SUPERFAMILY 1.75 HMM library and genome assignments server

GDNF receptor-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   GDNF receptor-like [ 110034]
Superfamily:   GDNF receptor-like [ 110035]
Families:   GDNF receptor-like [ 110036]

Superfamily statistics
Genomes (119) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 720 688 1
Proteins 526 512 1

Functional annotation
General category Regulation
Detailed category Receptor activity

Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.00002305 Least Informative Direct
Biological Process (BP) developmental process 0.000005474 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.00000356 Least Informative Direct
Biological Process (BP) response to stimulus 0.0000008526 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.01037 Least Informative Inherited
Biological Process (BP) signal transduction 0.00000000000003459 Moderately Informative Direct
Biological Process (BP) nervous system development 0.00001786 Moderately Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0 Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0 Highly Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0.000000001395 Informative Direct
Cellular Component (CC) membrane 0.0001864 Least Informative Direct
Cellular Component (CC) plasma membrane 0.003963 Moderately Informative Inherited
Cellular Component (CC) cell surface 0.00001906 Informative Direct
Cellular Component (CC) external side of plasma membrane 0.0000002355 Highly Informative Direct

Document: GO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.0851Least InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.002406Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.01175Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal autonomic nervous system morphology0.000001007Highly InformativeDirect

Document: MP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell membrane0.0002995Moderately InformativeDirect
Cellular componentGPI-anchor0InformativeDirect
DomainSignal0Least InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a GDNF receptor-like domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the GDNF receptor-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · UniProtKB KeyWords (KW) · Internal database links ]