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MFS general substrate transporter superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   MFS general substrate transporter [ 103472]
Superfamily:   MFS general substrate transporter [ 103473] (2)
Families:   Glycerol-3-phosphate transporter [ 103474]
  LacY-like proton/sugar symporter [ 103477]


Superfamily statistics
Genomes (3,212) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 191,781 814,685 2
Proteins 185,380 798,757 2


Functional annotation
General category Processes_IC
Detailed category Ion metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)localization00Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)protein metabolic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)multicellular organismal process11Least InformativeInherited
Biological Process (BP)ion transport0.000010560Moderately InformativeDirect
Biological Process (BP)organic substance transport0.000000019590Moderately InformativeDirect
Biological Process (BP)cellular response to stress11Moderately InformativeInherited
Biological Process (BP)system process11Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.95661Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process11Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)multi-organism process11Moderately InformativeInherited
Biological Process (BP)organelle organization11Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process11Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process11Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process0.46961Moderately InformativeInherited
Biological Process (BP)cellular lipid metabolic process11Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process11Moderately InformativeInherited
Biological Process (BP)cellular catabolic process11Moderately InformativeInherited
Biological Process (BP)anion transport0.0000061860InformativeDirect
Biological Process (BP)organic acid transport0.00000000031970InformativeDirect
Biological Process (BP)transmembrane transport00InformativeDirect
Biological Process (BP)nitrogen compound transport0.00080830InformativeDirect
Biological Process (BP)cellular membrane organization0.32981InformativeInherited
Biological Process (BP)synaptic transmission0.021810.4158InformativeInherited
Biological Process (BP)cellular chemical homeostasis0.0013740.003198InformativeInherited
Biological Process (BP)cation homeostasis0.26370.851InformativeInherited
Biological Process (BP)membrane lipid metabolic process0.029650.535InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.62191InformativeInherited
Biological Process (BP)regulation of response to external stimulus0.45221InformativeInherited
Biological Process (BP)regulation of cellular catabolic process0.55591InformativeInherited
Biological Process (BP)negative regulation of cell communication0.19961InformativeInherited
Biological Process (BP)response to other organism11InformativeInherited
Biological Process (BP)alcohol metabolic process0.1951InformativeInherited
Biological Process (BP)cellular biogenic amine metabolic process0.26430.8697InformativeInherited
Biological Process (BP)phospholipid metabolic process0.29241InformativeInherited
Biological Process (BP)response to nutrient levels0.020390.9626InformativeInherited
Biological Process (BP)regulation of neurotransmitter levels0.00026120.0009802Highly InformativeDirect
Biological Process (BP)lysosome organization0.000035980.000001709Highly InformativeDirect
Biological Process (BP)carbohydrate transport00Highly InformativeDirect
Biological Process (BP)organic hydroxy compound transport0.00038660.00000000000001772Highly InformativeDirect
Biological Process (BP)response to drug0.0000000000010040Highly InformativeDirect
Biological Process (BP)carbohydrate derivative transport0.00000000045170Highly InformativeDirect
Biological Process (BP)monovalent inorganic cation homeostasis0.00079670.1255Highly InformativeInherited
Biological Process (BP)negative regulation of response to external stimulus0.0019570.666Highly InformativeInherited
Biological Process (BP)regulation of cellular response to stress0.016281Highly InformativeInherited
Biological Process (BP)regulation of response to nutrient levels11Highly InformativeInherited
Biological Process (BP)dicarboxylic acid transport0.6980.2632Highly InformativeInherited
Biological Process (BP)amino acid transport0.053760.9348Highly InformativeInherited
Biological Process (BP)monocarboxylic acid transport0.040750.03735Highly InformativeInherited
Biological Process (BP)organophosphate ester transport0.005170.0445Highly InformativeInherited
Biological Process (BP)regulation of autophagy0.000061040.4014Highly InformativeInherited
