SUPERFAMILY 1.75 HMM library and genome assignments server


Proton glutamate symport protein superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Proton glutamate symport protein [ 118214]
Superfamily:   Proton glutamate symport protein [ 118215]
Families:   Proton glutamate symport protein [ 118216]


Superfamily statistics
Genomes (2,162) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 6,631 44,508 1
Proteins 6,549 44,442 1


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)localization00Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis0.03140.5649Least InformativeInherited
Biological Process (BP)developmental process0.036730.2608Least InformativeInherited
Biological Process (BP)response to stimulus0.23870.1953Least InformativeInherited
Biological Process (BP)multicellular organismal process0.012660.02647Least InformativeInherited
Biological Process (BP)single-organism cellular process0.81741Least InformativeInherited
Biological Process (BP)ion transport00Moderately InformativeDirect
Biological Process (BP)nervous system development0.00053880.00004831Moderately InformativeDirect
Biological Process (BP)organic substance transport00Moderately InformativeDirect
Biological Process (BP)macromolecular complex subunit organization0.012670.04527Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.041040.1681Moderately InformativeInherited
Biological Process (BP)system process0.0026460.0002768Moderately InformativeInherited
Biological Process (BP)regulation of localization0.041140.001737Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.011770.07482Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.035610.0005295Moderately InformativeInherited
Biological Process (BP)response to organic substance0.38560.5543Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.14450.04529Moderately InformativeInherited
Biological Process (BP)organ development0.34850.4591Moderately InformativeInherited
Biological Process (BP)reproduction0.049250.03321Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.61061Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.0020120.000001929Moderately InformativeInherited
Biological Process (BP)anion transport00InformativeDirect
Biological Process (BP)response to light stimulus0.0000031520.00000000000083InformativeDirect
Biological Process (BP)response to wounding0.000066940.0000000001381InformativeDirect
Biological Process (BP)organic acid transport00InformativeDirect
Biological Process (BP)regulation of system process0.000024730.000009078InformativeDirect
Biological Process (BP)single-organism behavior0.0000000032830InformativeDirect
Biological Process (BP)nitrogen compound transport0.0000000000000095890InformativeDirect
Biological Process (BP)protein complex assembly0.00007090.001892InformativeInherited
Biological Process (BP)single organism reproductive process0.079150.03303InformativeInherited
Biological Process (BP)response to organonitrogen compound0.001480.0000003369InformativeInherited
Biological Process (BP)growth0.0025630.00005656InformativeInherited
Biological Process (BP)central nervous system development0.0043290.0001261InformativeInherited
Biological Process (BP)positive regulation of transport0.0029260.000002942InformativeInherited
Biological Process (BP)cell-cell signaling0.0029280.01049InformativeInherited
Biological Process (BP)transmission of nerve impulse0.001920.01144InformativeInherited
Biological Process (BP)response to acid0.00001270.000000000001139Highly InformativeDirect
Biological Process (BP)dicarboxylic acid transport0.0000000018890Highly InformativeDirect
Biological Process (BP)amino acid transport0.000000000210Highly InformativeDirect
Biological Process (BP)aging0.0000056270.0000000001254Highly InformativeDirect
Biological Process (BP)telencephalon development0.000011390.00000000006016Highly InformativeDirect
Biological Process (BP)adult behavior0.00016850.00000001114Highly InformativeDirect
Biological Process (BP)response to drug0.000001720.000000000006181Highly InformativeDirect
Biological Process (BP)regulation of glucose import0.000000059780Highly InformativeDirect
Biological Process (BP)protein homooligomerization0.0000001760.00000233Highly InformativeDirect
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)transporter activity00Moderately InformativeDirect
Molecular Function (MF)anion binding0.018160.0001259Moderately InformativeInherited
Molecular Function (MF)anion transmembrane transporter activity0.0000012360InformativeDirect
Molecular Function (MF)carboxylic acid binding0.00004840.00000000001548InformativeDirect
Molecular Function (MF)active transmembrane transporter activity0.0067170.00003938InformativeInherited
Molecular Function (MF)metal ion transmembrane transporter activity0.000028950.004984InformativeInherited
Molecular Function (MF)inorganic cation transmembrane transporter activity0.42390.5596InformativeInherited
Molecular Function (MF)sodium ion transmembrane transporter activity0.00000000039360Highly InformativeDirect
Molecular Function (MF)secondary active transmembrane transporter activity00Highly InformativeDirect
Molecular Function (MF)amino acid binding0.0000021430.0000000000001255Highly InformativeDirect
Molecular Function (MF)amino acid transmembrane transporter activity0.004940.0000002467Highly InformativeInherited
Cellular Component (CC)membrane0.000000017380Least InformativeDirect
Cellular Component (CC)intracellular non-membrane-bounded organelle0.0057190.4788Least InformativeInherited
Cellular Component (CC)protein complex0.017630.5737Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.094830.9294Least InformativeInherited
Cellular Component (CC)plasma membrane0.000000019880Moderately InformativeDirect
Cellular Component (CC)intrinsic to membrane0.000000022180.00005265Moderately InformativeDirect
Cellular Component (CC)cell projection0.0000013610.00000000008833Moderately InformativeDirect
Cellular Component (CC)cytoskeleton0.000044640.01641Moderately InformativeInherited
Cellular Component (CC)integral to membrane0.000000010010.0000000005548InformativeDirect
Cellular Component (CC)cell leading edge0.00036390.0000001161InformativeDirect
Cellular Component (CC)neuron projection0.043970.09472InformativeInherited
Cellular Component (CC)leading edge membrane0.000065450.0000000007162Highly InformativeDirect
Cellular Component (CC)intermediate filament cytoskeleton0.00000000000014770.000000000475Highly InformativeDirect
Cellular Component (CC)cell projection membrane0.0075370.000001138Highly InformativeInherited
Cellular Component (CC)main axon0.15410.001373Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0.7478 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.8095 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.5649 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.02647 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.1953 Least Informative Inherited
Biological Process (BP) developmental process 0.2608 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) system process 0.0002768 Moderately Informative Direct
