SUPERFAMILY 1.75 HMM library and genome assignments server


MFS general substrate transporter superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   MFS general substrate transporter [ 103472]
Superfamily:   MFS general substrate transporter [ 103473] (2)
Families:   Glycerol-3-phosphate transporter [ 103474]
  LacY-like proton/sugar symporter [ 103477]


Superfamily statistics
Genomes (3,212) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 191,781 814,685 2
Proteins 185,380 798,757 2


Functional annotation
General category Processes_IC
Detailed category Ion metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)localization00Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)protein metabolic process11Least InformativeInherited
Biological Process (BP)multicellular organismal process11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)ion transport1.021e-050Moderately InformativeDirect
Biological Process (BP)organic substance transport1.411e-080Moderately InformativeDirect
Biological Process (BP)cellular response to stress11Moderately InformativeInherited
Biological Process (BP)system process11Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.971Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process11Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)multi-organism process11Moderately InformativeInherited
Biological Process (BP)organelle organization11Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process11Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process11Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process0.46741Moderately InformativeInherited
Biological Process (BP)lipid metabolic process11Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process11Moderately InformativeInherited
Biological Process (BP)cellular catabolic process11Moderately InformativeInherited
Biological Process (BP)anion transport6.705e-060InformativeDirect
Biological Process (BP)organic acid transport3.091e-100InformativeDirect
Biological Process (BP)transmembrane transport00InformativeDirect
Biological Process (BP)nitrogen compound transport0.00074680InformativeDirect
Biological Process (BP)cellular membrane organization0.32981InformativeInherited
Biological Process (BP)synaptic transmission0.023020.4274InformativeInherited
Biological Process (BP)cellular chemical homeostasis0.0011710.003201InformativeInherited
Biological Process (BP)cation homeostasis0.2790.8779InformativeInherited
Biological Process (BP)membrane lipid metabolic process0.030520.536InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.64841InformativeInherited
Biological Process (BP)regulation of response to external stimulus0.45551InformativeInherited
Biological Process (BP)regulation of cellular catabolic process0.51421InformativeInherited
Biological Process (BP)negative regulation of cell communication0.23031InformativeInherited
Biological Process (BP)alcohol metabolic process0.20221InformativeInherited
Biological Process (BP)cellular biogenic amine metabolic process0.26450.8688InformativeInherited
Biological Process (BP)phospholipid metabolic process0.29261InformativeInherited
Biological Process (BP)response to nutrient levels0.021220.9688InformativeInherited
Biological Process (BP)lysosome organization3.606e-051.86e-06Highly InformativeDirect
Biological Process (BP)carbohydrate transport00Highly InformativeDirect
Biological Process (BP)organic hydroxy compound transport0.00038251.435e-14Highly InformativeDirect
Biological Process (BP)response to drug1.181e-120Highly InformativeDirect
Biological Process (BP)carbohydrate derivative transport4.437e-100Highly InformativeDirect
Biological Process (BP)regulation of neurotransmitter levels0.00026210.001137Highly InformativeInherited
Biological Process (BP)monovalent inorganic cation homeostasis0.00075930.1241Highly InformativeInherited
Biological Process (BP)negative regulation of response to external stimulus0.001960.6827Highly InformativeInherited
Biological Process (BP)regulation of autophagy6.844e-050.4484Highly InformativeInherited
Biological Process (BP)regulation of cellular response to stress0.020761Highly InformativeInherited
Biological Process (BP)negative regulation of cellular catabolic process0.0012040.2926Highly InformativeInherited
Biological Process (BP)regulation of response to nutrient levels11Highly InformativeInherited
Biological Process (BP)dicarboxylic acid transport0.69820.2762Highly InformativeInherited
Biological Process (BP)amino acid transport0.0530.9394Highly InformativeInherited
Biological Process (BP)monocarboxylic acid transport0.04080.03119Highly InformativeInherited
Biological Process (BP)organophosphate ester transport0.005130.04384Highly InformativeInherited