Biological Process (BP)negative regulation of cellular catabolic process0.0011260.2617Highly InformativeInherited
Biological Process (BP)inorganic anion transport11Highly InformativeInherited
Biological Process (BP)ethanolamine-containing compound metabolic process0.000085030.09831Highly InformativeInherited
Biological Process (BP)glycosphingolipid metabolic process0.00014570.02196Highly InformativeInherited
Biological Process (BP)ceramide metabolic process0.0011290.01706Highly InformativeInherited
Biological Process (BP)membrane fusion0.01540.9907Highly InformativeInherited
Biological Process (BP)cellular response to starvation0.0035120.002402Highly InformativeInherited
Biological Process (BP)autophagy0.0018480.32Highly InformativeInherited
Biological Process (BP)organelle fusion0.00064890.2645Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)transporter activity00Moderately InformativeDirect
Molecular Function (MF)active transmembrane transporter activity10.8352InformativeInherited
Molecular Function (MF)inorganic cation transmembrane transporter activity11InformativeInherited
Molecular Function (MF)metal ion transmembrane transporter activity0.022551InformativeInherited
Molecular Function (MF)anion transmembrane transporter activity0.0066410InformativeInherited
Molecular Function (MF)sodium ion transmembrane transporter activity0.00000037370.00002509Highly InformativeDirect
Molecular Function (MF)carbohydrate transmembrane transporter activity0.0000000000015140Highly InformativeDirect
Molecular Function (MF)secondary active transmembrane transporter activity0.00000000000038090Highly InformativeDirect
Molecular Function (MF)carbohydrate derivative transporter activity0.00026060.00002983Highly InformativeDirect
Molecular Function (MF)ion gated channel activity0.50951Highly InformativeInherited
Molecular Function (MF)monosaccharide binding0.045550.03038Highly InformativeInherited
Cellular Component (CC)membrane0.0000012520Least InformativeDirect
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)plasma membrane0.00000000080550Moderately InformativeDirect
Cellular Component (CC)intrinsic to membrane00Moderately InformativeDirect
Cellular Component (CC)cell projection0.96161Moderately InformativeInherited
Cellular Component (CC)vesicle0.030520.1016Moderately InformativeInherited
Cellular Component (CC)organelle membrane0.095770.002108Moderately InformativeInherited
Cellular Component (CC)endomembrane system0.000025260.6433Moderately InformativeInherited
Cellular Component (CC)integral to membrane00.00000007188InformativeDirect
Cellular Component (CC)coated vesicle0.000058950.000000000000003092InformativeDirect
Cellular Component (CC)intrinsic to plasma membrane0.00000044230.000000000000008985InformativeDirect
Cellular Component (CC)vacuolar part0.0000055360InformativeDirect
Cellular Component (CC)synapse part0.000048460.00000005604InformativeDirect
Cellular Component (CC)secretory granule0.12810.8002InformativeInherited
Cellular Component (CC)integral to plasma membrane0.00074980.00000000363Highly InformativeDirect
Cellular Component (CC)brush border0.000110.00000001732Highly InformativeDirect
Cellular Component (CC)clathrin-coated vesicle0.000000039880Highly InformativeDirect
Cellular Component (CC)intrinsic to organelle membrane0.0000021580.0001705Highly InformativeDirect
Cellular Component (CC)cell projection membrane0.76190.7283Highly InformativeInherited
Cellular Component (CC)cytoplasmic vesicle membrane0.00027070.001443Highly InformativeInherited
Cellular Component (CC)sperm part0.0090550.4021Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) organic substance transport 0 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) anion transport 0 Informative Direct
Biological Process (BP) organic acid transport 0 Informative Direct
Biological Process (BP) transmembrane transport 0 Informative Direct
Biological Process (BP) nitrogen compound transport 0 Informative Direct
Biological Process (BP) cellular membrane organization 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) synaptic transmission 0.4158 Informative Inherited
Biological Process (BP) cation homeostasis 0.851 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.003198 Informative Inherited
Biological Process (BP) response to organonitrogen compound 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) membrane lipid metabolic process 0.535 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) organelle localization 1 Informative Inherited
Biological Process (BP) response to inorganic substance 1 Informative Inherited
Biological Process (BP) response to other organism 1 Informative Inherited
Biological Process (BP) alcohol metabolic process 1 Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 0.8697 Informative Inherited
