SUPERFAMILY 1.75 HMM library and genome assignments server

Proton glutamate symport protein superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Proton glutamate symport protein [ 118214]
Superfamily:   Proton glutamate symport protein [ 118215]
Families:   Proton glutamate symport protein [ 118216]


Superfamily statistics
Genomes (2,164) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 6,640 44,508 1
Proteins 6,560 44,442 1


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)localization00Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis0.039760.6997Least InformativeInherited
Biological Process (BP)positive regulation of biological process0.061270.02511Least InformativeInherited
Biological Process (BP)response to stimulus0.26850.1943Least InformativeInherited
Biological Process (BP)developmental process0.041450.2266Least InformativeInherited
Biological Process (BP)multicellular organismal process0.032760.1477Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)ion transport00Moderately InformativeDirect
Biological Process (BP)organic substance transport00Moderately InformativeDirect
Biological Process (BP)nervous system development0.00064780.00002061Moderately InformativeDirect
Biological Process (BP)cellular component biogenesis0.039490.1737Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.023160.1652Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.038580.0002089Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.14660.02746Moderately InformativeInherited
Biological Process (BP)response to organic substance0.40570.4996Moderately InformativeInherited
Biological Process (BP)organ development0.34190.3483Moderately InformativeInherited
Biological Process (BP)regulation of localization0.044120.0007874Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.0020290.0000006024Moderately InformativeInherited
Biological Process (BP)anion transport00InformativeDirect
Biological Process (BP)organic acid transport00InformativeDirect
Biological Process (BP)nitrogen compound transport0.0000000000000048440InformativeDirect
Biological Process (BP)single-organism behavior0.00000032490.0000000000004749InformativeDirect
Biological Process (BP)protein oligomerization0.00000083690.00002789InformativeDirect
Biological Process (BP)response to light stimulus0.0000034120.0000000000000883InformativeDirect
Biological Process (BP)synaptic transmission0.0000075920.00001825InformativeDirect
Biological Process (BP)positive regulation of transport0.0029950.0000004226InformativeInherited
Biological Process (BP)response to organonitrogen compound0.0015730.00000005523InformativeInherited
Biological Process (BP)response to acid chemical0.004630.000002297InformativeInherited
Biological Process (BP)growth0.0086220.0000405InformativeInherited
Biological Process (BP)central nervous system development0.0048460.00004083InformativeInherited
Biological Process (BP)amino acid transport0.00000000014510Highly InformativeDirect
Biological Process (BP)dicarboxylic acid transport0.000000002110Highly InformativeDirect
Biological Process (BP)regulation of glucose import0.000000062550Highly InformativeDirect
Biological Process (BP)protein homooligomerization0.00000022020.000003167Highly InformativeDirect
Biological Process (BP)response to drug0.0000014680.0000000000005412Highly InformativeDirect
Biological Process (BP)response to amino acid0.0000017250Highly InformativeDirect
Biological Process (BP)aging0.0000017750.00000000000183Highly InformativeDirect
Biological Process (BP)telencephalon development0.000014650.000000000003896Highly InformativeDirect
Biological Process (BP)adult behavior0.00011280.00000000009619Highly InformativeDirect
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)transporter activity00Moderately InformativeDirect
Molecular Function (MF)small molecule binding0.014060.00003524Moderately InformativeInherited
Molecular Function (MF)anion binding0.020740.0001954Moderately InformativeInherited
Molecular Function (MF)monovalent inorganic cation transmembrane transporter activity00InformativeDirect
Molecular Function (MF)metal ion transmembrane transporter activity0.0000014280.00007504InformativeDirect
Molecular Function (MF)anion transmembrane transporter activity0.0000018320InformativeDirect
Molecular Function (MF)carboxylic acid binding0.000054580.00000000002974InformativeDirect
Molecular Function (MF)active transmembrane transporter activity0.0075310.00002066InformativeInherited
Molecular Function (MF)secondary active transmembrane transporter activity00Highly InformativeDirect
Molecular Function (MF)sodium ion transmembrane transporter activity0.000000000034650Highly InformativeDirect
Molecular Function (MF)amino acid binding0.000002380.0000000000002411Highly InformativeDirect
Molecular Function (MF)amino acid transmembrane transporter activity0.0053770.0000001039Highly InformativeInherited
Cellular Component (CC)membrane0.000000054860Least InformativeDirect
Cellular Component (CC)non-membrane-bounded organelle0.0082640.5755Least InformativeInherited
Cellular Component (CC)protein complex0.019440.6228Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.10290.954Least InformativeInherited
Cellular Component (CC)intrinsic component of membrane0.000000034180.0001807Moderately InformativeDirect
Cellular Component (CC)cell projection0.0000017560.00000000003512Moderately InformativeDirect
Cellular Component (CC)plasma membrane part0.0027550.00002291Moderately InformativeInherited
Cellular Component (CC)cytoskeleton0.000053680.02403Moderately InformativeInherited
Cellular Component (CC)integral component of membrane0.000000016290.00005588InformativeDirect
Cellular Component (CC)cell leading edge0.00033250.000000009136InformativeDirect
Cellular Component (CC)neuron projection0.045940.05391InformativeInherited
Cellular Component (CC)intermediate filament cytoskeleton0.00000000000011250.0000000005159Highly InformativeDirect
Cellular Component (CC)cell projection membrane0.0071210.0000001894Highly InformativeInherited
Cellular Component (CC)main axon0.091720.0004027Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.6997 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 0.02511 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 0.2266 Least Informative Inherited
Biological Process (BP) response to stimulus 0.1943 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.8104 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.1477 Least Informative Inherited
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) organic substance transport 0 Moderately Informative Direct
