SUPERFAMILY 1.75 HMM library and genome assignments server


DNA mismatch repair protein MutL superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   DNA mismatch repair protein MutL [ 118115]
Superfamily:   DNA mismatch repair protein MutL [ 118116]
Families:   DNA mismatch repair protein MutL [ 118117]


Superfamily statistics
Genomes (2,543) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,114 15,846 1
Proteins 3,040 15,733 1


Functional annotation
General category Information
Detailed category DNA replication/repair

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) heterocycle metabolic process 2.769e-13 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 3.931e-13 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 1.669e-12 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 1.155e-11 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 2.71e-10 Least Informative Direct
Biological Process (BP) response to stimulus 2.087e-09 Least Informative Direct
Biological Process (BP) single-organism cellular process 4.125e-05 Least Informative Direct
Biological Process (BP) localization 0.1156 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.07557 Least Informative Inherited
Biological Process (BP) developmental process 0.3664 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.496 Least Informative Inherited
Biological Process (BP) cellular response to stress 0 Moderately Informative Direct
Biological Process (BP) reproduction 2.909e-11 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0001809 Moderately Informative Direct
Biological Process (BP) immune system process 0.0006249 Moderately Informative Direct
Biological Process (BP) organelle organization 0.0874 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.0211 Moderately Informative Inherited
Biological Process (BP) response to DNA damage stimulus 0 Informative Direct
Biological Process (BP) DNA metabolic process 0 Informative Direct
Biological Process (BP) cellular process involved in reproduction 3.77e-15 Informative Direct
Biological Process (BP) cell cycle process 2.875e-12 Informative Direct
Biological Process (BP) chromosome organization 7.258e-07 Informative Direct
Biological Process (BP) meiosis 0 Highly Informative Direct
Biological Process (BP) DNA recombination 0.03026 Highly Informative Inherited
Molecular Function (MF) binding 0.02296 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 5.418e-08 Moderately Informative Direct
Molecular Function (MF) DNA binding 7.83e-10 Informative Direct
Molecular Function (MF) chromatin binding 8.738e-06 Informative Direct
Cellular Component (CC) protein complex 3.56e-09 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.0003332 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.6866 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.03241 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.2898 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.001271 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.5832 Moderately Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 5.58e-05 Informative Direct
Cellular Component (CC) chromosome 0.01911 Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.005546 Highly Informative Inherited

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDNA damage0Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DNA mismatch repair protein MutL domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the DNA mismatch repair protein MutL superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]