SUPERFAMILY 1.75 HMM library and genome assignments server

ERO1-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   ERO1-like [ 110018]
Superfamily:   ERO1-like [ 110019]
Families:   ERO1-like [ 110020]


Superfamily statistics
Genomes (485) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 749 891 2
Proteins 729 876 2


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process0.00000000029490.00000000007203Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process0.0000000038010.00000001032Least InformativeDirect
Biological Process (BP)regulation of cellular process0.000028930.001088Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.35920.4481Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.0011970.1248Least InformativeInherited
Biological Process (BP)response to stimulus0.004120.01612Least InformativeInherited
Biological Process (BP)single-organism cellular process0.55340.9509Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.11850.6185Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.16540.7172Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.18030.7171Least InformativeInherited
Biological Process (BP)cellular response to stress0.00000004330.000000003349Moderately InformativeDirect
Biological Process (BP)monocarboxylic acid metabolic process0.00000058230.000004711Moderately InformativeDirect
Biological Process (BP)regulation of biological quality0.0003130.000006519Moderately InformativeDirect
Biological Process (BP)gene expression0.023060.2413Moderately InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.00061930.001154Moderately InformativeInherited
Biological Process (BP)cellular modified amino acid metabolic process0.0000000028050.000000005107InformativeDirect
Biological Process (BP)protein maturation0.0000025590.00001454InformativeDirect
Biological Process (BP)protein folding00Highly InformativeDirect
Biological Process (BP)response to endoplasmic reticulum stress0.0000000000000063590Highly InformativeDirect
Biological Process (BP)cell redox homeostasis0.0000000000055630.0000000000004112Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity0.000000000063310.000000000000001593Moderately InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on a sulfur group of donors0.00000017510.00000001698Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.067850.03126Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.071590.007665Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum0.0000028970.0000000003264Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0.00000000007203 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.00000001032 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.001088 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.4481 Least Informative Inherited
Biological Process (BP) response to stimulus 0.01612 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.1248 Least Informative Inherited
Biological Process (BP) localization 0.0848 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.9509 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.6185 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.7172 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.7171 Least Informative Inherited
Biological Process (BP) cellular response to stress 0.000000003349 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0.000004711 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.000006519 Moderately Informative Direct
Biological Process (BP) ion transport 0.0000257 Moderately Informative Direct
Biological Process (BP) cellular localization 0.0003699 Moderately Informative Direct
Biological Process (BP) signal transduction 0.001491 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.2269 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.003937 Moderately Informative Inherited
Biological Process (BP) gene expression 0.2413 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.001154 Moderately Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0.000000005107 Informative Direct
Biological Process (BP) protein maturation 0.00001454 Informative Direct
Biological Process (BP) cation homeostasis 0.000000176 Informative Direct
Biological Process (BP) metal ion transport 0.0000002444 Informative Direct
Biological Process (BP) apoptotic process 0.0000003839 Informative Direct
Biological Process (BP) cytoplasmic transport 0.0000007075 Informative Direct
Biological Process (BP) single-organism intracellular transport 0.000009391 Informative Direct
Biological Process (BP) intracellular signal transduction 0.03913 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.4502 Informative Inherited
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0 Highly Informative Direct
Biological Process (BP) cell redox homeostasis 0.0000000000004112 Highly Informative Direct
Biological Process (BP) negative regulation of homeostatic process 0.000000000005067 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 0.00000000005516 Highly Informative Direct
Biological Process (BP) intrinsic apoptotic signaling pathway 0.00000000009392 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0.00000000165 Highly Informative Direct
Biological Process (BP) calcium ion transport 0.000000001736 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0.000000001894 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity 0.000000000000001593 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on a sulfur group of donors 0.00000001698 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.03126 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.007665 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.0000000003264 Moderately Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processApoptosis0.00000002291Moderately InformativeDirect
Biological processElectron transport0InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainRedox-active center0InformativeDirect
Molecular functionFlavoprotein0Moderately InformativeDirect
Molecular functionFAD0InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationGlycoprotein0.00000000002975Least InformativeDirect
Post-translational modificationDisulfide bond0.000000001024Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR007266 SSF110019 Protein matches
Abstract Members of this family are required for the formation of disulphide bonds in the endoplasmic reticulum [PubMed10754564, PubMed10982384].

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ERO1-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the ERO1-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]