SUPERFAMILY 1.75 HMM library and genome assignments server

GAS2 domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   N domain of copper amine oxidase-like [ 55382] (5)
Superfamily:   GAS2 domain-like [ 143575]
Families:   GAS2 domain [ 143576]


Superfamily statistics
Genomes (296) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 974 1,044 1
Proteins 973 1,041 1


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) developmental process 0.00000000000114 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.00000000001247 Least Informative Direct
Biological Process (BP) response to stimulus 0.00000000002829 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.000000001742 Least Informative Direct
Biological Process (BP) localization 0.0001309 Least Informative Direct
Biological Process (BP) positive regulation of biological process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) single-organism organelle organization 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.000000000002918 Moderately Informative Direct
Biological Process (BP) tissue development 0.00000000004866 Moderately Informative Direct
Biological Process (BP) cellular localization 0.000000001773 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.000000005179 Moderately Informative Direct
Biological Process (BP) nervous system development 0.0000004193 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.000005885 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.0000173 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.00001745 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.00003997 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0001467 Moderately Informative Direct
Biological Process (BP) organic substance transport 0.0002078 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.2809 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.2895 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.3987 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.9242 Moderately Informative Inherited
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) generation of neurons 0 Informative Direct
Biological Process (BP) single-organism intracellular transport 0 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0 Informative Direct
Biological Process (BP) microtubule-based process 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0 Informative Direct
Biological Process (BP) tissue morphogenesis 0 Informative Direct
Biological Process (BP) regulation of organelle organization 0 Informative Direct
Biological Process (BP) regulation of growth 0.000000000000003707 Informative Direct
Biological Process (BP) protein transport 0.00000000000002089 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.000000000002183 Informative Direct
Biological Process (BP) actin filament-based process 0.000000000004955 Informative Direct
Biological Process (BP) locomotion 0.0000000000267 Informative Direct
Biological Process (BP) single-organism membrane organization 0.000000000035 Informative Direct
Biological Process (BP) cell projection organization 0.0000000000515 Informative Direct
Biological Process (BP) muscle structure development 0.0000000006024 Informative Direct
Biological Process (BP) central nervous system development 0.000000003474 Informative Direct
Biological Process (BP) single-organism cellular localization 0.000000005884 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.00000001681 Informative Direct
Biological Process (BP) tube development 0.00000008093 Informative Direct
Biological Process (BP) sensory organ development 0.0000001271 Informative Direct
Biological Process (BP) response to nutrient levels 0.000000132 Informative Direct
Biological Process (BP) cellular response to hormone stimulus 0.0000001368 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.0000005351 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0000052 Informative Direct
Biological Process (BP) embryonic morphogenesis 0.00001551 Informative Direct
Biological Process (BP) organ morphogenesis 0.0000707 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.0001389 Informative Direct
Biological Process (BP) protein localization to organelle 0.0002138 Informative Direct
Biological Process (BP) negative regulation of immune system process 0.0005123 Informative Direct
Biological Process (BP) epithelium development 0.7508 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.1688 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.1026 Informative Inherited
Biological Process (BP) cellular response to external stimulus 0.02376 Informative Inherited
Biological Process (BP) regulation of cell development 0.1062 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.006306 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.005955 Informative Inherited
Biological Process (BP) cell cycle process 0.06045 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.03005 Informative Inherited
Biological Process (BP) cell recognition 0 Highly Informative Direct
Biological Process (BP) positive regulation of neurogenesis 0 Highly Informative Direct
Biological Process (BP) respiratory system development 0 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 0 Highly Informative Direct
Biological Process (BP) regulation of protein complex disassembly 0 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0 Highly Informative Direct
Biological Process (BP) muscle organ development 0 Highly Informative Direct
Biological Process (BP) regulation of cell size 0 Highly Informative Direct
Biological Process (BP) protein localization to membrane 0 Highly Informative Direct
Biological Process (BP) branching morphogenesis of an epithelial tube 0 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0 Highly Informative Direct
Biological Process (BP) neuron projection development 0 Highly Informative Direct
Biological Process (BP) regulation of microtubule polymerization or depolymerization 0 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.0000000000001499 Highly Informative Direct
Biological Process (BP) cell fate commitment 0.00000000001239 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.00000000001284 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 0.00000000002518 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.00000000003462 Highly Informative Direct
Biological Process (BP) chemotaxis 0.000000001564 Highly Informative Direct
Biological Process (BP) negative regulation of homeostatic process 0.00000000682 Highly Informative Direct
Biological Process (BP) post-embryonic development 0.0000005388 Highly Informative Direct
Biological Process (BP) negative regulation of cell growth 0.000000956 Highly Informative Direct
Biological Process (BP) regulation of myeloid cell differentiation 0.00000162 Highly Informative Direct
Biological Process (BP) cell projection morphogenesis 0.000002249 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0.06179 Highly Informative Inherited
Biological Process (BP) microtubule-based movement 0.56 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) protein complex binding 0 Informative Direct
Molecular Function (MF) receptor binding 0.03788 Informative Inherited
Molecular Function (MF) tubulin binding 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.0003214 Highly Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) cell junction 0 Informative Direct
Cellular Component (CC) synapse 0 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.00000000000003132 Informative Direct
Cellular Component (CC) actin cytoskeleton 0.000000002035 Informative Direct
Cellular Component (CC) neuron projection 0.8017 Informative Inherited
Cellular Component (CC) adherens junction 0 Highly Informative Direct
Cellular Component (CC) growth cone 0.0000000001521 Highly Informative Direct
Cellular Component (CC) spindle 0.000001807 Highly Informative Direct
Cellular Component (CC) intermediate filament cytoskeleton 0.002886 Highly Informative Inherited

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell projection0.000000000759Moderately InformativeDirect
Cellular componentMicrotubule0.000000000000008828InformativeDirect
DomainRepeat0.0007078Least InformativeDirect
DomainSH3 domain0.000000000001232InformativeDirect
Molecular functionCalcium0.00000006446Moderately InformativeDirect
Molecular functionActin-binding2.32e-16InformativeDirect
Post-translational modificationPhosphoprotein0.000000000001345Least InformativeDirect

Document: KW annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a GAS2 domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the GAS2 domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]