SUPERFAMILY 1.75 HMM library and genome assignments server


HD-domain/PDEase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   HD-domain/PDEase-like [ 109603]
Superfamily:   HD-domain/PDEase-like [ 109604] (5)
Families:   HD domain [ 101340] (13)
  PDEase [ 48548] (6)
  modified HD domain [ 116973]
  MioX-like [ 140769]
  Ppx associated domain [ 140773]


Superfamily statistics
Genomes (3,150) Uniprot 2014_03 PDB chains (SCOP 1.75)
Domains 33,842 126,002 45
Proteins 33,170 123,849 45


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process12.551e-05Least InformativeInherited
Biological Process (BP)regulation of cellular process10.9718Least InformativeInherited
Biological Process (BP)regulation of biosynthetic process0.70731Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.35320.007875Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.97120.2048Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process0.000290.5563Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.023871Moderately InformativeInherited
Biological Process (BP)negative regulation of biosynthetic process0.067120.0002799InformativeInherited
Biological Process (BP)alcohol metabolic process5.796e-061InformativeInherited
Biological Process (BP)carbohydrate catabolic process5.885e-050.7046InformativeInherited
Biological Process (BP)cellular carbohydrate metabolic process2.484e-050.2881InformativeInherited
Biological Process (BP)regulation of lipid metabolic process0.0034666.759e-08InformativeInherited
Biological Process (BP)cellular carbohydrate catabolic process9.707e-135.005e-07Highly InformativeDirect
Biological Process (BP)alcohol catabolic process4.088e-112.667e-07Highly InformativeDirect
Biological Process (BP)negative regulation of hormone metabolic process2.789e-060Highly InformativeDirect
Biological Process (BP)negative regulation of lipid biosynthetic process2.126e-055.55e-15Highly InformativeDirect
Biological Process (BP)regulation of steroid biosynthetic process4.835e-050Highly InformativeDirect
Biological Process (BP)polyol metabolic process3.556e-090.001609Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)hydrolase activity0.75240Least InformativeInherited
Molecular Function (MF)cation binding0.0015141Moderately InformativeInherited
Molecular Function (MF)oxidoreductase activity0.0043371Moderately InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds0.025580Moderately InformativeInherited
Molecular Function (MF)transition metal ion binding8.715e-065.234e-05InformativeDirect
Molecular Function (MF)phosphoric ester hydrolase activity0.00035810InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on CH-OH group of donors0.13410.2084InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on single donors with incorporation of molecular oxygen2.898e-114.296e-10Highly InformativeDirect
Molecular Function (MF)phosphoric diester hydrolase activity0.00011370Highly InformativeDirect
Molecular Function (MF)iron ion binding0.0003240.003161Highly InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor0.0056920.1414Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) heterocycle metabolic process 1.92e-15 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 5.55e-15 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 8.244e-13 Least Informative Direct
Biological Process (BP) single-organism metabolic process 2.551e-05 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.002167 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.5881 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.9718 Least Informative Inherited
Biological Process (BP) response to stimulus 0.5118 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound catabolic process 0 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) system process 0 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0 Moderately Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 6.646e-14 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 4.658e-13 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 3.444e-10 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 6.873e-08 Moderately Informative Direct
Biological Process (BP) response to organic substance 1.449e-06 Moderately Informative Direct
Biological Process (BP) multi-organism process 2.678e-06 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.0002321 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.000615 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.01734 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.1119 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.5563 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.9716 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.8481 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.2048 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.007875 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.8854 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.01306 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.4484 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.6696 Moderately Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 6.759e-08 Informative Direct
Biological Process (BP) negative regulation of biosynthetic process 0.0002799 Informative Direct
Biological Process (BP) organophosphate catabolic process 0 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 2.005e-13 Informative Direct
Biological Process (BP) blood circulation 2.661e-11 Informative Direct
Biological Process (BP) intracellular signal transduction 9.218e-07 Informative Direct
Biological Process (BP) muscle system process 1.158e-06 Informative Direct
Biological Process (BP) regulation of establishment of protein localization 3.11e-06 Informative Direct
Biological Process (BP) localization of cell 9.306e-06 Informative Direct
Biological Process (BP) regulation of intracellular transport 9.44e-06 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 4.653e-05 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.0002594 Informative Direct
