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GlpP-like superfamily
SCOP classification
Superfamily statistics
Functional annotation
| General category | Regulation |
| Detailed category | DNA-binding |
Document: Function annotation of SCOP domain superfamilies
InterPro annotation
| Cross references | IPR006699 SSF110391 Protein matches |
| Abstract | Glycerol enters bacterial cells via facilitated diffusion, an
energy-independent transport process catalysed by the glycerol transport
facilitator GlpF, an integral membrane
protein of the aquaporin family. Intracellular
glycerol is usually converted to glycerol-3-P in an ATP-requiring
phosphorylation reaction catalysed by glycerol kinase (GlpK).
Glycerol-3-P, the inducer of the glpFK operon, is not a substrate for GlpF
and hence remains entrapped in the cell where it is metabolized further. In
some bacterial species, for example Bacillus subtilis, glycerol-3-P activates the antiterminator GlpP [ 1809833]. In Bacillus subtilis, glpF and glpK are organised in an operon followed by the
glycerol-3-P dehydrogenase-encoding glpD gene and preceded by glpP
coding for an antiterminator regulating the expression of glpFK, glpD and
glpTQ. Their induction
requires the inducer glycerol-3-P, which activates the antiterminator GlpP
by allowing it to bind to the leader region
of glpD and presumably also of glpFK and glpTQ
mRNAs. |
InterPro database
PDBeMotif information about ligands, sequence and structure motifs
PDBeMotif resource
Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation ]
Internal database links
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Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry
out SCOP domain assignments to all genomes at the superfamily level.
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Alignments of sequences to 1 models
in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical
are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.
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Browse and view proteins in genomes which have
different domain combinations including a GlpP-like domain.
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Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.
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Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.
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There are 1 hidden Markov models representing the GlpP-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.
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Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Internal database links ]
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