SUPERFAMILY 1.75 HMM library and genome assignments server

Please note: Superfamily is currently under maintenance and some functionality may be limited. Please bear with us as we fix these problems.


NAD kinase/diacylglycerol kinase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Multi-domain proteins (alpha and beta) [ 56572] (66)
Fold:   NAD kinase/diacylglycerol kinase-like [ 111330]
Superfamily:   NAD kinase/diacylglycerol kinase-like [ 111331] (2)
Families:   NAD kinase-like [ 111332]
  Diacylglycerol kinase-like [ 160984] (2)


Superfamily statistics
Genomes (3,077) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 11,788 46,259 7
Proteins 11,611 46,107 7


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process0.012020.6675Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.032811Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.02980.006254Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.033261Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.034041Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.012040.00000000001013Least InformativeInherited
Biological Process (BP)response to stimulus0.65090.006311Least InformativeInherited
Biological Process (BP)regulation of cellular process0.26150.004839Least InformativeInherited
Biological Process (BP)multicellular organismal process0.10340.02843Least InformativeInherited
Biological Process (BP)developmental process0.1120.4869Least InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.00011930Moderately InformativeDirect
Biological Process (BP)organophosphate metabolic process0.000096180.00005616Moderately InformativeDirect
Biological Process (BP)cofactor metabolic process0.00000080230.00000009309Moderately InformativeDirect
Biological Process (BP)nucleobase-containing small molecule metabolic process0.000025290.000007468Moderately InformativeDirect
Biological Process (BP)heterocycle biosynthetic process0.000037760.01672Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.000032740.01365Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.000096180.03731Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.00075940.009696Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.000018750.01523Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.0041Moderately InformativeInherited
Biological Process (BP)nervous system development0.000076660.01284Moderately InformativeInherited
Biological Process (BP)organ development0.0018450.7071Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.00034650.2834Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.019131Moderately InformativeInherited
Biological Process (BP)regulation of cytokine production0.000000013510.0005545InformativeDirect
Biological Process (BP)oxidoreduction coenzyme metabolic process0.000000000015530InformativeDirect
Biological Process (BP)nucleotide biosynthetic process0.0000000015890.0002633InformativeDirect
Biological Process (BP)response to wounding0.0000013280.0000000001225InformativeDirect
Biological Process (BP)pyridine-containing compound metabolic process0.000000000017920InformativeDirect
Biological Process (BP)coenzyme biosynthetic process0.0000000018410.007499InformativeInherited
Biological Process (BP)regulation of cell proliferation0.000010470.02033InformativeInherited
Biological Process (BP)central nervous system development0.00000013730.003038InformativeInherited
Biological Process (BP)cardiovascular system development0.00000017320.001701InformativeInherited
Biological Process (BP)regulation of interleukin-1 beta production0.000000000000091740.0000000000003027Highly InformativeDirect
Biological Process (BP)nicotinamide nucleotide metabolic process0.0000000000015680Highly InformativeDirect
Biological Process (BP)pyridine-containing compound biosynthetic process0.000000000000012510Highly InformativeDirect
Molecular Function (MF)transferase activity0.0000031530Least InformativeDirect
Molecular Function (MF)binding0.27740.8238Least InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups0.000000000016330Moderately InformativeDirect
Molecular Function (MF)anion binding0.0071720.1949Moderately InformativeInherited
Molecular Function (MF)nucleotide binding0.00000028810.0000001667InformativeDirect
Molecular Function (MF)kinase activity0.0000000000013840InformativeDirect
Molecular Function (MF)purine ribonucleoside binding0.000000037850.000000001236InformativeDirect
Molecular Function (MF)purine ribonucleoside triphosphate binding0.000000018120.000005174InformativeDirect
Molecular Function (MF)cofactor binding0.00000000077630.0000002948InformativeDirect
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor0.03430.1084InformativeInherited
Molecular Function (MF)ATP binding0.0000000000054730.000000000002115Highly InformativeDirect
Molecular Function (MF)NAD binding0.0000000000000013340.00000001255Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.00000000001013 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.006254 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.6675 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.02843 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.004839 Least Informative Inherited
Biological Process (BP) response to stimulus 0.006311 Least Informative Inherited
Biological Process (BP) developmental process 0.4869 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.00005616 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.00000009309 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.000007468 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 0.213 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.0254 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.8668 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.2834 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.1199 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.8226 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.1869 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.4998 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.0906 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.01672 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.01365 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.03731 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.009696 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.01523 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.01284 Moderately Informative Inherited
