SUPERFAMILY 1.75 HMM library and genome assignments server


Proton glutamate symport protein superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Proton glutamate symport protein [ 118214]
Superfamily:   Proton glutamate symport protein [ 118215]
Families:   Proton glutamate symport protein [ 118216]


Superfamily statistics
Genomes (1,636) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 5,099 18,097 1
Proteins 5,029 18,056 1


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)localization00Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis0.044250.7344Least InformativeInherited
Biological Process (BP)developmental process0.041240.3828Least InformativeInherited
Biological Process (BP)response to stimulus0.29620.3357Least InformativeInherited
Biological Process (BP)multicellular organismal process0.015390.05866Least InformativeInherited
Biological Process (BP)single-organism cellular process0.96571Least InformativeInherited
Biological Process (BP)ion transport00Moderately InformativeDirect
Biological Process (BP)nervous system development0.00065348.246e-05Moderately InformativeDirect
Biological Process (BP)organic substance transport00Moderately InformativeDirect
Biological Process (BP)macromolecular complex subunit organization0.0092170.04267Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.032380.1514Moderately InformativeInherited
Biological Process (BP)system process0.0023840.0002504Moderately InformativeInherited
Biological Process (BP)regulation of localization0.032290.001083Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.0095960.07604Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.034720.0004759Moderately InformativeInherited
Biological Process (BP)response to organic substance0.35990.5055Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.13170.03569Moderately InformativeInherited
Biological Process (BP)organ development0.32520.4423Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.51911Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.0018041.817e-06Moderately InformativeInherited
Biological Process (BP)reproduction0.0560.05189Moderately InformativeInherited
Biological Process (BP)anion transport00InformativeDirect
Biological Process (BP)synaptic transmission9.806e-061.859e-05InformativeDirect
Biological Process (BP)response to light stimulus4.564e-062.414e-12InformativeDirect
Biological Process (BP)response to external stimulus0.00032228.311e-07InformativeDirect
Biological Process (BP)response to wounding7.518e-052.033e-10InformativeDirect
Biological Process (BP)organic acid transport00InformativeDirect
Biological Process (BP)regulation of system process1.685e-059.278e-06InformativeDirect
Biological Process (BP)single-organism behavior2.895e-090InformativeDirect
Biological Process (BP)protein oligomerization2.083e-063.864e-05InformativeDirect
Biological Process (BP)nitrogen compound transport1.598e-150InformativeDirect
Biological Process (BP)single organism reproductive process0.060320.0253InformativeInherited
Biological Process (BP)response to organic nitrogen0.001773.602e-07InformativeInherited
Biological Process (BP)growth0.010050.0002954InformativeInherited
Biological Process (BP)central nervous system development0.004640.0001324InformativeInherited
Biological Process (BP)positive regulation of transport0.002022.142e-06InformativeInherited
Biological Process (BP)response to acid1.867e-051.05e-12Highly InformativeDirect
Biological Process (BP)amino acid transport3.451e-110Highly InformativeDirect
Biological Process (BP)aging8.893e-062.419e-10Highly InformativeDirect
Biological Process (BP)telencephalon development1.307e-059.359e-11Highly InformativeDirect
Biological Process (BP)adult behavior0.0001791.532e-08Highly InformativeDirect
Biological Process (BP)response to drug2.741e-067.29e-12Highly InformativeDirect
Biological Process (BP)protein homooligomerization6.725e-075.193e-06Highly InformativeDirect
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)transporter activity00Moderately InformativeDirect
Molecular Function (MF)anion binding0.027810.0002532Moderately InformativeInherited
Molecular Function (MF)anion transmembrane transporter activity2.655e-060InformativeDirect
Molecular Function (MF)carboxylic acid binding7.515e-053.734e-11InformativeDirect
Molecular Function (MF)active transmembrane transporter activity0.013356.694e-05InformativeInherited
Molecular Function (MF)metal ion transmembrane transporter activity0.0001390.02915InformativeInherited
Molecular Function (MF)inorganic cation transmembrane transporter activity0.22580.3831InformativeInherited
Molecular Function (MF)sodium ion transmembrane transporter activity2.219e-090Highly InformativeDirect
Molecular Function (MF)secondary active transmembrane transporter activity00Highly InformativeDirect
