SUPERFAMILY 1.75 HMM library and genome assignments server


Kelch motif superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   6-bladed beta-propeller [ 50938] (11)
Superfamily:   Kelch motif [ 117281]
Families:   Kelch motif [ 117282]


Superfamily statistics
Genomes (947) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 19,876 26,920 4
Proteins 17,604 24,372 4


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 7.859e-05 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.07455 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.1993 Least Informative Inherited
Biological Process (BP) localization 0.9532 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) regulation of cellular component organization 1.455e-08 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 2.884e-05 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0007972 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0.4603 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.09409 Moderately Informative Inherited
Biological Process (BP) organ development 0.2061 Moderately Informative Inherited
Biological Process (BP) system process 0.2511 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.02886 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.001497 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.3269 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.548 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.974 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.0122 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.2853 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.6427 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.07201 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.1373 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.1546 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.5796 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.305 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.5303 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.02455 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.1997 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.001416 Moderately Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 0 Informative Direct
Biological Process (BP) lipid localization 1.024e-09 Informative Direct
Biological Process (BP) protein catabolic process 1.656e-09 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 1.559e-08 Informative Direct
Biological Process (BP) tube development 5.714e-08 Informative Direct
Biological Process (BP) regulation of growth 1.963e-07 Informative Direct
Biological Process (BP) tissue morphogenesis 4.31e-07 Informative Direct
Biological Process (BP) regulation of response to external stimulus 1.984e-06 Informative Direct
Biological Process (BP) embryonic organ development 2.485e-06 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 2.042e-05 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 2.449e-05 Informative Direct
Biological Process (BP) regulation of cellular component movement 2.686e-05 Informative Direct
Biological Process (BP) proteolysis 4.613e-05 Informative Direct
Biological Process (BP) regulation of locomotion 4.684e-05 Informative Direct
Biological Process (BP) embryo development ending in birth or egg hatching 8.355e-05 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.0002224 Informative Direct
Biological Process (BP) embryonic morphogenesis 0.0002915 Informative Direct
Biological Process (BP) cardiovascular system development 0.0003354 Informative Direct
Biological Process (BP) organ morphogenesis 0.0009332 Informative Direct
Biological Process (BP) epithelium development 0.005215 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.7492 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.5225 Informative Inherited
Biological Process (BP) synaptic transmission 0.00718 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.003394 Informative Inherited
Biological Process (BP) generation of neurons 0.01575 Informative Inherited
Biological Process (BP) regulation of cell development 0.004027 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.001144 Informative Inherited
Biological Process (BP) protein localization to organelle 0.1504 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.04736 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.01341 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) secondary metabolic process 0.3041 Informative Inherited
Biological Process (BP) glycosyl compound catabolic process 0.9296 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.9499 Informative Inherited
Biological Process (BP) growth 0.009881 Informative Inherited
Biological Process (BP) cell projection organization 0.001518 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.4696 Informative Inherited
Biological Process (BP) cell cycle process 0.2114 Informative Inherited
Biological Process (BP) metal ion transport 0.2651 Informative Inherited
Biological Process (BP) protein ubiquitination 0 Highly Informative Direct
Biological Process (BP) regulation of cell size 3.741e-15 Highly Informative Direct
Biological Process (BP) limb morphogenesis 3.913e-13 Highly Informative Direct
Biological Process (BP) positive regulation of growth 4.763e-13 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 5.315e-13 Highly Informative Direct
Biological Process (BP) regulation of behavior 9.535e-12 Highly Informative Direct
Biological Process (BP) positive regulation of neurogenesis 2.434e-11 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 6.382e-10 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 2.082e-09 Highly Informative Direct
Biological Process (BP) cell growth 1.104e-08 Highly Informative Direct
Biological Process (BP) heart morphogenesis 1.975e-08 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 2.281e-08 Highly Informative Direct
Biological Process (BP) skeletal system development 1.309e-07 Highly Informative Direct
Biological Process (BP) pattern specification process 4.488e-06 Highly Informative Direct
Biological Process (BP) sulfur compound catabolic process 1.164e-05 Highly Informative Direct
Biological Process (BP) spindle checkpoint 1.341e-05 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 2.002e-05 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 6.296e-05 Highly Informative Direct
Biological Process (BP) cell division 0.0002496 Highly Informative Direct
Biological Process (BP) neuron projection development 0.0007355 Highly Informative Direct
Biological Process (BP) renal system development 0.1953 Highly Informative Inherited
Biological Process (BP) regulation of cell division 0.001441 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 0.6055 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 0.02338 Highly Informative Inherited
Biological Process (BP) negative regulation of cell cycle 0.04197 Highly Informative Inherited
Biological Process (BP) regulation of mitosis 0.008665 Highly Informative Inherited
Biological Process (BP) monovalent inorganic cation transport 0.07422 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 8.149e-07 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.001763 Informative Inherited
Molecular Function (MF) small conjugating protein ligase activity 1.218e-08 Highly Informative Direct
Cellular Component (CC) protein complex 2.386e-06 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.2186 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.03401 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.2917 Informative Inherited
Cellular Component (CC) cullin-RING ubiquitin ligase complex 0 Highly Informative Direct
Cellular Component (CC) spindle 0.001781 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.007019Least InformativeInherited
Enzyme Commission (EC)Racemases and epimerases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases4.386e-06Moderately InformativeDirect
Enzyme Commission (EC)Acting on carbohydrates and derivatives0InformativeDirect
Enzyme Commission (EC)Phosphoprotein phosphatase1.653e-10InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)reproductive system0Moderately InformativeDirect
Fly Anatomy (FA)germline cyst0InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases2.029e-05Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases0.0002176Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups0.002023Moderately InformativeInherited
Enzyme Commission (EC)Racemases and epimerases0InformativeDirect
Enzyme Commission (EC)Acting on carbohydrates and derivatives0Highly InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine phosphatase6.834e-10Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism2.703e-10Moderately InformativeDirect
Biological processHost-virus interaction5.288e-05Moderately InformativeDirect
Biological processCell cycle6.831e-05Moderately InformativeDirect
Biological processDifferentiation0.000394Moderately InformativeDirect
Biological processMitosis0InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processMeiosis1.485e-06InformativeDirect
Biological processSpermatogenesis3.902e-06Highly InformativeDirect
Cellular componentNucleus0.000936Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell projection3.649e-07Moderately InformativeDirect
Cellular componentPeriplasm0InformativeDirect
Cellular componentHost cytoplasm3.559e-08InformativeDirect
DomainRepeat0Least InformativeDirect
DomainKelch repeat0Highly InformativeDirect
DomainLaminin EGF-like domain1.965e-08Highly InformativeDirect
Molecular functionActin-binding0InformativeDirect
Molecular functionLectin0.0001201InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationDevelopmental protein0.0001856Moderately InformativeDirect
Post-translational modificationIsomerase0.0003132Moderately InformativeDirect
Post-translational modificationProtein phosphatase0.0004401InformativeDirect
Post-translational modificationPhosphoprotein0.0003743Least InformativeDirect
Post-translational modificationUbl conjugation4.562e-06Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Kelch motif domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Kelch motif superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]