SUPERFAMILY 1.75 HMM library and genome assignments server

ATP-dependent DNA ligase DNA-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   ATP-dependent DNA ligase DNA-binding domain [ 117017]
Superfamily:   ATP-dependent DNA ligase DNA-binding domain [ 117018]
Families:   ATP-dependent DNA ligase DNA-binding domain [ 117019]


Superfamily statistics
Genomes (878) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,679 2,476 1
Proteins 1,674 2,474 1


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0.000000001112 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.000000002411 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.00006127 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.3072 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.8273 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.04882 Least Informative Inherited
Biological Process (BP) cellular response to stress 0 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.001431 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.01497 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.6872 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.2734 Moderately Informative Inherited
Biological Process (BP) single-organism organelle organization 0.03094 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.09154 Moderately Informative Inherited
Biological Process (BP) DNA repair 0 Informative Direct
Biological Process (BP) anatomical structure homeostasis 0.000003241 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.0002313 Informative Direct
Biological Process (BP) response to inorganic substance 0.0003946 Informative Direct
Biological Process (BP) mitochondrion organization 0.0007146 Informative Direct
Biological Process (BP) chromosome organization 0.03205 Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.000000009586 Highly Informative Direct
Biological Process (BP) response to ionizing radiation 0.00000003994 Highly Informative Direct
Biological Process (BP) double-strand break repair 0.0001564 Highly Informative Direct
Molecular Function (MF) ligase activity 0 Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.000000000009673 Least Informative Direct
Cellular Component (CC) protein complex 0.2112 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.02189 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.002541 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.0000397 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.00005185 Moderately Informative Direct
Cellular Component (CC) chromosome 0.00001713 Informative Direct
Cellular Component (CC) nuclear chromosome part 0.0005323 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Ligases that form phosphoric-ester bonds1InformativeInherited

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body phenotype0Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal metabolism0Moderately InformativeDirect
Mammalian Phenotype (MP)preweaning lethality0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell proliferation0InformativeDirect
Mammalian Phenotype (MP)abnormal prenatal growth/weight/body size0InformativeDirect
Mammalian Phenotype (MP)lethality during fetal growth through weaning0InformativeDirect
Mammalian Phenotype (MP)postnatal growth retardation0Highly InformativeDirect

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gamete0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)gamete0InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Ligases that form phosphoric-ester bonds1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0Moderately InformativeDirect
Biological processDNA damage0Moderately InformativeDirect
Biological processDNA recombination0InformativeDirect
Biological processDNA replication0InformativeDirect
Cellular componentNucleus0.0000002981Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionMagnesium0.0009949Moderately InformativeDirect
Post-translational modificationLigase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ATP-dependent DNA ligase DNA-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the ATP-dependent DNA ligase DNA-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]