SUPERFAMILY 1.75 HMM library and genome assignments server

NAD kinase/diacylglycerol kinase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Multi-domain proteins (alpha and beta) [ 56572] (66)
Fold:   NAD kinase/diacylglycerol kinase-like [ 111330]
Superfamily:   NAD kinase/diacylglycerol kinase-like [ 111331] (2)
Families:   NAD kinase-like [ 111332]
  Diacylglycerol kinase-like [ 160984] (2)


Superfamily statistics
Genomes (3,078) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 11,799 46,259 7
Proteins 11,622 46,107 7


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)nitrogen compound metabolic process0.033060.00626Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.036921Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.035561Least InformativeInherited
Biological Process (BP)single-organism cellular process0.76040.001635Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.036921Least InformativeInherited
Biological Process (BP)biosynthetic process0.011940.6332Least InformativeInherited
Biological Process (BP)positive regulation of biological process0.02081Least InformativeInherited
Biological Process (BP)regulation of cellular process0.28770.007178Least InformativeInherited
Biological Process (BP)response to stimulus0.65070.006961Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.06690.000001458Least InformativeInherited
Biological Process (BP)multicellular organismal process0.091610.1088Least InformativeInherited
Biological Process (BP)developmental process0.11390.4863Least InformativeInherited
Biological Process (BP)cofactor metabolic process0.0000012280.0000001346Moderately InformativeDirect
Biological Process (BP)nucleobase-containing small molecule metabolic process0.000037310.0003851Moderately InformativeDirect
Biological Process (BP)organophosphate metabolic process0.00013080.00007639Moderately InformativeDirect
Biological Process (BP)phosphate-containing compound metabolic process0.0001780Moderately InformativeDirect
Biological Process (BP)heterocycle biosynthetic process0.000044340.01975Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.00072350.008801Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.000039160.01596Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.00025560.4226Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.00011030.04249Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.000022770.01806Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.0068141Moderately InformativeInherited
Biological Process (BP)nervous system development0.000083910.01352Moderately InformativeInherited
Biological Process (BP)organ development0.0018120.6923Moderately InformativeInherited
Biological Process (BP)defense response0.00012640.4242Moderately InformativeInherited
Biological Process (BP)oxidoreduction coenzyme metabolic process0.000000000013850InformativeDirect
Biological Process (BP)pyridine-containing compound metabolic process0.000000000031640InformativeDirect
Biological Process (BP)nucleotide biosynthetic process0.0000000016090.0001524InformativeDirect
Biological Process (BP)regulation of cytokine production0.000000013730.0002511InformativeDirect
Biological Process (BP)regulation of cell proliferation0.000011040.02001InformativeInherited
Biological Process (BP)central nervous system development0.00000016740.003292InformativeInherited
Biological Process (BP)coenzyme biosynthetic process0.000000003690.01116InformativeInherited
Biological Process (BP)cardiovascular system development0.00000017050.001661InformativeInherited
Biological Process (BP)pyridine-containing compound biosynthetic process0.000000000000039070Highly InformativeDirect
Biological Process (BP)regulation of interleukin-1 beta production0.000000000000090140.0000000000002907Highly InformativeDirect
Biological Process (BP)nicotinamide nucleotide metabolic process0.0000000000014430Highly InformativeDirect
Biological Process (BP)inflammatory response0.0000000045150.000002775Highly InformativeDirect
Molecular Function (MF)transferase activity0.000005870Least InformativeDirect
Molecular Function (MF)binding0.28510.8544Least InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups0.000000000016930Moderately InformativeDirect
Molecular Function (MF)carbohydrate derivative binding0.00000047060.0000008687Moderately InformativeDirect
Molecular Function (MF)small molecule binding0.0000030430.000004396Moderately InformativeDirect
Molecular Function (MF)anion binding0.0071840.1977Moderately InformativeInherited
Molecular Function (MF)kinase activity0.0000000000013650InformativeDirect
Molecular Function (MF)cofactor binding0.00000000078970.0000003133InformativeDirect
Molecular Function (MF)purine ribonucleoside triphosphate binding0.000000018240.000004826InformativeDirect
Molecular Function (MF)purine ribonucleoside binding0.000000037530.000000001224InformativeDirect
Molecular Function (MF)nucleotide binding0.00000028930.0000001749InformativeDirect
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor0.035440.1087InformativeInherited
Molecular Function (MF)NAD binding0.000000000000001340.00000001217Highly InformativeDirect
Molecular Function (MF)ATP binding0.0000000000054290.000000000002111Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.000001458 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.00626 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.9988 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.007178 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 1 Least Informative Inherited
Biological Process (BP) developmental process 0.4863 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.006961 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.001635 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.6332 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.1088 Least Informative Inherited
Biological Process (BP) cofactor metabolic process 0.0000001346 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.0003851 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.00007639 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.01975 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.008801 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.1907 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.2271 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.6988 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.6096 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.189 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.6108 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.01596 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.4226 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.8814 Moderately Informative Inherited
