SUPERFAMILY 1.75 HMM library and genome assignments server


NAD kinase/diacylglycerol kinase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Multi-domain proteins (alpha and beta) [ 56572] (66)
Fold:   NAD kinase/diacylglycerol kinase-like [ 111330]
Superfamily:   NAD kinase/diacylglycerol kinase-like [ 111331] (2)
Families:   NAD kinase-like [ 111332]
  Diacylglycerol kinase-like [ 160984] (2)


Superfamily statistics
Genomes (2,401) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 9,468 20,433 7
Proteins 9,333 20,327 7


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)heterocycle metabolic process0.39121Least InformativeInherited
Biological Process (BP)biosynthetic process0.28870.8345Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.40290.02361Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.48751Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.40271Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.20331.361e-11Least InformativeInherited
Biological Process (BP)response to stimulus0.52520.004917Least InformativeInherited
Biological Process (BP)regulation of cellular process0.17540.009767Least InformativeInherited
Biological Process (BP)multicellular organismal process0.059430.02665Least InformativeInherited
Biological Process (BP)developmental process0.065980.4767Least InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.02880.2175Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.032340.2532Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.042930.3808Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.048950.09537Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.061284.654e-12Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process0.043020.0001641Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process0.02230.0003798Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.019190.2236Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.0018330.9513Moderately InformativeInherited
Biological Process (BP)nervous system development3.952e-050.0182Moderately InformativeInherited
Biological Process (BP)organ development0.00082210.7309Moderately InformativeInherited
Biological Process (BP)cofactor metabolic process0.0055515.073e-05Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.00012850.1723Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.011341Moderately InformativeInherited
Biological Process (BP)regulation of cytokine production4.712e-090.0002683InformativeDirect
Biological Process (BP)oxidoreduction coenzyme metabolic process3.46e-052.091e-12InformativeDirect
Biological Process (BP)response to wounding9.106e-079.248e-11InformativeDirect
Biological Process (BP)pyridine-containing compound metabolic process3.63e-053.555e-11InformativeDirect
Biological Process (BP)coenzyme biosynthetic process0.00030710.1134InformativeInherited
Biological Process (BP)nucleotide biosynthetic process0.00023060.05292InformativeInherited
Biological Process (BP)regulation of cell proliferation5.182e-060.009275InformativeInherited
Biological Process (BP)central nervous system development7.217e-080.002208InformativeInherited
Biological Process (BP)cardiovascular system development7.826e-080.001417InformativeInherited
Biological Process (BP)regulation of interleukin-1 production2.893e-145.683e-13Highly InformativeDirect
Biological Process (BP)nicotinamide nucleotide metabolic process1.12e-059.36e-14Highly InformativeDirect
Biological Process (BP)pyridine-containing compound biosynthetic process7.722e-076.168e-10Highly InformativeDirect
Molecular Function (MF)transferase activity0.012710Least InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups4.47e-050Moderately InformativeDirect
Molecular Function (MF)kinase activity1.224e-050InformativeDirect
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor0.34860.2306InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 1.361e-11 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.02361 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.8365 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.8345 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.02665 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.009767 Least Informative Inherited
Biological Process (BP) response to stimulus 0.004917 Least Informative Inherited
Biological Process (BP) developmental process 0.4767 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.7225 Least Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 4.654e-12 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.0001641 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 5.073e-05 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.0003798 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.008262 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.08864 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.1006 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.1723 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.5724 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.4178 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.05256 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.8195 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.09537 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.2175 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.2532 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.3808 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.2236 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.9513 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.0182 Moderately Informative Inherited
Biological Process (BP) organ development 0.7309 Moderately Informative Inherited
Biological Process (BP) system process 0.9856 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.01168 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.05707 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) cell activation 3.082e-05 Informative Direct
Biological Process (BP) regulation of cytokine production 0.0002683 Informative Direct
Biological Process (BP) membrane lipid metabolic process 4.412e-11 Informative Direct
Biological Process (BP) oxidoreduction coenzyme metabolic process 2.091e-12 Informative Direct
Biological Process (BP) response to wounding 9.248e-11 Informative Direct
Biological Process (BP) regulation of body fluid levels 8.114e-07 Informative Direct
Biological Process (BP) protein oligomerization 3.424e-08 Informative Direct
Biological Process (BP) pyridine-containing compound metabolic process 3.555e-11 Informative Direct
Biological Process (BP) regulation of reproductive process 0.02188 Informative Inherited
Biological Process (BP) regulation of locomotion 0.002555 Informative Inherited
Biological Process (BP) response to external stimulus 0.2827 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.5922 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 0.1134 Informative Inherited
Biological Process (BP) nucleotide biosynthetic process 0.05292 Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.6512 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.009275 Informative Inherited
Biological Process (BP) central nervous system development 0.002208 Informative Inherited
Biological Process (BP) synaptic transmission 0.8094 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.01479 Informative Inherited
Biological Process (BP) cardiovascular system development 0.001417 Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 2.034e-13 Highly Informative Direct
Biological Process (BP) hemostasis 3.081e-09 Highly Informative Direct
Biological Process (BP) regulation of interleukin-1 production 5.683e-13 Highly Informative Direct
Biological Process (BP) diol metabolic process 8.013e-06 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0.0001214 Highly Informative Direct
Biological Process (BP) membrane lipid biosynthetic process 2.177e-05 Highly Informative Direct
Biological Process (BP) nicotinamide nucleotide metabolic process 9.36e-14 Highly Informative Direct
Biological Process (BP) regulation of Ras protein signal transduction 3.573e-05 Highly Informative Direct
Biological Process (BP) regulation of behavior 0.0005373 Highly Informative Direct
Biological Process (BP) coagulation 1.424e-08 Highly Informative Direct
Biological Process (BP) pyridine-containing compound biosynthetic process 6.168e-10 Highly Informative Direct
Biological Process (BP) lipid modification 0.05611 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.006259 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.03942 Highly Informative Inherited
Biological Process (BP) wound healing 0.3508 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) protein binding 1 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.02631 Moderately Informative Inherited
Molecular Function (MF) cation binding 0.2341 Moderately Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 1.012e-05 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) enzyme binding 7.41e-05 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.2306 Informative Inherited
Molecular Function (MF) magnesium ion binding 1.191e-06 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.002989 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.6727 Least Informative Inherited
Cellular Component (CC) endosome 0.0001716 Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.0003643 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)isothermal tracking behavior variant1.215e-06Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)sense organ0Moderately InformativeDirect
Fly Anatomy (FA)cell cluster organ0Moderately InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processLipid biosynthesis3.588e-05InformativeDirect
Biological processPlant defense0.0003079InformativeDirect
Biological processPhospholipid biosynthesis0Highly InformativeDirect
Biological processSphingolipid metabolism2.968e-05Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionMetal-binding1Least InformativeInherited
Molecular functionNAD0Moderately InformativeDirect
Molecular functionZinc-finger8.372e-06Moderately InformativeDirect
Molecular functionNADP0InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism3.729e-08Least InformativeDirect
UniPathway (UP)alcohol metabolism5.47e-11Moderately InformativeDirect
UniPathway (UP)glycerol metabolism1.842e-12InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a NAD kinase/diacylglycerol kinase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the NAD kinase/diacylglycerol kinase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]