SUPERFAMILY 1.75 HMM library and genome assignments server


Nqo5-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Nqo5-like [ 143242]
Superfamily:   Nqo5-like [ 143243]
Families:   Nqo5-like [ 143244]


Superfamily statistics
Genomes (2,028) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,025 16,186 1
Proteins 3,022 16,184 1


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.0054330.2503Least InformativeInherited
Biological Process (BP)regulation of signal transduction0.0000018550.0001444Moderately InformativeDirect
Biological Process (BP)regulation of cellular component organization0.0000006370.00004265Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process0.000031810.002902Moderately InformativeInherited
Biological Process (BP)negative regulation of cell communication0.0000000031720.0000003509InformativeDirect
Biological Process (BP)negative regulation of signaling0.0000000026930.0000003349InformativeDirect
Biological Process (BP)regulation of growth0.0000000093520.0000002348InformativeDirect
Biological Process (BP)regulation of apoptotic process0.00000015930.000001942InformativeDirect
Biological Process (BP)negative regulation of response to stimulus0.000000023470.000001431InformativeDirect
Biological Process (BP)regulation of cell growth0.00000000010830.0000000006688Highly InformativeDirect
Biological Process (BP)negative regulation of growth0.000000000072240.0000000001354Highly InformativeDirect
Biological Process (BP)negative regulation of apoptotic signaling pathway0.00000000000046380.0000000000003476Highly InformativeDirect
Biological Process (BP)regulation of intrinsic apoptotic signaling pathway0.00000000000025690.00000000000002604Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity0.000011230.00000003277Moderately InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on NAD(P)H0.000000000001550Highly InformativeDirect
Cellular Component (CC)protein complex0.00022810.0001525Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.1370.4327Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.000002180.001309Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.0000019130.007506Least InformativeInherited
Cellular Component (CC)membrane0.0089490.0009572Least InformativeInherited
Cellular Component (CC)organelle envelope0.00042150.00001424Moderately InformativeDirect
Cellular Component (CC)mitochondrial part0.0002270.000007537Moderately InformativeDirect
Cellular Component (CC)organelle membrane0.0010670.0005947Moderately InformativeInherited
Cellular Component (CC)mitochondrial membrane part0.00000000018860.000000001778InformativeDirect
Cellular Component (CC)respiratory chain0.0000000013550.000000000000108InformativeDirect
Cellular Component (CC)respiratory chain complex I0.0000000000000029150Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0.2503 Least Informative Inherited
Biological Process (BP) regulation of signal transduction 0.0001444 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.00004265 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.002902 Moderately Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.0000003509 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0000003349 Informative Direct
Biological Process (BP) regulation of growth 0.0000002348 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.000001942 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.000001431 Informative Direct
Biological Process (BP) regulation of cell growth 0.0000000006688 Highly Informative Direct
Biological Process (BP) negative regulation of growth 0.0000000001354 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic signaling pathway 0.0000000000003476 Highly Informative Direct
Biological Process (BP) regulation of intrinsic apoptotic signaling pathway 0.00000000000002604 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity 0.00000003277 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on NAD(P)H 0 Highly Informative Direct
Cellular Component (CC) membrane 0.0009572 Least Informative Direct
Cellular Component (CC) protein complex 0.0001525 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.4327 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.001309 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.007506 Least Informative Inherited
Cellular Component (CC) organelle membrane 0.0005947 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0.00001424 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 0.000007537 Moderately Informative Direct
Cellular Component (CC) mitochondrial membrane part 0.000000001778 Informative Direct
Cellular Component (CC) respiratory chain 0.000000000000108 Informative Direct
Cellular Component (CC) respiratory chain complex I 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0Moderately InformativeDirect
Enzyme Commission (EC)With other acceptors0InformativeDirect
Enzyme Commission (EC)NADH:ubiquinone reductase (H(+)-translocating)0InformativeDirect

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0InformativeDirect
Enzyme Commission (EC)NADH:ubiquinone reductase (H(+)-translocating)0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processElectron transport1InformativeInherited
Biological processRespiratory chain0.0000000003468Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentPlastid0Moderately InformativeDirect
Cellular componentCell membrane0.000000000003283Moderately InformativeDirect
Cellular componentMitochondrion0.174Moderately InformativeInherited
Cellular componentThylakoid0InformativeDirect
Cellular componentCell inner membrane0InformativeDirect
Cellular componentMitochondrion inner membrane0.000000000392InformativeDirect
Coding sequence diversityRNA editing0.00000000652Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionNADP0InformativeDirect
Molecular functionUbiquinone0Highly InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationQuinone0Highly InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Nqo5-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Nqo5-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]