SUPERFAMILY 1.75 HMM library and genome assignments server


Homeodomain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DNA/RNA-binding 3-helical bundle [ 46688] (14)
Superfamily:   Homeodomain-like [ 46689] (19)
Families:   Homeodomain [ 46690] (40)
  Recombinase DNA-binding domain [ 46728] (5)
  Myb/SANT domain [ 46739] (15)
  SLIDE domain [ 100998]
  GARP response regulators [ 81683]
  DNA-binding domain of telomeric protein [ 46745] (2)
  Paired domain [ 46748] (3)
  DNA-binding domain of rap1 [ 46753]
  Centromere-binding [ 46756] (2)
  FIS-like [ 100918] (4)
  AraC type transcriptional activator [ 46759] (2)
  Tetracyclin repressor-like, N-terminal domain [ 46764] (34)
  Middle operon regulator, Mor [ 109659]
  Psq domain [ 140213]
  Alr1493-like [ 140216]
  Nanomeric phage protein-like [ 140219]
  SWIRM domain [ 140222] (3)
  Cgl2762-like [ 158260]
  RpiR-like [ 158263]


Superfamily statistics
Genomes (2,937) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 203,826 428,233 207
Proteins 176,465 368,153 197


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process1.485e-130Least InformativeDirect
Biological Process (BP)developmental process5.89e-120Least InformativeDirect
Biological Process (BP)multicellular organismal process3.041e-100Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.00066490Least InformativeDirect
Biological Process (BP)single-organism cellular process0.0014577.004e-06Least InformativeInherited
Biological Process (BP)response to stimulus0.83380.9474Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.38070.3665Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.55942.523e-06Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.5692.737e-06Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.68650.0009218Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.69410.008042Least InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process00Moderately InformativeDirect
Biological Process (BP)regulation of cellular biosynthetic process00Moderately InformativeDirect
Biological Process (BP)regulation of gene expression00Moderately InformativeDirect
Biological Process (BP)cell differentiation1.604e-138.719e-12Moderately InformativeDirect
Biological Process (BP)single-organism developmental process2.301e-070Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process5.436e-060Moderately InformativeDirect
Biological Process (BP)regulation of developmental process4.501e-051.648e-05Moderately InformativeDirect
Biological Process (BP)anatomical structure morphogenesis0.017550Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.2740Moderately InformativeInherited
Biological Process (BP)signal transduction11Moderately InformativeInherited
Biological Process (BP)nervous system development0.87577.872e-07Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.019571Moderately InformativeInherited
Biological Process (BP)tissue development0.0062538.315e-06Moderately InformativeInherited
Biological Process (BP)organ development0.0060470Moderately InformativeInherited
Biological Process (BP)embryonic morphogenesis4.187e-060InformativeDirect
Biological Process (BP)negative regulation of developmental process0.00012594.648e-06InformativeDirect
Biological Process (BP)sensory organ development0.00015870InformativeDirect
Biological Process (BP)positive regulation of developmental process0.045660.01023InformativeInherited
Biological Process (BP)regulation of nervous system development0.45781.215e-05InformativeInherited
Biological Process (BP)regulation of cell development10.1493InformativeInherited
Biological Process (BP)enzyme linked receptor protein signaling pathway0.0035680.1841InformativeInherited
Biological Process (BP)central nervous system development0.62450InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.75611InformativeInherited
Biological Process (BP)epithelium development0.099520.232InformativeInherited
Biological Process (BP)DNA metabolic process0.00480.05097InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching0.014320.1262InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.005430.00163InformativeInherited
Biological Process (BP)generation of neurons0.26338.847e-07InformativeInherited
Biological Process (BP)organ morphogenesis0.040180InformativeInherited
Biological Process (BP)pattern specification process3.511e-110Highly InformativeDirect
Biological Process (BP)cell fate commitment6.782e-060Highly InformativeDirect
Biological Process (BP)regulation of epithelial cell differentiation4.654e-058.477e-07Highly InformativeDirect
Biological Process (BP)retina development in camera-type eye0.00022531.47e-12Highly InformativeDirect
Biological Process (BP)neural tube development0.00069479.078e-10Highly InformativeDirect
Biological Process (BP)diencephalon development0.00083610Highly InformativeDirect
Biological Process (BP)positive regulation of cell differentiation0.012190.002968Highly InformativeInherited
Biological Process (BP)epidermal cell differentiation0.0010050.004159Highly InformativeInherited
Biological Process (BP)DNA recombination4.178e-060.7757Highly InformativeInherited
Biological Process (BP)photoreceptor cell differentiation6.834e-060.2297Highly InformativeInherited
Biological Process (BP)eye morphogenesis0.15760.4123Highly InformativeInherited
Molecular Function (MF)binding0.0083790Least InformativeInherited
Molecular Function (MF)nucleic acid binding3.314e-070Moderately InformativeDirect
Molecular Function (MF)nucleic acid binding transcription factor activity00InformativeDirect
Molecular Function (MF)DNA binding4.278e-100InformativeDirect
Molecular Function (MF)chromatin binding5.997e-090InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.067530Least InformativeInherited
Cellular Component (CC)intracellular organelle part10.1045Least InformativeInherited
Cellular Component (CC)protein complex0.56067.227e-14Least InformativeInherited
