SUPERFAMILY 1.75 HMM library and genome assignments server

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HR1 repeat superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Long alpha-hairpin [ 46556] (20)
Superfamily:   HR1 repeat [ 46585]
Families:   HR1 repeat [ 46586]


Superfamily statistics
Genomes (353) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,571 1,767 2
Proteins 983 1,150 2


Functional annotation
General category Regulation
Detailed category Kinases/phosphatases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0.0000001116 Least Informative Direct
Biological Process (BP) localization 0.000001838 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.00095 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) developmental process 0.02336 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.003471 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.06748 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.002937 Least Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.000007457 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.00004169 Moderately Informative Direct
Biological Process (BP) tissue development 0.00007906 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.0001124 Moderately Informative Direct
Biological Process (BP) nervous system development 0.0003031 Moderately Informative Direct
Biological Process (BP) cellular localization 0.0006926 Moderately Informative Direct
Biological Process (BP) system process 0.0007413 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.01224 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1453 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.003356 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.2144 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.04249 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.1826 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.1378 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.03424 Moderately Informative Inherited
Biological Process (BP) organ development 0.04148 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) synaptic transmission 0.00000000007565 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.0000000002081 Informative Direct
Biological Process (BP) cellular membrane organization 0.0000000002904 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0000000003655 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.000000001195 Informative Direct
Biological Process (BP) regulation of cell development 0.000000001668 Informative Direct
Biological Process (BP) negative regulation of developmental process 0.000000005202 Informative Direct
Biological Process (BP) phosphorylation 0.00000000812 Informative Direct
Biological Process (BP) epithelium development 0.000000009152 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.0000000443 Informative Direct
Biological Process (BP) organ morphogenesis 0.0000006542 Informative Direct
Biological Process (BP) regulation of organelle organization 0.000001202 Informative Direct
Biological Process (BP) cell projection organization 0.000002484 Informative Direct
Biological Process (BP) generation of neurons 0.000002543 Informative Direct
Biological Process (BP) regulation of growth 0.000005912 Informative Direct
Biological Process (BP) locomotion 0.0001365 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.0001796 Informative Direct
Biological Process (BP) regulation of locomotion 0.0007683 Informative Direct
Biological Process (BP) cellular component movement 0.002916 Informative Inherited
Biological Process (BP) localization of cell 0.004494 Informative Inherited
Biological Process (BP) regulation of striated muscle tissue development 0 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 0 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 0.000000000000001931 Highly Informative Direct
Biological Process (BP) epidermal cell differentiation 0.000000000000003741 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.00000000000002782 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 0.000000000001928 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0.0000000004466 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 0.000000007072 Highly Informative Direct
Biological Process (BP) post-embryonic development 0.0000009565 Highly Informative Direct
Molecular Function (MF) transferase activity 0.000001568 Least Informative Direct
Molecular Function (MF) binding 0.01425 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.0000000005229 Moderately Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.00000000001104 Informative Direct
Molecular Function (MF) kinase activity 0.00000000005207 Informative Direct
Molecular Function (MF) enzyme binding 0.001506 Informative Inherited
Molecular Function (MF) protein kinase activity 0.0000000000001967 Highly Informative Direct
Cellular Component (CC) membrane 0.1181 Least Informative Inherited
Cellular Component (CC) vesicle 0.000001438 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.000005661 Moderately Informative Direct
Cellular Component (CC) midbody 0 Highly Informative Direct
Cellular Component (CC) cell division site part 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect

Document: EC annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect

Document: FP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0.000001618Moderately InformativeDirect
Biological processCell cycle0.000008637Moderately InformativeDirect
Biological processCell adhesion0.000000008819InformativeDirect
Cellular componentNucleus0.000003611Least InformativeDirect
Cellular componentCytoplasm0.00001664Least InformativeDirect
Cellular componentCell projection0.00000002829Moderately InformativeDirect
Cellular componentCell junction0.00000007552Moderately InformativeDirect
Cellular componentCytoskeleton0.00001595Moderately InformativeDirect
DomainRepeat0.00000001711Least InformativeDirect
DomainZinc-finger0.0004491Moderately InformativeDirect
Molecular functionNucleotide-binding0.0000005144Least InformativeDirect
Molecular functionZinc0.0006619Least InformativeDirect
Molecular functionATP-binding0.00000002504Moderately InformativeDirect
Post-translational modificationTransferase0.00000005314Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationPhosphoprotein0.000000000000001792Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011072 SSF46585 Protein matches
Abstract

The HR1 repeat was first described as a three times repeated homology region of the N-terminal non-catalytic part of protein kinase PRK1(PKN) [PubMed7851406]. The first two of these repeats were later shown to bind the small G protein rho [PubMed8647255, PubMed9446575] known to activate PKN in its GTP-bound form. Similar rho-binding domains also occur in a number of other protein kinases and in the rho-binding proteins rhophilin and rhotekin. Recently, the structure of the N-terminal HR1 repeat complexed with RhoA has been determined by X-ray crystallography [PubMed10619026]. It forms an antiparallel coiled-coil fold termed an ACC finger.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Fly Phenotype (FP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HR1 repeat domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the HR1 repeat superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Fly Phenotype (FP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]