SUPERFAMILY 1.75 HMM library and genome assignments server

Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Four-helical up-and-down bundle [ 47161] (28)
Superfamily:   Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain [ 109775]
Families:   Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain [ 109776]


Superfamily statistics
Genomes (93) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 326 432 1
Proteins 323 427 1


Functional annotation
General category General
Detailed category Small molecule binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0.0003092 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.1248 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 0.04011 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.3962 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.0828 Least Informative Inherited
Biological Process (BP) ion transport 0.000003369 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.00004383 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.00005641 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.000156 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0002088 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.0008754 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.0009195 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.004557 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.02237 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.0123 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.001536 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.002512 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.009368 Moderately Informative Inherited
Biological Process (BP) lipid localization 0.000000000000001913 Informative Direct
Biological Process (BP) organic acid transport 0.0000000001125 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.000000006735 Informative Direct
Biological Process (BP) anion transport 0.00000001143 Informative Direct
Biological Process (BP) negative regulation of catalytic activity 0.0000001738 Informative Direct
Biological Process (BP) positive regulation of catabolic process 0.0000004505 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.0000005966 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.00000248 Informative Direct
Biological Process (BP) negative regulation of signaling 0.000007569 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.000007846 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0000267 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.0002533 Informative Direct
Biological Process (BP) maintenance of location 0.00000000000006627 Highly Informative Direct
Biological Process (BP) monocarboxylic acid transport 0.00000000000006944 Highly Informative Direct
Biological Process (BP) regulation of lipid storage 0.00000000000006944 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 0.00000000002563 Highly Informative Direct
Biological Process (BP) regulation of reactive oxygen species metabolic process 0.00000000006015 Highly Informative Direct
Biological Process (BP) negative regulation of cellular catabolic process 0.0000000002335 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 0.0000000006604 Highly Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.0000000000002537 Least Informative Direct
Cellular Component (CC) lipid particle 0 Informative Direct

Document: GO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect
Mammalian Phenotype (MP)abnormal lipid homeostasis0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal triglyceride level0InformativeDirect
Mammalian Phenotype (MP)decreased triglyceride level0Highly InformativeDirect

Document: MP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentMembrane0.00008342Least InformativeDirect
Cellular componentMitochondrion0.0001069Moderately InformativeDirect
Cellular componentLipid droplet0Highly InformativeDirect
DomainCoiled coil0.000004982Moderately InformativeDirect
Post-translational modificationAcetylation0.0000952Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · UniProtKB KeyWords (KW) · Internal database links ]