited
Biological Process (BP) negative regulation of transcription, DNA-dependent 0.06701 Highly Informative Inherited
Biological Process (BP) protein localization to nucleus 0.05454 Highly Informative Inherited
Biological Process (BP) protein targeting to nucleus 0.1203 Highly Informative Inherited
Biological Process (BP) nuclear import 0.1373 Highly Informative Inherited
Biological Process (BP) protein import 0.2454 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) chromatin binding 0 Informative Direct
Molecular Function (MF) protein dimerization activity 0.00000000005999 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0.7377 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) enzyme activator activity 1 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.585 Informative Inherited
Molecular Function (MF) receptor activity 1 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0 Highly Informative Direct
Molecular Function (MF) deacetylase activity 0.00006548 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.007875 Highly Informative Inherited
Molecular Function (MF) protein kinase regulator activity 0.1368 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 0.06746 Highly Informative Inherited
Molecular Function (MF) structure-specific DNA binding 1 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) protein complex 0.00000000000003985 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.005093 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.00000000002706 Moderately Informative Direct
Cellular Component (CC) nucleoplasm part 0 Informative Direct
Cellular Component (CC) chromosome 0 Informative Direct
Cellular Component (CC) nuclear chromosome part 0.101 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

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EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.0000000007689Moderately InformativeDirect
Enzyme Commission (EC)Glucokinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

