SUPERFAMILY 1.75 HMM library and genome assignments server


HD-domain/PDEase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   HD-domain/PDEase-like [ 109603]
Superfamily:   HD-domain/PDEase-like [ 109604] (5)
Families:   HD domain [ 101340] (13)
  PDEase [ 48548] (6)
  modified HD domain [ 116973]
  MioX-like [ 140769]
  Ppx associated domain [ 140773]


Superfamily statistics
Genomes (3,114) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 33,534 75,846 45
Proteins 32,879 74,343 45


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process13.92e-05Least InformativeInherited
Biological Process (BP)regulation of cellular process10.9564Least InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.6861Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.35950.00683Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.97280.186Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process0.00032220.5372Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.025031Moderately InformativeInherited
Biological Process (BP)negative regulation of biosynthetic process0.0670.0002264InformativeInherited
Biological Process (BP)alcohol metabolic process6.265e-061InformativeInherited
Biological Process (BP)carbohydrate catabolic process6.317e-050.6695InformativeInherited
Biological Process (BP)cellular carbohydrate metabolic process2.511e-050.2638InformativeInherited
Biological Process (BP)regulation of lipid metabolic process0.0033356.949e-08InformativeInherited
Biological Process (BP)cellular carbohydrate catabolic process1.097e-124.755e-07Highly InformativeDirect
Biological Process (BP)alcohol catabolic process4.642e-113.074e-07Highly InformativeDirect
Biological Process (BP)negative regulation of hormone metabolic process2.933e-060Highly InformativeDirect
Biological Process (BP)negative regulation of lipid biosynthetic process2.238e-057.333e-15Highly InformativeDirect
Biological Process (BP)regulation of steroid biosynthetic process5.099e-050Highly InformativeDirect
Biological Process (BP)polyol metabolic process3.807e-090.001773Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)hydrolase activity0.770Least InformativeInherited
Molecular Function (MF)cation binding0.0015911Moderately InformativeInherited
Molecular Function (MF)oxidoreductase activity0.0050131Moderately InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds0.027760Moderately InformativeInherited
Molecular Function (MF)transition metal ion binding9.528e-065.851e-05InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on CH-OH group of donors0.13180.2165InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on single donors with incorporation of molecular oxygen2.882e-115.089e-10Highly InformativeDirect
Molecular Function (MF)phosphoric diester hydrolase activity0.00011530Highly InformativeDirect
Molecular Function (MF)iron ion binding0.00032470.00309Highly InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor0.0061480.1478Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) heterocycle metabolic process 2.112e-14 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 6.85e-14 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 7.783e-12 Least Informative Direct
Biological Process (BP) single-organism metabolic process 3.92e-05 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.002902 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.522 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.9564 Least Informative Inherited
Biological Process (BP) response to stimulus 0.4972 Least Informative Inherited
Biological Process (BP) organic cyclic compound catabolic process 0 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) system process 0 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0 Moderately Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 2.285e-14 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 6.956e-13 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 1.815e-10 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 1.157e-07 Moderately Informative Direct
Biological Process (BP) response to organic substance 1.252e-06 Moderately Informative Direct
Biological Process (BP) multi-organism process 4.484e-06 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.0002284 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0004617 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.8934 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.009451 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.06914 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.5372 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.84 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.186 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.00683 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.8914 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.01018 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.4161 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.6665 Moderately Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 6.949e-08 Informative Direct
Biological Process (BP) negative regulation of biosynthetic process 0.0002264 Informative Direct
Biological Process (BP) organophosphate catabolic process 0 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 5.084e-13 Informative Direct
Biological Process (BP) blood circulation 1.63e-11 Informative Direct
Biological Process (BP) intracellular signal transduction 4.188e-07 Informative Direct
Biological Process (BP) regulation of establishment of protein localization 3.056e-06 Informative Direct
Biological Process (BP) localization of cell 6.82e-06 Informative Direct
Biological Process (BP) regulation of intracellular transport 1.505e-05 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 4.811e-05 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.0003449 Informative Direct
Biological Process (BP) regulation of defense response 0.0003578 Informative Direct
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 0.07965 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.02593 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.159 Informative Inherited
