SUPERFAMILY 1.75 HMM library and genome assignments server


Proton glutamate symport protein superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Proton glutamate symport protein [ 118214]
Superfamily:   Proton glutamate symport protein [ 118215]
Families:   Proton glutamate symport protein [ 118216]


Superfamily statistics
Genomes (2,163) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 6,637 44,508 1
Proteins 6,557 44,442 1


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)localization00Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis0.038310.6621Least InformativeInherited
Biological Process (BP)developmental process0.041120.2273Least InformativeInherited
Biological Process (BP)response to stimulus0.27230.1945Least InformativeInherited
Biological Process (BP)multicellular organismal process0.014410.02329Least InformativeInherited
Biological Process (BP)single-organism cellular process0.81241Least InformativeInherited
Biological Process (BP)organic substance transport00Moderately InformativeDirect
Biological Process (BP)ion transport00Moderately InformativeDirect
Biological Process (BP)nervous system development0.0006281.977e-05Moderately InformativeDirect
Biological Process (BP)macromolecular complex subunit organization0.011760.04496Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.041980.1739Moderately InformativeInherited
Biological Process (BP)system process0.0027260.00054Moderately InformativeInherited
Biological Process (BP)regulation of localization0.042160.0006882Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.011920.09815Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.037610.0002052Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.14490.02644Moderately InformativeInherited
Biological Process (BP)response to organic substance0.39620.4912Moderately InformativeInherited
Biological Process (BP)organ development0.35360.3688Moderately InformativeInherited
Biological Process (BP)reproduction0.053040.01715Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.0020365.851e-07Moderately InformativeInherited
Biological Process (BP)organic acid transport00InformativeDirect
Biological Process (BP)anion transport00InformativeDirect
Biological Process (BP)nitrogen compound transport7.978e-150InformativeDirect
Biological Process (BP)single-organism behavior4.833e-090InformativeDirect
Biological Process (BP)protein oligomerization8.304e-072.764e-05InformativeDirect
Biological Process (BP)response to light stimulus3.501e-068.954e-14InformativeDirect
Biological Process (BP)synaptic transmission7.5e-061.828e-05InformativeDirect
Biological Process (BP)regulation of system process3.317e-051.517e-05InformativeDirect
Biological Process (BP)response to wounding6.109e-052.242e-11InformativeDirect
Biological Process (BP)single organism reproductive process0.079620.01434InformativeInherited
Biological Process (BP)response to organonitrogen compound0.0016035.507e-08InformativeInherited
Biological Process (BP)growth0.0087824.174e-05InformativeInherited
Biological Process (BP)central nervous system development0.0045653.604e-05InformativeInherited
Biological Process (BP)positive regulation of transport0.0031834.88e-07InformativeInherited
Biological Process (BP)amino acid transport1.725e-100Highly InformativeDirect
Biological Process (BP)dicarboxylic acid transport2.243e-090Highly InformativeDirect
Biological Process (BP)regulation of glucose import6.302e-080Highly InformativeDirect
Biological Process (BP)protein homooligomerization2.224e-073.192e-06Highly InformativeDirect
Biological Process (BP)response to amino acid stimulus1.737e-060Highly InformativeDirect
Biological Process (BP)response to drug2.013e-067.707e-13Highly InformativeDirect
Biological Process (BP)aging5.647e-061.176e-11Highly InformativeDirect
Biological Process (BP)telencephalon development1.282e-053.054e-12Highly InformativeDirect
Biological Process (BP)adult behavior0.00016177.287e-10Highly InformativeDirect
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)transporter activity00Moderately InformativeDirect
Molecular Function (MF)anion binding0.020640.000194Moderately InformativeInherited
Molecular Function (MF)anion transmembrane transporter activity1.188e-060InformativeDirect
Molecular Function (MF)carboxylic acid binding5.428e-052.874e-11InformativeDirect
Molecular Function (MF)active transmembrane transporter activity0.0064431.759e-05InformativeInherited
Molecular Function (MF)metal ion transmembrane transporter activity2.902e-050.003678InformativeInherited
Molecular Function (MF)inorganic cation transmembrane transporter activity0.42950.528InformativeInherited
Molecular Function (MF)secondary active transmembrane transporter activity00Highly InformativeDirect
Molecular Function (MF)sodium ion transmembrane transporter activity3.74e-100Highly InformativeDirect
Molecular Function (MF)amino acid binding2.375e-062.27e-13Highly InformativeDirect
Molecular Function (MF)amino acid transmembrane transporter activity0.0053461.783e-07Highly InformativeInherited
Cellular Component (CC)membrane5.414e-080Least InformativeDirect
Cellular Component (CC)intracellular non-membrane-bounded organelle0.0062690.5304Least InformativeInherited
Cellular Component (CC)protein complex0.019870.6324Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.10440.9734Least InformativeInherited
Cellular Component (CC)intrinsic to membrane2.417e-082.423e-05Moderately InformativeDirect
Cellular Component (CC)plasma membrane6.225e-080Moderately InformativeDirect
Cellular Component (CC)cell projection1.505e-062.245e-11Moderately InformativeDirect
Cellular Component (CC)cytoskeleton4.948e-050.02074Moderately InformativeInherited
Cellular Component (CC)integral to membrane1.102e-081.087e-10InformativeDirect
Cellular Component (CC)cell leading edge0.00033769.403e-09InformativeDirect
Cellular Component (CC)neuron projection0.051090.07058InformativeInherited
Cellular Component (CC)intermediate filament cytoskeleton1.147e-135.266e-10Highly InformativeDirect
Cellular Component (CC)cell projection membrane0.0075612.467e-07Highly InformativeInherited
Cellular Component (CC)main axon0.10340.0003186Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0.8099 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.8746 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.6621 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.02329 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.1945 Least Informative Inherited
Biological Process (BP) developmental process 0.2273 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) organic substance transport 0 Moderately Informative Direct
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) nervous system development 1.977e-05 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 5.851e-07 Moderately Informative Direct