Biological Process (BP) regulation of defense response 0.0003637 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0.07864 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.02148 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.1635 Informative Inherited
Biological Process (BP) protein localization to organelle 0.04532 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.006612 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.07233 Informative Inherited
Biological Process (BP) response to other organism 0.1313 Informative Inherited
Biological Process (BP) epithelium development 0.04427 Informative Inherited
Biological Process (BP) sensory organ development 0.1079 Informative Inherited
Biological Process (BP) immune effector process 0.894 Informative Inherited
Biological Process (BP) defense response 1 Informative Inherited
Biological Process (BP) cell-cell signaling 0.8992 Informative Inherited
Biological Process (BP) alcohol metabolic process 1 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 0.1902 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 1 Informative Inherited
Biological Process (BP) single-organism behavior 1 Informative Inherited
Biological Process (BP) single organism reproductive process 0.9122 Informative Inherited
Biological Process (BP) growth 0.07387 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.1932 Informative Inherited
Biological Process (BP) response to lipid 0.001351 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.001363 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.3416 Informative Inherited
Biological Process (BP) cellular component movement 0.01437 Informative Inherited
Biological Process (BP) locomotion 0.07013 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 0.7046 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.2881 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.02995 Informative Inherited
Biological Process (BP) response to light stimulus 0.02531 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.003803 Informative Inherited
Biological Process (BP) response to wounding 0.1103 Informative Inherited
Biological Process (BP) regulation of system process 0.3686 Informative Inherited
Biological Process (BP) mitochondrion organization 0.00894 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.1786 Informative Inherited
Biological Process (BP) protein transport 0.3496 Informative Inherited
Biological Process (BP) cellular carbohydrate catabolic process 5.005e-07 Highly Informative Direct
Biological Process (BP) alcohol catabolic process 2.667e-07 Highly Informative Direct
Biological Process (BP) negative regulation of hormone metabolic process 0 Highly Informative Direct
Biological Process (BP) negative regulation of lipid biosynthetic process 5.55e-15 Highly Informative Direct
Biological Process (BP) regulation of steroid biosynthetic process 0 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0 Highly Informative Direct
Biological Process (BP) response to drug 0 Highly Informative Direct
Biological Process (BP) leukocyte migration 0 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 2.52e-12 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 3.68e-12 Highly Informative Direct
Biological Process (BP) epithelial cell development 4.179e-10 Highly Informative Direct
Biological Process (BP) leukocyte homeostasis 5.933e-10 Highly Informative Direct
Biological Process (BP) vascular process in circulatory system 7.806e-09 Highly Informative Direct
Biological Process (BP) protein localization to mitochondrion 7.834e-09 Highly Informative Direct
Biological Process (BP) deoxyribonucleoside triphosphate metabolic process 1.455e-08 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular transport 8.776e-08 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 2.101e-07 Highly Informative Direct
Biological Process (BP) retina development in camera-type eye 2.252e-07 Highly Informative Direct
Biological Process (BP) detection of light stimulus 8.818e-07 Highly Informative Direct
Biological Process (BP) regulation of cyclic nucleotide metabolic process 1.223e-06 Highly Informative Direct
Biological Process (BP) negative regulation of protein transport 1.759e-06 Highly Informative Direct
Biological Process (BP) mitochondrial transport 3.658e-06 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 7.532e-06 Highly Informative Direct
Biological Process (BP) deoxyribose phosphate metabolic process 8.999e-06 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 5.669e-05 Highly Informative Direct
Biological Process (BP) multi-organism behavior 6.239e-05 Highly Informative Direct
Biological Process (BP) regulation of intracellular protein transport 7.502e-05 Highly Informative Direct
Biological Process (BP) hemostasis 8.891e-05 Highly Informative Direct
Biological Process (BP) chemotaxis 0.0001537 Highly Informative Direct
Biological Process (BP) coagulation 0.0001881 Highly Informative Direct
Biological Process (BP) establishment of protein localization to organelle 0.000239 Highly Informative Direct
Biological Process (BP) regulation of muscle contraction 0.0002575 Highly Informative Direct
Biological Process (BP) aging 0.0005606 Highly Informative Direct
Biological Process (BP) learning or memory 0.0006117 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 0.0009782 Highly Informative Direct
Biological Process (BP) response to virus 0.5299 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 0.003436 Highly Informative Inherited
Biological Process (BP) regulation of inflammatory response 0.003768 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.6214 Highly Informative Inherited
Biological Process (BP) deoxyribonucleotide metabolic process 0.006106 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 0.001609 Highly Informative Inherited