Cellular Component (CC)intracellular organelle lumen0.047790Moderately InformativeInherited
Cellular Component (CC)nuclear part0.63622.063e-12Moderately InformativeInherited
Cellular Component (CC)nucleoplasm part0.00035340InformativeDirect
Cellular Component (CC)transcription factor complex2.736e-070Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 7.004e-06 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 2.523e-06 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 2.737e-06 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.0009218 Least Informative Direct
Biological Process (BP) biosynthetic process 1.978e-06 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.008042 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.9474 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.3665 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.1068 Least Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 8.719e-12 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 1.648e-05 Moderately Informative Direct
Biological Process (BP) organ development 0 Moderately Informative Direct
Biological Process (BP) tissue development 8.315e-06 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0 Moderately Informative Direct
Biological Process (BP) reproduction 4.712e-09 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 2.28e-06 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 1.386e-07 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) nervous system development 7.872e-07 Moderately Informative Direct
Biological Process (BP) gene expression 0 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of programmed cell death 0.7906 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.004214 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.00181 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.03861 Moderately Informative Inherited
Biological Process (BP) immune system process 0.4204 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.0552 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.2287 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) embryonic morphogenesis 0 Informative Direct
Biological Process (BP) negative regulation of developmental process 4.648e-06 Informative Direct
Biological Process (BP) sensory organ development 0 Informative Direct
Biological Process (BP) embryonic organ development 0 Informative Direct
Biological Process (BP) organ morphogenesis 0 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 5.433e-08 Informative Direct
Biological Process (BP) tissue morphogenesis 9.004e-05 Informative Direct
Biological Process (BP) generation of neurons 8.847e-07 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1.086e-14 Informative Direct
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) regulation of nervous system development 1.215e-05 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 4.896e-10 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 1.109e-05 Informative Direct
Biological Process (BP) central nervous system development 0 Informative Direct
Biological Process (BP) response to hormone stimulus 0 Informative Direct
Biological Process (BP) response to lipid 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) gland development 0 Informative Direct
Biological Process (BP) chromosome organization 0 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) transcription, DNA-dependent 0 Informative Direct
Biological Process (BP) cellular component movement 2.707e-10 Informative Direct
Biological Process (BP) cell projection organization 3.839e-09 Informative Direct
Biological Process (BP) response to organic cyclic compound 0.0001453 Informative Direct
Biological Process (BP) cell-cell signaling 0.000332 Informative Direct
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of apoptotic signaling pathway 0.705 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.3345 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) regulation of secretion 0.2706 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) transmission of nerve impulse 1 Informative Inherited
Biological Process (BP) positive regulation of cell proliferation 0.03871 Informative Inherited
Biological Process (BP) regulation of cell cycle 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 1 Informative Inherited
Biological Process (BP) regulation of peptidase activity 0.2729 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) epithelium development 0.232 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) reproductive structure development 0.2492 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.01023 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of cell development 0.1493 Informative Inherited
Biological Process (BP) cardiovascular system development 1 Informative Inherited
Biological Process (BP) response to light stimulus 0.3013 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.4379 Informative Inherited
Biological Process (BP) response to inorganic substance 0.6676 Informative Inherited
Biological Process (BP) membrane lipid metabolic process 0.01067 Informative Inherited
Biological Process (BP) cell activation 0.3859 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.3061 Informative Inherited
Biological Process (BP) muscle structure development 0.02512 Informative Inherited
Biological Process (BP) muscle tissue development 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.3511 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) transmembrane transport 1 Informative Inherited
Biological Process (BP) organelle localization 1 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.1841 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 1 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.1262 Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 1 Informative Inherited
Biological Process (BP) secretion by cell 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.5744 Informative Inherited
