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HD-domain/PDEase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   HD-domain/PDEase-like [ 109603]
Superfamily:   HD-domain/PDEase-like [ 109604] (5)
Families:   HD domain [ 101340] (13)
  PDEase [ 48548] (6)
  modified HD domain [ 116973]
  MioX-like [ 140769]
  Ppx associated domain [ 140773]


Superfamily statistics
Genomes (3,158) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 34,155 160,707 45
Proteins 33,484 158,378 45


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)multicellular organismal process10.09267Least InformativeInherited
Biological Process (BP)single-organism metabolic process10.00002064Least InformativeInherited
Biological Process (BP)regulation of cellular process10.7205Least InformativeInherited
Biological Process (BP)response to stimulus10.0541Least InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.6841Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.37060.01335Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.97840.2738Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.33160.00000000000002119Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process0.00035590.5659Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.024161Moderately InformativeInherited
Biological Process (BP)reproduction0.78490.2396Moderately InformativeInherited
Biological Process (BP)system process0.43440Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.61740.0005835Moderately InformativeInherited
Biological Process (BP)negative regulation of biosynthetic process0.067980.0003825InformativeInherited
Biological Process (BP)alcohol metabolic process0.0000076551InformativeInherited
Biological Process (BP)single-organism behavior0.04040.9371InformativeInherited
Biological Process (BP)single organism reproductive process0.1190.002431InformativeInherited
Biological Process (BP)carbohydrate catabolic process0.000053230.7135InformativeInherited
Biological Process (BP)cellular carbohydrate metabolic process0.00002780.2893InformativeInherited
Biological Process (BP)regulation of lipid metabolic process0.0037130.00000009278InformativeInherited
Biological Process (BP)response to light stimulus0.04690.00000000251InformativeInherited
Biological Process (BP)defense response0.5580.01552InformativeInherited
Biological Process (BP)cellular carbohydrate catabolic process0.00000000000069060.0000005629Highly InformativeDirect
Biological Process (BP)alcohol catabolic process0.000000000099480.0000004508Highly InformativeDirect
Biological Process (BP)negative regulation of hormone metabolic process0.0000026040Highly InformativeDirect
Biological Process (BP)behavioral fear response0.0000058820.00000000000001086Highly InformativeDirect
Biological Process (BP)negative regulation of lipid biosynthetic process0.000024310.000000000000009148Highly InformativeDirect
Biological Process (BP)regulation of steroid biosynthetic process0.00004530Highly InformativeDirect
Biological Process (BP)neuromuscular process0.00010720.00000451Highly InformativeDirect
Biological Process (BP)learning or memory0.00090010.000000000000007347Highly InformativeDirect
Biological Process (BP)polyol metabolic process0.0000000047040.001773Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)hydrolase activity0.76230Least InformativeInherited
Molecular Function (MF)cation binding0.0020251Moderately InformativeInherited
Molecular Function (MF)oxidoreductase activity0.0049661Moderately InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds0.027870Moderately InformativeInherited
Molecular Function (MF)phosphoric ester hydrolase activity0.00038010InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on CH-OH group of donors0.12690.2243InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on single donors with incorporation of molecular oxygen0.000000000019940.0000000004456Highly InformativeDirect
Molecular Function (MF)phosphoric diester hydrolase activity0.00014230Highly InformativeDirect
Molecular Function (MF)iron ion binding0.00039980.005947Highly InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor0.0056980.1529Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) heterocycle metabolic process 0.000000000000003755 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0.000000000000009148 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.000000000001371 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.00002064 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.001585 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.09267 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.7205 Least Informative Inherited
Biological Process (BP) response to stimulus 0.0541 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) organic substance catabolic process 0.00000000000002119 Moderately Informative Direct
Biological Process (BP) system process 0 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.0005835 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.0000000000004336 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.0000000003703 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.0000004324 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.000002443 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.000005106 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.00112 Moderately Informative Inherited
Biological Process (BP) immune system process 0.02053 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.004873 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.5659 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.2396 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.003366 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.9046 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.2738 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.01335 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.2593 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.01374 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.4857 Moderately Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.00000009278 Informative Direct
Biological Process (BP) response to light stimulus 0.00000000251 Informative Direct