Molecular Function (MF)amino acid transmembrane transporter activity0.022172.532e-06Highly InformativeInherited
Cellular Component (CC)membrane5.87e-081.614e-15Least InformativeDirect
Cellular Component (CC)intracellular non-membrane-bounded organelle0.0082740.5683Least InformativeInherited
Cellular Component (CC)protein complex0.015630.5991Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.1221Least InformativeInherited
Cellular Component (CC)plasma membrane5.732e-080Moderately InformativeDirect
Cellular Component (CC)intrinsic to membrane4.875e-086.249e-05Moderately InformativeDirect
Cellular Component (CC)cell projection6.366e-077e-12Moderately InformativeDirect
Cellular Component (CC)cytoskeleton7.271e-050.02191Moderately InformativeInherited
Cellular Component (CC)integral to membrane2.374e-082.738e-10InformativeDirect
Cellular Component (CC)cell leading edge0.00028258.028e-08InformativeDirect
Cellular Component (CC)cell projection part3.719e-056.877e-09InformativeDirect
Cellular Component (CC)neuron part1.945e-081.494e-14InformativeDirect
Cellular Component (CC)leading edge membrane1.971e-054.197e-10Highly InformativeDirect
Cellular Component (CC)axon part2.499e-101.622e-06Highly InformativeDirect
Cellular Component (CC)cell body0.00056534.098e-06Highly InformativeDirect
Cellular Component (CC)intermediate filament cytoskeleton1.039e-136.934e-10Highly InformativeDirect
Cellular Component (CC)cell projection membrane0.0013581.905e-07Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0.7853 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.7921 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.7344 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.05866 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.3357 Least Informative Inherited
Biological Process (BP) developmental process 0.3828 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) system process 0.0002504 Moderately Informative Direct
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) nervous system development 8.246e-05 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 1.817e-06 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.0004759 Moderately Informative Direct
Biological Process (BP) organic substance transport 0 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0.01676 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.04267 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.1514 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.7819 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.2055 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.2025 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.001083 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.07604 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.03569 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.5055 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.004848 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.008229 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.0371 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.01328 Moderately Informative Inherited
Biological Process (BP) reproduction 0.05189 Moderately Informative Inherited
Biological Process (BP) organ development 0.4423 Moderately Informative Inherited
Biological Process (BP) anion transport 0 Informative Direct
Biological Process (BP) synaptic transmission 1.859e-05 Informative Direct
Biological Process (BP) central nervous system development 0.0001324 Informative Direct
Biological Process (BP) glutamine family amino acid metabolic process 1.769e-07 Informative Direct
Biological Process (BP) amine biosynthetic process 7.926e-08 Informative Direct
Biological Process (BP) response to light stimulus 2.414e-12 Informative Direct
Biological Process (BP) response to external stimulus 8.311e-07 Informative Direct
Biological Process (BP) response to wounding 2.033e-10 Informative Direct
Biological Process (BP) response to organic nitrogen 3.602e-07 Informative Direct
Biological Process (BP) organic acid transport 0 Informative Direct
Biological Process (BP) growth 0.0002954 Informative Direct
Biological Process (BP) regulation of system process 9.278e-06 Informative Direct
Biological Process (BP) single-organism behavior 0 Informative Direct
Biological Process (BP) positive regulation of transport 2.142e-06 Informative Direct
Biological Process (BP) protein oligomerization 3.864e-05 Informative Direct
Biological Process (BP) transmembrane transport 7.216e-06 Informative Direct
Biological Process (BP) nitrogen compound transport 0 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 6.345e-05 Informative Direct
