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MFS general substrate transporter superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   MFS general substrate transporter [ 103472]
Superfamily:   MFS general substrate transporter [ 103473] (2)
Families:   Glycerol-3-phosphate transporter [ 103474]
  LacY-like proton/sugar symporter [ 103477]

 Superfamily statistics
Genomes (2,461) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 158,380 356,816 2
Proteins 153,324 349,035 2

 Functional annotation
General category Processes_IC
Detailed category Ion metabolism and transport

Document: Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)localization00Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)protein metabolic process11Least InformativeInherited
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)response to stimulus0.45521Least InformativeInherited
Biological Process (BP)single-organism cellular process0.8291Least InformativeInherited
Biological Process (BP)multicellular organismal process11Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)ion transport0.00017020Moderately InformativeDirect
Biological Process (BP)homeostatic process3.587e-050.0002672Moderately InformativeDirect
Biological Process (BP)organic substance transport1.37e-080Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process0.7751Moderately InformativeInherited
Biological Process (BP)system process0.53310.3669Moderately InformativeInherited
Biological Process (BP)signal transduction11Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.47930.9595Moderately InformativeInherited
Biological Process (BP)response to organic substance11Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus11Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.89970.6439Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.94371Moderately InformativeInherited
Biological Process (BP)regulation of cell communication0.89031Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.84711Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.99731Moderately InformativeInherited
Biological Process (BP)regulation of cellular metabolic process11Moderately InformativeInherited
Biological Process (BP)multi-organism process11Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.09210.9835Moderately InformativeInherited
Biological Process (BP)organelle organization0.32451Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process11Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process11Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process0.023010.4626Moderately InformativeInherited
Biological Process (BP)cellular lipid metabolic process0.92071Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.97761Moderately InformativeInherited
Biological Process (BP)cellular catabolic process11Moderately InformativeInherited
Biological Process (BP)anion transport2.264e-090InformativeDirect
Biological Process (BP)synaptic transmission0.00078420.0001009InformativeDirect
Biological Process (BP)organic acid transport5.759e-090InformativeDirect
Biological Process (BP)cellular cation homeostasis7.998e-117.923e-05InformativeDirect
Biological Process (BP)transmembrane transport2.364e-130InformativeDirect
Biological Process (BP)nitrogen compound transport5.94e-050InformativeDirect
Biological Process (BP)cellular membrane organization0.041481InformativeInherited
Biological Process (BP)negative regulation of protein metabolic process0.050611InformativeInherited
Biological Process (BP)response to hormone stimulus0.074080.4043InformativeInherited
Biological Process (BP)response to organic nitrogen0.042640.0475InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus0.15321InformativeInherited
Biological Process (BP)cellular response to nitrogen compound0.0033880.1425InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.30820.8896InformativeInherited
Biological Process (BP)membrane lipid metabolic process0.0010650.1053InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.16911InformativeInherited
Biological Process (BP)regulation of response to external stimulus0.047571InformativeInherited
Biological Process (BP)regulation of cellular catabolic process0.029041InformativeInherited
Biological Process (BP)regulation of response to stress0.064421InformativeInherited
Biological Process (BP)negative regulation of cellular metabolic process0.69831InformativeInherited
Biological Process (BP)negative regulation of cell communication0.025911InformativeInherited
Biological Process (BP)response to other organism11InformativeInherited
Biological Process (BP)response to external stimulus0.022451InformativeInherited
Biological Process (BP)alcohol metabolic process0.012340.7517InformativeInherited
Biological Process (BP)cellular biogenic amine metabolic process0.029390.1282InformativeInherited
Biological Process (BP)phospholipid metabolic process0.040511InformativeInherited
Biological Process (BP)cellular amide metabolic process0.034720.7708InformativeInherited
Biological Process (BP)regulation of neurotransmitter levels7.642e-053.169e-07Highly InformativeDirect
