SUPERFAMILY 1.75 HMM library and genome assignments server


NAD kinase/diacylglycerol kinase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Multi-domain proteins (alpha and beta) [ 56572] (66)
Fold:   NAD kinase/diacylglycerol kinase-like [ 111330]
Superfamily:   NAD kinase/diacylglycerol kinase-like [ 111331] (2)
Families:   NAD kinase-like [ 111332]
  Diacylglycerol kinase-like [ 160984] (2)


Superfamily statistics
Genomes (3,033) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 11,135 20,433 7
Proteins 10,998 20,327 7


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process0.06480.8685Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.039721Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.055580.02282Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.065991Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.041371Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.05335.572e-09Least InformativeInherited
Biological Process (BP)response to stimulus0.56060.001758Least InformativeInherited
Biological Process (BP)regulation of cellular process0.21260.008251Least InformativeInherited
Biological Process (BP)multicellular organismal process0.076240.007481Least InformativeInherited
Biological Process (BP)developmental process0.085430.3077Least InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.00040030Moderately InformativeDirect
Biological Process (BP)organophosphate metabolic process0.00041250.0001591Moderately InformativeDirect
Biological Process (BP)cofactor metabolic process5.777e-064.423e-07Moderately InformativeDirect
Biological Process (BP)nucleobase-containing small molecule metabolic process0.00012498.767e-06Moderately InformativeDirect
Biological Process (BP)heterocycle biosynthetic process0.00018460.02457Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.00015640.01974Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.00042490.05184Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.00041250.00962Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.0001030.02295Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.0026991Moderately InformativeInherited
Biological Process (BP)nervous system development5.201e-050.004804Moderately InformativeInherited
Biological Process (BP)organ development0.0012320.5202Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.00021490.1519Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.014810.9789Moderately InformativeInherited
Biological Process (BP)regulation of cytokine production6.503e-090.0005398InformativeDirect
Biological Process (BP)positive regulation of cell proliferation3.099e-071.491e-06InformativeDirect
Biological Process (BP)nucleotide biosynthetic process2.216e-080.0005158InformativeDirect
Biological Process (BP)response to wounding1.062e-063.027e-11InformativeDirect
Biological Process (BP)cardiovascular system development1.119e-070.0009407InformativeDirect
Biological Process (BP)pyridine-containing compound metabolic process5.837e-100InformativeDirect
Biological Process (BP)coenzyme biosynthetic process2.614e-080.01134InformativeInherited
Biological Process (BP)central nervous system development9.115e-080.001374InformativeInherited
Biological Process (BP)regulation of interleukin-1 beta production7.591e-141.701e-13Highly InformativeDirect
Biological Process (BP)nicotinamide nucleotide metabolic process6.929e-110Highly InformativeDirect
Biological Process (BP)pyridine-containing compound biosynthetic process8.537e-130Highly InformativeDirect
Molecular Function (MF)binding0.29770.8814Least InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups2.105e-090Moderately InformativeDirect
Molecular Function (MF)anion binding0.014190.2217Moderately InformativeInherited
Molecular Function (MF)nucleotide binding2.596e-062.59e-07InformativeDirect
Molecular Function (MF)kinase activity2.728e-100InformativeDirect
Molecular Function (MF)purine ribonucleoside binding4.635e-072.428e-09InformativeDirect
Molecular Function (MF)purine ribonucleoside triphosphate binding2.335e-071.113e-06InformativeDirect
Molecular Function (MF)cofactor binding1.072e-081.006e-06InformativeDirect
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor0.080910.1681InformativeInherited
Molecular Function (MF)ATP binding1.421e-105.567e-12Highly InformativeDirect
Molecular Function (MF)NAD binding8.542e-141.039e-07Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 5.572e-09 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.02282 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.9066 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.8685 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.007481 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.008251 Least Informative Inherited
Biological Process (BP) response to stimulus 0.001758 Least Informative Inherited
Biological Process (BP) developmental process 0.3077 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.0001591 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 4.423e-07 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 8.767e-06 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 0.1367 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.01341 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.9817 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.1519 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.1338 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.628 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.3725 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.06462 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.02457 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.01974 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.05184 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.00962 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.02295 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.004804 Moderately Informative Inherited