Biological Process (BP) system process 0.00054 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.0002052 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0006882 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 0.01769 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.01745 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.04496 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.1739 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.84 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.09815 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.02644 Moderately Informative Inherited
Biological Process (BP) reproduction 0.01715 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.4912 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.004537 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.007237 Moderately Informative Inherited
Biological Process (BP) organ development 0.3688 Moderately Informative Inherited
Biological Process (BP) organic acid transport 0 Informative Direct
Biological Process (BP) anion transport 0 Informative Direct
Biological Process (BP) nitrogen compound transport 0 Informative Direct
Biological Process (BP) single-organism behavior 0 Informative Direct
Biological Process (BP) protein oligomerization 2.764e-05 Informative Direct
Biological Process (BP) response to light stimulus 8.954e-14 Informative Direct
Biological Process (BP) synaptic transmission 1.828e-05 Informative Direct
Biological Process (BP) regulation of system process 1.517e-05 Informative Direct
Biological Process (BP) response to wounding 2.242e-11 Informative Direct
Biological Process (BP) response to organonitrogen compound 5.507e-08 Informative Direct
Biological Process (BP) positive regulation of transport 4.88e-07 Informative Direct
Biological Process (BP) central nervous system development 3.604e-05 Informative Direct
Biological Process (BP) growth 4.174e-05 Informative Direct
Biological Process (BP) transmembrane transport 1.727e-05 Informative Direct
Biological Process (BP) alpha-amino acid biosynthetic process 2.693e-05 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 6.233e-05 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.006486 Informative Inherited
Biological Process (BP) single organism reproductive process 0.01434 Informative Inherited
Biological Process (BP) amino acid transport 0 Highly Informative Direct
Biological Process (BP) dicarboxylic acid transport 0 Highly Informative Direct
Biological Process (BP) regulation of glucose import 0 Highly Informative Direct
Biological Process (BP) protein homooligomerization 3.192e-06 Highly Informative Direct
Biological Process (BP) response to amino acid stimulus 0 Highly Informative Direct
Biological Process (BP) response to drug 7.707e-13 Highly Informative Direct
Biological Process (BP) aging 1.176e-11 Highly Informative Direct
Biological Process (BP) telencephalon development 3.054e-12 Highly Informative Direct
Biological Process (BP) adult behavior 7.287e-10 Highly Informative Direct
Biological Process (BP) glutamate metabolic process 2.346e-09 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 8.752e-06 Highly Informative Direct
Biological Process (BP) response to toxic substance 8.146e-05 Highly Informative Direct
Biological Process (BP) sensory perception 0.287 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.001265 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.000194 Moderately Informative Direct
Molecular Function (MF) anion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) carboxylic acid binding 2.874e-11 Informative Direct
Molecular Function (MF) active transmembrane transporter activity 1.759e-05 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0.003678 Informative Inherited
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.528 Informative Inherited
Molecular Function (MF) secondary active transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) sodium ion transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) amino acid binding 2.27e-13 Highly Informative Direct
Molecular Function (MF) amino acid transmembrane transporter activity 1.783e-07 Highly Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.5304 Least Informative Inherited
Cellular Component (CC) protein complex 0.6324 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.9734 Least Informative Inherited
Cellular Component (CC) intrinsic to membrane 2.423e-05 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) cell projection 2.245e-11 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.02074 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 0.003153 Moderately Informative Inherited
Cellular Component (CC) integral to membrane 1.087e-10 Informative Direct
Cellular Component (CC) cell leading edge 9.403e-09 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 0.0002983 Informative Direct
Cellular Component (CC) extracellular matrix 6.323e-05 Informative Direct
Cellular Component (CC) neuron projection 0.07058 Informative Inherited
Cellular Component (CC) intermediate filament cytoskeleton 5.266e-10 Highly Informative Direct
Cellular Component (CC) cell body 2.037e-05 Highly Informative Direct
Cellular Component (CC) cell projection membrane 2.467e-07 Highly Informative Direct
Cellular Component (CC) main axon 0.0003186 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 1.075e-06 Highly Informative Direct
Cellular Component (CC) proteinaceous extracellular matrix 0.0004481 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.1022Least InformativeInherited
Disease Ontology (DO)disease of mental health0Moderately InformativeDirect
Disease Ontology (DO)neurodegenerative disease0.01796Moderately InformativeInherited
Disease Ontology (DO)schizophrenia0InformativeDirect
Disease Ontology (DO)multiple sclerosis0.0006631InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.04438Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.006198Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.03346Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron number0.001242InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system electrophysiology0.009644Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)gamete0Moderately InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processAmino-acid transport0Highly InformativeDirect
Biological processSugar transport0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentCell inner membrane0InformativeDirect
DomainTransmembrane0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Proton glutamate symport protein domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Proton glutamate symport protein superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]