SUPERFAMILY 1.75 HMM library and genome assignments server

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Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Four-helical up-and-down bundle [ 47161] (28)
Superfamily:   Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain [ 109775]
Families:   Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain [ 109776]


Superfamily statistics
Genomes (93) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 326 432 1
Proteins 323 427 1


Functional annotation
General category General
Detailed category Small molecule binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0.0002606 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.3866 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.1149 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.0745 Least Informative Inherited
Biological Process (BP) ion transport 0.000001959 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.00004054 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.00007469 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.0001516 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.00019 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.0004544 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.0008437 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.01624 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.00169 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.0106 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.003631 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.002912 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.00915 Moderately Informative Inherited
Biological Process (BP) lipid localization 0 Informative Direct
Biological Process (BP) organic acid transport 0.0000000001123 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.000000006815 Informative Direct
Biological Process (BP) anion transport 0.000000009711 Informative Direct
Biological Process (BP) negative regulation of catalytic activity 0.0000001658 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.0000005427 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.000001546 Informative Direct
Biological Process (BP) negative regulation of signaling 0.000005415 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.000005627 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.00001815 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.0002437 Informative Direct
Biological Process (BP) monocarboxylic acid transport 0.00000000000006884 Highly Informative Direct
Biological Process (BP) regulation of lipid storage 0.00000000000007043 Highly Informative Direct
Biological Process (BP) negative regulation of cellular catabolic process 0.00000000002348 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 0.00000000002568 Highly Informative Direct
Biological Process (BP) regulation of reactive oxygen species metabolic process 0.00000000004851 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 0.0000000006517 Highly Informative Direct
Biological Process (BP) positive regulation of catabolic process 0.0000000009474 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.00000004033 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.0000902 Least Informative Direct

Document: GO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect
Mammalian Phenotype (MP)abnormal lipid homeostasis0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal triglyceride level0InformativeDirect
Mammalian Phenotype (MP)decreased triglyceride level0Highly InformativeDirect

Document: MP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentMembrane0.00008342Least InformativeDirect
Cellular componentMitochondrion0.0001069Moderately InformativeDirect
Cellular componentLipid droplet0Highly InformativeDirect
DomainCoiled coil0.000004982Moderately InformativeDirect
Post-translational modificationAcetylation0.0000952Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · UniProtKB KeyWords (KW) · Internal database links ]