Biological Process (BP)glycosphingolipid metabolic process5.783e-050.0008222Highly InformativeDirect
Biological Process (BP)carbohydrate transport00Highly InformativeDirect
Biological Process (BP)cellular response to starvation1.832e-056.37e-07Highly InformativeDirect
Biological Process (BP)response to drug2.671e-130Highly InformativeDirect
Biological Process (BP)regulation of intracellular pH4.883e-123.042e-12Highly InformativeDirect
Biological Process (BP)carbohydrate derivative transport1.126e-093.176e-13Highly InformativeDirect
Biological Process (BP)regulation of proteolysis0.0035590.2257Highly InformativeInherited
Biological Process (BP)response to insulin stimulus2.677e-050.03951Highly InformativeInherited
Biological Process (BP)cellular response to peptide hormone stimulus2.677e-050.003108Highly InformativeInherited
Biological Process (BP)negative regulation of response to external stimulus4.946e-050.07811Highly InformativeInherited
Biological Process (BP)regulation of cellular response to stress0.00020590.8313Highly InformativeInherited
Biological Process (BP)regulation of response to nutrient levels11Highly InformativeInherited
Biological Process (BP)amino acid transport0.0057430.5257Highly InformativeInherited
Biological Process (BP)organophosphate ester transport0.00047630.1569Highly InformativeInherited
Biological Process (BP)negative regulation of cellular catabolic process3.107e-050.006188Highly InformativeInherited
Biological Process (BP)lysosome organization0.0014030.001947Highly InformativeInherited
Biological Process (BP)pH reduction0.63280.3671Highly InformativeInherited
Biological Process (BP)ethanolamine-containing compound metabolic process2.932e-060.004581Highly InformativeInherited
Biological Process (BP)ceramide metabolic process0.0018130.00324Highly InformativeInherited
Biological Process (BP)cellular membrane fusion0.0017810.2Highly InformativeInherited
Biological Process (BP)autophagy3.363e-050.005424Highly InformativeInherited
Biological Process (BP)organelle fusion1.711e-050.01278Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)transporter activity00Moderately InformativeDirect
Molecular Function (MF)protein binding11Moderately InformativeInherited
Molecular Function (MF)active transmembrane transporter activity11InformativeInherited
Molecular Function (MF)inorganic cation transmembrane transporter activity11InformativeInherited
Molecular Function (MF)metal ion transmembrane transporter activity0.18441InformativeInherited
Molecular Function (MF)anion transmembrane transporter activity0.015140InformativeInherited
Molecular Function (MF)sodium ion transmembrane transporter activity0.00020870.0002159Highly InformativeDirect
Molecular Function (MF)carbohydrate transmembrane transporter activity1.057e-110Highly InformativeDirect
Molecular Function (MF)secondary active transmembrane transporter activity1.203e-110Highly InformativeDirect
Molecular Function (MF)ion channel activity0.58121Highly InformativeInherited
Molecular Function (MF)ion gated channel activity0.50291Highly InformativeInherited
Molecular Function (MF)monosaccharide binding0.065980.001464Highly InformativeInherited
Cellular Component (CC)membrane00Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.58531Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.7671Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)plasma membrane00Moderately InformativeDirect
Cellular Component (CC)endomembrane system4.644e-125.726e-09Moderately InformativeDirect
Cellular Component (CC)organelle membrane0.00084228.34e-13Moderately InformativeDirect
Cellular Component (CC)intrinsic to membrane2.534e-120Moderately InformativeDirect
Cellular Component (CC)vesicle6.178e-120Moderately InformativeDirect
Cellular Component (CC)cell projection0.23141Moderately InformativeInherited
Cellular Component (CC)endosome1.728e-101.524e-05InformativeDirect
Cellular Component (CC)vacuole9.313e-100InformativeDirect
Cellular Component (CC)Golgi apparatus0.00054145.051e-05InformativeDirect
Cellular Component (CC)integral to membrane02.353e-07InformativeDirect
Cellular Component (CC)coated vesicle2.123e-056.149e-15InformativeDirect
Cellular Component (CC)intrinsic to plasma membrane0.0003846.118e-14InformativeDirect
Cellular Component (CC)synapse2.482e-062.688e-10InformativeDirect
Cellular Component (CC)secretory granule0.092020.7647InformativeInherited
Cellular Component (CC)cell projection part0.40870.9951InformativeInherited
Cellular Component (CC)vacuolar membrane6.181e-080Highly InformativeDirect
Cellular Component (CC)trans-Golgi network3.769e-074.463e-05Highly InformativeDirect
Cellular Component (CC)brush border0.00012156.102e-11Highly InformativeDirect
Cellular Component (CC)vesicle membrane1.461e-081.622e-12Highly InformativeDirect
Cellular Component (CC)clathrin-coated vesicle5.564e-120Highly InformativeDirect
Cellular Component (CC)cytoplasmic vesicle part2.437e-141.614e-15Highly InformativeDirect
Cellular Component (CC)pronucleus1.55e-062.884e-06Highly InformativeDirect
Cellular Component (CC)cell projection membrane0.40330.5121Highly InformativeInherited
