SUPERFAMILY 1.75 HMM library and genome assignments server

Nqo5-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Nqo5-like [ 143242]
Superfamily:   Nqo5-like [ 143243]
Families:   Nqo5-like [ 143244]


Superfamily statistics
Genomes (2,033) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,030 16,186 1
Proteins 3,027 16,184 1


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.007110.3449Least InformativeInherited
Biological Process (BP)regulation of signal transduction0.0000026290.0002722Moderately InformativeDirect
Biological Process (BP)regulation of cellular component organization0.0000010140.0001005Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process0.000057960.005999Moderately InformativeInherited
Biological Process (BP)negative regulation of cell communication0.0000000079140.000001084InformativeDirect
Biological Process (BP)negative regulation of signaling0.0000000068730.000001039InformativeDirect
Biological Process (BP)regulation of growth0.000000014790.0000003865InformativeDirect
Biological Process (BP)regulation of apoptotic process0.00000019310.000003602InformativeDirect
Biological Process (BP)negative regulation of response to stimulus0.000000068810.000004552InformativeDirect
Biological Process (BP)negative regulation of cell death0.000000033140.0000003207InformativeDirect
Biological Process (BP)negative regulation of cell growth0.00000000000090650.000000000002834Highly InformativeDirect
Biological Process (BP)negative regulation of intracellular signal transduction0.000000000016360.00000000181Highly InformativeDirect
Biological Process (BP)negative regulation of apoptotic signaling pathway0.0000000000011960.000000000001724Highly InformativeDirect
Biological Process (BP)regulation of intrinsic apoptotic signaling pathway0.00000000000053610.0000000000001193Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity0.000014420.00000007527Moderately InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on NAD(P)H0.0000000000022440InformativeDirect
Molecular Function (MF)NADH dehydrogenase activity0.0000000000000020Highly InformativeDirect
Cellular Component (CC)protein complex0.00025240.0002709Least InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.0000020550.002227Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.13760.5071Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.0000023880.005559Least InformativeInherited
Cellular Component (CC)membrane0.014390.003326Least InformativeInherited
Cellular Component (CC)organelle envelope0.00042130.00001493Moderately InformativeDirect
Cellular Component (CC)mitochondrial part0.00022590.00001547Moderately InformativeDirect
Cellular Component (CC)mitochondrial membrane part0.00000000021340.000000001714InformativeDirect
Cellular Component (CC)respiratory chain0.0000000014660.0000000000001924InformativeDirect
Cellular Component (CC)oxidoreductase complex0.00000000030550.000000000000003071InformativeDirect
Cellular Component (CC)respiratory chain complex I0.000000000000002780Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0.3449 Least Informative Inherited
Biological Process (BP) regulation of signal transduction 0.0002722 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.0001005 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.005999 Moderately Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.000001084 Informative Direct
Biological Process (BP) negative regulation of signaling 0.000001039 Informative Direct
Biological Process (BP) regulation of growth 0.0000003865 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.000003602 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.000004552 Informative Direct
Biological Process (BP) negative regulation of cell death 0.0000003207 Informative Direct
Biological Process (BP) negative regulation of cell growth 0.000000000002834 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular signal transduction 0.00000000181 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic signaling pathway 0.000000000001724 Highly Informative Direct
Biological Process (BP) regulation of intrinsic apoptotic signaling pathway 0.0000000000001193 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity 0.00000007527 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on NAD(P)H 0 Informative Direct
Molecular Function (MF) NADH dehydrogenase activity 0 Highly Informative Direct
Cellular Component (CC) protein complex 0.0002709 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.002227 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.5071 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.005559 Least Informative Inherited
Cellular Component (CC) membrane 0.003326 Least Informative Inherited
Cellular Component (CC) organelle envelope 0.00001493 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 0.00001547 Moderately Informative Direct
Cellular Component (CC) mitochondrial membrane part 0.000000001714 Informative Direct
Cellular Component (CC) respiratory chain 0.0000000000001924 Informative Direct
Cellular Component (CC) oxidoreductase complex 0.000000000000003071 Informative Direct
Cellular Component (CC) respiratory chain complex I 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0Moderately InformativeDirect
Enzyme Commission (EC)With other acceptors0InformativeDirect
Enzyme Commission (EC)NADH:ubiquinone reductase (H(+)-translocating)0InformativeDirect

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0InformativeDirect
Enzyme Commission (EC)NADH:ubiquinone reductase (H(+)-translocating)0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processElectron transport1InformativeInherited
Biological processRespiratory chain0.0000000003396Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentPlastid0Moderately InformativeDirect
Cellular componentCell membrane0.000000000005936Moderately InformativeDirect
Cellular componentMitochondrion0.1736Moderately InformativeInherited
Cellular componentThylakoid0InformativeDirect
Cellular componentCell inner membrane0InformativeDirect
Cellular componentMitochondrion inner membrane0.0000000003756InformativeDirect
Coding sequence diversityRNA editing0.000000006445Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionNADP0InformativeDirect
Molecular functionUbiquinone0Highly InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationQuinone0Highly InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Nqo5-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Nqo5-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]