SUPERFAMILY 1.75 HMM library and genome assignments server


Mitochondrial carrier superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Mitochondrial carrier [ 103505]
Superfamily:   Mitochondrial carrier [ 103506]
Families:   Mitochondrial carrier [ 103507]


Superfamily statistics
Genomes (511) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 24,516 26,406 1
Proteins 24,142 26,123 1


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)localization00Least InformativeDirect
Biological Process (BP)single-organism cellular process1.035e-080.06798Least InformativeInherited
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)multicellular organismal process11Least InformativeInherited
Biological Process (BP)developmental process0.67461Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process10.9828Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)ion transport00Moderately InformativeDirect
Biological Process (BP)cellular localization1.464e-061.561e-12Moderately InformativeDirect
Biological Process (BP)organic substance transport2.078e-110Moderately InformativeDirect
Biological Process (BP)organelle organization11Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction11Moderately InformativeInherited
Biological Process (BP)regulation of localization0.18470.7692Moderately InformativeInherited
Biological Process (BP)regulation of programmed cell death0.0088771Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization11Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus11Moderately InformativeInherited
Biological Process (BP)macromolecule localization11Moderately InformativeInherited
Biological Process (BP)homeostatic process0.00066380.03799Moderately InformativeInherited
Biological Process (BP)immune system process0.961Moderately InformativeInherited
Biological Process (BP)cell differentiation0.95291Moderately InformativeInherited
Biological Process (BP)organ development0.26391Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.40260.3556Moderately InformativeInherited
Biological Process (BP)cellular catabolic process11Moderately InformativeInherited
Biological Process (BP)cellular lipid metabolic process0.61420.7032Moderately InformativeInherited
Biological Process (BP)anion transport1.393e-090InformativeDirect
Biological Process (BP)mitochondrion organization2.304e-099.898e-09InformativeDirect
Biological Process (BP)organic acid transport00InformativeDirect
Biological Process (BP)transmembrane transport00InformativeDirect
Biological Process (BP)nitrogen compound transport00InformativeDirect
Biological Process (BP)apoptotic process0.74570.5588InformativeInherited
Biological Process (BP)cellular membrane organization0.66070.3318InformativeInherited
Biological Process (BP)regulation of intracellular transport0.16720.2673InformativeInherited
Biological Process (BP)regulation of apoptotic signaling pathway0.018830.1286InformativeInherited
Biological Process (BP)response to inorganic substance0.46279.588e-05InformativeInherited
Biological Process (BP)protein localization to organelle0.075460.3438InformativeInherited
Biological Process (BP)cellular cation homeostasis0.63480.6783InformativeInherited
Biological Process (BP)metal ion homeostasis0.0024640.06453InformativeInherited
Biological Process (BP)hematopoietic or lymphoid organ development0.0014050.2329InformativeInherited
Biological Process (BP)negative regulation of cellular component organization0.10410.6948InformativeInherited
Biological Process (BP)regulation of organelle organization0.24811InformativeInherited
Biological Process (BP)carboxylic acid catabolic process0.05070.01135InformativeInherited
Biological Process (BP)fatty acid metabolic process0.0077990.01164InformativeInherited
Biological Process (BP)lipid catabolic process0.007190.007307InformativeInherited
Biological Process (BP)metal ion transport11InformativeInherited
Biological Process (BP)transition metal ion transport8.82e-064.61e-07Highly InformativeDirect
Biological Process (BP)dicarboxylic acid transport2.536e-088.487e-11Highly InformativeDirect
Biological Process (BP)mitochondrial transport00Highly InformativeDirect
Biological Process (BP)fatty acid catabolic process0.00024330.0008807Highly InformativeDirect
Biological Process (BP)regulation of mitochondrion organization2.631e-059.507e-05Highly InformativeDirect
Biological Process (BP)organophosphate ester transport00Highly InformativeDirect
Biological Process (BP)nucleobase-containing compound transport00Highly InformativeDirect
Biological Process (BP)erythrocyte differentiation2.661e-108.882e-08Highly InformativeDirect
Biological Process (BP)protein localization to mitochondrion1.345e-056.412e-06Highly InformativeDirect
Biological Process (BP)carbohydrate derivative transport00Highly InformativeDirect
Biological Process (BP)mitochondrial membrane organization0.014620.003415Highly InformativeInherited
Biological Process (BP)cell-type specific apoptotic process0.0037440.009278Highly InformativeInherited
Biological Process (BP)response to calcium ion0.0042275.406e-12Highly InformativeInherited
Biological Process (BP)cellular response to metal ion0.1050.005717Highly InformativeInherited
Biological Process (BP)cellular calcium ion homeostasis0.091880.2625Highly InformativeInherited
Biological Process (BP)response to drug0.024010.2283Highly InformativeInherited
Biological Process (BP)ion transmembrane transport7.681e-080.003088Highly InformativeInherited
Biological Process (BP)hydrogen transport0.0003060.003539Highly InformativeInherited
Biological Process (BP)monovalent inorganic cation transport0.96441Highly InformativeInherited
Biological Process (BP)amino acid transport0.95690.1758Highly InformativeInherited
Biological Process (BP)inorganic anion transport11Highly InformativeInherited
Molecular Function (MF)hydrolase activity11Least InformativeInherited
Molecular Function (MF)transporter activity00Moderately InformativeDirect
Molecular Function (MF)hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides0.86211Moderately InformativeInherited
Molecular Function (MF)anion transmembrane transporter activity7.691e-150InformativeDirect
Molecular Function (MF)active transmembrane transporter activity10.9627InformativeInherited
Molecular Function (MF)metal ion transmembrane transporter activity0.2241InformativeInherited
Molecular Function (MF)inorganic cation transmembrane transporter activity11InformativeInherited
Molecular Function (MF)secondary active transmembrane transporter activity1.341e-150Highly InformativeDirect
Molecular Function (MF)nucleoside-diphosphatase activity1.253e-082.753e-10Highly InformativeDirect