Biological Process (BP) negative regulation of biosynthetic process 0.0003825 Informative Direct
Biological Process (BP) organophosphate catabolic process 0 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0.00000000000002119 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.0000000000002192 Informative Direct
Biological Process (BP) blood circulation 0.00000000003138 Informative Direct
Biological Process (BP) negative regulation of transport 0.00000000005071 Informative Direct
Biological Process (BP) regulation of intracellular transport 0.00000951 Informative Direct
Biological Process (BP) localization of cell 0.00001135 Informative Direct
Biological Process (BP) muscle system process 0.00004693 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0.00005422 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0.0001296 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.0002264 Informative Direct
Biological Process (BP) intracellular signal transduction 0.0002346 Informative Direct
Biological Process (BP) regulation of defense response 0.0005089 Informative Direct
Biological Process (BP) response to cytokine stimulus 0.02022 Informative Inherited
Biological Process (BP) regulation of protein localization 0.009873 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.1741 Informative Inherited
Biological Process (BP) protein localization to organelle 0.04889 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.005331 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.07015 Informative Inherited
Biological Process (BP) epithelium development 0.04819 Informative Inherited
Biological Process (BP) sensory organ development 0.1112 Informative Inherited
Biological Process (BP) alcohol metabolic process 1 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 0.1755 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.9371 Informative Inherited
Biological Process (BP) single organism reproductive process 0.002431 Informative Inherited
Biological Process (BP) growth 0.2105 Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.03245 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 1 Informative Inherited
Biological Process (BP) response to lipid 0.001398 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.001661 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.3946 Informative Inherited
Biological Process (BP) cellular component movement 0.01526 Informative Inherited
Biological Process (BP) locomotion 0.07688 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 0.7135 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.2893 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.04218 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.00916 Informative Inherited
Biological Process (BP) response to wounding 0.1198 Informative Inherited
Biological Process (BP) regulation of system process 0.4075 Informative Inherited
Biological Process (BP) mitochondrion organization 0.01017 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.1962 Informative Inherited
Biological Process (BP) protein transport 0.3752 Informative Inherited
Biological Process (BP) response to bacterium 0.00358 Informative Inherited
Biological Process (BP) defense response 0.01552 Informative Inherited
Biological Process (BP) cellular carbohydrate catabolic process 0.0000005629 Highly Informative Direct
Biological Process (BP) alcohol catabolic process 0.0000004508 Highly Informative Direct
Biological Process (BP) negative regulation of hormone metabolic process 0 Highly Informative Direct
Biological Process (BP) behavioral fear response 0.00000000000001086 Highly Informative Direct
Biological Process (BP) negative regulation of lipid biosynthetic process 0.000000000000009148 Highly Informative Direct
Biological Process (BP) regulation of steroid biosynthetic process 0 Highly Informative Direct
Biological Process (BP) neuromuscular process 0.00000451 Highly Informative Direct
Biological Process (BP) learning or memory 0.000000000000007347 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0 Highly Informative Direct
Biological Process (BP) response to drug 0 Highly Informative Direct
Biological Process (BP) leukocyte migration 0 Highly Informative Direct
Biological Process (BP) regulation of cyclic nucleotide metabolic process 0.00000000000007357 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0.000000000003331 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 0.000000000004339 Highly Informative Direct
Biological Process (BP) epithelial cell development 0.0000000006498 Highly Informative Direct
Biological Process (BP) leukocyte homeostasis 0.0000000006549 Highly Informative Direct
Biological Process (BP) vascular process in circulatory system 0.000000007217 Highly Informative Direct
Biological Process (BP) protein localization to mitochondrion 0.00000001191 Highly Informative Direct
Biological Process (BP) deoxyribonucleoside triphosphate metabolic process 0.00000002112 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular transport 0.00000007306 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 0.0000001115 Highly Informative Direct
Biological Process (BP) retina development in camera-type eye 0.0000002268 Highly Informative Direct
Biological Process (BP) negative regulation of protein transport 0.000001278 Highly Informative Direct
Biological Process (BP) mitochondrial transport 0.000004595 Highly Informative Direct
Biological Process (BP) deoxyribose phosphate metabolic process 0.00001229 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 0.00001548 Highly Informative Direct
Biological Process (BP) regulation of intracellular protein transport 0.00005468 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 0.00006401 Highly Informative Direct
Biological Process (BP) hemostasis 0.0001001 Highly Informative Direct
Biological Process (BP) chemotaxis 0.0001033 Highly Informative Direct
Biological Process (BP) establishment of protein localization to organelle 0.0002454 Highly Informative Direct
Biological Process (BP) regulation of muscle contraction 0.0002798 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 0.0005822 Highly Informative Direct
Biological Process (BP) coagulation 0.0005822 Highly Informative Direct