Biological Process (BP) organ development 0.5202 Moderately Informative Inherited
Biological Process (BP) system process 0.994 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.01373 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.9789 Moderately Informative Inherited
Biological Process (BP) cell activation 3.574e-05 Informative Direct
Biological Process (BP) regulation of cytokine production 0.0005398 Informative Direct
Biological Process (BP) membrane lipid metabolic process 1.278e-11 Informative Direct
Biological Process (BP) positive regulation of cell proliferation 1.491e-06 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.0005158 Informative Direct
Biological Process (BP) response to wounding 3.027e-11 Informative Direct
Biological Process (BP) phosphorylation 1.309e-05 Informative Direct
Biological Process (BP) negative regulation of catalytic activity 0.0008238 Informative Direct
Biological Process (BP) regulation of body fluid levels 6.885e-07 Informative Direct
Biological Process (BP) cardiovascular system development 0.0009407 Informative Direct
Biological Process (BP) pyridine-containing compound metabolic process 0 Informative Direct
Biological Process (BP) protein complex assembly 0.003058 Informative Inherited
Biological Process (BP) cell-cell signaling 0.1034 Informative Inherited
Biological Process (BP) regulation of locomotion 0.001544 Informative Inherited
Biological Process (BP) response to nutrient levels 0.01605 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.5639 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.02947 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 0.01134 Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.8124 Informative Inherited
Biological Process (BP) central nervous system development 0.001374 Informative Inherited
Biological Process (BP) transmission of nerve impulse 0.5155 Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 2.006e-13 Highly Informative Direct
Biological Process (BP) hemostasis 1.229e-09 Highly Informative Direct
Biological Process (BP) polyol metabolic process 1.093e-05 Highly Informative Direct
Biological Process (BP) lipid modification 2.236e-08 Highly Informative Direct
Biological Process (BP) regulation of interleukin-1 beta production 1.701e-13 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0.0001389 Highly Informative Direct
Biological Process (BP) nicotinamide nucleotide metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of behavior 0.0004319 Highly Informative Direct
Biological Process (BP) coagulation 1.153e-08 Highly Informative Direct
Biological Process (BP) pyridine-containing compound biosynthetic process 0 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 0.0116 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.008678 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.02657 Highly Informative Inherited
Biological Process (BP) wound healing 0.3671 Highly Informative Inherited
Molecular Function (MF) binding 0.8814 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.2217 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.0207 Moderately Informative Inherited
Molecular Function (MF) cation binding 1 Moderately Informative Inherited
Molecular Function (MF) nucleotide binding 2.59e-07 Informative Direct
Molecular Function (MF) magnesium ion binding 3.309e-06 Informative Direct
Molecular Function (MF) enzyme inhibitor activity 2.391e-06 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) enzyme binding 5.301e-05 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 2.428e-09 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 1.113e-06 Informative Direct
Molecular Function (MF) cofactor binding 1.006e-06 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.1681 Informative Inherited
Molecular Function (MF) ATP binding 5.567e-12 Highly Informative Direct
Molecular Function (MF) Ras GTPase binding 1.753e-10 Highly Informative Direct
Molecular Function (MF) NAD binding 1.039e-07 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 3.38e-05 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.6034 Least Informative Inherited
Cellular Component (CC) cell projection 0.1441 Moderately Informative Inherited
Cellular Component (CC) endosome 0.0002842 Informative Direct
Cellular Component (CC) neuron projection 0.03855 Informative Inherited
Cellular Component (CC) perinuclear region of cytoplasm 0.0008332 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)isothermal tracking behavior variant1.215e-06Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)anatomical group0Least InformativeDirect
Fly Anatomy (FA)sense organ0Moderately InformativeDirect
Fly Anatomy (FA)cell cluster organ0Moderately InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase (ATP)0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processLipid biosynthesis2.625e-05InformativeDirect
Biological processPlant defense0.0003738InformativeDirect
Biological processPhospholipid metabolism0Highly InformativeDirect
Biological processSphingolipid metabolism4.901e-05Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
DomainZinc-finger9.983e-06Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionNADP0InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism7.769e-07Least InformativeDirect
UniPathway (UP)glycerol metabolism5.693e-11InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a NAD kinase/diacylglycerol kinase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the NAD kinase/diacylglycerol kinase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]