SUPERFAMILY 1.75 HMM library and genome assignments server


ERO1-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   ERO1-like [ 110018]
Superfamily:   ERO1-like [ 110019]
Families:   ERO1-like [ 110020]


Superfamily statistics
Genomes (484) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 748 891 2
Proteins 728 876 2


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process2.58e-106.184e-11Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process3.739e-091.01e-08Least InformativeDirect
Biological Process (BP)nitrogen compound metabolic process0.17670.7169Least InformativeInherited
Biological Process (BP)regulation of cellular process2.478e-050.001006Least InformativeInherited
Biological Process (BP)single-organism cellular process0.15390.6616Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.0011610.1149Least InformativeInherited
Biological Process (BP)response to stimulus0.021340.04864Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.33030.3929Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.1130.616Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.16290.7133Least InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process3.203e-072.59e-06Moderately InformativeDirect
Biological Process (BP)cellular response to stress1.49e-067.171e-08Moderately InformativeDirect
Biological Process (BP)regulation of biological quality0.00034077.298e-06Moderately InformativeDirect
Biological Process (BP)gene expression0.019480.2164Moderately InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.00069330.001233Moderately InformativeInherited
Biological Process (BP)cellular modified amino acid metabolic process3.355e-095.831e-09InformativeDirect
Biological Process (BP)protein folding00Highly InformativeDirect
Biological Process (BP)response to endoplasmic reticulum stress2.538e-120Highly InformativeDirect
Biological Process (BP)cell redox homeostasis6.307e-124.409e-13Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity6.277e-111.562e-15Moderately InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on a sulfur group of donors1.476e-071.565e-08Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.074790.03719Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.073350.007534Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum2.927e-063.268e-10Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 6.184e-11 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 1.01e-08 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.7169 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.001006 Least Informative Inherited
Biological Process (BP) response to stimulus 0.04864 Least Informative Inherited
Biological Process (BP) localization 0.07819 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.1149 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.3929 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.616 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.7133 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.6616 Least Informative Inherited
Biological Process (BP) ion transport 1.617e-05 Moderately Informative Direct
Biological Process (BP) signal transduction 0.0004181 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 2.59e-06 Moderately Informative Direct
Biological Process (BP) cellular response to stress 7.171e-08 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 7.298e-06 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.00363 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.003531 Moderately Informative Inherited
Biological Process (BP) gene expression 0.2164 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.001233 Moderately Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 5.831e-09 Informative Direct
Biological Process (BP) apoptotic process 3.854e-07 Informative Direct
Biological Process (BP) cytoplasmic transport 5.334e-07 Informative Direct
Biological Process (BP) metal ion transport 2.461e-07 Informative Direct
Biological Process (BP) cation homeostasis 1.976e-07 Informative Direct
Biological Process (BP) intracellular signal transduction 0.02948 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.478 Informative Inherited
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) calcium ion transport 2.111e-09 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 1.711e-09 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 1.937e-09 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0 Highly Informative Direct
Biological Process (BP) cell redox homeostasis 4.409e-13 Highly Informative Direct
Biological Process (BP) intrinsic apoptotic signaling pathway 9.579e-11 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 2.386e-10 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity 1.562e-15 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on a sulfur group of donors 1.565e-08 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.03719 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.007534 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 3.268e-10 Moderately Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processApoptosis2.291e-08Moderately InformativeDirect
Biological processElectron transport0InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainRedox-active center0InformativeDirect
Molecular functionFlavoprotein0Moderately InformativeDirect
Molecular functionFAD0InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationGlycoprotein2.975e-11Least InformativeDirect
Post-translational modificationDisulfide bond1.024e-09Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR007266 SSF110019 Protein matches
Abstract Members of this family are required for the formation of disulphide bonds in the endoplasmic reticulum [PubMed10754564, PubMed10982384].

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ERO1-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the ERO1-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]