Biological Process (BP) phospholipid metabolic process 1 Informative Inherited
Biological Process (BP) cellular metabolic compound salvage 0.5682 Informative Inherited
Biological Process (BP) glycosyl compound biosynthetic process 0.899 Informative Inherited
Biological Process (BP) purine ribonucleoside metabolic process 1 Informative Inherited
Biological Process (BP) purine-containing compound biosynthetic process 1 Informative Inherited
Biological Process (BP) response to nutrient levels 0.9626 Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.0009802 Highly Informative Direct
Biological Process (BP) hydrogen transport 0.0001652 Highly Informative Direct
Biological Process (BP) lysosome organization 0.000001709 Highly Informative Direct
Biological Process (BP) carbohydrate transport 0 Highly Informative Direct
Biological Process (BP) monoamine transport 0.0001699 Highly Informative Direct
Biological Process (BP) organic hydroxy compound transport 0.00000000000001772 Highly Informative Direct
Biological Process (BP) response to drug 0 Highly Informative Direct
Biological Process (BP) amide transport 0.00000000002074 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 0.00002254 Highly Informative Direct
Biological Process (BP) carbohydrate derivative transport 0 Highly Informative Direct
Biological Process (BP) response to carbohydrate stimulus 0.04559 Highly Informative Inherited
Biological Process (BP) monovalent inorganic cation homeostasis 0.1255 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.666 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 1 Highly Informative Inherited
Biological Process (BP) regulation of response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) monovalent inorganic cation transport 0.5156 Highly Informative Inherited
Biological Process (BP) dicarboxylic acid transport 0.2632 Highly Informative Inherited
Biological Process (BP) monocarboxylic acid transport 0.03735 Highly Informative Inherited
Biological Process (BP) nucleobase-containing compound transport 1 Highly Informative Inherited
Biological Process (BP) establishment of synaptic vesicle localization 0.6148 Highly Informative Inherited
Biological Process (BP) amino acid transport 0.9348 Highly Informative Inherited
Biological Process (BP) organophosphate ester transport 0.0445 Highly Informative Inherited
Biological Process (BP) regulation of autophagy 0.4014 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular catabolic process 0.2617 Highly Informative Inherited
Biological Process (BP) inorganic anion transport 1 Highly Informative Inherited
Biological Process (BP) ethanolamine-containing compound metabolic process 0.09831 Highly Informative Inherited
Biological Process (BP) glycosphingolipid metabolic process 0.02196 Highly Informative Inherited
Biological Process (BP) ceramide metabolic process 0.01706 Highly Informative Inherited
Biological Process (BP) membrane fusion 0.9907 Highly Informative Inherited
Biological Process (BP) cellular response to starvation 0.002402 Highly Informative Inherited
Biological Process (BP) autophagy 0.32 Highly Informative Inherited
Biological Process (BP) organelle fusion 0.2645 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) anion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) active transmembrane transporter activity 0.8352 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) inorganic cation transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) sodium ion transmembrane transporter activity 0.00002509 Highly Informative Direct
Molecular Function (MF) organic cation transmembrane transporter activity 0.000000007374 Highly Informative Direct
Molecular Function (MF) carbohydrate transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) secondary active transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) transition metal ion transmembrane transporter activity 0.0000006101 Highly Informative Direct
Molecular Function (MF) carbohydrate derivative transporter activity 0.00002983 Highly Informative Direct
Molecular Function (MF) organic hydroxy compound transmembrane transporter activity 0.00000001146 Highly Informative Direct
Molecular Function (MF) amino acid transmembrane transporter activity 1 Highly Informative Inherited
Molecular Function (MF) ion gated channel activity 1 Highly Informative Inherited
Molecular Function (MF) monosaccharide binding 0.03038 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0 Moderately Informative Direct
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.1016 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.002108 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.6433 Moderately Informative Inherited
Cellular Component (CC) integral to membrane 0.00000007188 Informative Direct
