SUPERFAMILY 1.75 HMM library and genome assignments server


GAS2 domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   N domain of copper amine oxidase-like [ 55382] (5)
Superfamily:   GAS2 domain-like [ 143575]
Families:   GAS2 domain [ 143576]


Superfamily statistics
Genomes (295) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 969 1,044 1
Proteins 968 1,041 1


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 6.999e-13 Least Informative Direct
Biological Process (BP) developmental process 1.177e-12 Least Informative Direct
Biological Process (BP) response to stimulus 2.873e-11 Least Informative Direct
Biological Process (BP) multicellular organismal process 5.167e-11 Least Informative Direct
Biological Process (BP) localization 9.376e-05 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) organelle organization 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 2.999e-12 Moderately Informative Direct
Biological Process (BP) tissue development 4.076e-10 Moderately Informative Direct
Biological Process (BP) cell differentiation 4.181e-09 Moderately Informative Direct
Biological Process (BP) nervous system development 3.277e-07 Moderately Informative Direct
Biological Process (BP) macromolecule localization 2.847e-05 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 4.01e-05 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 5.796e-05 Moderately Informative Direct
Biological Process (BP) cellular localization 7.085e-05 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 8.444e-05 Moderately Informative Direct
Biological Process (BP) organic substance transport 0.0002897 Moderately Informative Direct
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.4243 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.2789 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.9246 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.2708 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.7911 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.281 Moderately Informative Inherited
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0 Informative Direct
Biological Process (BP) tissue morphogenesis 0 Informative Direct
Biological Process (BP) regulation of organelle organization 0 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0 Informative Direct
Biological Process (BP) generation of neurons 0 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0 Informative Direct
Biological Process (BP) microtubule-based process 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) regulation of growth 3.755e-15 Informative Direct
Biological Process (BP) protein transport 1.953e-14 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 1.234e-12 Informative Direct
Biological Process (BP) locomotion 2.731e-11 Informative Direct
Biological Process (BP) actin filament-based process 4.804e-11 Informative Direct
Biological Process (BP) cell projection organization 8.717e-10 Informative Direct
Biological Process (BP) central nervous system development 2.751e-09 Informative Direct
Biological Process (BP) tube development 3.066e-09 Informative Direct
Biological Process (BP) positive regulation of developmental process 7.851e-09 Informative Direct
Biological Process (BP) muscle structure development 1.051e-08 Informative Direct
Biological Process (BP) response to nutrient levels 1.047e-07 Informative Direct
Biological Process (BP) sensory organ development 1.317e-06 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 4.816e-06 Informative Direct
Biological Process (BP) cellular component morphogenesis 9.527e-06 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 1.54e-05 Informative Direct
Biological Process (BP) response to hormone stimulus 1.737e-05 Informative Direct
Biological Process (BP) embryonic morphogenesis 9.333e-05 Informative Direct
Biological Process (BP) protein localization to organelle 0.0002259 Informative Direct
Biological Process (BP) negative regulation of gene expression 0.00042 Informative Direct
Biological Process (BP) organ morphogenesis 0.0005871 Informative Direct
Biological Process (BP) epithelium development 0.6867 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.005501 Informative Inherited
Biological Process (BP) regulation of cell development 0.1841 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.007077 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.0768 Informative Inherited
Biological Process (BP) cell cycle process 0.0984 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.01681 Informative Inherited
Biological Process (BP) regulation of neuron projection development 0 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0 Highly Informative Direct
Biological Process (BP) regulation of microtubule polymerization or depolymerization 0 Highly Informative Direct
Biological Process (BP) regulation of cell size 0 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0 Highly Informative Direct
Biological Process (BP) branching morphogenesis of an epithelial tube 0 Highly Informative Direct
Biological Process (BP) muscle organ development 0 Highly Informative Direct
Biological Process (BP) neuron projection development 0 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 0 Highly Informative Direct
Biological Process (BP) respiratory system development 0 Highly Informative Direct
Biological Process (BP) regulation of protein complex disassembly 0 Highly Informative Direct
Biological Process (BP) positive regulation of neurogenesis 0 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 1.026e-12 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 1.216e-11 Highly Informative Direct
Biological Process (BP) cell fate commitment 1.516e-11 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 5.213e-11 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 3.334e-10 Highly Informative Direct
Biological Process (BP) chemotaxis 1.603e-09 Highly Informative Direct
Biological Process (BP) establishment of protein localization to organelle 5.703e-09 Highly Informative Direct
Biological Process (BP) cellular response to starvation 5.086e-08 Highly Informative Direct
Biological Process (BP) post-embryonic development 2.899e-07 Highly Informative Direct
Biological Process (BP) negative regulation of cell growth 1.267e-06 Highly Informative Direct
Biological Process (BP) regulation of myeloid cell differentiation 1.648e-06 Highly Informative Direct
Biological Process (BP) cytoskeleton-dependent intracellular transport 1.36e-05 Highly Informative Direct
Biological Process (BP) cell part morphogenesis 1.706e-05 Highly Informative Direct
Biological Process (BP) negative regulation of cell cycle 8.496e-05 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0.04171 Highly Informative Inherited
Biological Process (BP) microtubule-based movement 0.5606 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) receptor binding 0.03829 Informative Inherited
Molecular Function (MF) tubulin binding 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.0003215 Highly Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1.093e-06 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) cell projection 1.33e-08 Moderately Informative Direct
Cellular Component (CC) cell junction 0 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 1.305e-13 Informative Direct
Cellular Component (CC) actin cytoskeleton 6.475e-09 Informative Direct
Cellular Component (CC) neuron projection 0.03388 Informative Inherited
Cellular Component (CC) adherens junction 0 Highly Informative Direct
Cellular Component (CC) growth cone 1.474e-14 Highly Informative Direct
Cellular Component (CC) spindle 9.066e-10 Highly Informative Direct
Cellular Component (CC) intermediate filament cytoskeleton 0.00371 Highly Informative Inherited

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell projection7.59e-10Moderately InformativeDirect
Cellular componentMicrotubule8.828e-15InformativeDirect
DomainRepeat0.0007078Least InformativeDirect
DomainSH3 domain1.232e-12InformativeDirect
Molecular functionCalcium6.446e-08Moderately InformativeDirect
Molecular functionActin-binding2.32e-16InformativeDirect
Post-translational modificationPhosphoprotein1.345e-12Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a GAS2 domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the GAS2 domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]