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CAPPD, an extracellular domain of amyloid beta A4 protein superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   STAT-like [ 47654] (6)
Superfamily:   CAPPD, an extracellular domain of amyloid beta A4 protein [ 109843]
Families:   CAPPD, an extracellular domain of amyloid beta A4 protein [ 109844]


Superfamily statistics
Genomes (126) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 414 512 2
Proteins 406 509 2


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.00000000000002458 Least Informative Direct
Biological Process (BP) response to stimulus 0.00000000002961 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.00000000009153 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0.0000000001284 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.00000007185 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.0000006844 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.000003153 Least Informative Direct
Biological Process (BP) localization 0.00001223 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.08268 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.003753 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.08536 Least Informative Inherited
Biological Process (BP) regulation of signal transduction 0 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0 Moderately Informative Direct
Biological Process (BP) reproduction 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0 Moderately Informative Direct
Biological Process (BP) gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) nervous system development 0 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0.000000000003204 Moderately Informative Direct
Biological Process (BP) system process 0.00000000001647 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.00000000004041 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.0000000002143 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.000000000918 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.000000001079 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.000000001479 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0.00000002682 Moderately Informative Direct
Biological Process (BP) cellular localization 0.000004316 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.000007376 Moderately Informative Direct
Biological Process (BP) tissue development 0.9059 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.4526 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.1927 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.6504 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.001187 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.001281 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.04974 Moderately Informative Inherited
Biological Process (BP) organ development 0.4289 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.6152 Moderately Informative Inherited
Biological Process (BP) RNA processing 0 Informative Direct
Biological Process (BP) cation homeostasis 0 Informative Direct
Biological Process (BP) synaptic transmission 0 Informative Direct
Biological Process (BP) regulation of kinase activity 0 Informative Direct
Biological Process (BP) single-organism behavior 0 Informative Direct
Biological Process (BP) alcohol metabolic process 0 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) response to light stimulus 0 Informative Direct
Biological Process (BP) generation of neurons 0 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0 Informative Direct
Biological Process (BP) regulation of mitotic cell cycle 0 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 0 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0 Informative Direct
Biological Process (BP) growth 0 Informative Direct
Biological Process (BP) locomotion 0.00000000000003459 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.00000000000004773 Informative Direct
Biological Process (BP) microtubule-based process 0.0000000000001396 Informative Direct
Biological Process (BP) cell projection organization 0.00000000001534 Informative Direct
Biological Process (BP) regulation of growth 0.00000000005262 Informative Direct
Biological Process (BP) central nervous system development 0.0000000002072 Informative Direct
Biological Process (BP) single organism reproductive process 0.0000000002569 Informative Direct
Biological Process (BP) apoptotic process 0.00000001441 Informative Direct
Biological Process (BP) cellular component movement 0.00000004593 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.0000003735 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0000009272 Informative Direct
Biological Process (BP) regulation of cell development 0.000002698 Informative Direct
Biological Process (BP) response to oxidative stress 0.000003573 Informative Direct
Biological Process (BP) negative regulation of developmental process 0.000005897 Informative Direct
Biological Process (BP) muscle tissue development 0.00004303 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.0003165 Informative Direct
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.0009651 Informative Direct
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) muscle structure development 0.02117 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.5702 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.7206 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.8891 Informative Inherited
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) cytoskeleton-dependent intracellular transport 0 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0 Highly Informative Direct
Biological Process (BP) regulation of translation 0 Highly Informative Direct
Biological Process (BP) mRNA processing 0 Highly Informative Direct
Biological Process (BP) adult behavior 0 Highly Informative Direct
Biological Process (BP) sterol metabolic process 0 Highly Informative Direct
Biological Process (BP) cell growth 0 Highly Informative Direct
Biological Process (BP) cell part morphogenesis 0 Highly Informative Direct
Biological Process (BP) neuron projection development 0 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0 Highly Informative Direct
Biological Process (BP) regulation of multicellular organism growth 0 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 0 Highly Informative Direct
Biological Process (BP) cell-type specific apoptotic process 0.000000000000003755 Highly Informative Direct
Biological Process (BP) chemotaxis 0.0000000000001797 Highly Informative Direct
Biological Process (BP) regulation of binding 0.000000000002974 Highly Informative Direct
Biological Process (BP) muscle fiber development 0.00000000001163 Highly Informative Direct
Biological Process (BP) neuromuscular process 0.00000000006525 Highly Informative Direct
Biological Process (BP) developmental growth 0.0000000001315 Highly Informative Direct
Biological Process (BP) locomotory behavior 0.00000001471 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.00000009714 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 0.0000006643 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0.000002634 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.0001276 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 1 Highly Informative Inherited
Biological Process (BP) learning or memory 0.002905 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.001963 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0.000000000003858 Moderately Informative Direct
Molecular Function (MF) DNA binding 0.000000000000006053 Informative Direct
Cellular Component (CC) membrane 0.0000000004911 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.00001039 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.704 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.4013 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.09043 Least Informative Inherited
Cellular Component (CC) protein complex 0.01915 Least Informative Inherited
Cellular Component (CC) intrinsic to membrane 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0.000000000000003095 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0000002122 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.0001828 Moderately Informative Direct
Cellular Component (CC) Golgi apparatus 0 Informative Direct
Cellular Component (CC) neuron projection 0 Informative Direct
Cellular Component (CC) integral to membrane 0 Informative Direct
Cellular Component (CC) cell junction 0.000001937 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.000003183 Informative Direct
Cellular Component (CC) coated vesicle 0.0001643 Informative Direct
Cellular Component (CC) cilium part 0.000000000003057 Highly Informative Direct
Cellular Component (CC) spindle 0.0000000009602 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.00000002022 Highly Informative Direct
Cellular Component (CC) transport vesicle 0.00002457 Highly Informative Direct

Document: GO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0Moderately InformativeDirect
Mammalian Phenotype (MP)preweaning lethality0Moderately InformativeDirect
Mammalian Phenotype (MP)decreased body size0InformativeDirect
Mammalian Phenotype (MP)lethality during fetal growth through weaning0InformativeDirect

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)immune system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)visual system0Moderately InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processEndocytosis0InformativeDirect
Biological processNotch signaling pathway0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCoated pit0Highly InformativeDirect
Coding sequence diversityAlternative splicing0.000000000007916Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionZinc0.0000000631Least InformativeDirect
Molecular functionMetal-binding0.00003869Least InformativeDirect
Molecular functionIron0.000001031Moderately InformativeDirect
Molecular functionCopper0InformativeDirect
Molecular functionHeparin-binding0InformativeDirect
Post-translational modificationProtease inhibitor0InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0.00002357Least InformativeDirect
Post-translational modificationProteoglycan0.0000000004177InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a CAPPD, an extracellular domain of amyloid beta A4 protein domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the CAPPD, an extracellular domain of amyloid beta A4 protein superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]