Biological Process (BP) DNA metabolic process 0.05097 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.5668 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 1 Informative Inherited
Biological Process (BP) isoprenoid metabolic process 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 1 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) cell death 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.00163 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.07074 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.07892 Informative Inherited
Biological Process (BP) pattern specification process 0 Highly Informative Direct
Biological Process (BP) cell fate commitment 0 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell differentiation 8.477e-07 Highly Informative Direct
Biological Process (BP) retina development in camera-type eye 1.47e-12 Highly Informative Direct
Biological Process (BP) neural tube development 9.078e-10 Highly Informative Direct
Biological Process (BP) diencephalon development 0 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 2.823e-11 Highly Informative Direct
Biological Process (BP) endocrine system development 0 Highly Informative Direct
Biological Process (BP) inner ear development 1.425e-12 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 4.369e-05 Highly Informative Direct
Biological Process (BP) skeletal system development 2.447e-14 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 6.336e-05 Highly Informative Direct
Biological Process (BP) hormone-mediated signaling pathway 0 Highly Informative Direct
Biological Process (BP) alpha-beta T cell activation 1.945e-13 Highly Informative Direct
Biological Process (BP) response to osmotic stress 2.532e-12 Highly Informative Direct
Biological Process (BP) regulation of neural precursor cell proliferation 9.803e-11 Highly Informative Direct
Biological Process (BP) sphingolipid biosynthetic process 3.571e-10 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 6.386e-09 Highly Informative Direct
Biological Process (BP) regulation of binding 1.325e-08 Highly Informative Direct
Biological Process (BP) limb morphogenesis 1.358e-08 Highly Informative Direct
Biological Process (BP) response to cadmium ion 1.801e-08 Highly Informative Direct
Biological Process (BP) chemotaxis 2.972e-08 Highly Informative Direct
Biological Process (BP) histone modification 7.862e-08 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 4.724e-07 Highly Informative Direct
Biological Process (BP) regulation of intrinsic apoptotic signaling pathway 6.462e-06 Highly Informative Direct
Biological Process (BP) cell proliferation 7.284e-06 Highly Informative Direct
Biological Process (BP) artery morphogenesis 9.198e-06 Highly Informative Direct
Biological Process (BP) tube formation 1.535e-05 Highly Informative Direct
Biological Process (BP) protein deacylation 7.406e-05 Highly Informative Direct
Biological Process (BP) renal system development 9.406e-05 Highly Informative Direct
Biological Process (BP) response to water deprivation 0.000115 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0.0002946 Highly Informative Direct
Biological Process (BP) cell part morphogenesis 0.000311 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 0.0004121 Highly Informative Direct
Biological Process (BP) telencephalon development 0.000651 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic signaling pathway 0.04782 Highly Informative Inherited
Biological Process (BP) positive regulation of programmed cell death 1 Highly Informative Inherited
Biological Process (BP) positive regulation of secretion 0.3628 Highly Informative Inherited
Biological Process (BP) regulation of peptide transport 0.02866 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.94 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 1 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.0033 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0.01489 Highly Informative Inherited
Biological Process (BP) positive regulation of peptidase activity 0.03728 Highly Informative Inherited
Biological Process (BP) epithelial tube morphogenesis 0.1594 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 1 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 1 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 1 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.6348 Highly Informative Inherited
Biological Process (BP) lung development 0.584 Highly Informative Inherited
Biological Process (BP) morphogenesis of a branching epithelium 0.04645 Highly Informative Inherited
Biological Process (BP) erythrocyte differentiation 0.04155 Highly Informative Inherited
Biological Process (BP) cardiocyte differentiation 0.575 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 1 Highly Informative Inherited
Biological Process (BP) cardiac muscle tissue development 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cell differentiation 0.002968 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.1131 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.4123 Highly Informative Inherited
Biological Process (BP) ceramide metabolic process 0.008476 Highly Informative Inherited
Biological Process (BP) regulation of cellular amine metabolic process 0.8685 Highly Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 1 Highly Informative Inherited
Biological Process (BP) meiosis 1 Highly Informative Inherited
Biological Process (BP) photoreceptor cell differentiation 0.2297 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.3775 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 0.4108 Highly Informative Inherited
Biological Process (BP) ion transmembrane transport 1 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 1 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.204 Highly Informative Inherited
Biological Process (BP) hormone transport 0.1038 Highly Informative Inherited
