SUPERFAMILY 1.75 HMM library and genome assignments server


NAD kinase/diacylglycerol kinase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Multi-domain proteins (alpha and beta) [ 56572] (66)
Fold:   NAD kinase/diacylglycerol kinase-like [ 111330]
Superfamily:   NAD kinase/diacylglycerol kinase-like [ 111331] (2)
Families:   NAD kinase-like [ 111332]
  Diacylglycerol kinase-like [ 160984] (2)


Superfamily statistics
Genomes (3,069) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 11,582 46,259 7
Proteins 11,409 46,107 7


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process0.057320.7741Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.034061Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.046770.008446Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.056741Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.035331Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.043645.231e-11Least InformativeInherited
Biological Process (BP)response to stimulus0.53850.007358Least InformativeInherited
Biological Process (BP)regulation of cellular process0.19850.006303Least InformativeInherited
Biological Process (BP)multicellular organismal process0.071660.03573Least InformativeInherited
Biological Process (BP)developmental process0.080340.5089Least InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.00031330Moderately InformativeDirect
Biological Process (BP)organophosphate metabolic process0.0003467.972e-05Moderately InformativeDirect
Biological Process (BP)cofactor metabolic process4.759e-062.109e-07Moderately InformativeDirect
Biological Process (BP)nucleobase-containing small molecule metabolic process0.00010692.988e-05Moderately InformativeDirect
Biological Process (BP)heterocycle biosynthetic process0.00016040.02633Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.00013710.02539Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.00036060.07094Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.00039560.0094Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process8.858e-050.02655Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.0025020.966Moderately InformativeInherited
Biological Process (BP)nervous system development4.757e-050.0145Moderately InformativeInherited
Biological Process (BP)organ development0.0011590.7308Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.00021460.2308Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.013041Moderately InformativeInherited
Biological Process (BP)regulation of cytokine production8.219e-090.0005553InformativeDirect
Biological Process (BP)oxidoreduction coenzyme metabolic process4.301e-100InformativeDirect
Biological Process (BP)nucleotide biosynthetic process2.22e-080.0005371InformativeDirect
Biological Process (BP)response to wounding8.179e-071.515e-10InformativeDirect
Biological Process (BP)pyridine-containing compound metabolic process4.888e-100InformativeDirect
Biological Process (BP)coenzyme biosynthetic process2.379e-080.01223InformativeInherited
Biological Process (BP)regulation of cell proliferation6.543e-060.01587InformativeInherited
Biological Process (BP)central nervous system development8.286e-080.003157InformativeInherited
Biological Process (BP)cardiovascular system development9.925e-080.00192InformativeInherited
Biological Process (BP)regulation of interleukin-1 beta production5.668e-143.328e-13Highly InformativeDirect
Biological Process (BP)nicotinamide nucleotide metabolic process5.735e-110Highly InformativeDirect
Biological Process (BP)pyridine-containing compound biosynthetic process8.903e-130Highly InformativeDirect
Molecular Function (MF)binding0.27610.8326Least InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups1.743e-090Moderately InformativeDirect
Molecular Function (MF)anion binding0.014850.1723Moderately InformativeInherited
Molecular Function (MF)nucleotide binding2.352e-061.1e-06InformativeDirect
Molecular Function (MF)kinase activity2.261e-100InformativeDirect
Molecular Function (MF)purine ribonucleoside binding4.131e-071.318e-08InformativeDirect
Molecular Function (MF)purine ribonucleoside triphosphate binding2.153e-071.479e-05InformativeDirect
Molecular Function (MF)cofactor binding1.026e-082.221e-06InformativeDirect
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor0.079790.1054InformativeInherited
Molecular Function (MF)ATP binding1.346e-103.474e-11Highly InformativeDirect
Molecular Function (MF)NAD binding6.975e-148.268e-08Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 5.231e-11 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.008446 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.7741 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.03573 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.006303 Least Informative Inherited
Biological Process (BP) response to stimulus 0.007358 Least Informative Inherited
Biological Process (BP) developmental process 0.5089 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 7.972e-05 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 2.109e-07 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 2.988e-05 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 0.2139 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.02757 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.966 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.876 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.2308 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.1416 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.8422 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.195 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.5063 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.06747 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.02633 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.02539 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.07094 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.0094 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.02655 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.0145 Moderately Informative Inherited