Biological Process (BP)inorganic anion transport11Highly InformativeInherited
Biological Process (BP)ethanolamine-containing compound metabolic process8.523e-050.09797Highly InformativeInherited
Biological Process (BP)glycosphingolipid metabolic process0.00014050.02187Highly InformativeInherited
Biological Process (BP)ceramide metabolic process0.0010480.01677Highly InformativeInherited
Biological Process (BP)membrane fusion0.015430.9987Highly InformativeInherited
Biological Process (BP)cellular response to starvation0.0036410.002909Highly InformativeInherited
Biological Process (BP)autophagy0.0017450.3189Highly InformativeInherited
Biological Process (BP)organelle fusion0.00065030.2781Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)transporter activity00Moderately InformativeDirect
Molecular Function (MF)active transmembrane transporter activity10.8369InformativeInherited
Molecular Function (MF)inorganic cation transmembrane transporter activity11InformativeInherited
Molecular Function (MF)metal ion transmembrane transporter activity0.022571InformativeInherited
Molecular Function (MF)anion transmembrane transporter activity0.0066340InformativeInherited
Molecular Function (MF)sodium ion transmembrane transporter activity3.727e-072.477e-05Highly InformativeDirect
Molecular Function (MF)carbohydrate transmembrane transporter activity1.512e-120Highly InformativeDirect
Molecular Function (MF)secondary active transmembrane transporter activity3.802e-130Highly InformativeDirect
Molecular Function (MF)carbohydrate derivative transporter activity0.00025813.087e-05Highly InformativeDirect
Molecular Function (MF)ion gated channel activity0.50891Highly InformativeInherited
Molecular Function (MF)monosaccharide binding0.04550.03024Highly InformativeInherited
Cellular Component (CC)membrane1.288e-060Least InformativeDirect
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)plasma membrane7.427e-100Moderately InformativeDirect
Cellular Component (CC)intrinsic to membrane00Moderately InformativeDirect
Cellular Component (CC)cell projection0.98161Moderately InformativeInherited
Cellular Component (CC)vesicle0.031140.1036Moderately InformativeInherited
Cellular Component (CC)organelle membrane0.1010.002383Moderately InformativeInherited
Cellular Component (CC)endomembrane system6.642e-050.857Moderately InformativeInherited
Cellular Component (CC)integral to membrane08.263e-08InformativeDirect
Cellular Component (CC)coated vesicle6.255e-054.609e-15InformativeDirect
Cellular Component (CC)intrinsic to plasma membrane4.944e-078.984e-15InformativeDirect
Cellular Component (CC)vacuolar part5.52e-060InformativeDirect
Cellular Component (CC)synapse part7.361e-051.566e-07InformativeDirect
Cellular Component (CC)secretory granule0.12690.8098InformativeInherited
Cellular Component (CC)integral to plasma membrane0.00089763.755e-09Highly InformativeDirect
Cellular Component (CC)brush border0.00011011.712e-08Highly InformativeDirect
Cellular Component (CC)clathrin-coated vesicle4.387e-080Highly InformativeDirect
Cellular Component (CC)intrinsic to organelle membrane2.159e-060.0001683Highly InformativeDirect
Cellular Component (CC)cell projection membrane0.75970.7359Highly InformativeInherited
Cellular Component (CC)cytoplasmic vesicle membrane0.00026230.001571Highly InformativeInherited
Cellular Component (CC)sperm part0.009590.4209Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) organic substance transport 0 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) anion transport 0 Informative Direct
Biological Process (BP) organic acid transport 0 Informative Direct
Biological Process (BP) transmembrane transport 0 Informative Direct
Biological Process (BP) nitrogen compound transport 0 Informative Direct
Biological Process (BP) cellular membrane organization 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) synaptic transmission 0.4274 Informative Inherited
Biological Process (BP) cation homeostasis 0.8779 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.003201 Informative Inherited
Biological Process (BP) response to organonitrogen compound 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) membrane lipid metabolic process 0.536 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) organelle localization 1 Informative Inherited
Biological Process (BP) response to inorganic substance 1 Informative Inherited
Biological Process (BP) alcohol metabolic process 1 Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 0.8688 Informative Inherited
Biological Process (BP) phospholipid metabolic process 1 Informative Inherited
Biological Process (BP) cellular metabolic compound salvage 0.5672 Informative Inherited
