SUPERFAMILY 1.75 HMM library and genome assignments server

DNA mismatch repair protein MutL superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   DNA mismatch repair protein MutL [ 118115]
Superfamily:   DNA mismatch repair protein MutL [ 118116]
Families:   DNA mismatch repair protein MutL [ 118117]


Superfamily statistics
Genomes (2,545) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,117 15,846 1
Proteins 3,043 15,733 1


Functional annotation
General category Information
Detailed category DNA replication/repair

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) heterocycle metabolic process 0.00000000000006308 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0.00000000000008989 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.0000000000003876 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.000000000002835 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.00000000005264 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.0000000003167 Least Informative Direct
Biological Process (BP) response to stimulus 0.0000000003394 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.000000246 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00007981 Least Informative Direct
Biological Process (BP) localization 0.09317 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.3566 Least Informative Inherited
Biological Process (BP) developmental process 0.2867 Least Informative Inherited
Biological Process (BP) cellular response to stress 0 Moderately Informative Direct
Biological Process (BP) single-organism organelle organization 0.00005849 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0001177 Moderately Informative Direct
Biological Process (BP) immune system process 0.0003837 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 0.6118 Moderately Informative Inherited
Biological Process (BP) DNA repair 0 Informative Direct
Biological Process (BP) cell division 0.000000000000001913 Informative Direct
Biological Process (BP) organelle fission 0.000000000004953 Informative Direct
Biological Process (BP) cell cycle process 0.000001768 Informative Direct
Biological Process (BP) chromosome organization 0.1047 Informative Inherited
Biological Process (BP) nuclear division 0 Highly Informative Direct
Biological Process (BP) meiotic cell cycle 0 Highly Informative Direct
Biological Process (BP) DNA recombination 0.03251 Highly Informative Inherited
Molecular Function (MF) binding 0.01454 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0.00000005499 Moderately Informative Direct
Molecular Function (MF) DNA binding 0.0000000003962 Informative Direct
Molecular Function (MF) chromatin binding 0.000009371 Informative Direct
Molecular Function (MF) sequence-specific DNA binding 0.2195 Highly Informative Inherited
Cellular Component (CC) protein complex 0.00000000007471 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.0002736 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.03316 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.5725 Least Informative Inherited
Cellular Component (CC) nuclear part 0.0004887 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.2926 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.4369 Moderately Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.0000409 Informative Direct
Cellular Component (CC) chromosome 0.01649 Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.008221 Highly Informative Inherited

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDNA damage0Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DNA mismatch repair protein MutL domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the DNA mismatch repair protein MutL superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]