SUPERFAMILY 1.75 HMM library and genome assignments server


Homeodomain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DNA/RNA-binding 3-helical bundle [ 46688] (14)
Superfamily:   Homeodomain-like [ 46689] (19)
Families:   Homeodomain [ 46690] (40)
  Recombinase DNA-binding domain [ 46728] (5)
  Myb/SANT domain [ 46739] (15)
  SLIDE domain [ 100998]
  GARP response regulators [ 81683]
  DNA-binding domain of telomeric protein [ 46745] (2)
  Paired domain [ 46748] (3)
  DNA-binding domain of rap1 [ 46753]
  Centromere-binding [ 46756] (2)
  FIS-like [ 100918] (4)
  AraC type transcriptional activator [ 46759] (2)
  Tetracyclin repressor-like, N-terminal domain [ 46764] (34)
  Middle operon regulator, Mor [ 109659]
  Psq domain [ 140213]
  Alr1493-like [ 140216]
  Nanomeric phage protein-like [ 140219]
  SWIRM domain [ 140222] (3)
  Cgl2762-like [ 158260]
  RpiR-like [ 158263]


Superfamily statistics
Genomes (2,979) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 216,587 919,205 207
Proteins 188,044 784,857 197


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process9.279e-120Least InformativeDirect
Biological Process (BP)developmental process1.962e-100Least InformativeDirect
Biological Process (BP)multicellular organismal process1.49e-090Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.00077480Least InformativeDirect
Biological Process (BP)single-organism cellular process0.0015521.214e-06Least InformativeInherited
Biological Process (BP)response to stimulus0.90331Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.44080.3851Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.62246.722e-06Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.62977.328e-06Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.74760.002004Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.76120.01751Least InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process00Moderately InformativeDirect
Biological Process (BP)regulation of cellular biosynthetic process00Moderately InformativeDirect
Biological Process (BP)regulation of gene expression00Moderately InformativeDirect
Biological Process (BP)cell differentiation1.014e-129.614e-11Moderately InformativeDirect
Biological Process (BP)single-organism developmental process2.355e-070Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process7.94e-060Moderately InformativeDirect
Biological Process (BP)regulation of developmental process2.43e-052.934e-05Moderately InformativeDirect
Biological Process (BP)anatomical structure morphogenesis0.011190Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.23040Moderately InformativeInherited
Biological Process (BP)signal transduction11Moderately InformativeInherited
Biological Process (BP)nervous system development0.94492.409e-06Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.016121Moderately InformativeInherited
Biological Process (BP)tissue development0.0045732.856e-06Moderately InformativeInherited
Biological Process (BP)organ development0.003320Moderately InformativeInherited
Biological Process (BP)embryonic morphogenesis4.88e-060InformativeDirect
Biological Process (BP)negative regulation of developmental process0.00013252.19e-05InformativeDirect
Biological Process (BP)sensory organ development0.00016340InformativeDirect
Biological Process (BP)positive regulation of developmental process0.038940.005699InformativeInherited
Biological Process (BP)regulation of nervous system development0.490.0001162InformativeInherited
Biological Process (BP)regulation of cell development10.2045InformativeInherited
Biological Process (BP)enzyme linked receptor protein signaling pathway0.0033670.2354InformativeInherited
Biological Process (BP)central nervous system development0.58180InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.70631InformativeInherited
Biological Process (BP)epithelium development0.098540.2383InformativeInherited
Biological Process (BP)DNA metabolic process0.0053540.02305InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching0.021350.2017InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.0040490.001237InformativeInherited
Biological Process (BP)generation of neurons0.26928.79e-07InformativeInherited
Biological Process (BP)organ morphogenesis0.043420InformativeInherited
Biological Process (BP)pattern specification process1.819e-110Highly InformativeDirect
Biological Process (BP)cell fate commitment4.228e-060Highly InformativeDirect
Biological Process (BP)regulation of epithelial cell differentiation5.054e-051.272e-07Highly InformativeDirect
Biological Process (BP)retina development in camera-type eye0.00016557.986e-14Highly InformativeDirect
Biological Process (BP)diencephalon development0.00060240Highly InformativeDirect
Biological Process (BP)neural tube development0.00085882.054e-10Highly InformativeDirect
Biological Process (BP)epidermal cell differentiation0.0010420.003691Highly InformativeInherited
Biological Process (BP)DNA recombination5.338e-060.9787Highly InformativeInherited
Biological Process (BP)photoreceptor cell differentiation9.274e-060.1256Highly InformativeInherited
Biological Process (BP)eye morphogenesis0.15610.3032Highly InformativeInherited
Molecular Function (MF)binding0.018280Least InformativeInherited
Molecular Function (MF)nucleic acid binding6.618e-080Moderately InformativeDirect
Molecular Function (MF)nucleic acid binding transcription factor activity00InformativeDirect
Molecular Function (MF)DNA binding5.256e-110InformativeDirect
Molecular Function (MF)chromatin binding4.973e-090InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.0520Least InformativeInherited
Cellular Component (CC)intracellular organelle part10.002744Least InformativeInherited
Cellular Component (CC)protein complex0.62342.048e-14Least InformativeInherited
Cellular Component (CC)intracellular organelle lumen0.11630Moderately InformativeInherited
Cellular Component (CC)nuclear part0.8211.63e-11Moderately InformativeInherited
