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Band 7/SPFH domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   EF-Ts domain-like [ 54712] (2)
Superfamily:   Band 7/SPFH domain [ 117892]
Families:   Band 7/SPFH domain [ 117893]

 Superfamily statistics
Genomes (2,249) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 9,190 23,252 1
Proteins 8,984 21,939 1

 Functional annotation
General category Processes_IC
Detailed category Ion metabolism and transport

Document: Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0.9465 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) localization 0.2415 Least Informative Inherited
Biological Process (BP) organelle organization 0.718 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.06829 Moderately Informative Inherited
Biological Process (BP) mitochondrion organization 1.551e-05 Informative Direct
Biological Process (BP) cellular membrane organization 2.052e-05 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.007304 Informative Inherited
Biological Process (BP) mitochondrial transport 7.311e-05 Highly Informative Direct
Biological Process (BP) organelle fusion 9.511e-06 Highly Informative Direct
Cellular Component (CC) membrane 2.495e-14 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1.05e-05 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.006178 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.01607 Least Informative Inherited
Cellular Component (CC) protein complex 0.008157 Least Informative Inherited
Cellular Component (CC) plasma membrane 3.569e-09 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0 Moderately Informative Direct
Cellular Component (CC) organelle envelope 2.736e-12 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 5.979e-14 Moderately Informative Direct
Cellular Component (CC) vesicle 0.001099 Moderately Informative Inherited
Cellular Component (CC) endosome 3.553e-08 Informative Direct
Cellular Component (CC) vacuole 3.702e-08 Informative Direct
Cellular Component (CC) cell junction 5.707e-05 Informative Direct
Cellular Component (CC) mitochondrial membrane part 0.0005356 Informative Direct
Cellular Component (CC) respiratory chain 0.0002634 Informative Direct
Cellular Component (CC) mitochondrial respiratory chain complex I 0.0003473 Highly Informative Direct
Cellular Component (CC) cell-cell junction 2.425e-06 Highly Informative Direct
Cellular Component (CC) membrane raft 0 Highly Informative Direct
Cellular Component (CC) symplast 1.306e-05 Highly Informative Direct

Document: GO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant5.897e-05Least InformativeDirect
Worm Phenotype (WP)organ system development variant8.275e-05Moderately InformativeDirect
Worm Phenotype (WP)mechanosensation variant1.32e-08InformativeDirect
Worm Phenotype (WP)nervous system development variant1.798e-06Highly InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)male genitalia0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)shoot apex0Least InformativeDirect
Plant ANatomical entity (PAN)root0Least InformativeDirect
Plant ANatomical entity (PAN)plant cell0.01504Least InformativeInherited
Plant ANatomical entity (PAN)portion of meristem tissue0.04233Least InformativeInherited
Plant ANatomical entity (PAN)primordium2.452e-08InformativeDirect
Plant ANatomical entity (PAN)root tip3.213e-07InformativeDirect
Plant ANatomical entity (PAN)cultured plant cell4.274e-12Highly InformativeDirect
Plant ANatomical entity (PAN)vegetative shoot apex9.623e-10Highly InformativeDirect
Plant ANatomical entity (PAN)phyllome primordium1.162e-09Highly InformativeDirect
Plant ANatomical entity (PAN)root meristem1.396e-09Highly InformativeDirect
Plant ANatomical entity (PAN)trichome7.11e-09Highly InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell adhesion2.851e-06InformativeDirect
Biological processNodulation8.355e-11Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentMitochondrion1.42e-14Moderately InformativeDirect
Cellular componentMitochondrion inner membrane2.427e-11InformativeDirect
DomainTransmembrane6.806e-08Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainSignal-anchor1.757e-08Moderately InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationProtease0.0006591Moderately InformativeDirect
Post-translational modificationSerine protease1.788e-08InformativeDirect
Post-translational modificationPalmitate0.0006737Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Human Phenotype (HP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Band 7/SPFH domain domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Band 7/SPFH domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Human Phenotype (HP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]
Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

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© Copyright 2013 The SUPERFAMILY authors and Julian Gough.