Cellular Component (CC)acrosomal vesicle0.037790.3347Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) homeostatic process 0.0002672 Moderately Informative Direct
Biological Process (BP) organic substance transport 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.6439 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.9595 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.9835 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.4626 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) system process 0.3669 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) anion transport 0 Informative Direct
Biological Process (BP) synaptic transmission 0.0001009 Informative Direct
Biological Process (BP) organic acid transport 0 Informative Direct
Biological Process (BP) cellular cation homeostasis 7.923e-05 Informative Direct
Biological Process (BP) transmembrane transport 0 Informative Direct
Biological Process (BP) nitrogen compound transport 0 Informative Direct
Biological Process (BP) secretion 1 Informative Inherited
Biological Process (BP) cellular membrane organization 1 Informative Inherited
Biological Process (BP) response to external stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 1 Informative Inherited
Biological Process (BP) metal ion homeostasis 1 Informative Inherited
Biological Process (BP) response to organic nitrogen 0.0475 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.4043 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 1 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.1425 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.8896 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.9643 Informative Inherited
Biological Process (BP) membrane lipid metabolic process 0.1053 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 1 Informative Inherited
Biological Process (BP) regulation of response to stress 1 Informative Inherited
Biological Process (BP) negative regulation of cellular metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) response to inorganic substance 0.9155 Informative Inherited
Biological Process (BP) response to other organism 1 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.7517 Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 0.1282 Informative Inherited
Biological Process (BP) phospholipid metabolic process 1 Informative Inherited
Biological Process (BP) cellular amide metabolic process 0.7708 Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 3.169e-07 Highly Informative Direct
Biological Process (BP) leukocyte homeostasis 0.000373 Highly Informative Direct
Biological Process (BP) glycosphingolipid metabolic process 0.0008222 Highly Informative Direct
Biological Process (BP) cellular iron ion homeostasis 9.957e-05 Highly Informative Direct
Biological Process (BP) carbohydrate transport 0 Highly Informative Direct
Biological Process (BP) cellular response to starvation 6.37e-07 Highly Informative Direct
Biological Process (BP) monoamine transport 0.0004186 Highly Informative Direct
Biological Process (BP) organic hydroxy compound transport 9.516e-10 Highly Informative Direct
Biological Process (BP) response to drug 0 Highly Informative Direct
Biological Process (BP) amide transport 2.644e-11 Highly Informative Direct
Biological Process (BP) regulation of intracellular pH 3.042e-12 Highly Informative Direct
Biological Process (BP) carbohydrate derivative transport 3.176e-13 Highly Informative Direct
Biological Process (BP) regulation of proteolysis 0.2257 Highly Informative Inherited
Biological Process (BP) lysosome organization 0.001947 Highly Informative Inherited
Biological Process (BP) response to insulin stimulus 0.03951 Highly Informative Inherited
Biological Process (BP) cellular response to peptide hormone stimulus 0.003108 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.07811 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.8313 Highly Informative Inherited
Biological Process (BP) regulation of response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) monocarboxylic acid transport 0.2143 Highly Informative Inherited
Biological Process (BP) synaptic vesicle transport 1 Highly Informative Inherited
Biological Process (BP) amino acid transport 0.5257 Highly Informative Inherited
Biological Process (BP) organophosphate ester transport 0.1569 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular catabolic process 0.006188 Highly Informative Inherited
Biological Process (BP) pH reduction 0.3671 Highly Informative Inherited
Biological Process (BP) inorganic anion transport 1 Highly Informative Inherited
Biological Process (BP) ethanolamine-containing compound metabolic process 0.004581 Highly Informative Inherited
Biological Process (BP) ceramide metabolic process 0.00324 Highly Informative Inherited
Biological Process (BP) cellular membrane fusion 0.2 Highly Informative Inherited
Biological Process (BP) autophagy 0.005424 Highly Informative Inherited
Biological Process (BP) organelle fusion 0.01278 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) protein binding 1 Moderately Informative Inherited
