SUPERFAMILY 1.75 HMM library and genome assignments server


CAPPD, an extracellular domain of amyloid beta A4 protein superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   STAT-like [ 47654] (6)
Superfamily:   CAPPD, an extracellular domain of amyloid beta A4 protein [ 109843]
Families:   CAPPD, an extracellular domain of amyloid beta A4 protein [ 109844]


Superfamily statistics
Genomes (126) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 414 512 2
Proteins 406 509 2


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 2.458e-14 Least Informative Direct
Biological Process (BP) response to stimulus 2.961e-11 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 9.153e-11 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 1.284e-10 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 7.185e-08 Least Informative Direct
Biological Process (BP) regulation of metabolic process 6.844e-07 Least Informative Direct
Biological Process (BP) single-organism cellular process 3.153e-06 Least Informative Direct
Biological Process (BP) localization 1.223e-05 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.08268 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.003753 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.08536 Least Informative Inherited
Biological Process (BP) regulation of signal transduction 0 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0 Moderately Informative Direct
Biological Process (BP) reproduction 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0 Moderately Informative Direct
Biological Process (BP) gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) nervous system development 0 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 3.204e-12 Moderately Informative Direct
Biological Process (BP) system process 1.647e-11 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 4.041e-11 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 2.143e-10 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 9.18e-10 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 1.079e-09 Moderately Informative Direct
Biological Process (BP) cell differentiation 1.479e-09 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 2.682e-08 Moderately Informative Direct
Biological Process (BP) cellular localization 4.316e-06 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 7.376e-06 Moderately Informative Direct
Biological Process (BP) tissue development 0.9059 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.4526 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.1927 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.6504 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.001187 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.001281 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.04974 Moderately Informative Inherited
Biological Process (BP) organ development 0.4289 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.6152 Moderately Informative Inherited
Biological Process (BP) RNA processing 0 Informative Direct
Biological Process (BP) cation homeostasis 0 Informative Direct
Biological Process (BP) synaptic transmission 0 Informative Direct
Biological Process (BP) regulation of kinase activity 0 Informative Direct
Biological Process (BP) single-organism behavior 0 Informative Direct
Biological Process (BP) alcohol metabolic process 0 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) response to light stimulus 0 Informative Direct
Biological Process (BP) generation of neurons 0 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0 Informative Direct
Biological Process (BP) regulation of mitotic cell cycle 0 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 0 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0 Informative Direct
Biological Process (BP) growth 0 Informative Direct
Biological Process (BP) locomotion 3.459e-14 Informative Direct
Biological Process (BP) vesicle-mediated transport 4.773e-14 Informative Direct
Biological Process (BP) microtubule-based process 1.396e-13 Informative Direct
Biological Process (BP) cell projection organization 1.534e-11 Informative Direct
Biological Process (BP) regulation of growth 5.262e-11 Informative Direct
Biological Process (BP) central nervous system development 2.072e-10 Informative Direct
Biological Process (BP) single organism reproductive process 2.569e-10 Informative Direct
Biological Process (BP) apoptotic process 1.441e-08 Informative Direct
Biological Process (BP) cellular component movement 4.593e-08 Informative Direct
Biological Process (BP) cellular component morphogenesis 3.735e-07 Informative Direct
Biological Process (BP) regulation of nervous system development 9.272e-07 Informative Direct
Biological Process (BP) regulation of cell development 2.698e-06 Informative Direct
Biological Process (BP) response to oxidative stress 3.573e-06 Informative Direct
Biological Process (BP) negative regulation of developmental process 5.897e-06 Informative Direct
Biological Process (BP) muscle tissue development 4.303e-05 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.0003165 Informative Direct
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.0009651 Informative Direct
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) muscle structure development 0.02117 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.5702 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.7206 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.8891 Informative Inherited
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) cytoskeleton-dependent intracellular transport 0 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0 Highly Informative Direct
Biological Process (BP) regulation of translation 0 Highly Informative Direct
Biological Process (BP) mRNA processing 0 Highly Informative Direct
Biological Process (BP) adult behavior 0 Highly Informative Direct
Biological Process (BP) sterol metabolic process 0 Highly Informative Direct
Biological Process (BP) cell growth 0 Highly Informative Direct
Biological Process (BP) cell part morphogenesis 0 Highly Informative Direct
Biological Process (BP) neuron projection development 0 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0 Highly Informative Direct
Biological Process (BP) regulation of multicellular organism growth 0 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 0 Highly Informative Direct
Biological Process (BP) cell-type specific apoptotic process 3.755e-15 Highly Informative Direct
Biological Process (BP) chemotaxis 1.797e-13 Highly Informative Direct
Biological Process (BP) regulation of binding 2.974e-12 Highly Informative Direct
Biological Process (BP) muscle fiber development 1.163e-11 Highly Informative Direct
Biological Process (BP) neuromuscular process 6.525e-11 Highly Informative Direct
Biological Process (BP) developmental growth 1.315e-10 Highly Informative Direct
Biological Process (BP) locomotory behavior 1.471e-08 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 9.714e-08 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 6.643e-07 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 2.634e-06 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.0001276 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 1 Highly Informative Inherited
Biological Process (BP) learning or memory 0.002905 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.001963 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) nucleic acid binding 3.858e-12 Moderately Informative Direct
Molecular Function (MF) DNA binding 6.053e-15 Informative Direct
Cellular Component (CC) membrane 4.911e-10 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1.039e-05 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.704 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.4013 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.09043 Least Informative Inherited
Cellular Component (CC) protein complex 0.01915 Least Informative Inherited
Cellular Component (CC) intrinsic to membrane 0 Moderately Informative Direct
Cellular Component (CC) cell projection 3.095e-15 Moderately Informative Direct
Cellular Component (CC) vesicle 2.122e-07 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.0001828 Moderately Informative Direct
Cellular Component (CC) Golgi apparatus 0 Informative Direct
Cellular Component (CC) neuron projection 0 Informative Direct
Cellular Component (CC) integral to membrane 0 Informative Direct
Cellular Component (CC) cell junction 1.937e-06 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 3.183e-06 Informative Direct
Cellular Component (CC) coated vesicle 0.0001643 Informative Direct
Cellular Component (CC) cilium part 3.057e-12 Highly Informative Direct
Cellular Component (CC) spindle 9.602e-10 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 2.022e-08 Highly Informative Direct
Cellular Component (CC) transport vesicle 2.457e-05 Highly Informative Direct

Document: GO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0Moderately InformativeDirect
Mammalian Phenotype (MP)preweaning lethality0Moderately InformativeDirect
Mammalian Phenotype (MP)decreased body size0InformativeDirect
Mammalian Phenotype (MP)lethality during fetal growth through weaning0InformativeDirect

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)immune system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)visual system0Moderately InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processEndocytosis0InformativeDirect
Biological processNotch signaling pathway0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCoated pit0Highly InformativeDirect
Coding sequence diversityAlternative splicing7.916e-12Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionZinc6.31e-08Least InformativeDirect
Molecular functionMetal-binding3.869e-05Least InformativeDirect
Molecular functionIron1.031e-06Moderately InformativeDirect
Molecular functionCopper0InformativeDirect
Molecular functionHeparin-binding0InformativeDirect
Post-translational modificationProtease inhibitor0InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond2.357e-05Least InformativeDirect
Post-translational modificationProteoglycan4.177e-10InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a CAPPD, an extracellular domain of amyloid beta A4 protein domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the CAPPD, an extracellular domain of amyloid beta A4 protein superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]