Biological Process (BP) amide transport 0.1403 Highly Informative Inherited
Biological Process (BP) signal release 0.8673 Highly Informative Inherited
Biological Process (BP) glial cell differentiation 0.02677 Highly Informative Inherited
Biological Process (BP) stem cell development 0.004422 Highly Informative Inherited
Biological Process (BP) mesenchyme development 0.05386 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 1 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 1 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.004159 Highly Informative Inherited
Biological Process (BP) isoprenoid biosynthetic process 0.9703 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.1472 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.5844 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.6194 Highly Informative Inherited
Biological Process (BP) developmental maturation 1 Highly Informative Inherited
Biological Process (BP) DNA recombination 0.7757 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.5042 Highly Informative Inherited
Biological Process (BP) epithelial cell development 1 Highly Informative Inherited
Biological Process (BP) negative regulation of transcription, DNA-dependent 0.2548 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) chromatin binding 0 Informative Direct
Molecular Function (MF) protein dimerization activity 5.093e-11 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0.6458 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) enzyme activator activity 1 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 0.2899 Informative Inherited
Molecular Function (MF) receptor activity 1 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0 Highly Informative Direct
Molecular Function (MF) deacetylase activity 0.005542 Highly Informative Inherited
Molecular Function (MF) protein kinase regulator activity 0.125 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 0.06763 Highly Informative Inherited
Molecular Function (MF) structure-specific DNA binding 1 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) protein complex 7.227e-14 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.1045 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0 Moderately Informative Direct
Cellular Component (CC) nuclear part 2.063e-12 Moderately Informative Direct
Cellular Component (CC) nucleoplasm part 0 Informative Direct
Cellular Component (CC) chromosome 0 Informative Direct
Cellular Component (CC) transcription factor complex 0 Highly Informative Direct
Cellular Component (CC) histone deacetylase complex 0 Highly Informative Direct
Cellular Component (CC) condensed chromosome 1 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.1882 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

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EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep7.689e-10Moderately InformativeDirect
Enzyme Commission (EC)Glucokinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

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DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.7786Least InformativeInherited
Disease Ontology (DO)endocrine system disease0.9118Moderately InformativeInherited
Disease Ontology (DO)rhabdomyosarcoma0.1869Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance5.331e-05Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.8435Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the globe0.5354Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia affecting the eye0.0001849InformativeDirect
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the central nervous system0.3602InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the fundus0.5112InformativeInherited
Phenotypic Abnormality (PA)Optic nerve hypoplasia0.0003885Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype6.423e-08Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging2.807e-06Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.01685Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.7716Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.894Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype1Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype1Least InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology6.999e-15Moderately InformativeDirect
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype6.874e-06Moderately InformativeDirect
Mammalian Phenotype (MP)preweaning lethality0.0001426Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.0001622Moderately InformativeDirect
Mammalian Phenotype (MP)digestive/alimentary phenotype0.0002646Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.0004095Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system development0.04156Moderately InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.08817Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.1002Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.214Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.3791Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.5644Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.6315Moderately InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.9024Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.9886Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal vertebrae morphology1.026e-05InformativeDirect
Mammalian Phenotype (MP)lethality during fetal growth through weaning1.966e-05InformativeDirect
Mammalian Phenotype (MP)abnormal gas homeostasis0.001168InformativeInherited
Mammalian Phenotype (MP)abnormal systemic artery morphology0.003942InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.005546InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.0311InformativeInherited
Mammalian Phenotype (MP)abnormal neuron physiology0.04688InformativeInherited
Mammalian Phenotype (MP)abnormal thymus morphology0.1455InformativeInherited