Biological Process (BP) protein localization to organelle 0.0462 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.006555 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.08378 Informative Inherited
Biological Process (BP) epithelium development 0.03728 Informative Inherited
Biological Process (BP) sensory organ development 0.09667 Informative Inherited
Biological Process (BP) immune effector process 0.932 Informative Inherited
Biological Process (BP) defense response 1 Informative Inherited
Biological Process (BP) alcohol metabolic process 1 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 0.2044 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 1 Informative Inherited
Biological Process (BP) cell-cell signaling 0.7548 Informative Inherited
Biological Process (BP) single organism reproductive process 0.7764 Informative Inherited
Biological Process (BP) single-organism behavior 1 Informative Inherited
Biological Process (BP) growth 0.03796 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.2768 Informative Inherited
Biological Process (BP) response to lipid 0.001761 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.001106 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.3199 Informative Inherited
Biological Process (BP) cellular component movement 0.01114 Informative Inherited
Biological Process (BP) locomotion 0.05532 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 0.6695 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.2638 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.3967 Informative Inherited
Biological Process (BP) response to light stimulus 0.02528 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.004454 Informative Inherited
Biological Process (BP) response to wounding 0.1097 Informative Inherited
Biological Process (BP) regulation of system process 0.3548 Informative Inherited
Biological Process (BP) mitochondrion organization 0.008982 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.182 Informative Inherited
Biological Process (BP) protein transport 0.3555 Informative Inherited
Biological Process (BP) response to bacterium 0.003812 Informative Inherited
Biological Process (BP) cellular carbohydrate catabolic process 4.755e-07 Highly Informative Direct
Biological Process (BP) alcohol catabolic process 3.074e-07 Highly Informative Direct
Biological Process (BP) negative regulation of hormone metabolic process 0 Highly Informative Direct
Biological Process (BP) negative regulation of lipid biosynthetic process 7.333e-15 Highly Informative Direct
Biological Process (BP) regulation of steroid biosynthetic process 0 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0 Highly Informative Direct
Biological Process (BP) response to drug 0 Highly Informative Direct
Biological Process (BP) leukocyte migration 0 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 1.989e-12 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 6.067e-12 Highly Informative Direct
Biological Process (BP) epithelial cell development 3.251e-10 Highly Informative Direct
Biological Process (BP) leukocyte homeostasis 1.133e-09 Highly Informative Direct
Biological Process (BP) establishment of protein localization to mitochondrion 5.095e-09 Highly Informative Direct
Biological Process (BP) vascular process in circulatory system 1.255e-08 Highly Informative Direct
Biological Process (BP) deoxyribonucleoside triphosphate metabolic process 1.345e-08 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular transport 1.1e-07 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 1.669e-07 Highly Informative Direct
Biological Process (BP) retina development in camera-type eye 1.764e-07 Highly Informative Direct
Biological Process (BP) detection of light stimulus 9.184e-07 Highly Informative Direct
Biological Process (BP) regulation of cyclic nucleotide metabolic process 1.391e-06 Highly Informative Direct
Biological Process (BP) negative regulation of protein transport 2.329e-06 Highly Informative Direct
Biological Process (BP) mitochondrial transport 3.842e-06 Highly Informative Direct
Biological Process (BP) deoxyribose phosphate metabolic process 7.248e-06 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 7.92e-06 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 6.147e-05 Highly Informative Direct
Biological Process (BP) regulation of intracellular protein transport 8.386e-05 Highly Informative Direct
Biological Process (BP) hemostasis 9.716e-05 Highly Informative Direct
Biological Process (BP) chemotaxis 0.0001778 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0.0002021 Highly Informative Direct
Biological Process (BP) coagulation 0.0002483 Highly Informative Direct
Biological Process (BP) regulation of muscle contraction 0.0002805 Highly Informative Direct
Biological Process (BP) cellular response to organic cyclic compound 0.0005899 Highly Informative Direct
Biological Process (BP) aging 0.0006124 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 0.000934 Highly Informative Direct
Biological Process (BP) cell growth 0.1348 Highly Informative Inherited
Biological Process (BP) developmental growth 0.4301 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 1 Highly Informative Inherited
Biological Process (BP) neuron projection development 1 Highly Informative Inherited
Biological Process (BP) response to virus 0.518 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 0.001562 Highly Informative Inherited
Biological Process (BP) regulation of inflammatory response 0.003643 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) response to ethanol 0.002661 Highly Informative Inherited
Biological Process (BP) adult behavior 0.07532 Highly Informative Inherited
Biological Process (BP) deoxyribonucleotide metabolic process 0.005269 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.01368 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.409 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 0.001773 Highly Informative Inherited
