SUPERFAMILY 1.75 HMM library and genome assignments server

HSP90 C-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   HSP90 C-terminal domain [ 110941]
Superfamily:   HSP90 C-terminal domain [ 110942]
Families:   HSP90 C-terminal domain [ 110943]


Superfamily statistics
Genomes (1,934) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,425 10,715 1
Proteins 3,421 10,710 1


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0.00006988 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.6404 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.009944 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.0604 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 0.2185 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.8175 Least Informative Inherited
Biological Process (BP) response to stimulus 0.002283 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.579 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.6405 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.5006 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.5382 Least Informative Inherited
Biological Process (BP) cellular catabolic process 0.000000006929 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.00000001169 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.00002142 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.00002577 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.0002046 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.0002208 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.0003739 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.0007522 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.007965 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.3408 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.1004 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.0299 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.4996 Moderately Informative Inherited
Biological Process (BP) nucleoside monophosphate metabolic process 0.000000001395 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 0.00000002162 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0.00000006345 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 0.0000001158 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0.0000005523 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.0001315 Informative Direct
Biological Process (BP) protein catabolic process 0.0002117 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.0002508 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.0005805 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.0005981 Informative Direct
Biological Process (BP) proteolysis 0.008534 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.002838 Informative Inherited
Biological Process (BP) regulation of nitric oxide biosynthetic process 0 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 0.00000000004538 Highly Informative Direct
Biological Process (BP) response to heat 0.0000000001207 Highly Informative Direct
Biological Process (BP) protein folding 0.0000000001533 Highly Informative Direct
Biological Process (BP) ribonucleoside triphosphate catabolic process 0.000000001992 Highly Informative Direct
Biological Process (BP) purine nucleoside triphosphate catabolic process 0.000000002228 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 0.000000002372 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 0.000000003307 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 0.000000003902 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 0.00000006754 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 0.0001216 Highly Informative Direct
Molecular Function (MF) binding 0.000001153 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.05073 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.00000001338 Moderately Informative Direct
Molecular Function (MF) anion binding 0.06924 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.1204 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 0.5123 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.1861 Moderately Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 0.000001274 Informative Direct
Molecular Function (MF) RNA binding 0.00008742 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.0007336 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 0.0009591 Informative Direct
Molecular Function (MF) nucleotide binding 0.005657 Informative Inherited
Molecular Function (MF) enzyme binding 0.1046 Informative Inherited
Molecular Function (MF) protein domain specific binding 0.00000003752 Highly Informative Direct
Molecular Function (MF) unfolded protein binding 0.000003608 Highly Informative Direct
Molecular Function (MF) ATP binding 0.00009645 Highly Informative Direct
Molecular Function (MF) kinase binding 0.003258 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.000001082 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.5899 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.3222 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 0.003512 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.000003742 Moderately Informative Direct
Cellular Component (CC) vesicle 0.09549 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.1075 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 0.1729 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.07606 Moderately Informative Inherited
Cellular Component (CC) lipid particle 0.00000000005631 Informative Direct
Cellular Component (CC) mitochondrial matrix 0.0002834 Informative Direct
Cellular Component (CC) external encapsulating structure 0.001711 Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)cell type cancer0Moderately InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)preweaning lethality0Moderately InformativeDirect

Document: MP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ovary0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)endomesoderm0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)immune system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)visual system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)skeletal muscle0InformativeDirect
Xenopus ANatomical entity (XAN)spleen0InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processStress response0InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationAcetylation0.00001116Least InformativeDirect
Post-translational modificationPhosphoprotein0.0003914Least InformativeDirect
Post-translational modificationUbl conjugation0.0000002271Moderately InformativeDirect
Post-translational modificationS-nitrosylation0.00000000000001828InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HSP90 C-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the HSP90 C-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]