SUPERFAMILY 1.75 HMM library and genome assignments server


Rap/Ran-GAP superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Multi-domain proteins (alpha and beta) [ 56572] (66)
Fold:   Rap/Ran-GAP [ 111346]
Superfamily:   Rap/Ran-GAP [ 111347]
Families:   Rap/Ran-GAP [ 111348]


Superfamily statistics
Genomes (314) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 1,809 1,758 1
Proteins 1,717 1,702 1


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) response to stimulus 8.101e-07 Least Informative Direct
Biological Process (BP) regulation of metabolic process 3.374e-05 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.001615 Least Informative Inherited
Biological Process (BP) localization 0.1061 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.7403 Least Informative Inherited
Biological Process (BP) developmental process 0.314 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.536 Least Informative Inherited
Biological Process (BP) regulation of cell communication 0 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 2.258e-14 Moderately Informative Direct
Biological Process (BP) regulation of cellular metabolic process 2.846e-06 Moderately Informative Direct
Biological Process (BP) regulation of localization 6.965e-06 Moderately Informative Direct
Biological Process (BP) nervous system development 0.0003213 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.000323 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.01671 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.5828 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.3609 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.2568 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.02707 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 0.3191 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.7469 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.8126 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.9924 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.005323 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.01248 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.002726 Moderately Informative Inherited
Biological Process (BP) organ development 0.1627 Moderately Informative Inherited
Biological Process (BP) tissue development 0.003115 Moderately Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0 Informative Direct
Biological Process (BP) nucleocytoplasmic transport 6.358e-10 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 1.089e-09 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 5.153e-09 Informative Direct
Biological Process (BP) cytoplasmic transport 1.27e-06 Informative Direct
Biological Process (BP) chordate embryonic development 1.854e-06 Informative Direct
Biological Process (BP) tube development 2.752e-06 Informative Direct
Biological Process (BP) tissue morphogenesis 5.753e-06 Informative Direct
Biological Process (BP) embryonic morphogenesis 6.552e-06 Informative Direct
Biological Process (BP) intracellular signal transduction 1.947e-05 Informative Direct
Biological Process (BP) cardiovascular system development 2.065e-05 Informative Direct
Biological Process (BP) epithelium development 2.3e-05 Informative Direct
Biological Process (BP) response to external stimulus 9.253e-05 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.0002147 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.0003871 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.0004923 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0005357 Informative Direct
Biological Process (BP) regulation of protein localization 0.01657 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.001456 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.7689 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.2976 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.3873 Informative Inherited
Biological Process (BP) protein localization to organelle 0.002042 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.0122 Informative Inherited
Biological Process (BP) negative regulation of cellular metabolic process 0.7841 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.003678 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.009275 Informative Inherited
Biological Process (BP) locomotion 0.001226 Informative Inherited
Biological Process (BP) protein transport 0.002078 Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of Ras protein signal transduction 0 Highly Informative Direct
Biological Process (BP) regulation of purine nucleotide catabolic process 0 Highly Informative Direct
Biological Process (BP) tube formation 9.391e-13 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 1.645e-12 Highly Informative Direct
Biological Process (BP) protein localization to nucleus 1.075e-11 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 1.151e-11 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 1.774e-11 Highly Informative Direct
Biological Process (BP) nuclear import 3.125e-11 Highly Informative Direct
Biological Process (BP) morphogenesis of embryonic epithelium 6.416e-11 Highly Informative Direct
Biological Process (BP) response to hypoxia 1.982e-10 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 2.388e-10 Highly Informative Direct
Biological Process (BP) protein import 4.619e-10 Highly Informative Direct
Biological Process (BP) epithelial tube morphogenesis 1.948e-08 Highly Informative Direct
Biological Process (BP) multi-organism behavior 1.26e-06 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 3.625e-06 Highly Informative Direct
Biological Process (BP) negative regulation of phosphorylation 1.7e-05 Highly Informative Direct
Biological Process (BP) chemotaxis 0.0001914 Highly Informative Direct
Biological Process (BP) regulation of cellular component size 0.0002706 Highly Informative Direct
Biological Process (BP) negative regulation of signal transduction 0.4181 Highly Informative Inherited
Biological Process (BP) small GTPase mediated signal transduction 0.008938 Highly Informative Inherited
Molecular Function (MF) binding 0.03676 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) protein binding 3.728e-05 Moderately Informative Direct
Molecular Function (MF) enzyme activator activity 0 Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) protein dimerization activity 0.0003558 Informative Direct
Molecular Function (MF) GTPase activator activity 0 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 0.0007829 Highly Informative Direct
Molecular Function (MF) small GTPase regulator activity 0.01707 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)tumorigenesis0Moderately InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male genitalia0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)intestine0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)gamete0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0Moderately InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
DomainCoiled coil7.792e-14Moderately InformativeDirect
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0.0007993Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Rap/Ran-GAP domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Rap/Ran-GAP superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]