SUPERFAMILY 1.75 HMM library and genome assignments server


HSP90 C-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   HSP90 C-terminal domain [ 110941]
Superfamily:   HSP90 C-terminal domain [ 110942]
Families:   HSP90 C-terminal domain [ 110943]


Superfamily statistics
Genomes (1,932) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,414 10,715 1
Proteins 3,410 10,710 1


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 5.602e-05 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.04546 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.4972 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.6345 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.5343 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.64 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.5453 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.009592 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.5457 Least Informative Inherited
Biological Process (BP) response to stimulus 0.002109 Least Informative Inherited
Biological Process (BP) response to abiotic stimulus 2.46e-05 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.0001704 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 6.332e-09 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.0009991 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 1.413e-05 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.0002853 Moderately Informative Direct
Biological Process (BP) organic cyclic compound catabolic process 0.0001848 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0.504 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.05856 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.001192 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.02136 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.4855 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.00335 Moderately Informative Inherited
Biological Process (BP) nucleoside monophosphate metabolic process 4.393e-10 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 8.283e-09 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 5.209e-08 Informative Direct
Biological Process (BP) protein catabolic process 0.0002073 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.0002673 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 5.553e-07 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.0005501 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 2.721e-08 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.0003023 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 8.684e-05 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.0007052 Informative Direct
Biological Process (BP) glycosyl compound catabolic process 0.0007474 Informative Direct
Biological Process (BP) proteolysis 0.0084 Informative Inherited
Biological Process (BP) protein folding 1.693e-10 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 5.69e-08 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 5.281e-11 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 3.897e-09 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate catabolic process 1.985e-09 Highly Informative Direct
Biological Process (BP) response to heat 1.078e-10 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 1.723e-09 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 0.0001183 Highly Informative Direct
Biological Process (BP) regulation of nitric oxide biosynthetic process 0 Highly Informative Direct
Biological Process (BP) ATP metabolic process 9.112e-11 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 3.298e-09 Highly Informative Direct
Molecular Function (MF) binding 8.222e-07 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.05037 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.745e-06 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 1.225e-07 Moderately Informative Direct
Molecular Function (MF) anion binding 0.06839 Moderately Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 1.296e-06 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 0.0009593 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.0007302 Informative Direct
Molecular Function (MF) nucleotide binding 0.005543 Informative Inherited
Molecular Function (MF) enzyme binding 0.1014 Informative Inherited
Molecular Function (MF) ATP binding 9.619e-05 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 3.5e-08 Highly Informative Direct
Molecular Function (MF) unfolded protein binding 3.743e-06 Highly Informative Direct
Molecular Function (MF) kinase binding 0.00321 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 1.468e-07 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 0.007142 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.302 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 2.971e-06 Moderately Informative Direct
Cellular Component (CC) vesicle 0.08354 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.1784 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 0.1787 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.04175 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.07354 Moderately Informative Inherited
Cellular Component (CC) mitochondrial matrix 0.0001854 Informative Direct
Cellular Component (CC) external encapsulating structure 0.00175 Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)cell type cancer0Moderately InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)preweaning lethality0Moderately InformativeDirect

Document: MP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ovary0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)endomesoderm0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)immune system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)visual system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)skeletal muscle0InformativeDirect
Xenopus ANatomical entity (XAN)spleen0InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processStress response0InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationAcetylation1.093e-05Least InformativeDirect
Post-translational modificationPhosphoprotein0.0003743Least InformativeDirect
Post-translational modificationUbl conjugation2.066e-07Moderately InformativeDirect
Post-translational modificationS-nitrosylation1.87e-14InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HSP90 C-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the HSP90 C-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]