SUPERFAMILY 1.75 HMM library and genome assignments server


Hormone receptor domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Hormone receptor domain [ 111417]
Superfamily:   Hormone receptor domain [ 111418]
Families:   Hormone receptor domain [ 111419] (2)


Superfamily statistics
Genomes (120) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 1,868 1,975 2
Proteins 1,845 1,937 2


Functional annotation
General category Regulation
Detailed category Receptor activity

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 1.965e-12 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.0006049 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.04289 Least Informative Inherited
Biological Process (BP) developmental process 0.4601 Least Informative Inherited
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) response to organic substance 1.431e-05 Moderately Informative Direct
Biological Process (BP) homeostatic process 0.0001673 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.8188 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 0.3704 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.4044 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.01668 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.7529 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.8992 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.001151 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.4854 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.3298 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.001457 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.06009 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.7175 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of phosphorus metabolic process 1.937e-13 Informative Direct
Biological Process (BP) metal ion homeostasis 1.417e-12 Informative Direct
Biological Process (BP) cellular cation homeostasis 1.542e-11 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 6.41e-09 Informative Direct
Biological Process (BP) response to hormone stimulus 6.019e-08 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 4.53e-07 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 7.825e-06 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 5.154e-05 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0001288 Informative Direct
Biological Process (BP) response to organic nitrogen 0.0005885 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0005942 Informative Direct
Biological Process (BP) regulation of secretion 0.002467 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.002267 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.002233 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.01578 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.001497 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.002855 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.01839 Informative Inherited
Biological Process (BP) cardiovascular system development 0.03121 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.2374 Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 0 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 4.008e-15 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 1.043e-10 Highly Informative Direct
Biological Process (BP) angiogenesis 0.000182 Highly Informative Direct
Biological Process (BP) cellular response to peptide hormone stimulus 0.004718 Highly Informative Inherited
Biological Process (BP) negative regulation of signal transduction 0.002695 Highly Informative Inherited
Molecular Function (MF) binding 0.01183 Least Informative Inherited
Molecular Function (MF) protein binding 0.2322 Moderately Informative Inherited
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) receptor binding 0.0007564 Informative Direct
Molecular Function (MF) peptide binding 0 Highly Informative Direct
Molecular Function (MF) G-protein coupled receptor activity 0 Highly Informative Direct
Molecular Function (MF) hormone binding 0 Highly Informative Direct
Cellular Component (CC) membrane 1.78e-14 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.5965 Least Informative Inherited
Cellular Component (CC) plasma membrane 3.006e-09 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 7.927e-08 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0.0001045 Moderately Informative Direct
Cellular Component (CC) vesicle 0.01137 Moderately Informative Inherited
Cellular Component (CC) integral to membrane 0 Informative Direct
Cellular Component (CC) cell surface 1.126e-08 Informative Direct
Cellular Component (CC) secretory granule 1.371e-05 Informative Direct
Cellular Component (CC) Golgi apparatus 8.299e-05 Informative Direct

Document: GO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.0001164Least InformativeDirect
Mammalian Phenotype (MP)abnormal hormone level0.0007857Moderately InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect

Document: XA annotation of SCOP domains

DrugBank ATC (DB)

(show details) Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationTransducer0InformativeDirect
Post-translational modificationG-protein coupled receptor0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Hormone receptor domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Hormone receptor domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · Internal database links ]