Mammalian Phenotype (MP)abnormal uvea morphology0.1614InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.2436InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube morphology/development0.3249InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle morphology0.3717InformativeInherited
Mammalian Phenotype (MP)abnormal internal male genitalia morphology0.4861InformativeInherited
Mammalian Phenotype (MP)abnormal limb morphology0.6351InformativeInherited
Mammalian Phenotype (MP)abnormal head morphology0.6565InformativeInherited
Mammalian Phenotype (MP)abnormal cerebrum morphology0.6857InformativeInherited
Mammalian Phenotype (MP)abnormal cranium morphology0.9218InformativeInherited
Mammalian Phenotype (MP)abnormal spleen morphology0.9479InformativeInherited
Mammalian Phenotype (MP)abnormal membranous labyrinth morphology0.9561InformativeInherited
Mammalian Phenotype (MP)abnormal sex gland morphology1InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system physiology1InformativeInherited
Mammalian Phenotype (MP)abnormal middle ear morphology4.167e-08Highly InformativeDirect
Mammalian Phenotype (MP)cyanosis1.455e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal secondary palate development6.748e-06Highly InformativeDirect
Mammalian Phenotype (MP)perinatal lethality8.043e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal brain ventricle morphology2.75e-05Highly InformativeDirect
Mammalian Phenotype (MP)microphthalmia7.279e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mandibular coronoid process morphology8.583e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal maxilla morphology0.0001854Highly InformativeDirect
Mammalian Phenotype (MP)abnormal rib morphology0.0002366Highly InformativeDirect
Mammalian Phenotype (MP)abnormal temporal bone morphology0.0003812Highly InformativeDirect
Mammalian Phenotype (MP)abnormal rib attachment0.0004326Highly InformativeDirect
Mammalian Phenotype (MP)abnormal nose morphology0.0005424Highly InformativeDirect
Mammalian Phenotype (MP)taste/olfaction phenotype0.0008303Highly InformativeDirect
Mammalian Phenotype (MP)abnormal tongue morphology0.00149Highly InformativeInherited
Mammalian Phenotype (MP)abnormal pituitary gland morphology0.004278Highly InformativeInherited
Mammalian Phenotype (MP)abnormal kidney development0.005706Highly InformativeInherited
Mammalian Phenotype (MP)abnormal limb long bone morphology0.07815Highly InformativeInherited
Mammalian Phenotype (MP)abnormal midbrain morphology0.08841Highly InformativeInherited
Mammalian Phenotype (MP)abnormal sphenoid bone morphology0.159Highly InformativeInherited
Mammalian Phenotype (MP)impaired hearing0.1869Highly InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system tract morphology0.1973Highly InformativeInherited
Mammalian Phenotype (MP)abnormal brain white matter morphology0.2508Highly InformativeInherited
Mammalian Phenotype (MP)abnormal trabecular meshwork morphology0.2936Highly InformativeInherited
Mammalian Phenotype (MP)abnormal alveolar process morphology0.3213Highly InformativeInherited
Mammalian Phenotype (MP)abnormal epididymis morphology0.3959Highly InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton development0.6015Highly InformativeInherited
Mammalian Phenotype (MP)abnormal hippocampus morphology0.7673Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.02187Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.1775Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.1932Least InformativeInherited
Worm Phenotype (WP)growth variant1Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant1.488e-07Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant7.69e-05Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.5001Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant1Moderately InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant1Moderately InformativeInherited
Worm Phenotype (WP)male morphology variant1.205e-05InformativeDirect
Worm Phenotype (WP)neuron development variant0.0001453InformativeDirect
Worm Phenotype (WP)exploded through vulva0.0005865InformativeDirect
Worm Phenotype (WP)protein metabolism variant0.001447InformativeInherited
Worm Phenotype (WP)sensillum morphology variant0.2154InformativeInherited
Worm Phenotype (WP)egg laying variant0.3229InformativeInherited
Worm Phenotype (WP)mechanosensation variant0.3772InformativeInherited
Worm Phenotype (WP)drug resistant0.5864InformativeInherited
Worm Phenotype (WP)lineage variant1.323e-08Highly InformativeDirect
Worm Phenotype (WP)ectopic expression transgene4.909e-07Highly InformativeDirect
Worm Phenotype (WP)growth rate variant6.604e-05Highly InformativeDirect
Worm Phenotype (WP)carbon dioxide avoidance variant8.213e-05Highly InformativeDirect
Worm Phenotype (WP)protein degradation variant9.267e-05Highly InformativeDirect
Worm Phenotype (WP)touch resistant0.0005528Highly InformativeDirect
Worm Phenotype (WP)egg laying defective0.03149Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

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FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.000111Least InformativeDirect
Fly Phenotype (FP)visible1.566e-12Moderately InformativeDirect
Fly Phenotype (FP)lethal - all die before end of P-stage0.004172Moderately InformativeInherited
Fly Phenotype (FP)lethal - all die before end of first instar larval stage6.003e-10InformativeDirect
Fly Phenotype (FP)wild-type0.000672InformativeDirect
Fly Phenotype (FP)some die during P-stage0.2243InformativeInherited
Fly Phenotype (FP)lethal - all die before end of embryonic stage6.638e-11Highly InformativeDirect
Fly Phenotype (FP)homeotic5.822e-09Highly InformativeDirect
Fly Phenotype (FP)pair rule phenotype2.466e-07Highly InformativeDirect
Fly Phenotype (FP)some die during embryonic stage1.047e-06Highly InformativeDirect
Fly Phenotype (FP)some die during pharate adult stage0.0001831Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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