SUPERFAMILY 1.75 HMM library and genome assignments server

eIF2alpha middle domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   SAM domain-like [ 47768] (16)
Superfamily:   eIF2alpha middle domain-like [ 116742]
Families:   eIF2alpha middle domain-like [ 116743]

Superfamily statistics
Genomes (650) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 778 1,053 4
Proteins 760 1,039 4

Functional annotation
General category Information
Detailed category Translation

Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0.00000002186 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.02077 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.002382 Least Informative Inherited
Biological Process (BP) gene expression 0.0004595 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0.0005788 Moderately Informative Direct
Biological Process (BP) translational initiation 0.0000000001065 Highly Informative Direct
Molecular Function (MF) binding 0.01 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0.0000004163 Moderately Informative Direct
Molecular Function (MF) RNA binding 0.0000000003884 Informative Direct
Molecular Function (MF) translation factor activity, nucleic acid binding 8.006e-16 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) ribonucleoprotein complex 0.00001596 Moderately Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processProtein biosynthesis0InformativeDirect
Biological processTranslation regulation0.0000000002887InformativeDirect
Molecular functionRNA-binding0Moderately InformativeDirect
Post-translational modificationInitiation factor0InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a eIF2alpha middle domain-like domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the eIF2alpha middle domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]