SUPERFAMILY 1.75 HMM library and genome assignments server


Nqo5-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Nqo5-like [ 143242]
Superfamily:   Nqo5-like [ 143243]
Families:   Nqo5-like [ 143244]


Superfamily statistics
Genomes (2,006) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 2,894 9,325 1
Proteins 2,892 9,323 1


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.0059430.2825Least InformativeInherited
Biological Process (BP)regulation of signal transduction2.001e-060.0001693Moderately InformativeDirect
Biological Process (BP)regulation of programmed cell death3.063e-074.425e-06Moderately InformativeDirect
Biological Process (BP)regulation of cellular component organization7.692e-075.033e-05Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process3.637e-050.00344Moderately InformativeInherited
Biological Process (BP)negative regulation of cell communication3.677e-094.032e-07InformativeDirect
Biological Process (BP)negative regulation of signaling3.159e-093.839e-07InformativeDirect
Biological Process (BP)regulation of growth1.032e-082.977e-07InformativeDirect
Biological Process (BP)negative regulation of response to stimulus2.59e-081.674e-06InformativeDirect
Biological Process (BP)regulation of apoptotic signaling pathway4.055e-111.323e-10InformativeDirect
Biological Process (BP)regulation of cell growth1.168e-109.155e-10Highly InformativeDirect
Biological Process (BP)negative regulation of growth8.777e-111.549e-10Highly InformativeDirect
Biological Process (BP)negative regulation of apoptotic signaling pathway5.532e-134.939e-13Highly InformativeDirect
Biological Process (BP)regulation of intrinsic apoptotic signaling pathway3.332e-133.114e-14Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity1.436e-054.927e-08Moderately InformativeDirect
Molecular Function (MF)NADH dehydrogenase activity2.589e-150Highly InformativeDirect
Cellular Component (CC)protein complex0.00024660.0001924Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.12240.3818Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle1.695e-060.001172Least InformativeInherited
Cellular Component (CC)cytoplasmic part2.13e-060.009696Least InformativeInherited
Cellular Component (CC)membrane0.010190.001152Least InformativeInherited
Cellular Component (CC)organelle envelope0.00052121.623e-05Moderately InformativeDirect
Cellular Component (CC)mitochondrial part0.00027371.037e-05Moderately InformativeDirect
Cellular Component (CC)organelle membrane0.0012310.0006572Moderately InformativeInherited
Cellular Component (CC)mitochondrial membrane part2.037e-101.868e-09InformativeDirect
Cellular Component (CC)respiratory chain1.48e-091.537e-13InformativeDirect
Cellular Component (CC)mitochondrial respiratory chain1.589e-122.355e-06Highly InformativeDirect
Cellular Component (CC)respiratory chain complex I2.676e-150Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0.2825 Least Informative Inherited
Biological Process (BP) regulation of signal transduction 0.0001693 Moderately Informative Direct
Biological Process (BP) regulation of programmed cell death 4.425e-06 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 5.033e-05 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.00344 Moderately Informative Inherited
Biological Process (BP) negative regulation of cell communication 4.032e-07 Informative Direct
Biological Process (BP) negative regulation of signaling 3.839e-07 Informative Direct
Biological Process (BP) regulation of growth 2.977e-07 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 1.674e-06 Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 1.323e-10 Informative Direct
Biological Process (BP) regulation of cell growth 9.155e-10 Highly Informative Direct
Biological Process (BP) negative regulation of growth 1.549e-10 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic signaling pathway 4.939e-13 Highly Informative Direct
Biological Process (BP) regulation of intrinsic apoptotic signaling pathway 3.114e-14 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity 4.927e-08 Moderately Informative Direct
Molecular Function (MF) NADH dehydrogenase activity 0 Highly Informative Direct
Cellular Component (CC) protein complex 0.0001924 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.3818 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.001172 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.009696 Least Informative Inherited
Cellular Component (CC) membrane 0.001152 Least Informative Inherited
Cellular Component (CC) organelle membrane 0.0006572 Moderately Informative Direct
Cellular Component (CC) organelle envelope 1.623e-05 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 1.037e-05 Moderately Informative Direct
Cellular Component (CC) mitochondrial membrane part 1.868e-09 Informative Direct
Cellular Component (CC) respiratory chain 1.537e-13 Informative Direct
Cellular Component (CC) mitochondrial respiratory chain 2.355e-06 Highly Informative Direct
Cellular Component (CC) respiratory chain complex I 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0Moderately InformativeDirect
Enzyme Commission (EC)With other acceptors0InformativeDirect
Enzyme Commission (EC)NADH:ubiquinone reductase (H(+)-translocating)0InformativeDirect

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0InformativeDirect
Enzyme Commission (EC)NADH:ubiquinone reductase (H(+)-translocating)0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processElectron transport1InformativeInherited
Biological processRespiratory chain3.486e-10Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentPlastid0Moderately InformativeDirect
Cellular componentCell membrane2.614e-12Moderately InformativeDirect
Cellular componentMitochondrion0.1752Moderately InformativeInherited
Cellular componentThylakoid0InformativeDirect
Cellular componentCell inner membrane0InformativeDirect
Cellular componentMitochondrion inner membrane3.878e-10InformativeDirect
Coding sequence diversityRNA editing6.478e-09Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionNADP0InformativeDirect
Molecular functionUbiquinone0Highly InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationQuinone0Highly InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Nqo5-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Nqo5-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]