Molecular Function (MF)transition metal ion transmembrane transporter activity0.00068751.133e-06Highly InformativeDirect
Molecular Function (MF)carbohydrate derivative transporter activity8.152e-120Highly InformativeDirect
Cellular Component (CC)membrane03.128e-15Least InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle00Least InformativeDirect
Cellular Component (CC)cytoplasmic part00Least InformativeDirect
Cellular Component (CC)intracellular organelle part8.435e-070.00068Least InformativeDirect
Cellular Component (CC)intracellular non-membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)protein complex11Least InformativeInherited
Cellular Component (CC)organelle membrane00Moderately InformativeDirect
Cellular Component (CC)organelle envelope00Moderately InformativeDirect
Cellular Component (CC)mitochondrial part00Moderately InformativeDirect
Cellular Component (CC)cytoskeleton11Moderately InformativeInherited
Cellular Component (CC)microtubule cytoskeleton0.45390.9576InformativeInherited
Cellular Component (CC)organelle outer membrane0.00073830.0001984Highly InformativeDirect
Cellular Component (CC)spindle0.017590.2265Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.06798 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.9828 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) cellular localization 1.561e-12 Moderately Informative Direct
Biological Process (BP) organic substance transport 0 Moderately Informative Direct
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.7692 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.03799 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.3556 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.7032 Moderately Informative Inherited
Biological Process (BP) anion transport 0 Informative Direct
Biological Process (BP) mitochondrion organization 9.898e-09 Informative Direct
Biological Process (BP) response to inorganic substance 9.588e-05 Informative Direct
Biological Process (BP) organic acid transport 0 Informative Direct
Biological Process (BP) energy derivation by oxidation of organic compounds 0.0002016 Informative Direct
Biological Process (BP) transmembrane transport 0 Informative Direct
Biological Process (BP) nitrogen compound transport 0 Informative Direct
Biological Process (BP) regulation of intracellular transport 0.2673 Informative Inherited
Biological Process (BP) regulation of apoptotic signaling pathway 0.1286 Informative Inherited
Biological Process (BP) protein localization to organelle 0.3438 Informative Inherited
Biological Process (BP) organelle localization 1 Informative Inherited
Biological Process (BP) cellular cation homeostasis 0.6783 Informative Inherited
Biological Process (BP) metal ion homeostasis 0.06453 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) cellular membrane organization 0.3318 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.1266 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.2329 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.6948 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.01135 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.01164 Informative Inherited
Biological Process (BP) lipid catabolic process 0.007307 Informative Inherited
Biological Process (BP) apoptotic process 0.5588 Informative Inherited
Biological Process (BP) transition metal ion transport 4.61e-07 Highly Informative Direct
Biological Process (BP) dicarboxylic acid transport 8.487e-11 Highly Informative Direct
Biological Process (BP) mitochondrial transport 0 Highly Informative Direct
Biological Process (BP) fatty acid catabolic process 0.0008807 Highly Informative Direct
Biological Process (BP) regulation of mitochondrion organization 9.507e-05 Highly Informative Direct
Biological Process (BP) organophosphate ester transport 0 Highly Informative Direct
Biological Process (BP) nucleobase-containing compound transport 0 Highly Informative Direct
Biological Process (BP) erythrocyte differentiation 8.882e-08 Highly Informative Direct
Biological Process (BP) monosaccharide biosynthetic process 0.0003593 Highly Informative Direct
Biological Process (BP) response to calcium ion 5.406e-12 Highly Informative Direct
Biological Process (BP) protein localization to mitochondrion 6.412e-06 Highly Informative Direct
Biological Process (BP) carbohydrate derivative transport 0 Highly Informative Direct
Biological Process (BP) cell-type specific apoptotic process 0.009278 Highly Informative Inherited
Biological Process (BP) cellular response to metal ion 0.005717 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.2625 Highly Informative Inherited
Biological Process (BP) mitochondrial membrane organization 0.003415 Highly Informative Inherited
Biological Process (BP) response to drug 0.2283 Highly Informative Inherited
Biological Process (BP) electron transport chain 0.002673 Highly Informative Inherited
Biological Process (BP) ion transmembrane transport 0.003088 Highly Informative Inherited
Biological Process (BP) hydrogen transport 0.003539 Highly Informative Inherited
Biological Process (BP) monovalent inorganic cation transport 1 Highly Informative Inherited
Biological Process (BP) amino acid transport 0.1758 Highly Informative Inherited
Biological Process (BP) inorganic anion transport 1 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 Moderately Informative Inherited
Molecular Function (MF) cation binding 0.02684 Moderately Informative Inherited
Molecular Function (MF) anion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) active transmembrane transporter activity 0.9627 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) inorganic cation transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) calcium ion binding 1.593e-09 Highly Informative Direct
Molecular Function (MF) secondary active transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) nucleoside-diphosphatase activity 2.753e-10 Highly Informative Direct
Molecular Function (MF) transition metal ion transmembrane transporter activity 1.133e-06 Highly Informative Direct
Molecular Function (MF) carbohydrate derivative transporter activity 0 Highly Informative Direct
Cellular Component (CC) membrane 3.128e-15 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.00068 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) organelle membrane 0 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.9576 Informative Inherited
Cellular Component (CC) plastid 0.289 Informative Inherited
Cellular Component (CC) organelle outer membrane 0.0001984 Highly Informative Direct
Cellular Component (CC) spindle 0.2265 Highly Informative Inherited

