SUPERFAMILY 1.75 HMM library and genome assignments server

HR1 repeat superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Long alpha-hairpin [ 46556] (20)
Superfamily:   HR1 repeat [ 46585]
Families:   HR1 repeat [ 46586]


Superfamily statistics
Genomes (353) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,571 1,767 2
Proteins 983 1,150 2


Functional annotation
General category Regulation
Detailed category Kinases/phosphatases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.0002013 Least Informative Direct
Biological Process (BP) localization 0.000002867 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0000000406 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.06892 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.003953 Least Informative Inherited
Biological Process (BP) developmental process 0.00462 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.01792 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0.00004333 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.0001821 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0001623 Moderately Informative Direct
Biological Process (BP) tissue development 0.0007368 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.2218 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.006667 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.06251 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.07209 Moderately Informative Inherited
Biological Process (BP) organ development 0.01713 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.09567 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.008976 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.007627 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.05476 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.1207 Moderately Informative Inherited
Biological Process (BP) synaptic transmission 0.000000603 Informative Direct
Biological Process (BP) organ morphogenesis 0.000001378 Informative Direct
Biological Process (BP) phosphorylation 0.00000003451 Informative Direct
Biological Process (BP) cell projection organization 0.0000006105 Informative Direct
Biological Process (BP) regulation of organelle organization 0.0000037 Informative Direct
Biological Process (BP) regulation of growth 0.000006856 Informative Direct
Biological Process (BP) locomotion 0.0001373 Informative Direct
Biological Process (BP) regulation of locomotion 0.0009403 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.000000002768 Informative Direct
Biological Process (BP) single-organism membrane organization 0.0000000001036 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.0000006622 Informative Direct
Biological Process (BP) generation of neurons 0.000002684 Informative Direct
Biological Process (BP) negative regulation of developmental process 0.000000216 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.000000004686 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.000000284 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.0002229 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0000000004137 Informative Direct
Biological Process (BP) epithelium development 0.00000002781 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.000000001072 Informative Direct
Biological Process (BP) localization of cell 0.003884 Informative Inherited
Biological Process (BP) cellular component movement 0.001254 Informative Inherited
Biological Process (BP) protein phosphorylation 0.0000000004486 Highly Informative Direct
Biological Process (BP) plasma membrane organization 0 Highly Informative Direct
Biological Process (BP) epidermis development 0.0000000004946 Highly Informative Direct
Biological Process (BP) post-embryonic development 0.000002755 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 0.000000000000001913 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 0.000000005058 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 0.000000000004777 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.00000000000003082 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 0 Highly Informative Direct
Biological Process (BP) negative regulation of nervous system development 0.000000000000003707 Highly Informative Direct
Molecular Function (MF) transferase activity 0.000006075 Least Informative Direct
Molecular Function (MF) binding 0.01611 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.0000000005228 Moderately Informative Direct
Molecular Function (MF) kinase activity 0.00000000005033 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.00000000001099 Informative Direct
Molecular Function (MF) enzyme binding 0.001581 Informative Inherited
Molecular Function (MF) protein kinase activity 0.0000000000001878 Highly Informative Direct
Cellular Component (CC) membrane 0.1212 Least Informative Inherited
Cellular Component (CC) vesicle 0.000001539 Moderately Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) synapse 0.0000000001353 Informative Direct
Cellular Component (CC) midbody 0 Highly Informative Direct
Cellular Component (CC) cell division site part 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect

Document: EC annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect

Document: FP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0.000001647Moderately InformativeDirect
Biological processCell cycle0.00000804Moderately InformativeDirect
Biological processCell adhesion0.000000008853InformativeDirect
Cellular componentNucleus0.000003668Least InformativeDirect
Cellular componentCytoplasm0.00001666Least InformativeDirect
Cellular componentCell projection0.00000002935Moderately InformativeDirect
Cellular componentCell junction0.00000007585Moderately InformativeDirect
Cellular componentCytoskeleton0.00001615Moderately InformativeDirect
DomainRepeat0.00000001743Least InformativeDirect
DomainZinc-finger0.0004447Moderately InformativeDirect
Molecular functionNucleotide-binding0.0000005122Least InformativeDirect
Molecular functionZinc0.0006944Least InformativeDirect
Molecular functionATP-binding0.00000002494Moderately InformativeDirect
Post-translational modificationTransferase0.00000005326Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationPhosphoprotein0.000000000000001793Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011072 SSF46585 Protein matches
Abstract

The HR1 repeat was first described as a three times repeated homology region of the N-terminal non-catalytic part of protein kinase PRK1(PKN) [PubMed7851406]. The first two of these repeats were later shown to bind the small G protein rho [PubMed8647255, PubMed9446575] known to activate PKN in its GTP-bound form. Similar rho-binding domains also occur in a number of other protein kinases and in the rho-binding proteins rhophilin and rhotekin. Recently, the structure of the N-terminal HR1 repeat complexed with RhoA has been determined by X-ray crystallography [PubMed10619026]. It forms an antiparallel coiled-coil fold termed an ACC finger.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Fly Phenotype (FP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HR1 repeat domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the HR1 repeat superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Fly Phenotype (FP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]