SUPERFAMILY 1.75 HMM library and genome assignments server


ERO1-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   ERO1-like [ 110018]
Superfamily:   ERO1-like [ 110019]
Families:   ERO1-like [ 110020]


Superfamily statistics
Genomes (435) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 708 632 2
Proteins 688 626 2


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process3.049e-094.686e-10Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process3.255e-085.495e-08Least InformativeDirect
Biological Process (BP)regulation of cellular process7.402e-060.0004898Least InformativeDirect
Biological Process (BP)single-organism cellular process0.077730.505Least InformativeInherited
Biological Process (BP)response to stimulus0.011420.03037Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.00054690.0833Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.19420.2876Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.057570.5077Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.086670.6037Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.094950.606Least InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.00028840.0007518Moderately InformativeDirect
Biological Process (BP)monocarboxylic acid metabolic process1.508e-071.847e-06Moderately InformativeDirect
Biological Process (BP)cellular response to stress7.374e-073.661e-08Moderately InformativeDirect
Biological Process (BP)homeostatic process4.544e-103.596e-11Moderately InformativeDirect
Biological Process (BP)gene expression0.0078990.1522Moderately InformativeInherited
Biological Process (BP)cellular modified amino acid metabolic process1.485e-093.885e-09InformativeDirect
Biological Process (BP)protein folding00Highly InformativeDirect
Biological Process (BP)extracellular matrix organization1.471e-131.45e-09Highly InformativeDirect
Biological Process (BP)response to endoplasmic reticulum stress1.507e-120Highly InformativeDirect
Biological Process (BP)cell redox homeostasis3.504e-122.487e-13Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity1.126e-094.602e-14Moderately InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on a sulfur group of donors1.772e-083.217e-09Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.14720.05881Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.15610.01678Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum5.551e-055.746e-09Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 4.686e-10 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 5.495e-08 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.0004898 Least Informative Direct
Biological Process (BP) response to stimulus 0.03037 Least Informative Inherited
Biological Process (BP) localization 0.0584 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.0833 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.2876 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.5077 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.6037 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.505 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.606 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.0007518 Moderately Informative Direct
Biological Process (BP) ion transport 1.154e-05 Moderately Informative Direct
Biological Process (BP) signal transduction 0.0004998 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 1.847e-06 Moderately Informative Direct
Biological Process (BP) cellular response to stress 3.661e-08 Moderately Informative Direct
Biological Process (BP) homeostatic process 3.596e-11 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.003138 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.003371 Moderately Informative Inherited
Biological Process (BP) gene expression 0.1522 Moderately Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 3.885e-09 Informative Direct
Biological Process (BP) cell death 2.453e-05 Informative Direct
Biological Process (BP) cytoplasmic transport 3.729e-07 Informative Direct
Biological Process (BP) metal ion transport 1.621e-07 Informative Direct
Biological Process (BP) cation homeostasis 1.013e-07 Informative Direct
Biological Process (BP) intracellular signal transduction 0.03212 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.5168 Informative Inherited
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) calcium ion transport 1.461e-09 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 1.123e-09 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 1.45e-09 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0 Highly Informative Direct
Biological Process (BP) cell redox homeostasis 2.487e-13 Highly Informative Direct
Biological Process (BP) intrinsic apoptotic signaling pathway 7.235e-11 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 1.098e-10 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity 4.602e-14 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on a sulfur group of donors 3.217e-09 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.05881 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.01678 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 5.746e-09 Moderately Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processApoptosis2.277e-08Moderately InformativeDirect
Biological processElectron transport0InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainRedox-active center0InformativeDirect
Molecular functionFlavoprotein0Moderately InformativeDirect
Molecular functionFAD0InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationGlycoprotein2.956e-11Least InformativeDirect
Post-translational modificationDisulfide bond1.053e-09Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR007266 SSF110019 Protein matches
Abstract Members of this family are required for the formation of disulphide bonds in the endoplasmic reticulum [PubMed10754564, PubMed10982384].

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ERO1-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the ERO1-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]