Biological Process (BP) glycosyl compound biosynthetic process 0.8982 Informative Inherited
Biological Process (BP) purine ribonucleoside metabolic process 1 Informative Inherited
Biological Process (BP) purine-containing compound biosynthetic process 1 Informative Inherited
Biological Process (BP) response to nutrient levels 0.9688 Informative Inherited
Biological Process (BP) hydrogen transport 0.0001617 Highly Informative Direct
Biological Process (BP) lysosome organization 1.86e-06 Highly Informative Direct
Biological Process (BP) carbohydrate transport 0 Highly Informative Direct
Biological Process (BP) monoamine transport 0.0001669 Highly Informative Direct
Biological Process (BP) organic hydroxy compound transport 1.435e-14 Highly Informative Direct
Biological Process (BP) response to drug 0 Highly Informative Direct
Biological Process (BP) amide transport 9.027e-12 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 3.047e-05 Highly Informative Direct
Biological Process (BP) carbohydrate derivative transport 0 Highly Informative Direct
Biological Process (BP) response to carbohydrate stimulus 0.04793 Highly Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.001137 Highly Informative Inherited
Biological Process (BP) monovalent inorganic cation homeostasis 0.1241 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.6827 Highly Informative Inherited
Biological Process (BP) regulation of autophagy 0.4484 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular catabolic process 0.2926 Highly Informative Inherited
Biological Process (BP) regulation of response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) monovalent inorganic cation transport 0.5214 Highly Informative Inherited
Biological Process (BP) dicarboxylic acid transport 0.2762 Highly Informative Inherited
Biological Process (BP) monocarboxylic acid transport 0.03119 Highly Informative Inherited
Biological Process (BP) nucleobase-containing compound transport 1 Highly Informative Inherited
Biological Process (BP) establishment of synaptic vesicle localization 0.6199 Highly Informative Inherited
Biological Process (BP) amino acid transport 0.9394 Highly Informative Inherited
Biological Process (BP) organophosphate ester transport 0.04384 Highly Informative Inherited
Biological Process (BP) inorganic anion transport 1 Highly Informative Inherited
Biological Process (BP) ethanolamine-containing compound metabolic process 0.09797 Highly Informative Inherited
Biological Process (BP) glycosphingolipid metabolic process 0.02187 Highly Informative Inherited
Biological Process (BP) ceramide metabolic process 0.01677 Highly Informative Inherited
Biological Process (BP) membrane fusion 0.9987 Highly Informative Inherited
Biological Process (BP) cellular response to starvation 0.002909 Highly Informative Inherited
Biological Process (BP) autophagy 0.3189 Highly Informative Inherited
Biological Process (BP) organelle fusion 0.2781 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) anion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) active transmembrane transporter activity 0.8369 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) inorganic cation transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) sodium ion transmembrane transporter activity 2.477e-05 Highly Informative Direct
Molecular Function (MF) organic cation transmembrane transporter activity 7.382e-09 Highly Informative Direct
Molecular Function (MF) carbohydrate transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) secondary active transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) transition metal ion transmembrane transporter activity 6.046e-07 Highly Informative Direct
Molecular Function (MF) carbohydrate derivative transporter activity 3.087e-05 Highly Informative Direct
Molecular Function (MF) organic hydroxy compound transmembrane transporter activity 1.213e-08 Highly Informative Direct
Molecular Function (MF) amino acid transmembrane transporter activity 1 Highly Informative Inherited
Molecular Function (MF) ion gated channel activity 1 Highly Informative Inherited
Molecular Function (MF) monosaccharide binding 0.03024 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0 Moderately Informative Direct
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.1036 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.002383 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.857 Moderately Informative Inherited
Cellular Component (CC) integral to membrane 8.263e-08 Informative Direct
Cellular Component (CC) coated vesicle 4.609e-15 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 8.984e-15 Informative Direct
Cellular Component (CC) vacuolar part 0 Informative Direct
Cellular Component (CC) synapse part 1.566e-07 Informative Direct