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DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)endocrine system disease0.8451Moderately InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0.00008384Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.8087Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis1Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of carbohydrate metabolism/homeostasis0.4865Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the globe0.5438Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of brain morphology0.8746Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia affecting the eye0.0001377InformativeDirect
Phenotypic Abnormality (PA)Abnormality of prenatal development or birth0.2699InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the central nervous system0.3253InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the fundus0.4941InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebrum1InformativeInherited
Phenotypic Abnormality (PA)Optic nerve hypoplasia0.00003815Highly InformativeDirect
Phenotypic Abnormality (PA)Absent septum pellucidum0.0003215Highly InformativeDirect
Phenotypic Abnormality (PA)Prenatal maternal abnormality0.01731Highly InformativeInherited
Phenotypic Abnormality (PA)Diabetes mellitus0.1625Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.00000001154Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0.0000008646Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body phenotype0.0000158Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.03071Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.6254Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.8494Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.9773Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype1Least InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.00000001195Moderately InformativeDirect
Mammalian Phenotype (MP)digestive/alimentary phenotype0.00001943Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.00004802Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.00005256Moderately InformativeDirect
Mammalian Phenotype (MP)preweaning lethality0.0001882Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system development0.007478Moderately InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.03394Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.07938Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.155Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.3692Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.4031Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.5475Moderately InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.9225Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.993Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.0000006195InformativeDirect
Mammalian Phenotype (MP)abnormal vertebrae morphology0.000001648InformativeDirect
Mammalian Phenotype (MP)abnormal cell differentiation0.0002481InformativeDirect
Mammalian Phenotype (MP)abnormal thoracic cage morphology0.0005031InformativeDirect
Mammalian Phenotype (MP)abnormal respiration0.0007518InformativeDirect
Mammalian Phenotype (MP)abnormal systemic artery morphology0.001261InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial development0.002927InformativeInherited
Mammalian Phenotype (MP)abnormal gas homeostasis0.003322InformativeInherited
Mammalian Phenotype (MP)abnormal eye development0.003993InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.004839InformativeInherited
Mammalian Phenotype (MP)abnormal consumption behavior0.0133InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.01413InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.03396InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube morphology/development0.1336InformativeInherited
Mammalian Phenotype (MP)abnormal uvea morphology0.147InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.1757InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle morphology0.256InformativeInherited
Mammalian Phenotype (MP)abnormal facial morphology0.2973InformativeInherited
Mammalian Phenotype (MP)abnormal internal male genitalia morphology0.4939InformativeInherited
Mammalian Phenotype (MP)abnormal limb morphology0.5596InformativeInherited
Mammalian Phenotype (MP)abnormal cranium morphology0.913InformativeInherited
Mammalian Phenotype (MP)abnormal spleen morphology0.9261InformativeInherited
Mammalian Phenotype (MP)abnormal metencephalon morphology0.9427InformativeInherited
Mammalian Phenotype (MP)abnormal membranous labyrinth morphology0.9951InformativeInherited
Mammalian Phenotype (MP)abnormal sex gland morphology1InformativeInherited
Mammalian Phenotype (MP)abnormal telencephalon morphology1InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system physiology1InformativeInherited
Mammalian Phenotype (MP)abnormal middle ear morphology0.00000002142Highly InformativeDirect
Mammalian Phenotype (MP)perinatal lethality0.0000001567Highly InformativeDirect
Mammalian Phenotype (MP)cyanosis0.0000009709Highly InformativeDirect
Mammalian Phenotype (MP)abnormal brain ventricle morphology0.000009927Highly InformativeDirect
Mammalian Phenotype (MP)abnormal secondary palate development0.00001372Highly InformativeDirect
Mammalian Phenotype (MP)taste/olfaction phenotype0.00005042Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mandibular coronoid process morphology0.000114Highly InformativeDirect
Mammalian Phenotype (MP)abnormal maxilla morphology0.000134Highly InformativeDirect
Mammalian Phenotype (MP)abnormal neurocranium morphology0.0002644Highly InformativeDirect
Mammalian Phenotype (MP)abnormal rib attachment0.0002707Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cranial nerve morphology0.000285Highly InformativeDirect
Mammalian Phenotype (MP)abnormal rib morphology0.0003644Highly InformativeDirect
Mammalian Phenotype (MP)abnormal telencephalon development0.0004302Highly InformativeDirect
Mammalian Phenotype (MP)abnormal tongue morphology0.0005941Highly InformativeDirect
Mammalian Phenotype (MP)microphthalmia0.0006059Highly InformativeDirect
Mammalian Phenotype (MP)abnormal aortic arch morphology0.0008952Highly InformativeDirect
Mammalian Phenotype (MP)abnormal nose morphology0.001123Highly InformativeInherited
Mammalian Phenotype (MP)abnormal midbrain morphology0.007603Highly InformativeInherited
Mammalian Phenotype (MP)abnormal pituitary gland morphology0.01725Highly InformativeInherited
Mammalian Phenotype (MP)abnormal kidney development0.02002Highly InformativeInherited
Mammalian Phenotype (MP)abnormal hindbrain development0.04399Highly InformativeInherited
Mammalian Phenotype (MP)abnormal limb long bone morphology0.04936Highly InformativeInherited
Mammalian Phenotype (MP)abnormal food intake0.2241Highly InformativeInherited
Mammalian Phenotype (MP)impaired hearing0.2266Highly InformativeInherited
Mammalian Phenotype (MP)abnormal trabecular meshwork morphology0.2608Highly InformativeInherited
Mammalian Phenotype (MP)abnormal alveolar process morphology0.2985Highly InformativeInherited
Mammalian Phenotype (MP)abnormal sternum morphology0.3216Highly InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton development0.42Highly InformativeInherited
Mammalian Phenotype (MP)abnormal epididymis morphology0.4428Highly InformativeInherited
Mammalian Phenotype (MP)abnormal hippocampus morphology0.9245Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.02187Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.1775Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.1932Least InformativeInherited
Worm Phenotype (WP)growth variant1Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.0000001488Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.0000769Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.5001Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant1Moderately InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant1Moderately InformativeInherited
Worm Phenotype (WP)male morphology variant0.00001205InformativeDirect
Worm Phenotype (WP)neuron development variant0.0001453InformativeDirect
Worm Phenotype (WP)exploded through vulva0.0005865InformativeDirect
Worm Phenotype (WP)protein metabolism variant0.001447InformativeInherited
Worm Phenotype (WP)sensillum morphology variant0.2154InformativeInherited
Worm Phenotype (WP)egg laying variant0.3229InformativeInherited
Worm Phenotype (WP)mechanosensation variant0.3772InformativeInherited
Worm Phenotype (WP)drug resistant0.5864InformativeInherited
Worm Phenotype (WP)lineage variant0.00000001323Highly InformativeDirect
Worm Phenotype (WP)ectopic expression transgene0.0000004909Highly InformativeDirect
Worm Phenotype (WP)growth rate variant0.00006604Highly InformativeDirect
Worm Phenotype (WP)carbon dioxide avoidance variant0.00008213Highly InformativeDirect
Worm Phenotype (WP)protein degradation variant0.00009267Highly InformativeDirect
Worm Phenotype (WP)touch resistant0.0005528Highly InformativeDirect
Worm Phenotype (WP)egg laying defective0.03149Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

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FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.08874Least InformativeInherited
Fly Phenotype (FP)lethal - all die before end of P-stage0.006093Moderately InformativeInherited
Fly Phenotype (FP)visible0.000000000742InformativeDirect
Fly Phenotype (FP)lethal - all die before end of larval stage0.0000004855InformativeDirect
Fly Phenotype (FP)wild-type0.0004859InformativeDirect
Fly Phenotype (FP)lethal - all die before end of embryonic stage0.00000000006567Highly InformativeDirect
Fly Phenotype (FP)homeotic0.00000002577Highly InformativeDirect
Fly Phenotype (FP)some die during embryonic stage0.000001516Highly InformativeDirect
Fly Phenotype (FP)some die during P-stage0.2304Highly InformativeInherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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