Biological Process (BP) organ development 0.7071 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.01841 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cytokine production 0.0005545 Informative Direct
Biological Process (BP) membrane lipid metabolic process 0.000000000002155 Informative Direct
Biological Process (BP) oxidoreduction coenzyme metabolic process 0 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.0002633 Informative Direct
Biological Process (BP) response to wounding 0.0000000001225 Informative Direct
Biological Process (BP) phosphorylation 0.00002522 Informative Direct
Biological Process (BP) negative regulation of catalytic activity 0.00005573 Informative Direct
Biological Process (BP) regulation of body fluid levels 0.0000005904 Informative Direct
Biological Process (BP) protein oligomerization 0.0000002348 Informative Direct
Biological Process (BP) pyridine-containing compound metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.4858 Informative Inherited
Biological Process (BP) regulation of locomotion 0.002939 Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0.01874 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.1002 Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 0.04063 Informative Inherited
Biological Process (BP) response to nutrient levels 0.02694 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.4077 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.04184 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 0.007499 Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.7904 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.02033 Informative Inherited
Biological Process (BP) central nervous system development 0.003038 Informative Inherited
Biological Process (BP) synaptic transmission 0.8571 Informative Inherited
Biological Process (BP) cardiovascular system development 0.001701 Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 0.00000000000007655 Highly Informative Direct
Biological Process (BP) hemostasis 0.000000002497 Highly Informative Direct
Biological Process (BP) polyol metabolic process 0.00001691 Highly Informative Direct
Biological Process (BP) lipid modification 0.000000002932 Highly Informative Direct
Biological Process (BP) regulation of interleukin-1 beta production 0.0000000000003027 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0.0002167 Highly Informative Direct
Biological Process (BP) nicotinamide nucleotide metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of behavior 0.0007209 Highly Informative Direct
Biological Process (BP) coagulation 0.000000009615 Highly Informative Direct
Biological Process (BP) pyridine-containing compound biosynthetic process 0 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 0.01616 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.01268 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.03776 Highly Informative Inherited
Biological Process (BP) wound healing 0.3901 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.8238 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.1949 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.003505 Moderately Informative Inherited
Molecular Function (MF) cation binding 1 Moderately Informative Inherited
Molecular Function (MF) nucleotide binding 0.0000001667 Informative Direct
Molecular Function (MF) magnesium ion binding 0.00006818 Informative Direct
Molecular Function (MF) enzyme inhibitor activity 0.00000003491 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) enzyme binding 0.000009806 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 0.000000001236 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.000005174 Informative Direct
Molecular Function (MF) cofactor binding 0.0000002948 Informative Direct
Molecular Function (MF) GTPase regulator activity 0.004294 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.1084 Informative Inherited
Molecular Function (MF) ATP binding 0.000000000002115 Highly Informative Direct
Molecular Function (MF) Ras GTPase binding 0.000000000001272 Highly Informative Direct
Molecular Function (MF) NAD binding 0.00000001255 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.000009902 Least Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) perinuclear region of cytoplasm 0.0001173 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)isothermal tracking behavior variant0.000001215Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)anatomical group0Least InformativeDirect
Fly Anatomy (FA)external sensory organ0Moderately InformativeDirect
Fly Anatomy (FA)sensillum0Moderately InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase (ATP)0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processLipid biosynthesis0.00002317InformativeDirect
Biological processPlant defense0.0004593InformativeDirect
Biological processPhospholipid metabolism0Highly InformativeDirect
Biological processSphingolipid metabolism0.00005115Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
DomainZinc-finger0.00001045Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionNADP0InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)polyol metabolism0.00000000000001258InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a NAD kinase/diacylglycerol kinase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the NAD kinase/diacylglycerol kinase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]