Cellular Component (CC)nucleoplasm part0.00042040InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 1.214e-06 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 6.722e-06 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 7.328e-06 Least Informative Direct
Biological Process (BP) biosynthetic process 2.996e-05 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.01751 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.002004 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.3851 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.06195 Least Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 9.614e-11 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 2.934e-05 Moderately Informative Direct
Biological Process (BP) organ development 0 Moderately Informative Direct
Biological Process (BP) tissue development 2.856e-06 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0 Moderately Informative Direct
Biological Process (BP) reproduction 6.178e-09 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0009296 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 8.66e-10 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 8.476e-08 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) nervous system development 2.409e-06 Moderately Informative Direct
Biological Process (BP) gene expression 0 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.008233 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.06352 Moderately Informative Inherited
Biological Process (BP) immune system process 0.7642 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.0188 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.1996 Moderately Informative Inherited
Biological Process (BP) embryonic morphogenesis 0 Informative Direct
Biological Process (BP) negative regulation of developmental process 2.19e-05 Informative Direct
Biological Process (BP) sensory organ development 0 Informative Direct
Biological Process (BP) embryonic organ development 0 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 1.279e-10 Informative Direct
Biological Process (BP) organ morphogenesis 0 Informative Direct
Biological Process (BP) tissue morphogenesis 0.0001562 Informative Direct
Biological Process (BP) tube development 1.699e-05 Informative Direct
Biological Process (BP) generation of neurons 8.79e-07 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1.936e-15 Informative Direct
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 2.654e-10 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0001162 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 4.622e-06 Informative Direct
Biological Process (BP) central nervous system development 0 Informative Direct
Biological Process (BP) response to hormone stimulus 0 Informative Direct
Biological Process (BP) response to lipid 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) gland development 0 Informative Direct
Biological Process (BP) chromosome organization 0 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) transcription, DNA-dependent 0 Informative Direct
Biological Process (BP) cellular component movement 2.073e-11 Informative Direct
Biological Process (BP) cell projection organization 3.887e-09 Informative Direct
Biological Process (BP) leukocyte activation 0.0002012 Informative Direct
Biological Process (BP) response to organic cyclic compound 0.000899 Informative Direct
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.5137 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.3903 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) regulation of secretion 0.3314 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.9479 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 1 Informative Inherited
Biological Process (BP) regulation of peptidase activity 0.3013 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) positive regulation of protein modification process 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) epithelium development 0.2383 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) synaptic transmission 1 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) organelle localization 0.5971 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) microtubule-based process 1 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.005699 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of cell development 0.2045 Informative Inherited
Biological Process (BP) cardiovascular system development 1 Informative Inherited
Biological Process (BP) response to light stimulus 0.1895 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.9267 Informative Inherited
Biological Process (BP) response to inorganic substance 0.744 Informative Inherited
Biological Process (BP) membrane lipid metabolic process 0.01511 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.2526 Informative Inherited
Biological Process (BP) muscle structure development 0.03124 Informative Inherited
Biological Process (BP) muscle tissue development 1 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 1 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) transmembrane transport 1 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.2354 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 1 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.2017 Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 1 Informative Inherited
Biological Process (BP) secretion by cell 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.6514 Informative Inherited
Biological Process (BP) DNA metabolic process 0.02305 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.3616 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.02733 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 1 Informative Inherited
Biological Process (BP) isoprenoid metabolic process 1 Informative Inherited
Biological Process (BP) response to other organism 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 1 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) apoptotic process 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.001237 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.1122 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.01158 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.009308 Informative Inherited
