SUPERFAMILY 1.75 HMM library and genome assignments server

Kelch motif superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   6-bladed beta-propeller [ 50938] (11)
Superfamily:   Kelch motif [ 117281]
Families:   Kelch motif [ 117282]


Superfamily statistics
Genomes (949) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 20,012 26,920 4
Proteins 17,712 24,372 4


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0.0001303 Least Informative Direct
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.2131 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.8802 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.06954 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.00000007109 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.00002784 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0007118 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.6903 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.3983 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.1518 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.4417 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.09977 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.03344 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.06388 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.0385 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.01353 Moderately Informative Inherited
Biological Process (BP) tissue development 0.002863 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.4967 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.3201 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.06044 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.1182 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.8271 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.06449 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.4479 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.00263 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.652 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.9365 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.2071 Moderately Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 0 Informative Direct
Biological Process (BP) lipid localization 0.000000001433 Informative Direct
Biological Process (BP) protein catabolic process 0.000000001742 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.00000001992 Informative Direct
Biological Process (BP) regulation of growth 0.0000001899 Informative Direct
Biological Process (BP) tissue morphogenesis 0.0000004105 Informative Direct
Biological Process (BP) tube development 0.0000006222 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.000001473 Informative Direct
Biological Process (BP) embryonic organ development 0.000002592 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.00002601 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.00003104 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.00003692 Informative Direct
Biological Process (BP) proteolysis 0.00004788 Informative Direct
Biological Process (BP) regulation of locomotion 0.00005853 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.00006274 Informative Direct
Biological Process (BP) embryo development ending in birth or egg hatching 0.00008191 Informative Direct
Biological Process (BP) embryonic morphogenesis 0.0002986 Informative Direct
Biological Process (BP) cardiovascular system development 0.0003294 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.0003998 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0008779 Informative Direct
Biological Process (BP) organ morphogenesis 0.00096 Informative Direct
Biological Process (BP) regulation of organelle organization 0.6488 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.09641 Informative Inherited
Biological Process (BP) generation of neurons 0.01716 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.04484 Informative Inherited
Biological Process (BP) cell projection organization 0.001806 Informative Inherited
Biological Process (BP) mitotic cell cycle 1 Informative Inherited
Biological Process (BP) cell cycle process 0.3552 Informative Inherited
Biological Process (BP) monovalent inorganic cation transport 0.2181 Informative Inherited
Biological Process (BP) epithelium development 0.07638 Informative Inherited
Biological Process (BP) synaptic transmission 0.01741 Informative Inherited
Biological Process (BP) muscle structure development 0.1674 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.01136 Informative Inherited
Biological Process (BP) protein localization to organelle 0.1612 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.4551 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.7183 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.02729 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.9338 Informative Inherited
Biological Process (BP) secondary metabolic process 0.3132 Informative Inherited
Biological Process (BP) growth 0.01007 Informative Inherited
Biological Process (BP) regulation of cell development 0.001677 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.003819 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.603 Informative Inherited
Biological Process (BP) negative regulation of protein processing 0.05726 Informative Inherited
Biological Process (BP) metal ion transport 0.2649 Informative Inherited
Biological Process (BP) protein ubiquitination 0 Highly Informative Direct
Biological Process (BP) positive regulation of behavior 0 Highly Informative Direct
Biological Process (BP) regulation of chemotaxis 0.000000000000001913 Highly Informative Direct
Biological Process (BP) limb morphogenesis 0.000000000000003707 Highly Informative Direct
Biological Process (BP) cell recognition 0.000000000000003707 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.000000000000009016 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0.000000000003941 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 0.000000000006742 Highly Informative Direct
Biological Process (BP) positive regulation of neurogenesis 0.00000000005114 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.0000000006124 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 0.000000003027 Highly Informative Direct
Biological Process (BP) cell growth 0.00000001283 Highly Informative Direct
Biological Process (BP) heart morphogenesis 0.00000001847 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 0.0000000226 Highly Informative Direct
Biological Process (BP) skeletal system development 0.0000001371 Highly Informative Direct
Biological Process (BP) pattern specification process 0.00000468 Highly Informative Direct
Biological Process (BP) spindle checkpoint 0.00001186 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.00003667 Highly Informative Direct
Biological Process (BP) negative regulation of cell division 0.00004814 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.00006412 Highly Informative Direct
Biological Process (BP) negative regulation of protein catabolic process 0.0001034 Highly Informative Direct
Biological Process (BP) sodium ion transport 0.0001709 Highly Informative Direct
Biological Process (BP) regulation of proteolysis involved in cellular protein catabolic process 0.0002013 Highly Informative Direct
Biological Process (BP) neuron projection development 0.0006512 Highly Informative Direct
Biological Process (BP) regulation of nuclear division 0.02251 Highly Informative Inherited
Biological Process (BP) kidney development 0.1115 Highly Informative Inherited
Biological Process (BP) muscle fiber development 0.03315 Highly Informative Inherited
Biological Process (BP) negative regulation of chromosome organization 0.002677 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 0.2744 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular catabolic process 0.001388 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 0.6565 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.01376 Highly Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.001814 Informative Inherited
Molecular Function (MF) ubiquitin-protein transferase activity 0.00000001101 Highly Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.2509 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.004553 Least Informative Inherited
Cellular Component (CC) transferase complex 0.00000000004998 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.04572 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0 Informative Direct
Cellular Component (CC) contractile fiber part 0.1053 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.2421 Informative Inherited
Cellular Component (CC) spindle 0.0001499 Highly Informative Direct
Cellular Component (CC) sarcomere 0.05914 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.007019Least InformativeInherited
Enzyme Commission (EC)Racemases and epimerases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000004386Moderately InformativeDirect
Enzyme Commission (EC)Acting on carbohydrates and derivatives0InformativeDirect
Enzyme Commission (EC)Phosphoprotein phosphatase0.0000000001653InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)reproductive system0Moderately InformativeDirect
Fly Anatomy (FA)germline cyst0InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.00002021Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases0.0002165Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups0.001998Moderately InformativeInherited
Enzyme Commission (EC)Racemases and epimerases0InformativeDirect
Enzyme Commission (EC)Acting on carbohydrates and derivatives0Highly InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine phosphatase0.0000000006758Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0.0000000002673Moderately InformativeDirect
Biological processHost-virus interaction0.00005297Moderately InformativeDirect
Biological processCell cycle0.00005738Moderately InformativeDirect
Biological processDifferentiation0.0004164Moderately InformativeDirect
Biological processMitosis0InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processMeiosis0.000001509InformativeDirect
Biological processSpermatogenesis0.000003849Highly InformativeDirect
Cellular componentNucleus0.0009684Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell projection0.0000003911Moderately InformativeDirect
Cellular componentPeriplasm0InformativeDirect
Cellular componentHost cytoplasm0.00000003527InformativeDirect
DiseaseDisease mutation0.000728Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainKelch repeat0Highly InformativeDirect
DomainLaminin EGF-like domain0.00000001941Highly InformativeDirect
Molecular functionActin-binding0InformativeDirect
Molecular functionLectin0.0001494InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationDevelopmental protein0.0001827Moderately InformativeDirect
Post-translational modificationIsomerase0.0003107Moderately InformativeDirect
Post-translational modificationProtein phosphatase0.0004375InformativeDirect
Post-translational modificationPhosphoprotein0.0003924Least InformativeDirect
Post-translational modificationUbl conjugation0.000004993Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect
UniPathway (UP)tRNA modification0.001165InformativeInherited
UniPathway (UP)tRNA post-transcriptional modification0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Kelch motif domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Kelch motif superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]