SUPERFAMILY 1.75 HMM library and genome assignments server


Cytochrome c superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Cytochrome c [ 46625]
Superfamily:   Cytochrome c [ 46626] (8)
Families:   monodomain cytochrome c [ 46627] (15)
  N-terminal (heme c) domain of cytochrome cd1-nitrite reductase [ 46671]
  Quinoprotein alcohol dehydrogenase, C-terminal domain [ 68952]
  Cytochrome bc1 domain [ 46676]
  Two-domain cytochrome c [ 46680] (2)
  Di-heme cytochrome c SoxA [ 81677]
  Di-heme cytochrome c peroxidase [ 46685]
  Quinohemoprotein amine dehydrogenase A chain, domains 1 and 2 [ 68956]


Superfamily statistics
Genomes (2,127) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 23,505 81,775 122
Proteins 17,264 57,671 113


Functional annotation
General category Metabolism
Detailed category E- transfer

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)heterocycle metabolic process0.12931Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.64210.0005414Least InformativeInherited
Biological Process (BP)single-organism cellular process0.35091Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.0002460.7882Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.23671Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.00074920.6157Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.1361Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.58411Least InformativeInherited
Biological Process (BP)organic cyclic compound catabolic process2.798e-092.82e-05Moderately InformativeDirect
Biological Process (BP)phosphate-containing compound metabolic process0.022040.3143Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.0025640.02914Moderately InformativeInherited
Biological Process (BP)DNA metabolic process1.908e-136.25e-05InformativeDirect
Biological Process (BP)apoptotic process07.322e-10InformativeDirect
Biological Process (BP)nucleobase-containing compound catabolic process4.303e-122.872e-06InformativeDirect
Biological Process (BP)cellular macromolecule catabolic process1.333e-133.647e-08InformativeDirect
Biological Process (BP)nucleic acid phosphodiester bond hydrolysis03.861e-11InformativeDirect
Biological Process (BP)energy derivation by oxidation of organic compounds0.10270.9407InformativeInherited
Biological Process (BP)phosphorylation1.112e-050.01056InformativeInherited
Biological Process (BP)oxidative phosphorylation7.675e-085.447e-10Highly InformativeDirect
Biological Process (BP)DNA catabolic process00Highly InformativeDirect
Biological Process (BP)cellular component disassembly02.462e-14Highly InformativeDirect
Biological Process (BP)electron transport chain1.235e-060.0003644Highly InformativeDirect
Biological Process (BP)execution phase of apoptosis00Highly InformativeDirect
Molecular Function (MF)binding0.90371Least InformativeInherited
Molecular Function (MF)electron carrier activity00InformativeDirect
Molecular Function (MF)tetrapyrrole binding8.36e-050InformativeDirect
Molecular Function (MF)heme binding6.545e-050Highly InformativeDirect
Cellular Component (CC)membrane0.36460.9457Least InformativeInherited
Cellular Component (CC)cytoplasmic part1.222e-070.02208Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.64250.9194Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.17221Least InformativeInherited
Cellular Component (CC)organelle envelope9.311e-061.375e-08Moderately InformativeDirect
Cellular Component (CC)mitochondrial part0.0011469.603e-10Moderately InformativeInherited
Cellular Component (CC)organelle membrane0.0046920.0002988Moderately InformativeInherited
Cellular Component (CC)respiratory chain2.933e-052.363e-09InformativeDirect
Cellular Component (CC)mitochondrial membrane part0.0015581.556e-07InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.0005414 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.7882 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.6157 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) sulfur compound metabolic process 6.012e-07 Moderately Informative Direct
Biological Process (BP) organic cyclic compound catabolic process 2.82e-05 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.3143 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.02914 Moderately Informative Inherited
Biological Process (BP) DNA metabolic process 6.25e-05 Informative Direct
Biological Process (BP) apoptotic process 7.322e-10 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 2.872e-06 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 3.647e-08 Informative Direct
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 3.861e-11 Informative Direct
Biological Process (BP) energy derivation by oxidation of organic compounds 0.9407 Informative Inherited
Biological Process (BP) phosphorylation 0.01056 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.0303 Informative Inherited
Biological Process (BP) oxidative phosphorylation 5.447e-10 Highly Informative Direct
Biological Process (BP) DNA catabolic process 0 Highly Informative Direct
Biological Process (BP) cellular component disassembly 2.462e-14 Highly Informative Direct
Biological Process (BP) electron transport chain 0.0003644 Highly Informative Direct
Biological Process (BP) execution phase of apoptosis 0 Highly Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0.0002215 Moderately Informative Direct
Molecular Function (MF) transporter activity 0.04036 Moderately Informative Inherited
Molecular Function (MF) electron carrier activity 0 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 3.426e-06 Informative Direct
Molecular Function (MF) tetrapyrrole binding 0 Informative Direct
Molecular Function (MF) protein dimerization activity 0.03723 Informative Inherited
Molecular Function (MF) transition metal ion binding 0.03758 Informative Inherited
Molecular Function (MF) iron ion binding 5.839e-06 Highly Informative Direct
Molecular Function (MF) heme-copper terminal oxidase activity 0.0009508 Highly Informative Direct
Molecular Function (MF) hydrogen ion transmembrane transporter activity 8.097e-12 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on a sulfur group of donors 7.852e-10 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor 8.833e-10 Highly Informative Direct
Molecular Function (MF) heme binding 0 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 0.0001321 Highly Informative Direct
Cellular Component (CC) intracellular organelle part 0.9194 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.02208 Least Informative Inherited
Cellular Component (CC) membrane 0.9457 Least Informative Inherited
Cellular Component (CC) organelle membrane 0.0002988 Moderately Informative Direct
Cellular Component (CC) organelle envelope 1.375e-08 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 9.603e-10 Moderately Informative Direct
Cellular Component (CC) mitochondrial membrane part 1.556e-07 Informative Direct
Cellular Component (CC) respiratory chain 2.363e-09 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)cotyledon0Moderately InformativeDirect
Plant ANatomical entity (PAN)inflorescence meristem0Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors0.02191Moderately InformativeInherited
Enzyme Commission (EC)Acting on other nitrogenous compounds as donors0.0008049InformativeDirect
Enzyme Commission (EC)Acting on a peroxide as acceptor0.01518InformativeInherited
Enzyme Commission (EC)With a cytochrome as acceptor3.154e-12Highly InformativeDirect
Enzyme Commission (EC)With other acceptors1.223e-11Highly InformativeDirect
Enzyme Commission (EC)With a cytochrome as acceptor3.678e-11Highly InformativeDirect
Enzyme Commission (EC)Peroxidases1.124e-05Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processApoptosis7.476e-12Moderately InformativeDirect
Biological processIon transport1Moderately InformativeInherited
Biological processElectron transport0InformativeDirect
Biological processPhotosynthesis0InformativeDirect
Biological processHydrogen ion transport3.512e-06Highly InformativeDirect
Cellular componentMembrane1.476e-05Least InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentPlastid0.0003523Moderately InformativeDirect
Cellular componentThylakoid0InformativeDirect
Cellular componentPeriplasm0InformativeDirect
Cellular componentPhotosystem II0Highly InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular functionHeme0InformativeDirect
Post-translational modificationOxidoreductase3.155e-05Moderately InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect
Post-translational modificationMethylation0Moderately InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)energy metabolism0Moderately InformativeDirect
UniPathway (UP)one-carbon metabolism4.807e-05Moderately InformativeDirect
UniPathway (UP)oxidative phosphorylation0Highly InformativeDirect
UniPathway (UP)methylamine degradation3.302e-13Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR009056 SSF46626 Protein matches
Abstract