Biological Process (BP) pattern specification process 0 Highly Informative Direct
Biological Process (BP) cell fate commitment 0 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell differentiation 1.272e-07 Highly Informative Direct
Biological Process (BP) retina development in camera-type eye 7.986e-14 Highly Informative Direct
Biological Process (BP) diencephalon development 0 Highly Informative Direct
Biological Process (BP) neural tube development 2.054e-10 Highly Informative Direct
Biological Process (BP) endocrine system development 0 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 6.223e-11 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 6.881e-05 Highly Informative Direct
Biological Process (BP) skeletal system development 1.255e-13 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 5.594e-05 Highly Informative Direct
Biological Process (BP) alpha-beta T cell activation 6.377e-13 Highly Informative Direct
Biological Process (BP) hormone-mediated signaling pathway 7.661e-13 Highly Informative Direct
Biological Process (BP) limb morphogenesis 8.593e-11 Highly Informative Direct
Biological Process (BP) response to alcohol 2.019e-10 Highly Informative Direct
Biological Process (BP) sphingolipid biosynthetic process 6.203e-10 Highly Informative Direct
Biological Process (BP) chemotaxis 1.861e-09 Highly Informative Direct
Biological Process (BP) regulation of neural precursor cell proliferation 2.83e-09 Highly Informative Direct
Biological Process (BP) histone modification 1.197e-08 Highly Informative Direct
Biological Process (BP) response to cadmium ion 2.538e-08 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 5.619e-08 Highly Informative Direct
Biological Process (BP) regulation of binding 6.888e-08 Highly Informative Direct
Biological Process (BP) response to salt stress 3.106e-07 Highly Informative Direct
Biological Process (BP) protein deacylation 1.001e-06 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 2.977e-06 Highly Informative Direct
Biological Process (BP) artery morphogenesis 3.165e-06 Highly Informative Direct
Biological Process (BP) cell projection morphogenesis 3.993e-06 Highly Informative Direct
Biological Process (BP) epithelial tube formation 4.763e-06 Highly Informative Direct
Biological Process (BP) regulation of intrinsic apoptotic signaling pathway 1.282e-05 Highly Informative Direct
Biological Process (BP) renal system development 9.114e-05 Highly Informative Direct
Biological Process (BP) response to water deprivation 0.0001121 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0.0002187 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 0.0003318 Highly Informative Direct
Biological Process (BP) stem cell development 0.0003934 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.00041 Highly Informative Direct
Biological Process (BP) telencephalon development 0.0008445 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic signaling pathway 0.05199 Highly Informative Inherited
Biological Process (BP) positive regulation of programmed cell death 1 Highly Informative Inherited
Biological Process (BP) regulation of peptide transport 0.02487 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.00482 Highly Informative Inherited
Biological Process (BP) positive regulation of endopeptidase activity 0.02167 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 1 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 1 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Highly Informative Inherited
Biological Process (BP) response to cytokinin stimulus 0.0784 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 1 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.6069 Highly Informative Inherited
Biological Process (BP) respiratory tube development 0.6277 Highly Informative Inherited
Biological Process (BP) respiratory system development 1 Highly Informative Inherited
Biological Process (BP) erythrocyte differentiation 0.03959 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.8469 Highly Informative Inherited
Biological Process (BP) cardiocyte differentiation 0.5487 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 1 Highly Informative Inherited
Biological Process (BP) cardiac muscle tissue development 1 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.3465 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of neurogenesis 0.8266 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.1026 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.3032 Highly Informative Inherited
Biological Process (BP) ceramide metabolic process 0.006759 Highly Informative Inherited
Biological Process (BP) regulation of cellular amine metabolic process 0.7544 Highly Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 1 Highly Informative Inherited
Biological Process (BP) meiosis 1 Highly Informative Inherited
Biological Process (BP) photoreceptor cell differentiation 0.1256 Highly Informative Inherited
Biological Process (BP) ear development 0.107 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.3089 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 0.4457 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 1 Highly Informative Inherited
Biological Process (BP) hormone transport 0.1262 Highly Informative Inherited
Biological Process (BP) amide transport 0.193 Highly Informative Inherited
Biological Process (BP) signal release 0.9108 Highly Informative Inherited
Biological Process (BP) neural precursor cell proliferation 0.002562 Highly Informative Inherited
Biological Process (BP) glial cell differentiation 0.06661 Highly Informative Inherited
Biological Process (BP) mesenchyme development 0.004226 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 1 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 1 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.003691 Highly Informative Inherited
Biological Process (BP) regulation of cell division 0.007065 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.0645 Highly Informative Inherited
