SUPERFAMILY 1.75 HMM library and genome assignments server


V-type ATP synthase subunit C superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   V-type ATP synthase subunit C [ 103485]
Superfamily:   V-type ATP synthase subunit C [ 103486]
Families:   V-type ATP synthase subunit C [ 103487]


Superfamily statistics
Genomes (814) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 1,087 1,768 1
Proteins 1,075 1,756 1


Functional annotation
General category Metabolism
Detailed category E- transfer

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Cellular Component (CC)membrane3.141e-072.21e-06Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.015270.04452Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.47650.4951Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.11560.01351Least InformativeInherited
Cellular Component (CC)organelle membrane0.00050278.093e-05Moderately InformativeDirect
Cellular Component (CC)plasma membrane part8.535e-050.0008454Moderately InformativeDirect
Cellular Component (CC)endosome3.63e-055.399e-05InformativeDirect
Cellular Component (CC)vacuolar part2.115e-105.883e-10InformativeDirect
Cellular Component (CC)apical plasma membrane1.126e-067.796e-07Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Cellular Component (CC) membrane 2.21e-06 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.04452 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.4951 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.01351 Least Informative Inherited
Cellular Component (CC) organelle membrane 8.093e-05 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 0.0008454 Moderately Informative Direct
Cellular Component (CC) endosome 5.399e-05 Informative Direct
Cellular Component (CC) vacuolar part 5.883e-10 Informative Direct
Cellular Component (CC) apical plasma membrane 7.796e-07 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processATP synthesis0Highly InformativeDirect
Biological processHydrogen ion transport1.553e-10Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR002843 SSF103486 Protein matches
Abstract

The V-ATPases (or V1V0-ATPase) and A-ATPases (or A1A0-ATPase) are each composed of two linked complexes: the V1 or A1 complex contains the catalytic core that hydrolyses/synthesizes ATP, and the V0 or A0 complex that forms the membrane-spanning pore. The V- and A-ATPases both contain rotary motors, one that drives proton translocation across the membrane and one that drives ATP synthesis/hydrolysis [PubMed11309608, PubMed15629643, PubMed15168615]. The V- and A-ATPases more closely resemble one another in subunit structure than they do the F-ATPases, although the function of A-ATPases is closer to that of F-ATPases.

This entry represents subunit C from the A0 complex of A-ATPases, and subunits C and D from the V0 complex of V-ATPases, all of which are involved in the translocation of protons across a membrane. There is more than one type of D subunit in V-ATPases, where the D1 subunit is ubiquitous, while the D2 subunit has limited tissue expressivity, possibly to account for differential functions, targeting or regulation of V-ATPase activity [PubMed15800125].

More information about this protein can be found at Protein of the Month: ATP Synthases.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a V-type ATP synthase subunit C domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the V-type ATP synthase subunit C superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]