SUPERFAMILY 1.75 HMM library and genome assignments server

Mitochondrial carrier superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Mitochondrial carrier [ 103505]
Superfamily:   Mitochondrial carrier [ 103506]
Families:   Mitochondrial carrier [ 103507]


Superfamily statistics
Genomes (512) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 24,624 26,406 1
Proteins 24,245 26,123 1


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)localization00Least InformativeDirect
Biological Process (BP)single-organism cellular process0.38791Least InformativeInherited
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)multicellular organismal process0.99131Least InformativeInherited
Biological Process (BP)developmental process0.63511Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)ion transport00Moderately InformativeDirect
Biological Process (BP)oxidation-reduction process0.00010980.000000007313Moderately InformativeDirect
Biological Process (BP)organic substance transport0.00000000000099670Moderately InformativeDirect
Biological Process (BP)regulation of biological quality0.0045130.8739Moderately InformativeInherited
Biological Process (BP)single-organism organelle organization11Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction11Moderately InformativeInherited
Biological Process (BP)regulation of localization0.20650.8027Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.33440.2767Moderately InformativeInherited
Biological Process (BP)cellular catabolic process11Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process0.92491Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process11Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus11Moderately InformativeInherited
Biological Process (BP)cellular localization0.85170.9754Moderately InformativeInherited
Biological Process (BP)macromolecule localization11Moderately InformativeInherited
Biological Process (BP)immune system process0.94241Moderately InformativeInherited
Biological Process (BP)cell differentiation0.87651Moderately InformativeInherited
Biological Process (BP)organ development0.3031Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization11Moderately InformativeInherited
Biological Process (BP)anion transport0.0000000000019670InformativeDirect
Biological Process (BP)mitochondrion organization0.0000000018980.000000007917InformativeDirect
Biological Process (BP)organic acid transport00InformativeDirect
Biological Process (BP)energy derivation by oxidation of organic compounds0.000024460.000000000002106InformativeDirect
Biological Process (BP)nitrogen compound transport00InformativeDirect
Biological Process (BP)apoptotic process0.70560.4746InformativeInherited
Biological Process (BP)single-organism membrane organization0.56070.1625InformativeInherited
Biological Process (BP)single-organism intracellular transport0.15530.04035InformativeInherited
Biological Process (BP)regulation of intracellular transport0.17060.2813InformativeInherited
Biological Process (BP)regulation of apoptotic process0.70881InformativeInherited
Biological Process (BP)regulation of organelle organization0.27631InformativeInherited
Biological Process (BP)negative regulation of cell communication0.24261InformativeInherited
Biological Process (BP)negative regulation of signaling0.22441InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.62731InformativeInherited
Biological Process (BP)negative regulation of transport0.02680.1208InformativeInherited
Biological Process (BP)negative regulation of cell death0.013230.08347InformativeInherited
Biological Process (BP)ion transmembrane transport0.000024970.114InformativeInherited
Biological Process (BP)carboxylic acid catabolic process0.021950.00408InformativeInherited
Biological Process (BP)response to inorganic substance0.45850.00009671InformativeInherited
Biological Process (BP)protein localization to organelle0.07560.3408InformativeInherited
Biological Process (BP)organelle localization11InformativeInherited
Biological Process (BP)cation homeostasis0.0045960.0945InformativeInherited
Biological Process (BP)cellular chemical homeostasis0.27190.311InformativeInherited
Biological Process (BP)hematopoietic or lymphoid organ development0.0012370.2178InformativeInherited
Biological Process (BP)negative regulation of cellular component organization0.13970.7794InformativeInherited
Biological Process (BP)metal ion transport11InformativeInherited
Biological Process (BP)transition metal ion transport0.00028990.0000007574Highly InformativeDirect
Biological Process (BP)dicarboxylic acid transport0.000000023150.00000000008547Highly InformativeDirect
Biological Process (BP)mitochondrial transport00Highly InformativeDirect
Biological Process (BP)mitochondrial membrane organization0.00027540.00007575Highly InformativeDirect
Biological Process (BP)regulation of mitochondrion organization0.000025130.000101Highly InformativeDirect
Biological Process (BP)organophosphate ester transport00Highly InformativeDirect
Biological Process (BP)nucleobase-containing compound transport00Highly InformativeDirect
Biological Process (BP)erythrocyte differentiation0.00000000025360.00000008077Highly InformativeDirect
Biological Process (BP)protein localization to mitochondrion0.000011410.000005982Highly InformativeDirect
Biological Process (BP)regulation of membrane permeability0.00029090.000006293Highly InformativeDirect
Biological Process (BP)anion transmembrane transport0.000000000039290.0000000000001008Highly InformativeDirect
Biological Process (BP)carbohydrate derivative transport00Highly InformativeDirect
Biological Process (BP)negative regulation of intracellular transport0.00023980.001835Highly InformativeInherited
Biological Process (BP)negative regulation of apoptotic signaling pathway0.0011380.008068Highly InformativeInherited
Biological Process (BP)cell-type specific apoptotic process0.0037670.0105Highly InformativeInherited
Biological Process (BP)response to calcium ion0.0038920.000000000004288Highly InformativeInherited
Biological Process (BP)cellular response to metal ion0.099070.006076Highly InformativeInherited
Biological Process (BP)cellular calcium ion homeostasis0.23020.4689Highly InformativeInherited
Biological Process (BP)amino acid transport0.96960.1958Highly InformativeInherited
Biological Process (BP)inorganic anion transport11Highly InformativeInherited
Molecular Function (MF)hydrolase activity11Least InformativeInherited
Molecular Function (MF)transporter activity00Moderately InformativeDirect
Molecular Function (MF)anion transmembrane transporter activity00InformativeDirect
Molecular Function (MF)metal ion transmembrane transporter activity0.00032610.09362InformativeInherited
Molecular Function (MF)active transmembrane transporter activity10.9752InformativeInherited
Molecular Function (MF)organic cation transmembrane transporter activity0.00075490.000000001824Highly InformativeDirect
Molecular Function (MF)secondary active transmembrane transporter activity6.814e-160Highly InformativeDirect