After cytochrome c is synthesized in the cytoplasm as apocytochrome c, it is transported through the outer mitochondrial membrane to the intermembrane space, where haem is covalently attached by thioester bonds to two cysteine residues located in the cytochrome c centre. Cytochrome c is required during oxidative phosphorylation as an electron shuttle between Complex III (cytochrome c reductase) and IV (cytochrome c oxidase). In addition, cytochrome c is involved in apoptosis in more complex organisms such as Xenopus, rats and humans. Cellular stress can induce cytochrome c release from the mitochondrial membrane. In mammals, cytochrome c triggers the assembly of the apoptosome, consisting of cytochrome c, Apaf-1 and dATP, which activates caspase-9, leading to cell death [PubMed12729583, PubMed10707095]. There are several different members of the cytochrome c family with different functional roles, for instance cytochrome c549 is associated with photosystem II [PubMed11315568].

The known structures of c-type cytochromes have six different classes of fold. Of these, four are unique to c-type cytochromes [PubMed12594933, PubMed2166169]. The consensus sequence for the cytochrome c centre is Cys-X-X-Cys-His, where the histidine residue is one of the two axial ligands of the haem iron [PubMed10647174]. This arrangement is shared by all proteins known to belong to the cytochrome c family, which presently includes both mono-haem proteins and multi-haem proteins. This entry represents mono-haem cytochrome c proteins (excluding class II and f-type cytochromes), such as cytochromes c, c1, c2, c5, c555, c550 to c553, c556, and c6.

Cytochrome c-type centres are also found in the active sites of many enzymes, including cytochrome cd1-nitrite reductase as the N-terminal haem c domain, in quinoprotein alcohol dehydrogenase as the C-terminal domain, in Quinohemoprotein amine dehydrogenase A chain as domains 1 and 2, and in the cytochrome bc1 complex as the cytochrome bc1 domain.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 72 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cytochrome c domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 72 hidden Markov models representing the Cytochrome c superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]