Biological Process (BP) regulation of phosphorus metabolic process 0.6685 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.01701 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.1087 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.04249 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.01806 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.01352 Moderately Informative Inherited
Biological Process (BP) organ development 0.6923 Moderately Informative Inherited
Biological Process (BP) defense response 0.4242 Moderately Informative Inherited
Biological Process (BP) oxidoreduction coenzyme metabolic process 0 Informative Direct
Biological Process (BP) pyridine-containing compound metabolic process 0 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.0001524 Informative Direct
Biological Process (BP) regulation of cytokine production 0.0002511 Informative Direct
Biological Process (BP) phosphorylation 0.0002027 Informative Direct
Biological Process (BP) membrane lipid metabolic process 0.000000000002047 Informative Direct
Biological Process (BP) protein oligomerization 0.0000002535 Informative Direct
Biological Process (BP) regulation of body fluid levels 0.0000002825 Informative Direct
Biological Process (BP) negative regulation of catalytic activity 0.00006234 Informative Direct
Biological Process (BP) positive regulation of intracellular signal transduction 0.04356 Informative Inherited
Biological Process (BP) regulation of locomotion 0.002938 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.03932 Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0.01826 Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 0.04078 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.1328 Informative Inherited
Biological Process (BP) response to nutrient levels 0.03148 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.5164 Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.747 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.02001 Informative Inherited
Biological Process (BP) central nervous system development 0.003292 Informative Inherited
Biological Process (BP) synaptic transmission 0.5561 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 0.01116 Informative Inherited
Biological Process (BP) cardiovascular system development 0.001661 Informative Inherited
Biological Process (BP) pyridine-containing compound biosynthetic process 0 Highly Informative Direct
Biological Process (BP) regulation of interleukin-1 beta production 0.0000000000002907 Highly Informative Direct
Biological Process (BP) nicotinamide nucleotide metabolic process 0 Highly Informative Direct
Biological Process (BP) inflammatory response 0.000002775 Highly Informative Direct
Biological Process (BP) G-protein coupled receptor signaling pathway 0.00000000000007575 Highly Informative Direct
Biological Process (BP) hemostasis 0.00000000237 Highly Informative Direct
Biological Process (BP) lipid modification 0.000000003031 Highly Informative Direct
Biological Process (BP) coagulation 0.000000003048 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0.0004735 Highly Informative Direct
Biological Process (BP) regulation of reproductive process 0.006957 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.03845 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.03659 Highly Informative Inherited
Biological Process (BP) regulation of Ras GTPase activity 0.4525 Highly Informative Inherited
Biological Process (BP) wound healing 0.03005 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.8544 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.0000008687 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.000004396 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.0007642 Moderately Informative Direct
Molecular Function (MF) anion binding 0.1977 Moderately Informative Inherited
Molecular Function (MF) cation binding 1 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) cofactor binding 0.0000003133 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.000004826 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 0.000000001224 Informative Direct
Molecular Function (MF) nucleotide binding 0.0000001749 Informative Direct
Molecular Function (MF) enzyme inhibitor activity 0.00000003586 Informative Direct
Molecular Function (MF) enzyme binding 0.00001132 Informative Direct
Molecular Function (MF) magnesium ion binding 0.00006973 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.1087 Informative Inherited
Molecular Function (MF) NAD binding 0.00000001217 Highly Informative Direct
Molecular Function (MF) ATP binding 0.000000000002111 Highly Informative Direct
Molecular Function (MF) Ras GTPase binding 0.000000000001495 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.00001134 Least Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) perinuclear region of cytoplasm 0.000125 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)isothermal tracking behavior variant0.000001215Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)anatomical group0Least InformativeDirect
Fly Anatomy (FA)external sensory organ0Moderately InformativeDirect
Fly Anatomy (FA)sensillum0Moderately InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase (ATP)0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processLipid biosynthesis0.00002301InformativeDirect
Biological processPlant defense0.000481InformativeDirect
Biological processPhospholipid metabolism0Highly InformativeDirect
Biological processSphingolipid metabolism0.00005591Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
DomainZinc-finger0.00001114Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionNADP0InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0.00000003721Least InformativeDirect
UniPathway (UP)alcohol metabolism0.00000000005467Moderately InformativeDirect
UniPathway (UP)glycerol metabolism0.000000000001901InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a NAD kinase/diacylglycerol kinase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the NAD kinase/diacylglycerol kinase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]