Document: GO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.1753Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.4322Least InformativeInherited
Mammalian Phenotype (MP)abnormal gas homeostasis0.04489InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)life span variant0.0003766InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0.0003663Least InformativeDirect
Plant ANatomical entity (PAN)seed0.0005974Least InformativeDirect
Plant ANatomical entity (PAN)flower0.00115Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.002768Least InformativeInherited
Plant ANatomical entity (PAN)shoot axis0.006707Least InformativeInherited
Plant ANatomical entity (PAN)sporangium0.01008Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.01714Least InformativeInherited
Plant ANatomical entity (PAN)megasporophyll0.02914Least InformativeInherited
Plant ANatomical entity (PAN)inflorescence0.2127Least InformativeInherited
Plant ANatomical entity (PAN)microsporophyll0.2997Least InformativeInherited
Plant ANatomical entity (PAN)leaf0.3743Least InformativeInherited
Plant ANatomical entity (PAN)vascular system0.197InformativeInherited
Plant ANatomical entity (PAN)vascular bundle0.0001374Highly InformativeDirect
Plant structure DEvelopment stage (PDE)pollen development stage7.222e-07Moderately InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentMitochondrion inner membrane0InformativeDirect
Cellular componentPeroxisome2.773e-08InformativeDirect
DiseaseDisease mutation0.0001541Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionCalcium1.001e-14Moderately InformativeDirect
Molecular functionIron1Moderately InformativeInherited
Molecular functionIron transport0Highly InformativeDirect
Post-translational modificationAcetylation1.285e-09Least InformativeDirect
Post-translational modificationS-nitrosylation9.541e-08InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001993 SSF103506 Protein matches
Abstract

A variety of substrate carrier proteins that are involved in energy transfer are found in the inner mitochondrial membrane or integral to the membrane of other eukaryotic organelles such as the peroxisome [PubMed2158156, PubMed8140286, PubMed8487299, PubMed8206158, PubMed8291088]. Such proteins include: ADP,ATP carrier protein (ADP/ATP translocase); 2-oxoglutarate/malate carrier protein; phosphate carrier protein; tricarboxylate transport protein (or citrate transport protein); Graves disease carrier protein; yeast mitochondrial proteins MRS3 and MRS4; yeast mitochondrial FAD carrier protein; and many others. Structurally, these proteins can consist of up to three tandem repeats of a domain of approximately 100 residues, each domain containing two transmembrane regions.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Mitochondrial carrier domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Mitochondrial carrier superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]