SUPERFAMILY 1.75 HMM library and genome assignments server


eIF-2-alpha, C-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Ferredoxin-like [ 54861] (59)
Superfamily:   eIF-2-alpha, C-terminal domain [ 110993]
Families:   eIF-2-alpha, C-terminal domain [ 110994]


Superfamily statistics
Genomes (644) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 755 1,028 3
Proteins 753 1,025 3


Functional annotation
General category Information
Detailed category Translation

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 2.407e-09 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.003426 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.03508 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.01225 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.001052 Least Informative Inherited
Biological Process (BP) gene expression 0.0001442 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0.000164 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 2.662e-06 Moderately Informative Direct
Biological Process (BP) translational initiation 2.961e-10 Highly Informative Direct
Molecular Function (MF) binding 0.003786 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 1.03e-06 Moderately Informative Direct
Molecular Function (MF) RNA binding 1.042e-09 Informative Direct
Molecular Function (MF) translation factor activity, nucleic acid binding 1.557e-15 Highly Informative Direct
Cellular Component (CC) ribonucleoprotein complex 3.292e-05 Moderately Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processProtein biosynthesis0InformativeDirect
Biological processTranslation regulation2.855e-10InformativeDirect
Molecular functionRNA-binding0Moderately InformativeDirect
Post-translational modificationInitiation factor0InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a eIF-2-alpha, C-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the eIF-2-alpha, C-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]