SUPERFAMILY 1.75 HMM library and genome assignments server

Band 7/SPFH domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   EF-Ts domain-like [ 54712] (2)
Superfamily:   Band 7/SPFH domain [ 117892]
Families:   Band 7/SPFH domain [ 117893]


Superfamily statistics
Genomes (2,862) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 11,375 43,682 1
Proteins 11,105 40,712 1


Functional annotation
General category Processes_IC
Detailed category Ion metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0.2974 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.9031 Least Informative Inherited
Biological Process (BP) cellular localization 0.1157 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.09295 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) mitochondrion organization 0.0000008031 Informative Direct
Biological Process (BP) single-organism membrane organization 0.000003637 Informative Direct
Biological Process (BP) single-organism cellular localization 0.006583 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.005266 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.208 Informative Inherited
Biological Process (BP) organelle fusion 0.00003262 Highly Informative Direct
Biological Process (BP) mitochondrial transport 0.0001128 Highly Informative Direct
Biological Process (BP) plasma membrane organization 0.0402 Highly Informative Inherited
Biological Process (BP) protein localization to membrane 0.04457 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.001508 Highly Informative Inherited
Cellular Component (CC) membrane 0.000000000000006018 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.000002537 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.0002702 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.0009043 Least Informative Direct
Cellular Component (CC) protein complex 0.001877 Least Informative Inherited
Cellular Component (CC) mitochondrial part 0.0000000000001287 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0.000000000003841 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 0.0000001639 Moderately Informative Direct
Cellular Component (CC) membrane region 0.0000003346 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) vacuolar part 0.0000000005087 Informative Direct
Cellular Component (CC) endosome 0.00000556 Informative Direct
Cellular Component (CC) oxidoreductase complex 0.00001729 Informative Direct
Cellular Component (CC) plasma membrane region 0.00002662 Informative Direct
Cellular Component (CC) cell junction 0.00008781 Informative Direct
Cellular Component (CC) mitochondrial membrane part 0.0003881 Informative Direct
Cellular Component (CC) respiratory chain 0.01907 Informative Inherited
Cellular Component (CC) respiratory chain complex I 0.0000000002072 Highly Informative Direct
Cellular Component (CC) symplast 0.00001133 Highly Informative Direct

Document: GO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.00005897Least InformativeDirect
Worm Phenotype (WP)organ system development variant0.00008275Moderately InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.0000000132InformativeDirect
Worm Phenotype (WP)nervous system development variant0.000001798Highly InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.716Least InformativeInherited
Plant ANatomical entity (PAN)root system0.7595Least InformativeInherited
Plant ANatomical entity (PAN)portion of meristem tissue0.8796Least InformativeInherited
Plant ANatomical entity (PAN)shoot axis0.9358Least InformativeInherited
Plant ANatomical entity (PAN)primordium0.00000005234InformativeDirect
Plant ANatomical entity (PAN)root tip0.000001171InformativeDirect
Plant ANatomical entity (PAN)cultured plant cell0.000000000006049Highly InformativeDirect
Plant ANatomical entity (PAN)vegetative shoot apex0.000000001556Highly InformativeDirect
Plant ANatomical entity (PAN)phyllome primordium0.000000001891Highly InformativeDirect
Plant ANatomical entity (PAN)root meristem0.000000004591Highly InformativeDirect
Plant ANatomical entity (PAN)trichome0.00000006705Highly InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell adhesion0.000001858InformativeDirect
Biological processNodulation0.00000000008173Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndosome6.436e-16Moderately InformativeDirect
Cellular componentMitochondrion0.00000000000001378Moderately InformativeDirect
Cellular componentMitochondrion inner membrane0.00000000001424InformativeDirect
DomainTransmembrane0.000000004571Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainSignal-anchor0.000000003498InformativeDirect
Post-translational modificationPalmitate0.0008444Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Human Phenotype (HP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Band 7/SPFH domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Band 7/SPFH domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Human Phenotype (HP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]