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Hormone receptor domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Hormone receptor domain [ 111417]
Superfamily:   Hormone receptor domain [ 111418]
Families:   Hormone receptor domain [ 111419] (2)


Superfamily statistics
Genomes (136) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,123 2,354 2
Proteins 2,096 2,314 2


Functional annotation
General category Regulation
Detailed category Receptor activity

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0.000000000007856 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.000509 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 0.5724 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.00859 Least Informative Inherited
Biological Process (BP) developmental process 0.6152 Least Informative Inherited
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.00003093 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.000002313 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.00000000002835 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.0001108 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.0002075 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.29 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.5195 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.1912 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.249 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.001254 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.898 Moderately Informative Inherited
Biological Process (BP) system process 0.01567 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.001485 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.2366 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.997 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.9445 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.009345 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.6295 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) response to hormone stimulus 0.000000001273 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.00009411 Informative Direct
Biological Process (BP) regulation of hormone levels 0.0003384 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.00000000000007996 Informative Direct
Biological Process (BP) secretion by cell 0.0004426 Informative Direct
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.0000003633 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0.00000001032 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0002408 Informative Direct
Biological Process (BP) regulation of secretion 0.00003072 Informative Direct
Biological Process (BP) cation homeostasis 0.00000001305 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0.0004057 Informative Direct
Biological Process (BP) nitrogen compound transport 0.00001976 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0.00000002229 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.0002298 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.06209 Informative Inherited
Biological Process (BP) regulation of system process 0.01712 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.009158 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.012 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.03606 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.006545 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.04297 Informative Inherited
Biological Process (BP) cardiovascular system development 0.01465 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.1527 Informative Inherited
Biological Process (BP) angiogenesis 0.0000774 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0.000000000001328 Highly Informative Direct
Biological Process (BP) G-protein coupled receptor signaling pathway 0 Highly Informative Direct
Biological Process (BP) hormone transport 0.000000000002063 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.000002264 Highly Informative Direct
Biological Process (BP) regulation of cyclic nucleotide metabolic process 0.00000000000001778 Highly Informative Direct
Biological Process (BP) amide transport 0.00000000005945 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 0.00002033 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 0.00000000122 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 0.00000000002604 Highly Informative Direct
Biological Process (BP) regulation of behavior 0.0009979 Highly Informative Direct
Biological Process (BP) regulation of peptide transport 0.0005825 Highly Informative Direct
Biological Process (BP) cellular response to peptide 0.0000000000155 Highly Informative Direct
Biological Process (BP) signal release 0.001556 Highly Informative Inherited
Molecular Function (MF) binding 0.004152 Least Informative Inherited
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) amide binding 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) receptor binding 0.002035 Informative Inherited
Molecular Function (MF) G-protein coupled receptor activity 0 Highly Informative Direct
Molecular Function (MF) peptide binding 0 Highly Informative Direct
Molecular Function (MF) hormone binding 0 Highly Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) protein complex 0.5851 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.657 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.0002341 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.000000000000006088 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0.0000000005921 Moderately Informative Direct
Cellular Component (CC) Golgi apparatus 0.0001771 Informative Direct
Cellular Component (CC) cell surface 0.0000004936 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 0.00006803 Informative Direct
Cellular Component (CC) receptor complex 0.00003063 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of mental health0.4282Moderately InformativeInherited
Disease Ontology (DO)anxiety disorder0.00005644Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.0001714Least InformativeDirect
Mammalian Phenotype (MP)abnormal hormone level0.0006248Moderately InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentEndosome0.00008161Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationTransducer0InformativeDirect
Post-translational modificationG-protein coupled receptor0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Hormone receptor domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Hormone receptor domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]