Biological Process (BP) sensory perception 0.009406 Highly Informative Inherited
Biological Process (BP) wound healing 0.008562 Highly Informative Inherited
Biological Process (BP) purine ribonucleotide catabolic process 1 Highly Informative Inherited
Biological Process (BP) regulation of peptide transport 0.01557 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) anion binding 2.562e-05 Moderately Informative Direct
Molecular Function (MF) cation binding 1 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) transition metal ion binding 5.234e-05 Informative Direct
Molecular Function (MF) phosphoric ester hydrolase activity 0 Informative Direct
Molecular Function (MF) nucleotide binding 0 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 0.2084 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 4.296e-10 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) drug binding 0 Highly Informative Direct
Molecular Function (MF) iron ion binding 0.003161 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.1414 Highly Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cell projection 0.1297 Moderately Informative Inherited
Cellular Component (CC) synapse part 0.008858 Informative Inherited
Cellular Component (CC) perinuclear region of cytoplasm 4.967e-08 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.7809Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compoun0Moderately InformativeDirect
Enzyme Commission (EC)Diphosphotransferases0InformativeDirect
Enzyme Commission (EC)Acting on single donors with incorporation of mole2.853e-07InformativeDirect
Enzyme Commission (EC)[Protein-PII] uridylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)GTP diphosphokinase0Highly InformativeDirect
Enzyme Commission (EC)3',5'-cyclic-nucleotide phosphodiesterase0Highly InformativeDirect
Enzyme Commission (EC)Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.656Least InformativeInherited
Disease Ontology (DO)hematologic cancer0.1189Moderately InformativeInherited
Disease Ontology (DO)chronic leukemia0.0004902InformativeDirect
Disease Ontology (DO)lymphoblastic leukemia0.001233InformativeInherited
Disease Ontology (DO)chronic lymphocytic leukemia2.656e-05Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Growth abnormality0.05934Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body weight0.005582InformativeInherited
Phenotypic Abnormality (PA)Obesity9.462e-06Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.7359Least InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.1411Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.2555Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.3816Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.01178InformativeInherited
Mammalian Phenotype (MP)abnormal neuron number0.03497InformativeInherited
Mammalian Phenotype (MP)decreased retinal photoreceptor cell number0.0001129Highly InformativeDirect
Mammalian Phenotype (MP)neuron degeneration0.01399Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.1429Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.2715Least InformativeInherited
Plant ANatomical entity (PAN)root system0.4034Least InformativeInherited
Plant ANatomical entity (PAN)vascular system1.579e-06InformativeDirect
Plant ANatomical entity (PAN)portion of ground tissue2.308e-05InformativeDirect
Plant ANatomical entity (PAN)fruit0.0004173InformativeDirect
Plant ANatomical entity (PAN)root stele2.485e-06Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases2.781e-12Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1.307e-05Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compounds0InformativeDirect
Enzyme Commission (EC)Acting on single donors with incorporation of molecular oxygen5.412e-07InformativeDirect
Enzyme Commission (EC)Diphosphotransferases0Highly InformativeDirect
Enzyme Commission (EC)[Protein-PII] uridylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Diphosphoric monoester hydrolases0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processProtein biosynthesis0InformativeDirect
Biological processNitrogen fixation9.885e-07InformativeDirect
Biological processSensory transduction0.0003892InformativeDirect
Biological processVision4.237e-07Highly InformativeDirect
Biological processAntiviral defense4.207e-06Highly InformativeDirect
Cellular componentMembrane4.824e-06Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
DomainRepeat4.735e-11Least InformativeDirect
DomainTransmembrane6.154e-11Least InformativeDirect
Molecular functionNucleotide-binding1.009e-06Least InformativeDirect
Molecular functionMagnesium2.867e-09Moderately InformativeDirect
Molecular functionRNA-binding3.032e-06Moderately InformativeDirect
Molecular functionCalmodulin-binding0.0001948InformativeDirect
Molecular functioncAMP0Highly InformativeDirect
Molecular functioncGMP0Highly InformativeDirect
Molecular functioncAMP-binding3.308e-05Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationLigase0Moderately InformativeDirect
Post-translational modificationNuclease0Moderately InformativeDirect
Post-translational modificationNucleotidyltransferase0Moderately InformativeDirect
Post-translational modificationAminoacyl-tRNA synthetase0InformativeDirect
Post-translational modificationEndonuclease3.141e-13InformativeDirect
Post-translational modificationPrenylation4.607e-16InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)nucleotide metabolism0Moderately InformativeDirect
UniPathway (UP)purine metabolism0Moderately InformativeDirect
UniPathway (UP)alcohol metabolism1.454e-11Moderately InformativeDirect
UniPathway (UP)polyol degradation2.686e-15InformativeDirect
UniPathway (UP)ppGpp biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 24 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HD-domain/PDEase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 24 hidden Markov models representing the HD-domain/PDEase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]