Molecular Function (MF)nucleoside-diphosphatase activity0.00000001080.0000000002469Highly InformativeDirect
Molecular Function (MF)transition metal ion transmembrane transporter activity0.00026330.0000001829Highly InformativeDirect
Molecular Function (MF)carbohydrate derivative transporter activity00Highly InformativeDirect
Cellular Component (CC)membrane00.00000000000000158Least InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle00Least InformativeDirect
Cellular Component (CC)cytoplasmic part00Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.0000014730.0003934Least InformativeDirect
Cellular Component (CC)protein complex11Least InformativeInherited
Cellular Component (CC)non-membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)organelle envelope00Moderately InformativeDirect
Cellular Component (CC)mitochondrial part00Moderately InformativeDirect
Cellular Component (CC)cytoskeleton11Moderately InformativeInherited
Cellular Component (CC)lipid particle0.0004120.0001941InformativeDirect
Cellular Component (CC)microtubule cytoskeleton0.42040.9434InformativeInherited
Cellular Component (CC)organelle outer membrane0.00073170.0002058Highly InformativeDirect
Cellular Component (CC)spindle0.016390.2201Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0.000000007313 Moderately Informative Direct
Biological Process (BP) organic substance transport 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.8739 Moderately Informative Inherited
Biological Process (BP) single-organism organelle organization 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.8027 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.2767 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.9754 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) anion transport 0 Informative Direct
Biological Process (BP) mitochondrion organization 0.000000007917 Informative Direct
Biological Process (BP) response to inorganic substance 0.00009671 Informative Direct
Biological Process (BP) organic acid transport 0 Informative Direct
Biological Process (BP) energy derivation by oxidation of organic compounds 0.000000000002106 Informative Direct
Biological Process (BP) nitrogen compound transport 0 Informative Direct
Biological Process (BP) single-organism intracellular transport 0.04035 Informative Inherited
Biological Process (BP) single-organism membrane organization 0.1625 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.2813 Informative Inherited
Biological Process (BP) regulation of apoptotic process 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of transport 0.1208 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.08347 Informative Inherited
Biological Process (BP) ion transmembrane transport 0.114 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.00408 Informative Inherited
Biological Process (BP) protein localization to organelle 0.3408 Informative Inherited
Biological Process (BP) organelle localization 1 Informative Inherited
Biological Process (BP) cation homeostasis 0.0945 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.311 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.123 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.2178 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.7794 Informative Inherited
Biological Process (BP) apoptotic process 0.4746 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) hexose metabolic process 0.001202 Informative Inherited
Biological Process (BP) transition metal ion transport 0.0000007574 Highly Informative Direct
Biological Process (BP) glucose metabolic process 0.0002568 Highly Informative Direct
Biological Process (BP) dicarboxylic acid transport 0.00000000008547 Highly Informative Direct
Biological Process (BP) mitochondrial transport 0 Highly Informative Direct
Biological Process (BP) mitochondrial membrane organization 0.00007575 Highly Informative Direct
Biological Process (BP) regulation of mitochondrion organization 0.000101 Highly Informative Direct
Biological Process (BP) organophosphate ester transport 0 Highly Informative Direct
Biological Process (BP) nucleobase-containing compound transport 0 Highly Informative Direct
Biological Process (BP) electron transport chain 0.00000007698 Highly Informative Direct
Biological Process (BP) erythrocyte differentiation 0.00000008077 Highly Informative Direct
Biological Process (BP) monosaccharide biosynthetic process 0.0006114 Highly Informative Direct
Biological Process (BP) response to calcium ion 0.000000000004288 Highly Informative Direct
Biological Process (BP) protein localization to mitochondrion 0.000005982 Highly Informative Direct
Biological Process (BP) regulation of membrane permeability 0.000006293 Highly Informative Direct
Biological Process (BP) anion transmembrane transport 0.0000000000001008 Highly Informative Direct
Biological Process (BP) carbohydrate derivative transport 0 Highly Informative Direct
Biological Process (BP) amino acid transport 0.1958 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular transport 0.001835 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic signaling pathway 0.008068 Highly Informative Inherited
Biological Process (BP) cell-type specific apoptotic process 0.0105 Highly Informative Inherited
Biological Process (BP) cellular response to metal ion 0.006076 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.4689 Highly Informative Inherited
Biological Process (BP) inorganic anion transport 1 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0.03015 Moderately Informative Inherited
Molecular Function (MF) anion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0.09362 Informative Inherited
Molecular Function (MF) active transmembrane transporter activity 0.9752 Informative Inherited
Molecular Function (MF) calcium ion binding 0.000000001452 Highly Informative Direct
Molecular Function (MF) organic cation transmembrane transporter activity 0.000000001824 Highly Informative Direct
Molecular Function (MF) secondary active transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) nucleoside-diphosphatase activity 0.0000000002469 Highly Informative Direct
Molecular Function (MF) transition metal ion transmembrane transporter activity 0.0000001829 Highly Informative Direct
Molecular Function (MF) carbohydrate derivative transporter activity 0 Highly Informative Direct
Molecular Function (MF) inorganic anion transmembrane transporter activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 0.00000000000000158 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.0003934 Least Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) organelle envelope 0 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) lipid particle 0.0001941 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.9434 Informative Inherited
Cellular Component (CC) plastid 0.3098 Informative Inherited
Cellular Component (CC) organelle outer membrane 0.0002058 Highly Informative Direct
Cellular Component (CC) spindle 0.2201 Highly Informative Inherited

