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Gamma-glutamyl cyclotransferase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Gamma-glutamyl cyclotransferase-like [ 110856]
Superfamily:   Gamma-glutamyl cyclotransferase-like [ 110857]
Families:   Gamma-glutamyl cyclotransferase-like [ 110858] (3)

Superfamily statistics
Genomes (1,263) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 2,987 6,764 3
Proteins 2,933 6,682 3

 Functional annotation
General category Other
Detailed category Unknown function

Document: Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)nitrogen compound metabolic process0.0083720.1042Least InformativeInherited
Biological Process (BP)regulation of cellular process0.5621Least InformativeInherited
Biological Process (BP)response to stimulus0.63960.849Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.002180.01302Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)cellular amino acid metabolic process1.94e-071.832e-07Moderately InformativeDirect
Biological Process (BP)cellular catabolic process0.00032560.0001303Moderately InformativeDirect
Biological Process (BP)organic substance catabolic process0.00037730.0003988Moderately InformativeDirect
Biological Process (BP)signal transduction0.043270.254Moderately InformativeInherited
Biological Process (BP)cellular modified amino acid metabolic process0.00024451.868e-05InformativeDirect
Biological Process (BP)apoptotic process0.00085980.0002618InformativeDirect
Biological Process (BP)carboxylic acid catabolic process1.055e-061.591e-07InformativeDirect
Biological Process (BP)organonitrogen compound catabolic process9.772e-068.809e-06InformativeDirect
Biological Process (BP)apoptotic signaling pathway3.837e-056.907e-07Highly InformativeDirect
Molecular Function (MF)transferase activity3.369e-050.0007803Least InformativeDirect
Molecular Function (MF)transferase activity, transferring acyl groups1.695e-132.481e-13InformativeDirect
Molecular Function (MF)transferase activity, transferring amino-acyl groups00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) nitrogen compound metabolic process 0.1042 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.849 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.01302 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 1.832e-07 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.0001303 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.0003988 Moderately Informative Direct
Biological Process (BP) signal transduction 0.254 Moderately Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 1.868e-05 Informative Direct
Biological Process (BP) apoptotic process 0.0002618 Informative Direct
Biological Process (BP) carboxylic acid catabolic process 1.591e-07 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 8.809e-06 Informative Direct
Biological Process (BP) apoptotic signaling pathway 6.907e-07 Highly Informative Direct
Molecular Function (MF) transferase activity 0.0007803 Least Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 2.481e-13 Informative Direct
Molecular Function (MF) transferase activity, transferring amino-acyl groups 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)shoot apex0Least InformativeDirect
Plant ANatomical entity (PAN)shoot internode0Least InformativeDirect
Plant ANatomical entity (PAN)vascular leaf0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)sepal0Least InformativeDirect
Plant ANatomical entity (PAN)stem0Least InformativeDirect
Plant ANatomical entity (PAN)androecium0Least InformativeDirect
Plant ANatomical entity (PAN)collective leaf structure0Least InformativeDirect
Plant ANatomical entity (PAN)stalk0Least InformativeDirect
Plant ANatomical entity (PAN)phyllome apex0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Post-translational modificationTransferase1.418e-09Least InformativeDirect
Post-translational modificationAcyltransferase0InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Gamma-glutamyl cyclotransferase-like domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Gamma-glutamyl cyclotransferase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]
Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

Please send feedback, comments or questions to superfamily@cs.bris.ac.uk or use the feedback form.

© Copyright 2013 The SUPERFAMILY authors and Julian Gough.