SUPERFAMILY 1.75 HMM library and genome assignments server


Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Four-helical up-and-down bundle [ 47161] (28)
Superfamily:   Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain [ 109775]
Families:   Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain [ 109776]


Superfamily statistics
Genomes (88) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 304 432 1
Proteins 301 427 1


Functional annotation
General category General
Detailed category Small molecule binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0.0001998 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.3434 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.09789 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.06301 Least Informative Inherited
Biological Process (BP) ion transport 1.639e-06 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 3.391e-05 Moderately Informative Direct
Biological Process (BP) macromolecule localization 7.33e-05 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.0001264 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0001446 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.0003366 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.0006543 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.01273 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.00837 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.001293 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.008312 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.003015 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.003057 Moderately Informative Inherited
Biological Process (BP) lipid localization 0 Informative Direct
Biological Process (BP) organic acid transport 9.931e-11 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 5.155e-09 Informative Direct
Biological Process (BP) anion transport 7.88e-09 Informative Direct
Biological Process (BP) negative regulation of catalytic activity 1.349e-07 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 4.688e-07 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 1.163e-06 Informative Direct
Biological Process (BP) negative regulation of signaling 3.793e-06 Informative Direct
Biological Process (BP) negative regulation of cell communication 3.948e-06 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 1.301e-05 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.0001954 Informative Direct
Biological Process (BP) regulation of lipid storage 5.37e-14 Highly Informative Direct
Biological Process (BP) monocarboxylic acid transport 5.694e-14 Highly Informative Direct
Biological Process (BP) negative regulation of cellular catabolic process 7.654e-12 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 2.205e-11 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 4.387e-10 Highly Informative Direct
Biological Process (BP) positive regulation of catabolic process 4.667e-10 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 2.272e-08 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 6.515e-05 Least Informative Direct
Cellular Component (CC) lipid particle 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect
Mammalian Phenotype (MP)abnormal lipid homeostasis0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal triglyceride level0InformativeDirect
Mammalian Phenotype (MP)decreased triglyceride level0Highly InformativeDirect

Document: MP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentMembrane8.116e-05Least InformativeDirect
Cellular componentMitochondrion0.0001072Moderately InformativeDirect
Cellular componentLipid droplet0Highly InformativeDirect
DomainCoiled coil4.956e-06Moderately InformativeDirect
Post-translational modificationAcetylation9.107e-05Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · UniProtKB KeyWords (KW) · Internal database links ]