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Mediator hinge subcomplex-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Mediator hinge subcomplex-like [ 140717]
Superfamily:   Mediator hinge subcomplex-like [ 140718] (2)
Families:   CSE2-like [ 140719]
  MED7 hinge region [ 140722]


Superfamily statistics
Genomes (480) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,194 1,267 3
Proteins 1,188 1,261 3


Functional annotation
General category Regulation
Detailed category RNA binding, metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)nitrogen compound metabolic process0.0046080.002003Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.0025150.006765Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.0012060.0004898Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.0011690.0004245Least InformativeInherited
Biological Process (BP)biosynthetic process0.002140.0002873Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.0020860.0009012Least InformativeInherited
Biological Process (BP)RNA metabolic process0.0000012350.0000002813Moderately InformativeDirect
Biological Process (BP)cellular macromolecule biosynthetic process0.0000030160.0000003166Moderately InformativeDirect
Biological Process (BP)aromatic compound biosynthetic process0.0000033310.00000003524Moderately InformativeDirect
Biological Process (BP)gene expression0.0000048490.0000007218Moderately InformativeDirect
Biological Process (BP)cellular nitrogen compound biosynthetic process0.0000052130.00000003402Moderately InformativeDirect
Biological Process (BP)heterocycle biosynthetic process0.0000058530.00000003518Moderately InformativeDirect
Biological Process (BP)organic cyclic compound biosynthetic process0.000012410.0000001486Moderately InformativeDirect
Biological Process (BP)transcription, DNA-dependent0.00000000037870.00000000001438InformativeDirect
Biological Process (BP)transcription from RNA polymerase II promoter0.000000000010060.000000000000344Highly InformativeDirect
Molecular Function (MF)protein binding transcription factor activity0.0000000000043660.0000000003702Highly InformativeDirect
Cellular Component (CC)protein complex0.00000000016590Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.0000000084630.000000000000003092Least InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.0000093040.000000001741Least InformativeDirect
Cellular Component (CC)intracellular organelle lumen0.000000000000089290.00000006448Moderately InformativeDirect
Cellular Component (CC)nuclear part0.00000000000012970Moderately InformativeDirect
Cellular Component (CC)nucleoplasm part00.00000000001472InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) heterocycle metabolic process 0.0004245 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0.0004898 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.0009012 Least Informative Direct
Biological Process (BP) biosynthetic process 0.0002873 Least Informative Direct
Biological Process (BP) developmental process 0.1179 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.002003 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.006765 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.05035 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.1879 Least Informative Inherited
Biological Process (BP) RNA metabolic process 0.0000002813 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0.0000003166 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.00000003524 Moderately Informative Direct
Biological Process (BP) gene expression 0.0000007218 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.00000003402 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.00000003518 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.0000001486 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.01716 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.002342 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.002419 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.04575 Moderately Informative Inherited
Biological Process (BP) transcription, DNA-dependent 0.00000000001438 Informative Direct
Biological Process (BP) negative regulation of developmental process 0.00003128 Informative Direct
Biological Process (BP) transcription from RNA polymerase II promoter 0.000000000000344 Highly Informative Direct
Biological Process (BP) stem cell development 0.000000002254 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0.00001543 Highly Informative Direct
Molecular Function (MF) protein binding transcription factor activity 0.0000000003702 Highly Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.000000000000003092 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.000000001741 Least Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.00000006448 Moderately Informative Direct
Cellular Component (CC) nuclear part 0 Moderately Informative Direct
Cellular Component (CC) nucleoplasm part 0.00000000001472 Informative Direct

Document: GO annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Cellular componentNucleus0Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Mediator hinge subcomplex-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Mediator hinge subcomplex-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]