Biological Process (BP) alpha-amino acid biosynthetic process 3.625e-05 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.005542 Informative Inherited
Biological Process (BP) single organism reproductive process 0.0253 Informative Inherited
Biological Process (BP) response to acid 1.05e-12 Highly Informative Direct
Biological Process (BP) amino acid transport 0 Highly Informative Direct
Biological Process (BP) aging 2.419e-10 Highly Informative Direct
Biological Process (BP) glutamine family amino acid biosynthetic process 1.085e-09 Highly Informative Direct
Biological Process (BP) response to toxic substance 0.0001469 Highly Informative Direct
Biological Process (BP) telencephalon development 9.359e-11 Highly Informative Direct
Biological Process (BP) adult behavior 1.532e-08 Highly Informative Direct
Biological Process (BP) response to drug 7.29e-12 Highly Informative Direct
Biological Process (BP) dicarboxylic acid metabolic process 1.075e-06 Highly Informative Direct
Biological Process (BP) protein homooligomerization 5.193e-06 Highly Informative Direct
Biological Process (BP) regulation of neurological system process 0.1006 Highly Informative Inherited
Biological Process (BP) sensory perception 0.3057 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.001831 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0002532 Moderately Informative Direct
Molecular Function (MF) anion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) active transmembrane transporter activity 6.694e-05 Informative Direct
Molecular Function (MF) carboxylic acid binding 3.734e-11 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0.02915 Informative Inherited
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.3831 Informative Inherited
Molecular Function (MF) sodium ion transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) amino acid transmembrane transporter activity 2.532e-06 Highly Informative Direct
Molecular Function (MF) secondary active transmembrane transporter activity 0 Highly Informative Direct
Cellular Component (CC) membrane 1.614e-15 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.5683 Least Informative Inherited
Cellular Component (CC) protein complex 0.5991 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 6.249e-05 Moderately Informative Direct
Cellular Component (CC) cell projection 7e-12 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.02191 Moderately Informative Inherited
Cellular Component (CC) extracellular region 0.0395 Moderately Informative Inherited
Cellular Component (CC) integral to membrane 2.738e-10 Informative Direct
Cellular Component (CC) extracellular matrix 6.691e-05 Informative Direct
Cellular Component (CC) cell leading edge 8.028e-08 Informative Direct
Cellular Component (CC) cell projection part 6.877e-09 Informative Direct
Cellular Component (CC) neuron part 1.494e-14 Informative Direct
Cellular Component (CC) proteinaceous extracellular matrix 9.515e-06 Highly Informative Direct
Cellular Component (CC) cell projection membrane 1.905e-07 Highly Informative Direct
Cellular Component (CC) leading edge membrane 4.197e-10 Highly Informative Direct
Cellular Component (CC) axon part 1.622e-06 Highly Informative Direct
Cellular Component (CC) cell body 4.098e-06 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 1.282e-06 Highly Informative Direct
Cellular Component (CC) intermediate filament cytoskeleton 6.934e-10 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.1458Least InformativeInherited
Disease Ontology (DO)cognitive disorder0Moderately InformativeDirect
Disease Ontology (DO)neurodegenerative disease0.01787Moderately InformativeInherited
Disease Ontology (DO)multiple sclerosis0.0006303InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal neuron morphology0.01261Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron number0.0003191InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system electrophysiology0.008222Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)male genitalia0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)gamete0Moderately InformativeDirect

Document: XA annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)digestives, incl. enzymes0Moderately InformativeDirect
Drugbank ATC_code (DB)glutamic acid hydrochloride0InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processAmino-acid transport0Highly InformativeDirect
Biological processSugar transport0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentCell inner membrane0InformativeDirect
DomainTransmembrane0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Proton glutamate symport protein domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Proton glutamate symport protein superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · Internal database links ]