Biological Process (BP) sensory perception 0.01526 Highly Informative Inherited
Biological Process (BP) wound healing 0.008304 Highly Informative Inherited
Biological Process (BP) purine ribonucleotide catabolic process 1 Highly Informative Inherited
Biological Process (BP) regulation of peptide transport 0.0162 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) anion binding 3.574e-05 Moderately Informative Direct
Molecular Function (MF) cation binding 1 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) transition metal ion binding 5.851e-05 Informative Direct
Molecular Function (MF) nucleotide binding 0 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 0.2165 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 5.089e-10 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) drug binding 0 Highly Informative Direct
Molecular Function (MF) iron ion binding 0.00309 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.1478 Highly Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cell projection 0.1192 Moderately Informative Inherited
Cellular Component (CC) synapse part 0.006572 Informative Inherited
Cellular Component (CC) perinuclear region of cytoplasm 2.813e-08 Highly Informative Direct
Cellular Component (CC) synaptic membrane 5.425e-06 Highly Informative Direct
Cellular Component (CC) cilium 6.958e-06 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.7809Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compoun0Moderately InformativeDirect
Enzyme Commission (EC)Diphosphotransferases0InformativeDirect
Enzyme Commission (EC)Acting on single donors with incorporation of mole2.853e-07InformativeDirect
Enzyme Commission (EC)[Protein-PII] uridylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)GTP diphosphokinase0Highly InformativeDirect
Enzyme Commission (EC)3',5'-cyclic-nucleotide phosphodiesterase0Highly InformativeDirect
Enzyme Commission (EC)Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.6608Least InformativeInherited
Disease Ontology (DO)hematologic cancer0.1198Moderately InformativeInherited
Disease Ontology (DO)chronic leukemia0.0004909InformativeDirect
Disease Ontology (DO)lymphoblastic leukemia0.001236InformativeInherited
Disease Ontology (DO)chronic lymphocytic leukemia2.656e-05Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Growth abnormality0.05948Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body weight0.005591InformativeInherited
Phenotypic Abnormality (PA)Obesity9.469e-06Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.7326Least InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.1409Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.2541Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.3808Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.5523Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.01163InformativeInherited
Mammalian Phenotype (MP)abnormal neuron number0.03523InformativeInherited
Mammalian Phenotype (MP)decreased retinal photoreceptor cell number0.0001161Highly InformativeDirect
Mammalian Phenotype (MP)neuron degeneration0.01403Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.1429Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.2715Least InformativeInherited
Plant ANatomical entity (PAN)root system0.4034Least InformativeInherited
Plant ANatomical entity (PAN)vascular system1.579e-06InformativeDirect
Plant ANatomical entity (PAN)portion of ground tissue2.308e-05InformativeDirect
Plant ANatomical entity (PAN)fruit0.0004173InformativeDirect
Plant ANatomical entity (PAN)root stele2.485e-06Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases2.568e-12Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1.51e-05Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compounds0InformativeDirect
Enzyme Commission (EC)Acting on single donors with incorporation of molecular oxygen5.883e-07InformativeDirect
Enzyme Commission (EC)Diphosphotransferases0Highly InformativeDirect
Enzyme Commission (EC)[Protein-PII] uridylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Diphosphoric monoester hydrolases0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processProtein biosynthesis0InformativeDirect
Biological processNitrogen fixation1.018e-06InformativeDirect
Biological processSensory transduction0.0003687InformativeDirect
Biological processVision4.069e-07Highly InformativeDirect
Biological processAntiviral defense4.629e-06Highly InformativeDirect
Cellular componentMembrane5.705e-06Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
DomainRepeat4.878e-11Least InformativeDirect
DomainTransmembrane8.143e-11Least InformativeDirect
Molecular functionNucleotide-binding2.318e-06Least InformativeDirect
Molecular functionMagnesium5.689e-10Moderately InformativeDirect
Molecular functionRNA-binding3.793e-06Moderately InformativeDirect
Molecular functionCalmodulin-binding0.0002012InformativeDirect
Molecular functioncAMP0Highly InformativeDirect
Molecular functioncGMP0Highly InformativeDirect
Molecular functioncAMP-binding3.382e-05Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationLigase0Moderately InformativeDirect
Post-translational modificationNuclease0Moderately InformativeDirect
Post-translational modificationNucleotidyltransferase0Moderately InformativeDirect
Post-translational modificationAminoacyl-tRNA synthetase0InformativeDirect
Post-translational modificationEndonuclease1.397e-13InformativeDirect
Post-translational modificationPrenylation4.617e-16InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)nucleotide metabolism0Moderately InformativeDirect
UniPathway (UP)heterocycle metabolism0Moderately InformativeDirect
UniPathway (UP)purine nucleotide metabolism0InformativeDirect
UniPathway (UP)purine biosynthesis1InformativeInherited
UniPathway (UP)ppGpp biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 24 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HD-domain/PDEase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 24 hidden Markov models representing the HD-domain/PDEase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


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