Biological Process (BP) isoprenoid biosynthetic process 0.9653 Highly Informative Inherited
Biological Process (BP) axon development 0.01025 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in neuron differentiation 0.1046 Highly Informative Inherited
Biological Process (BP) learning or memory 1 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.118 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.6021 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.6791 Highly Informative Inherited
Biological Process (BP) developmental maturation 1 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.2038 Highly Informative Inherited
Biological Process (BP) DNA recombination 0.9787 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.4907 Highly Informative Inherited
Biological Process (BP) epithelial cell development 1 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 0.4135 Highly Informative Inherited
Biological Process (BP) negative regulation of transcription, DNA-dependent 0.06279 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) chromatin binding 0 Informative Direct
Molecular Function (MF) protein dimerization activity 8.229e-11 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0.7379 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) enzyme activator activity 1 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.5857 Informative Inherited
Molecular Function (MF) receptor activity 1 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0 Highly Informative Direct
Molecular Function (MF) protein binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) deacetylase activity 5.606e-05 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.07697 Highly Informative Inherited
Molecular Function (MF) protein kinase regulator activity 0.1352 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 0.0677 Highly Informative Inherited
Molecular Function (MF) structure-specific DNA binding 1 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) protein complex 2.048e-14 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.002744 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0 Moderately Informative Direct
Cellular Component (CC) nuclear part 1.63e-11 Moderately Informative Direct
Cellular Component (CC) nucleoplasm part 0 Informative Direct
Cellular Component (CC) chromosome 0 Informative Direct
Cellular Component (CC) nuclear chromosome part 0.1783 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

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EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep7.689e-10Moderately InformativeDirect
Enzyme Commission (EC)Glucokinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

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DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)endocrine system disease0.8485Moderately InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance5.224e-05Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.8348Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis1Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of carbohydrate metabolism/homeostasis0.504Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the globe0.5331Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of brain morphology0.8739Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia affecting the eye0.0001768InformativeDirect
Phenotypic Abnormality (PA)Abnormality of prenatal development or birth0.2828InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the central nervous system0.3435InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the fundus0.4144InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebrum1InformativeInherited
Phenotypic Abnormality (PA)Optic nerve hypoplasia3.92e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the pituitary gland0.0003422Highly InformativeDirect
Phenotypic Abnormality (PA)Absent septum pellucidum0.000347Highly InformativeDirect
Phenotypic Abnormality (PA)Prenatal maternal abnormality0.01737Highly InformativeInherited
Phenotypic Abnormality (PA)Diabetes mellitus0.2027Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype1.807e-07Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging3.45e-06Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body phenotype3.256e-05Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.03445Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.8664Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype1Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype1Least InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology1.428e-14Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology3.025e-07Moderately InformativeDirect
Mammalian Phenotype (MP)preweaning lethality0.0001171Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.0002081Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.0003153Moderately InformativeDirect
Mammalian Phenotype (MP)digestive/alimentary phenotype0.0003747Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system development0.03756Moderately InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.07512Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.09546Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.3483Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.5901Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.6242Moderately InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.9106Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.9527Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal vertebrae morphology9.167e-06InformativeDirect
Mammalian Phenotype (MP)lethality during fetal growth through weaning1.044e-05InformativeDirect
Mammalian Phenotype (MP)abnormal gas homeostasis0.001531InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial development0.004122InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.005102InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.02752InformativeInherited
Mammalian Phenotype (MP)abnormal neuron physiology0.05964InformativeInherited
Mammalian Phenotype (MP)abnormal consumption behavior0.06459InformativeInherited
