SUPERFAMILY 1.75 HMM library and genome assignments server

CAPPD, an extracellular domain of amyloid beta A4 protein superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   STAT-like [ 47654] (6)
Superfamily:   CAPPD, an extracellular domain of amyloid beta A4 protein [ 109843]
Families:   CAPPD, an extracellular domain of amyloid beta A4 protein [ 109844]


Superfamily statistics
Genomes (126) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 414 512 2
Proteins 406 509 2


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.0000000000000325 Least Informative Direct
Biological Process (BP) response to stimulus 0.00000000002922 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.000000000114 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0.0000000001603 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.00000007417 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.000001381 Least Informative Direct
Biological Process (BP) localization 0.00001611 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0001308 Least Informative Direct
Biological Process (BP) positive regulation of biological process 0.4397 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.08733 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.003748 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.06734 Least Informative Inherited
Biological Process (BP) RNA metabolic process 0 Moderately Informative Direct
Biological Process (BP) nervous system development 0 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0 Moderately Informative Direct
Biological Process (BP) gene expression 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) reproductive process 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.000000000000007248 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0.000000000007169 Moderately Informative Direct
Biological Process (BP) cellular localization 0.00000000001139 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.00000000002419 Moderately Informative Direct
Biological Process (BP) regulation of phosphorus metabolic process 0.00000000005549 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.0000000002193 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0000000008102 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.000000001741 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.000000001946 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0.00000001949 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.000007599 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.0005865 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0.5283 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.2892 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.4523 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.04955 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.4062 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.9384 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.001173 Moderately Informative Inherited
Biological Process (BP) organ development 0.3954 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.001274 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) response to light stimulus 0 Informative Direct
Biological Process (BP) alcohol metabolic process 0 Informative Direct
Biological Process (BP) sexual reproduction 0 Informative Direct
Biological Process (BP) neurological system process 0 Informative Direct
Biological Process (BP) regulation of mitotic cell cycle 0 Informative Direct
Biological Process (BP) single-organism behavior 0 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0 Informative Direct
Biological Process (BP) cation homeostasis 0 Informative Direct
Biological Process (BP) single-organism intracellular transport 0 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 0 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0 Informative Direct
Biological Process (BP) generation of neurons 0 Informative Direct
Biological Process (BP) RNA processing 0 Informative Direct
Biological Process (BP) regulation of transferase activity 0 Informative Direct
Biological Process (BP) growth 0 Informative Direct
Biological Process (BP) phosphorylation 0.000000000000007248 Informative Direct
Biological Process (BP) microtubule-based process 0.00000000000002089 Informative Direct
Biological Process (BP) locomotion 0.00000000000003411 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.00000000000005029 Informative Direct
Biological Process (BP) synaptic transmission 0.000000000001411 Informative Direct
Biological Process (BP) cell projection organization 0.000000000001432 Informative Direct
Biological Process (BP) regulation of growth 0.00000000003748 Informative Direct
Biological Process (BP) central nervous system development 0.0000000002734 Informative Direct
Biological Process (BP) cellular component movement 0.000000007729 Informative Direct
Biological Process (BP) apoptotic process 0.00000001429 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0000009491 Informative Direct
Biological Process (BP) regulation of cell development 0.000001423 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.000002407 Informative Direct
Biological Process (BP) response to oxidative stress 0.000003972 Informative Direct
Biological Process (BP) negative regulation of developmental process 0.0000343 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.0003295 Informative Direct
Biological Process (BP) positive regulation of RNA metabolic process 0.0006649 Informative Direct
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.7399 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.007632 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.6882 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.5292 Informative Inherited
Biological Process (BP) adult behavior 0 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0 Highly Informative Direct
Biological Process (BP) sterol metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of multicellular organism growth 0 Highly Informative Direct
Biological Process (BP) neuron projection development 0 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0 Highly Informative Direct
Biological Process (BP) positive regulation of mitotic cell cycle 0 Highly Informative Direct
Biological Process (BP) cell projection morphogenesis 0 Highly Informative Direct
Biological Process (BP) regulation of translation 0 Highly Informative Direct
Biological Process (BP) mRNA processing 0 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 0 Highly Informative Direct
Biological Process (BP) regulation of peptidyl-tyrosine phosphorylation 0 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) cell growth 0 Highly Informative Direct
Biological Process (BP) cell recognition 0 Highly Informative Direct
Biological Process (BP) learning or memory 0 Highly Informative Direct
Biological Process (BP) cell-type specific apoptotic process 0.000000000000003707 Highly Informative Direct
Biological Process (BP) chemotaxis 0.0000000000001742 Highly Informative Direct
Biological Process (BP) regulation of binding 0.000000000005817 Highly Informative Direct
Biological Process (BP) developmental growth 0.00000000001012 Highly Informative Direct
Biological Process (BP) locomotory behavior 0.00000000006292 Highly Informative Direct
Biological Process (BP) negative regulation of nervous system development 0.0000000004319 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.00000007367 Highly Informative Direct
Biological Process (BP) neuromuscular process 0.0000001505 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 0.0000004422 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0.00001733 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-templated 0.003491 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 1 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0.00000000001179 Moderately Informative Direct
Molecular Function (MF) DNA binding 0.000000000000006187 Informative Direct
Cellular Component (CC) membrane 0.0000000004933 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.00001231 Least Informative Direct
Cellular Component (CC) protein complex 0.01845 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.681 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.06109 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.409 Least Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0.00000000000000457 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0000002288 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.0002252 Moderately Informative Direct
Cellular Component (CC) neuron projection 0 Informative Direct
Cellular Component (CC) integral component of membrane 0 Informative Direct
Cellular Component (CC) Golgi apparatus 0 Informative Direct
Cellular Component (CC) synapse 0.000000001254 Informative Direct
Cellular Component (CC) cell junction 0.000001897 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.000003401 Informative Direct
Cellular Component (CC) ciliary part 0.00000000004019 Highly Informative Direct
Cellular Component (CC) spindle 0.000000001018 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.0000000204 Highly Informative Direct
Cellular Component (CC) transport vesicle 0.000001085 Highly Informative Direct
Cellular Component (CC) coated vesicle 0.00002734 Highly Informative Direct

Document: GO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0Moderately InformativeDirect
Mammalian Phenotype (MP)preweaning lethality0Moderately InformativeDirect
Mammalian Phenotype (MP)decreased body size0InformativeDirect
Mammalian Phenotype (MP)lethality during fetal growth through weaning0InformativeDirect

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)visual system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)immune system0Moderately InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processEndocytosis0InformativeDirect
Biological processNotch signaling pathway0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCoated pit0Highly InformativeDirect
Coding sequence diversityAlternative splicing0.000000000007916Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionZinc0.0000000631Least InformativeDirect
Molecular functionMetal-binding0.00003869Least InformativeDirect
Molecular functionIron0.000001031Moderately InformativeDirect
Molecular functionCopper0InformativeDirect
Molecular functionHeparin-binding0InformativeDirect
Post-translational modificationProtease inhibitor0InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0.00002357Least InformativeDirect
Post-translational modificationProteoglycan0.0000000004177InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a CAPPD, an extracellular domain of amyloid beta A4 protein domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the CAPPD, an extracellular domain of amyloid beta A4 protein superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]