SUPERFAMILY 1.75 HMM library and genome assignments server

Hormone receptor domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Hormone receptor domain [ 111417]
Superfamily:   Hormone receptor domain [ 111418]
Families:   Hormone receptor domain [ 111419] (2)


Superfamily statistics
Genomes (136) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,123 2,354 2
Proteins 2,096 2,314 2


Functional annotation
General category Regulation
Detailed category Receptor activity

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00000004262 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.0008549 Least Informative Direct
Biological Process (BP) localization 0.6132 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.004564 Least Informative Inherited
Biological Process (BP) developmental process 0.6142 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 0.5667 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphorus metabolic process 0.0000000000258 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.00000000003594 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.00000258 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.00003212 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.00008196 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.0002265 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.1471 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.314 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.598 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.1411 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.8982 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.5196 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.00297 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.01592 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.001528 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.01086 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.2715 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) cellular response to hormone stimulus 0.00000000001997 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.00000000006239 Informative Direct
Biological Process (BP) cation homeostasis 0.00000001048 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0.00000002177 Informative Direct
Biological Process (BP) nitrogen compound transport 0.00002023 Informative Direct
Biological Process (BP) regulation of secretion 0.0000304 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.00009108 Informative Direct
Biological Process (BP) secretion by cell 0.0001399 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.0002359 Informative Direct
Biological Process (BP) regulation of hormone levels 0.0003638 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0003917 Informative Direct
Biological Process (BP) regulation of system process 0.0006223 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0009121 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.005903 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.006353 Informative Inherited
Biological Process (BP) cardiovascular system development 0.01504 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.001381 Informative Inherited
Biological Process (BP) positive regulation of intracellular signal transduction 0.002624 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.05529 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.05317 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.1548 Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 0 Highly Informative Direct
Biological Process (BP) positive regulation of cyclic nucleotide metabolic process 0 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0.000000000001233 Highly Informative Direct
Biological Process (BP) hormone transport 0.000000000002587 Highly Informative Direct
Biological Process (BP) cellular response to peptide 0.00000000001454 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 0.00000000002659 Highly Informative Direct
Biological Process (BP) amide transport 0.0000000001175 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.000001446 Highly Informative Direct
Biological Process (BP) signal release 0.000008851 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0.00001995 Highly Informative Direct
Biological Process (BP) angiogenesis 0.00005832 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular signal transduction 0.001678 Highly Informative Inherited
Molecular Function (MF) binding 0.0047 Least Informative Inherited
Molecular Function (MF) amide binding 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) receptor binding 0.002015 Informative Inherited
Molecular Function (MF) hormone binding 0 Highly Informative Direct
Molecular Function (MF) peptide binding 0 Highly Informative Direct
Molecular Function (MF) transmembrane signaling receptor activity 0.000007491 Highly Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) protein complex 0.5732 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.6607 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) plasma membrane part 0.00000000000000158 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.0000000004544 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0.0002346 Moderately Informative Direct
Cellular Component (CC) cell surface 0.00000107 Informative Direct
Cellular Component (CC) integral component of membrane 0.000001255 Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0.00002896 Informative Direct
Cellular Component (CC) Golgi apparatus 0.00006805 Informative Direct
Cellular Component (CC) receptor complex 0.00003567 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of mental health0.4282Moderately InformativeInherited
Disease Ontology (DO)anxiety disorder0.00005644Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.0001714Least InformativeDirect
Mammalian Phenotype (MP)abnormal hormone level0.0006248Moderately InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect

Document: XA annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)systemic hormonal preparations, excl. sex hormones and insulins0.000000000009129Moderately InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentEndosome0.00008161Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationTransducer0InformativeDirect
Post-translational modificationG-protein coupled receptor0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Hormone receptor domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Hormone receptor domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · Internal database links ]