Mammalian Phenotype (MP)abnormal uvea morphology0.1581InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.2472InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube morphology/development0.293InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle morphology0.3491InformativeInherited
Mammalian Phenotype (MP)abnormal thymus morphology0.367InformativeInherited
Mammalian Phenotype (MP)abnormal internal male genitalia morphology0.4197InformativeInherited
Mammalian Phenotype (MP)abnormal facial morphology0.4802InformativeInherited
Mammalian Phenotype (MP)abnormal limb morphology0.6456InformativeInherited
Mammalian Phenotype (MP)abnormal cerebrum morphology0.7132InformativeInherited
Mammalian Phenotype (MP)abnormal cranium morphology0.9274InformativeInherited
Mammalian Phenotype (MP)abnormal membranous labyrinth morphology0.951InformativeInherited
Mammalian Phenotype (MP)abnormal spleen morphology0.9547InformativeInherited
Mammalian Phenotype (MP)abnormal sex gland morphology1InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system physiology1InformativeInherited
Mammalian Phenotype (MP)abnormal middle ear morphology4.771e-08Highly InformativeDirect
Mammalian Phenotype (MP)cyanosis1.193e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal secondary palate development6.28e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal brain ventricle morphology3.309e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mandibular coronoid process morphology8.274e-05Highly InformativeDirect
Mammalian Phenotype (MP)microphthalmia9.548e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal maxilla morphology0.0001186Highly InformativeDirect
Mammalian Phenotype (MP)abnormal rib morphology0.000225Highly InformativeDirect
Mammalian Phenotype (MP)abnormal rib attachment0.0003892Highly InformativeDirect
Mammalian Phenotype (MP)abnormal temporal bone morphology0.0004678Highly InformativeDirect
Mammalian Phenotype (MP)abnormal nose morphology0.0005204Highly InformativeDirect
Mammalian Phenotype (MP)abnormal neuronal precursor proliferation0.0006369Highly InformativeDirect
Mammalian Phenotype (MP)taste/olfaction phenotype0.0009721Highly InformativeDirect
Mammalian Phenotype (MP)abnormal tongue morphology0.001726Highly InformativeInherited
Mammalian Phenotype (MP)abnormal pituitary gland morphology0.004442Highly InformativeInherited
Mammalian Phenotype (MP)abnormal kidney development0.005903Highly InformativeInherited
Mammalian Phenotype (MP)abnormal parathyroid gland morphology0.04321Highly InformativeInherited
Mammalian Phenotype (MP)abnormal limb long bone morphology0.07683Highly InformativeInherited
Mammalian Phenotype (MP)abnormal midbrain morphology0.08221Highly InformativeInherited
Mammalian Phenotype (MP)abnormal sphenoid bone morphology0.1552Highly InformativeInherited
Mammalian Phenotype (MP)impaired hearing0.1884Highly InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system tract morphology0.2082Highly InformativeInherited
Mammalian Phenotype (MP)abnormal brain white matter morphology0.2562Highly InformativeInherited
Mammalian Phenotype (MP)abnormal trabecular meshwork morphology0.2946Highly InformativeInherited
Mammalian Phenotype (MP)abnormal alveolar process morphology0.3053Highly InformativeInherited
Mammalian Phenotype (MP)abnormal food intake0.3562Highly InformativeInherited
Mammalian Phenotype (MP)abnormal epididymis morphology0.4371Highly InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton development0.5775Highly InformativeInherited
Mammalian Phenotype (MP)abnormal hippocampus morphology0.7831Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.02187Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.1775Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.1932Least InformativeInherited
Worm Phenotype (WP)growth variant1Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant1.488e-07Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant7.69e-05Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.5001Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant1Moderately InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant1Moderately InformativeInherited
Worm Phenotype (WP)male morphology variant1.205e-05InformativeDirect
Worm Phenotype (WP)neuron development variant0.0001453InformativeDirect
Worm Phenotype (WP)exploded through vulva0.0005865InformativeDirect
Worm Phenotype (WP)protein metabolism variant0.001447InformativeInherited
Worm Phenotype (WP)sensillum morphology variant0.2154InformativeInherited
Worm Phenotype (WP)egg laying variant0.3229InformativeInherited
Worm Phenotype (WP)mechanosensation variant0.3772InformativeInherited
Worm Phenotype (WP)drug resistant0.5864InformativeInherited
Worm Phenotype (WP)lineage variant1.323e-08Highly InformativeDirect
Worm Phenotype (WP)ectopic expression transgene4.909e-07Highly InformativeDirect
Worm Phenotype (WP)growth rate variant6.604e-05Highly InformativeDirect
Worm Phenotype (WP)carbon dioxide avoidance variant8.213e-05Highly InformativeDirect
Worm Phenotype (WP)protein degradation variant9.267e-05Highly InformativeDirect
Worm Phenotype (WP)touch resistant0.0005528Highly InformativeDirect
Worm Phenotype (WP)egg laying defective0.03149Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

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FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.08839Least InformativeInherited
Fly Phenotype (FP)lethal - all die before end of P-stage0.006016Moderately InformativeInherited
Fly Phenotype (FP)visible7.534e-10InformativeDirect
Fly Phenotype (FP)lethal - all die before end of larval stage4.898e-07InformativeDirect
Fly Phenotype (FP)wild-type0.0004882InformativeDirect
Fly Phenotype (FP)lethal - all die before end of embryonic stage6.626e-11Highly InformativeDirect
Fly Phenotype (FP)homeotic2.587e-08Highly InformativeDirect
Fly Phenotype (FP)some die during embryonic stage1.54e-06Highly InformativeDirect
Fly Phenotype (FP)some die during P-stage0.2279Highly InformativeInherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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