Cellular Component (CC) coated vesicle 0.000000000000003092 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 0.000000000000008985 Informative Direct
Cellular Component (CC) vacuolar part 0 Informative Direct
Cellular Component (CC) synapse part 0.00000005604 Informative Direct
Cellular Component (CC) secretory granule 0.8002 Informative Inherited
Cellular Component (CC) lytic vacuole 0.8095 Informative Inherited
Cellular Component (CC) integral to plasma membrane 0.00000000363 Highly Informative Direct
Cellular Component (CC) brush border 0.00000001732 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 0.00000077 Highly Informative Direct
Cellular Component (CC) clathrin-coated vesicle 0 Highly Informative Direct
Cellular Component (CC) intrinsic to organelle membrane 0.0001705 Highly Informative Direct
Cellular Component (CC) cell projection membrane 0.7283 Highly Informative Inherited
Cellular Component (CC) cytoplasmic vesicle membrane 0.001443 Highly Informative Inherited
Cellular Component (CC) sperm part 0.4021 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of metabolism0.0028Moderately InformativeInherited
Disease Ontology (DO)endocrine system disease0.3868Moderately InformativeInherited
Disease Ontology (DO)pancreas disease0.05863InformativeInherited
Disease Ontology (DO)glucose metabolism disease1InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.05713Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.4676Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.1881InformativeInherited
Phenotypic Abnormality (PA)Hypouricemia0.000003219Highly InformativeDirect
Phenotypic Abnormality (PA)Conjugated hyperbilirubinemia0.00007307Highly InformativeDirect
Phenotypic Abnormality (PA)Gait disturbance0.3598Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.0007037Least InformativeDirect
Mammalian Phenotype (MP)renal/urinary system phenotype0.00271Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.3882Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal urine homeostasis0.005256InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system physiology0.09307InformativeInherited
Mammalian Phenotype (MP)abnormal digestion0.008028Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant1Least InformativeInherited
Worm Phenotype (WP)organism stress response variant0.256InformativeInherited
Worm Phenotype (WP)organism osmotic stress response variant0.04267Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0.6679Least InformativeInherited
Yeast Phenotype (YP)nutrient utilization1Moderately InformativeInherited

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0.0002769Least InformativeDirect
Fly Phenotype (FP)fertile0.0001883Moderately InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.8908Least InformativeInherited
Plant ANatomical entity (PAN)portion of ground tissue0.004879InformativeInherited
Plant ANatomical entity (PAN)cortex0.1867Highly InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport1Moderately InformativeInherited
Biological processProtein transport1Moderately InformativeInherited
Biological processAntibiotic resistance0InformativeDirect
Biological processLipid transport0.00000003376InformativeDirect
Biological processAutophagy0Highly InformativeDirect
Biological processNeurotransmitter transport0Highly InformativeDirect
Biological processNitrate assimilation0Highly InformativeDirect
Biological processSodium transport0Highly InformativeDirect
Biological processSugar transport0Highly InformativeDirect
Biological processAmino-acid transport0.00000008429Highly InformativeDirect
Biological processDetoxification0.0003516Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell membrane6.428e-16Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.000000000001953Moderately InformativeDirect
Cellular componentCell junction0.0000005503Moderately InformativeDirect
Cellular componentVacuole0InformativeDirect
Cellular componentCell inner membrane0.000000001625InformativeDirect
Cellular componentSynapse0.00000003081InformativeDirect
Cellular componentLysosome0.0000002584InformativeDirect
Cellular componentSynaptosome0.00008005Highly InformativeDirect
DiseaseDisease mutation0.000001547Least InformativeDirect
DiseaseDiabetes mellitus0.00001837Highly InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionIron1Moderately InformativeInherited
Molecular functionSodium0InformativeDirect
Molecular functionIron transport0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details) Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a MFS general substrate transporter domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the MFS general substrate transporter superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]