Document: GO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.1778Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.4536Least InformativeInherited
Mammalian Phenotype (MP)abnormal gas homeostasis0.04554InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)life span variant0.0003766InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0.0005038Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0.0003663Least InformativeDirect
Plant ANatomical entity (PAN)seed0.0005974Least InformativeDirect
Plant ANatomical entity (PAN)flower0.00115Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.002768Least InformativeInherited
Plant ANatomical entity (PAN)shoot axis0.006707Least InformativeInherited
Plant ANatomical entity (PAN)sporangium0.01008Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.01714Least InformativeInherited
Plant ANatomical entity (PAN)megasporophyll0.02914Least InformativeInherited
Plant ANatomical entity (PAN)inflorescence0.2127Least InformativeInherited
Plant ANatomical entity (PAN)microsporophyll0.2997Least InformativeInherited
Plant ANatomical entity (PAN)leaf0.3743Least InformativeInherited
Plant ANatomical entity (PAN)vascular system0.197InformativeInherited
Plant ANatomical entity (PAN)vascular bundle0.0001374Highly InformativeDirect
Plant structure DEvelopment stage (PDE)pollen development stage0.0000007222Moderately InformativeDirect

Document: AP annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)musculo-skeletal system0.01691Moderately InformativeInherited
Drugbank ATC_code (DB)clodronic acid0.00000004453Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentMitochondrion inner membrane0InformativeDirect
Cellular componentPeroxisome0.00000002752InformativeDirect
DiseaseDisease mutation0.0001605Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionCalcium0.00000000000001338Moderately InformativeDirect
Molecular functionIron1Moderately InformativeInherited
Molecular functionIron transport0Highly InformativeDirect
Post-translational modificationAcetylation0.000000001236Least InformativeDirect
Post-translational modificationS-nitrosylation0.00000009331InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001993 SSF103506 Protein matches
Abstract

A variety of substrate carrier proteins that are involved in energy transfer are found in the inner mitochondrial membrane or integral to the membrane of other eukaryotic organelles such as the peroxisome [PubMed2158156, PubMed8140286, PubMed8487299, PubMed8206158, PubMed8291088]. Such proteins include: ADP,ATP carrier protein (ADP/ATP translocase); 2-oxoglutarate/malate carrier protein; phosphate carrier protein; tricarboxylate transport protein (or citrate transport protein); Graves disease carrier protein; yeast mitochondrial proteins MRS3 and MRS4; yeast mitochondrial FAD carrier protein; and many others. Structurally, these proteins can consist of up to three tandem repeats of a domain of approximately 100 residues, each domain containing two transmembrane regions.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Mitochondrial carrier domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Mitochondrial carrier superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · Internal database links ]