Biological Process (BP) aging 0.0006739 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 0.004258 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.6187 Highly Informative Inherited
Biological Process (BP) purine nucleoside triphosphate catabolic process 0.2413 Highly Informative Inherited
Biological Process (BP) deoxyribonucleotide metabolic process 0.007322 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 0.001773 Highly Informative Inherited
Biological Process (BP) sensory perception 0.4005 Highly Informative Inherited
Biological Process (BP) wound healing 0.009492 Highly Informative Inherited
Biological Process (BP) purine ribonucleotide catabolic process 1 Highly Informative Inherited
Biological Process (BP) regulation of peptide transport 0.01951 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.00004203 Moderately Informative Direct
Molecular Function (MF) cation binding 1 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) phosphoric ester hydrolase activity 0 Informative Direct
Molecular Function (MF) nucleotide binding 0 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 0.2243 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 0.0000000004456 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) drug binding 0 Highly Informative Direct
Molecular Function (MF) iron ion binding 0.005947 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.1529 Highly Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cell projection 0.1726 Moderately Informative Inherited
Cellular Component (CC) synapse part 0.01326 Informative Inherited
Cellular Component (CC) perinuclear region of cytoplasm 0.00000008464 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.7809Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compoun0Moderately InformativeDirect
Enzyme Commission (EC)Diphosphotransferases0InformativeDirect
Enzyme Commission (EC)Acting on single donors with incorporation of mole0.0000002853InformativeDirect
Enzyme Commission (EC)[Protein-PII] uridylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)GTP diphosphokinase0Highly InformativeDirect
Enzyme Commission (EC)3',5'-cyclic-nucleotide phosphodiesterase0Highly InformativeDirect
Enzyme Commission (EC)Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.5792Least InformativeInherited
Disease Ontology (DO)hematologic cancer0.09478Moderately InformativeInherited
Disease Ontology (DO)lymphoblastic leukemia0.0008917InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Growth abnormality0.05833Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body weight0.005667InformativeInherited
Phenotypic Abnormality (PA)Obesity0.00001177Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.672Least InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.1235Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.224Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.3408Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.009824InformativeInherited
Mammalian Phenotype (MP)abnormal neuron number0.03035InformativeInherited
Mammalian Phenotype (MP)decreased retinal photoreceptor cell number0.00008647Highly InformativeDirect
Mammalian Phenotype (MP)neurodegeneration0.02145Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.1429Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.2715Least InformativeInherited
Plant ANatomical entity (PAN)root system0.4034Least InformativeInherited
Plant ANatomical entity (PAN)vascular system0.000001579InformativeDirect
Plant ANatomical entity (PAN)portion of ground tissue0.00002308InformativeDirect
Plant ANatomical entity (PAN)fruit0.0004173InformativeDirect
Plant ANatomical entity (PAN)root stele0.000002485Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.00000000001654Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups0.00000007674Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compounds0InformativeDirect
Enzyme Commission (EC)Acting on single donors with incorporation of molecular oxygen0.0000007036InformativeDirect
Enzyme Commission (EC)Diphosphotransferases0Highly InformativeDirect
Enzyme Commission (EC)[Protein-PII] uridylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Diphosphoric monoester hydrolases0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processProtein biosynthesis0InformativeDirect
Biological processNitrogen fixation0.000001077InformativeDirect
Biological processSensory transduction0.0004548InformativeDirect
Biological processVision0.0000003875Highly InformativeDirect
Biological processAntiviral defense0.000005483Highly InformativeDirect
Cellular componentMembrane0.00001308Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
DomainRepeat0.00000000007708Least InformativeDirect
DomainTransmembrane0.000000001926Least InformativeDirect
Molecular functionNucleotide-binding0.00000002546Least InformativeDirect
Molecular functionMagnesium0.00000002851Moderately InformativeDirect
Molecular functionRNA-binding0.000005992Moderately InformativeDirect
Molecular functionCalmodulin-binding0.0002086InformativeDirect
Molecular functioncAMP0Highly InformativeDirect
Molecular functioncGMP0Highly InformativeDirect
Molecular functioncAMP-binding0.00004181Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationLigase0Moderately InformativeDirect
Post-translational modificationNuclease0Moderately InformativeDirect
Post-translational modificationNucleotidyltransferase0Moderately InformativeDirect
Post-translational modificationAminoacyl-tRNA synthetase0InformativeDirect
Post-translational modificationEndonuclease0.0000000000001965InformativeDirect
Post-translational modificationPrenylation9.055e-16InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)nucleotide metabolism0Moderately InformativeDirect
UniPathway (UP)purine metabolism0Moderately InformativeDirect
UniPathway (UP)alcohol metabolism0.00000000001993Moderately InformativeDirect
UniPathway (UP)polyol degradation0.000000000000003122InformativeDirect
UniPathway (UP)ppGpp biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 24 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HD-domain/PDEase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 24 hidden Markov models representing the HD-domain/PDEase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]