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) nervous system development 0.00004831 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.000001929 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.0005295 Moderately Informative Direct
Biological Process (BP) organic substance transport 0 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 0.01336 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.01301 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.04527 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.1681 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.765 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.001737 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.07482 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.04529 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.03321 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.5543 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.003487 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.005637 Moderately Informative Inherited
Biological Process (BP) organ development 0.4591 Moderately Informative Inherited
Biological Process (BP) anion transport 0 Informative Direct
Biological Process (BP) central nervous system development 0.0001261 Informative Direct
Biological Process (BP) response to light stimulus 0.00000000000083 Informative Direct
Biological Process (BP) response to wounding 0.0000000001381 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.0000003369 Informative Direct
Biological Process (BP) organic acid transport 0 Informative Direct
Biological Process (BP) growth 0.00005656 Informative Direct
Biological Process (BP) regulation of system process 0.000009078 Informative Direct
Biological Process (BP) single-organism behavior 0 Informative Direct
Biological Process (BP) positive regulation of transport 0.000002942 Informative Direct
Biological Process (BP) transmembrane transport 0.00001472 Informative Direct
Biological Process (BP) nitrogen compound transport 0 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.00004376 Informative Direct
Biological Process (BP) alpha-amino acid biosynthetic process 0.00001815 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.00495 Informative Inherited
Biological Process (BP) protein complex assembly 0.001892 Informative Inherited
Biological Process (BP) single organism reproductive process 0.03303 Informative Inherited
Biological Process (BP) cell-cell signaling 0.01049 Informative Inherited
Biological Process (BP) transmission of nerve impulse 0.01144 Informative Inherited
Biological Process (BP) response to acid 0.000000000001139 Highly Informative Direct
Biological Process (BP) glutamate metabolic process 0.000000001806 Highly Informative Direct
Biological Process (BP) dicarboxylic acid transport 0 Highly Informative Direct
Biological Process (BP) amino acid transport 0 Highly Informative Direct
Biological Process (BP) aging 0.0000000001254 Highly Informative Direct
Biological Process (BP) response to toxic substance 0.00004692 Highly Informative Direct
Biological Process (BP) telencephalon development 0.00000000006016 Highly Informative Direct
Biological Process (BP) adult behavior 0.00000001114 Highly Informative Direct
Biological Process (BP) response to drug 0.000000000006181 Highly Informative Direct
Biological Process (BP) regulation of glucose import 0 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 0.00000532 Highly Informative Direct
Biological Process (BP) protein homooligomerization 0.00000233 Highly Informative Direct
Biological Process (BP) sensory perception 0.2961 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.001171 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0001259 Moderately Informative Direct
Molecular Function (MF) anion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) active transmembrane transporter activity 0.00003938 Informative Direct
Molecular Function (MF) carboxylic acid binding 0.00000000001548 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0.004984 Informative Inherited
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.5596 Informative Inherited
Molecular Function (MF) sodium ion transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) amino acid transmembrane transporter activity 0.0000002467 Highly Informative Direct
Molecular Function (MF) secondary active transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) amino acid binding 0.0000000000001255 Highly Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.4788 Least Informative Inherited
Cellular Component (CC) protein complex 0.5737 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.9294 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0.00005265 Moderately Informative Direct
Cellular Component (CC) cell projection 0.00000000008833 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.01641 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 0.001528 Moderately Informative Inherited
Cellular Component (CC) integral to membrane 0.0000000005548 Informative Direct
Cellular Component (CC) extracellular matrix 0.00003826 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 0.0006139 Informative Direct
Cellular Component (CC) cell leading edge 0.0000001161 Informative Direct
Cellular Component (CC) neuron projection 0.09472 Informative Inherited
Cellular Component (CC) proteinaceous extracellular matrix 0.0004921 Highly Informative Direct
Cellular Component (CC) cell projection membrane 0.000001138 Highly Informative Direct
Cellular Component (CC) leading edge membrane 0.0000000007162 Highly Informative Direct
Cellular Component (CC) cell body 0.00001813 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 0.0000006252 Highly Informative Direct
Cellular Component (CC) intermediate filament cytoskeleton 0.000000000475 Highly Informative Direct
Cellular Component (CC) main axon 0.001373 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.1164Least InformativeInherited
Disease Ontology (DO)disease of mental health0Moderately InformativeDirect
Disease Ontology (DO)neurodegenerative disease0.01739Moderately InformativeInherited
Disease Ontology (DO)schizophrenia0InformativeDirect
Disease Ontology (DO)multiple sclerosis0.0006101InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.04355Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.006138Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.03216Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron number0.001121InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system electrophysiology0.009317Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)gamete0Moderately InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processAmino-acid transport0Highly InformativeDirect
Biological processSugar transport0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentCell inner membrane0InformativeDirect
DomainTransmembrane0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Proton glutamate symport protein domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Proton glutamate symport protein superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]