SUPERFAMILY 1.75 HMM library and genome assignments server


Hormone receptor domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Hormone receptor domain [ 111417]
Superfamily:   Hormone receptor domain [ 111418]
Families:   Hormone receptor domain [ 111419] (2)


Superfamily statistics
Genomes (131) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,976 2,354 2
Proteins 1,953 2,314 2


Functional annotation
General category Regulation
Detailed category Receptor activity

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 8.085e-12 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.000548 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 0.5102 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.00533 Least Informative Inherited
Biological Process (BP) developmental process 0.5437 Least Informative Inherited
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 1.609e-11 Moderately Informative Direct
Biological Process (BP) response to organic substance 1.57e-06 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 1.882e-05 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.0001237 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.0001983 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.2765 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.4973 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.1669 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.2582 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.001073 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.8922 Moderately Informative Inherited
Biological Process (BP) system process 0.01501 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.001179 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.2291 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.9386 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.01776 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.001664 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 3.095e-14 Informative Direct
Biological Process (BP) metal ion homeostasis 7.001e-10 Informative Direct
Biological Process (BP) cellular cation homeostasis 9.246e-10 Informative Direct
Biological Process (BP) response to hormone stimulus 9.619e-10 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 6.676e-09 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 2.245e-08 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 2.971e-07 Informative Direct
Biological Process (BP) nitrogen compound transport 1.583e-05 Informative Direct
Biological Process (BP) regulation of secretion 2.537e-05 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.0001162 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0002142 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.0002209 Informative Direct
Biological Process (BP) regulation of hormone levels 0.0003869 Informative Direct
Biological Process (BP) secretion by cell 0.0004214 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0.0005529 Informative Direct
Biological Process (BP) regulation of system process 0.01561 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.008288 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.0109 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.0364 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.006997 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.04256 Informative Inherited
Biological Process (BP) cell-cell signaling 1 Informative Inherited
Biological Process (BP) cardiovascular system development 0.01497 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.1453 Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 0 Highly Informative Direct
Biological Process (BP) regulation of cyclic nucleotide metabolic process 1.422e-14 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 8.945e-13 Highly Informative Direct
Biological Process (BP) hormone transport 1.495e-12 Highly Informative Direct
Biological Process (BP) cellular response to peptide 1.673e-11 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 2.094e-11 Highly Informative Direct
Biological Process (BP) amide transport 5.74e-11 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 9.409e-10 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 1.444e-06 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 3.146e-05 Highly Informative Direct
Biological Process (BP) angiogenesis 7.892e-05 Highly Informative Direct
Biological Process (BP) regulation of peptide transport 0.0005002 Highly Informative Direct
Biological Process (BP) signal release 0.001514 Highly Informative Inherited
Molecular Function (MF) binding 0.002127 Least Informative Inherited
Molecular Function (MF) amide binding 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) receptor binding 0.002083 Informative Inherited
Molecular Function (MF) peptide binding 0 Highly Informative Direct
Molecular Function (MF) G-protein coupled receptor activity 0 Highly Informative Direct
Molecular Function (MF) hormone binding 0 Highly Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) protein complex 0.5353 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.5645 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 1.608e-15 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 8.686e-10 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0.0001765 Moderately Informative Direct
Cellular Component (CC) cell surface 4.925e-07 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 6.489e-05 Informative Direct
Cellular Component (CC) Golgi apparatus 0.0001498 Informative Direct
Cellular Component (CC) receptor complex 2.676e-05 Highly Informative Direct

Document: GO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.0001677Least InformativeDirect
Mammalian Phenotype (MP)abnormal hormone level0.0005939Moderately InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentEndosome7.889e-05Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationTransducer0InformativeDirect
Post-translational modificationG-protein coupled receptor0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Hormone receptor domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Hormone receptor domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]