Biological Process (BP) nervous system development 0.00002061 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.0000006024 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.00008678 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.0002089 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0007874 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0.007485 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.1737 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.1652 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.9146 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.02746 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.4996 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.01755 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.01015 Moderately Informative Inherited
Biological Process (BP) organ development 0.3483 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.007042 Moderately Informative Inherited
Biological Process (BP) anion transport 0 Informative Direct
Biological Process (BP) organic acid transport 0 Informative Direct
Biological Process (BP) nitrogen compound transport 0 Informative Direct
Biological Process (BP) single-organism behavior 0.0000000000004749 Informative Direct
Biological Process (BP) protein oligomerization 0.00002789 Informative Direct
Biological Process (BP) response to light stimulus 0.0000000000000883 Informative Direct
Biological Process (BP) synaptic transmission 0.00001825 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.00000005523 Informative Direct
Biological Process (BP) neurological system process 0.00054 Informative Direct
Biological Process (BP) positive regulation of transport 0.0000004226 Informative Direct
Biological Process (BP) response to acid chemical 0.000002297 Informative Direct
Biological Process (BP) central nervous system development 0.00004083 Informative Direct
Biological Process (BP) growth 0.0000405 Informative Direct
Biological Process (BP) cellular response to external stimulus 0.00003207 Informative Direct
Biological Process (BP) alpha-amino acid biosynthetic process 0.00002413 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.0000624 Informative Direct
Biological Process (BP) amino acid transport 0 Highly Informative Direct
Biological Process (BP) dicarboxylic acid transport 0 Highly Informative Direct
Biological Process (BP) regulation of glucose import 0 Highly Informative Direct
Biological Process (BP) protein homooligomerization 0.000003167 Highly Informative Direct
Biological Process (BP) response to drug 0.0000000000005412 Highly Informative Direct
Biological Process (BP) response to amino acid 0 Highly Informative Direct
Biological Process (BP) aging 0.00000000000183 Highly Informative Direct
Biological Process (BP) telencephalon development 0.000000000003896 Highly Informative Direct
Biological Process (BP) adult behavior 0.00000000009619 Highly Informative Direct
Biological Process (BP) glutamate metabolic process 0.000000002313 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 0.000008973 Highly Informative Direct
Biological Process (BP) neuromuscular process 0.0000689 Highly Informative Direct
Biological Process (BP) response to toxic substance 0.00008794 Highly Informative Direct
Biological Process (BP) sensory perception 0.06365 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.00003524 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0001954 Moderately Informative Direct
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0.00007504 Informative Direct
Molecular Function (MF) anion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) carboxylic acid binding 0.00000000002974 Informative Direct
Molecular Function (MF) active transmembrane transporter activity 0.00002066 Informative Direct
Molecular Function (MF) secondary active transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) sodium ion transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) amino acid binding 0.0000000000002411 Highly Informative Direct
Molecular Function (MF) amino acid transmembrane transporter activity 0.0000001039 Highly Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.5755 Least Informative Inherited
Cellular Component (CC) protein complex 0.6228 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.954 Least Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.0001807 Moderately Informative Direct
Cellular Component (CC) cell projection 0.00000000003512 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 0.00002291 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.02403 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 0.003184 Moderately Informative Inherited
Cellular Component (CC) integral component of membrane 0.00005588 Informative Direct
Cellular Component (CC) cell leading edge 0.000000009136 Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0.0005301 Informative Direct
Cellular Component (CC) extracellular matrix 0.00005591 Informative Direct
Cellular Component (CC) neuron projection 0.05391 Informative Inherited
Cellular Component (CC) intermediate filament cytoskeleton 0.0000000005159 Highly Informative Direct
Cellular Component (CC) cell body 0.0000204 Highly Informative Direct
Cellular Component (CC) cell projection membrane 0.0000001894 Highly Informative Direct
Cellular Component (CC) integral component of plasma membrane 0.0002386 Highly Informative Direct
Cellular Component (CC) main axon 0.0004027 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 0.0000006543 Highly Informative Direct
Cellular Component (CC) proteinaceous extracellular matrix 0.0003265 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.1022Least InformativeInherited
Disease Ontology (DO)disease of mental health0Moderately InformativeDirect
Disease Ontology (DO)neurodegenerative disease0.01796Moderately InformativeInherited
Disease Ontology (DO)schizophrenia0InformativeDirect
Disease Ontology (DO)multiple sclerosis0.0006631InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.04438Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.006198Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.03346Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron number0.001242InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system electrophysiology0.009644Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)gamete0Moderately InformativeDirect

Document: XA annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)alimentary tract and metabolism0Least InformativeDirect
Drugbank ATC_code (DB)glutamic acid hydrochloride0InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processAmino-acid transport0Highly InformativeDirect
Biological processSugar transport0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentCell inner membrane0InformativeDirect
DomainTransmembrane0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Proton glutamate symport protein domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Proton glutamate symport protein superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · Internal database links ]