Biological Process (BP) organ development 0.7308 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.01186 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cytokine production 0.0005553 Informative Direct
Biological Process (BP) membrane lipid metabolic process 3.741e-11 Informative Direct
Biological Process (BP) oxidoreduction coenzyme metabolic process 0 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.0005371 Informative Direct
Biological Process (BP) response to wounding 1.515e-10 Informative Direct
Biological Process (BP) phosphorylation 9.866e-05 Informative Direct
Biological Process (BP) negative regulation of catalytic activity 6.332e-05 Informative Direct
Biological Process (BP) regulation of body fluid levels 5.902e-07 Informative Direct
Biological Process (BP) pyridine-containing compound metabolic process 0 Informative Direct
Biological Process (BP) protein complex assembly 0.0028 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.4858 Informative Inherited
Biological Process (BP) cell-cell signaling 0.1365 Informative Inherited
Biological Process (BP) regulation of locomotion 0.002283 Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0.01731 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.09725 Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 0.03894 Informative Inherited
Biological Process (BP) response to nutrient levels 0.02484 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.449 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.03456 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 0.01223 Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.7476 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.01587 Informative Inherited
Biological Process (BP) central nervous system development 0.003157 Informative Inherited
Biological Process (BP) transmission of nerve impulse 0.5728 Informative Inherited
Biological Process (BP) cardiovascular system development 0.00192 Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 9.018e-14 Highly Informative Direct
Biological Process (BP) hemostasis 2.615e-09 Highly Informative Direct
Biological Process (BP) polyol metabolic process 1.817e-05 Highly Informative Direct
Biological Process (BP) lipid modification 5.851e-09 Highly Informative Direct
Biological Process (BP) regulation of interleukin-1 beta production 3.328e-13 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0.0002168 Highly Informative Direct
Biological Process (BP) nicotinamide nucleotide metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of behavior 0.0007925 Highly Informative Direct
Biological Process (BP) coagulation 8.704e-09 Highly Informative Direct
Biological Process (BP) pyridine-containing compound biosynthetic process 0 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 0.01434 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.01083 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.04149 Highly Informative Inherited
Biological Process (BP) wound healing 0.3763 Highly Informative Inherited
Molecular Function (MF) binding 0.8326 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.1723 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.002789 Moderately Informative Inherited
Molecular Function (MF) cation binding 1 Moderately Informative Inherited
Molecular Function (MF) nucleotide binding 1.1e-06 Informative Direct
Molecular Function (MF) magnesium ion binding 6.402e-06 Informative Direct
Molecular Function (MF) enzyme inhibitor activity 3.983e-08 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) enzyme binding 8.144e-06 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 1.318e-08 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 1.479e-05 Informative Direct
Molecular Function (MF) cofactor binding 2.221e-06 Informative Direct
Molecular Function (MF) GTPase regulator activity 0.004475 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.1054 Informative Inherited
Molecular Function (MF) ATP binding 3.474e-11 Highly Informative Direct
Molecular Function (MF) Ras GTPase binding 1.002e-12 Highly Informative Direct
Molecular Function (MF) NAD binding 8.268e-08 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 3.325e-05 Least Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cell projection 0.2613 Moderately Informative Inherited
Cellular Component (CC) neuron projection 0.03728 Informative Inherited
Cellular Component (CC) perinuclear region of cytoplasm 9.239e-05 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)isothermal tracking behavior variant1.215e-06Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)anatomical group0Least InformativeDirect
Fly Anatomy (FA)cell0.2987Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.5008Least InformativeInherited
Fly Anatomy (FA)organ system0.8512Least InformativeInherited
Fly Anatomy (FA)sense organ0Moderately InformativeDirect
Fly Anatomy (FA)cell cluster organ0Moderately InformativeDirect
Fly Anatomy (FA)neuron0.08463Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.1016Moderately InformativeInherited
Fly Anatomy (FA)cell component0.02952InformativeInherited

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase (ATP)0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processLipid biosynthesis3.185e-05InformativeDirect
Biological processPlant defense0.0004584InformativeDirect
Biological processPhospholipid metabolism0Highly InformativeDirect
Biological processSphingolipid metabolism4.817e-05Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
DomainZinc-finger1.038e-05Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionNADP0InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism3.647e-08Least InformativeDirect
UniPathway (UP)alcohol metabolism5.048e-11Moderately InformativeDirect
UniPathway (UP)glycerol metabolism1.658e-12InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a NAD kinase/diacylglycerol kinase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the NAD kinase/diacylglycerol kinase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]