Cellular Component (CC) secretory granule 0.8098 Informative Inherited
Cellular Component (CC) lytic vacuole 0.8342 Informative Inherited
Cellular Component (CC) integral to plasma membrane 3.755e-09 Highly Informative Direct
Cellular Component (CC) brush border 1.712e-08 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 7.816e-07 Highly Informative Direct
Cellular Component (CC) clathrin-coated vesicle 0 Highly Informative Direct
Cellular Component (CC) intrinsic to organelle membrane 0.0001683 Highly Informative Direct
Cellular Component (CC) cell projection membrane 0.7359 Highly Informative Inherited
Cellular Component (CC) cytoplasmic vesicle membrane 0.001571 Highly Informative Inherited
Cellular Component (CC) sperm part 0.4209 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of metabolism0.002813Moderately InformativeInherited
Disease Ontology (DO)endocrine system disease0.3879Moderately InformativeInherited
Disease Ontology (DO)pancreas disease0.05873InformativeInherited
Disease Ontology (DO)glucose metabolism disease1InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.05703Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.4678Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.1896InformativeInherited
Phenotypic Abnormality (PA)Hypouricemia3.164e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Conjugated hyperbilirubinemia7.207e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Gait disturbance0.3619Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.000731Least InformativeDirect
Mammalian Phenotype (MP)renal/urinary system phenotype0.006491Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.3962Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal urine homeostasis0.01327InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system physiology0.09379InformativeInherited
Mammalian Phenotype (MP)abnormal digestion0.007025Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant1Least InformativeInherited
Worm Phenotype (WP)organism stress response variant0.256InformativeInherited
Worm Phenotype (WP)organism osmotic stress response variant0.04267Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0.6722Least InformativeInherited
Yeast Phenotype (YP)nutrient utilization1Moderately InformativeInherited

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0.0002734Least InformativeDirect
Fly Phenotype (FP)fertile0.0001861Moderately InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.8908Least InformativeInherited
Plant ANatomical entity (PAN)portion of ground tissue0.004879InformativeInherited
Plant ANatomical entity (PAN)cortex0.1867Highly InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport1Moderately InformativeInherited
Biological processProtein transport1Moderately InformativeInherited
Biological processAntibiotic resistance0InformativeDirect
Biological processLipid transport3.244e-08InformativeDirect
Biological processAutophagy0Highly InformativeDirect
Biological processNeurotransmitter transport0Highly InformativeDirect
Biological processNitrate assimilation0Highly InformativeDirect
Biological processSodium transport0Highly InformativeDirect
Biological processSugar transport0Highly InformativeDirect
Biological processAmino-acid transport8.094e-08Highly InformativeDirect
Biological processDetoxification0.0003534Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell membrane6.436e-16Moderately InformativeDirect
Cellular componentCytoplasmic vesicle2.421e-12Moderately InformativeDirect
Cellular componentCell junction5.714e-07Moderately InformativeDirect
Cellular componentVacuole0InformativeDirect
Cellular componentCell inner membrane4.556e-09InformativeDirect
Cellular componentSynapse3.216e-08InformativeDirect
Cellular componentLysosome2.704e-07InformativeDirect
Cellular componentSynaptosome7.761e-05Highly InformativeDirect
DiseaseDisease mutation1.837e-06Least InformativeDirect
DiseaseDiabetes mellitus1.821e-05Highly InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionIron1Moderately InformativeInherited
Molecular functionSodium0InformativeDirect
Molecular functionIron transport0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)glycan metabolism0Moderately InformativeDirect
UniPathway (UP)amine and polyamine metabolism0.0004733Moderately InformativeDirect
UniPathway (UP)putrescine metabolism1.591e-07InformativeDirect
UniPathway (UP)amine and polyamine biosynthesis1.802e-05InformativeDirect
UniPathway (UP)sucrose metabolism0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a MFS general substrate transporter domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the MFS general substrate transporter superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]