SUPERFAMILY 1.75 HMM library and genome assignments server

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HIV integrase-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   N-cbl like [ 47667] (5)
Superfamily:   HIV integrase-binding domain [ 140576]
Families:   HIV integrase-binding domain [ 140577]


Superfamily statistics
Genomes (116) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 249 262 2
Proteins 249 262 2


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) heterocycle metabolic process 0.0000000004541 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0.0000000005516 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.000000001262 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.000000003854 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.00000001591 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.00000002247 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0000001631 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.000002397 Least Informative Direct
Biological Process (BP) response to stimulus 0.00001424 Least Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.000000000000003755 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.00000000000004119 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0.00000000000004447 Moderately Informative Direct
Biological Process (BP) gene expression 0.0000000000001427 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 0.0000000000002388 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.000000000002275 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0.0000000000539 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0.00000000009581 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.0000000001703 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0.0000000001863 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0000000003616 Moderately Informative Direct
Biological Process (BP) response to oxidative stress 0 Informative Direct
Biological Process (BP) cellular macromolecular complex assembly 0 Informative Direct
Biological Process (BP) RNA processing 0 Informative Direct
Biological Process (BP) ribonucleoprotein complex biogenesis 0 Informative Direct
Biological Process (BP) positive regulation of gene expression 0.00000000000001086 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.00000000000001778 Informative Direct
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.00000000000002119 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.00000000000002458 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.00000000000003788 Informative Direct
Biological Process (BP) RNA splicing 0 Highly Informative Direct
Biological Process (BP) ribonucleoprotein complex subunit organization 0 Highly Informative Direct
Biological Process (BP) response to heat 0 Highly Informative Direct
Biological Process (BP) mRNA processing 0 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.000000000000005594 Highly Informative Direct
Molecular Function (MF) binding 0.00006067 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0.0000000000006401 Moderately Informative Direct
Molecular Function (MF) chromatin binding 0 Informative Direct
Molecular Function (MF) DNA binding 0.00000000000001044 Informative Direct
Molecular Function (MF) transcription factor binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 8.006e-16 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.0000002756 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.000006494 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.0001088 Least Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.00000000000263 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.00001116 Moderately Informative Direct
Cellular Component (CC) chromosome 0 Informative Direct
Cellular Component (CC) chromatin 0 Highly Informative Direct
Cellular Component (CC) nuclear chromosome part 0 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0.0000007283Moderately InformativeDirect
Cellular componentNucleus0.0000007494Least InformativeDirect
Coding sequence diversityAlternative splicing0.000002932Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
Molecular functionDNA-binding0.000005012Least InformativeDirect
Post-translational modificationPhosphoprotein0.00000003762Least InformativeDirect
Post-translational modificationCitrullination0.00000000000001529Highly InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HIV integrase-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the HIV integrase-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]