Molecular Function (MF) anion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) active transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) inorganic cation transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) sodium ion transmembrane transporter activity 0.0002159 Highly Informative Direct
Molecular Function (MF) carbohydrate transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) secondary active transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) transition metal ion transmembrane transporter activity 5.425e-07 Highly Informative Direct
Molecular Function (MF) organic hydroxy compound transmembrane transporter activity 6.216e-06 Highly Informative Direct
Molecular Function (MF) macromolecule transmembrane transporter activity 1 Highly Informative Inherited
Molecular Function (MF) amino acid transmembrane transporter activity 1 Highly Informative Inherited
Molecular Function (MF) ion channel activity 1 Highly Informative Inherited
Molecular Function (MF) ion gated channel activity 1 Highly Informative Inherited
Molecular Function (MF) monosaccharide binding 0.001464 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) endomembrane system 5.726e-09 Moderately Informative Direct
Cellular Component (CC) organelle membrane 8.34e-13 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) endosome 1.524e-05 Informative Direct
Cellular Component (CC) vacuole 0 Informative Direct
Cellular Component (CC) Golgi apparatus 5.051e-05 Informative Direct
Cellular Component (CC) integral to membrane 2.353e-07 Informative Direct
Cellular Component (CC) coated vesicle 6.149e-15 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 6.118e-14 Informative Direct
Cellular Component (CC) synapse 2.688e-10 Informative Direct
Cellular Component (CC) secretory granule 0.7647 Informative Inherited
Cellular Component (CC) cell projection part 0.9951 Informative Inherited
Cellular Component (CC) vacuolar membrane 0 Highly Informative Direct
Cellular Component (CC) trans-Golgi network 4.463e-05 Highly Informative Direct
Cellular Component (CC) integral to plasma membrane 1.912e-08 Highly Informative Direct
Cellular Component (CC) brush border 6.102e-11 Highly Informative Direct
Cellular Component (CC) vesicle membrane 1.622e-12 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 1.086e-05 Highly Informative Direct
Cellular Component (CC) clathrin-coated vesicle 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 1.614e-15 Highly Informative Direct
Cellular Component (CC) pronucleus 2.884e-06 Highly Informative Direct
Cellular Component (CC) cell projection membrane 0.5121 Highly Informative Inherited
Cellular Component (CC) acrosomal vesicle 0.3347 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of metabolism0.006259Moderately InformativeInherited
Disease Ontology (DO)endocrine system disease0.35Moderately InformativeInherited
Disease Ontology (DO)bone disease0.4047Moderately InformativeInherited
Disease Ontology (DO)pancreas disease0.05487InformativeInherited
Disease Ontology (DO)arthritis0.3198InformativeInherited
Disease Ontology (DO)glucose metabolism disease1InformativeInherited
Disease Ontology (DO)gout0.0009781Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.08248Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.1587Moderately InformativeInherited
Phenotypic Abnormality (PA)Gait disturbance0.3758InformativeInherited
Phenotypic Abnormality (PA)Hypouricemia3.147e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Conjugated hyperbilirubinemia6.838e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Inability to walk0.0002878Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.002018Least InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.001159Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.4678Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal urine homeostasis0.005316InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system physiology0.1857InformativeInherited
Mammalian Phenotype (MP)abnormal kidney physiology1InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant1Least InformativeInherited
Worm Phenotype (WP)organism stress response variant0.256InformativeInherited
Worm Phenotype (WP)organism osmotic stress response variant0.04267Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)nutrient utilization1Moderately InformativeInherited

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable8.715e-05Least InformativeDirect
Fly Phenotype (FP)fertile9.104e-05Least InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0Least InformativeDirect

Document: ZA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root0.6161Least InformativeInherited
Plant ANatomical entity (PAN)portion of ground tissue0.003747InformativeInherited
Plant ANatomical entity (PAN)cortex0.179Highly InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processDifferentiation1Moderately InformativeInherited
Biological processIon transport1Moderately InformativeInherited
Biological processProtein transport1Moderately InformativeInherited
Biological processAntibiotic resistance0InformativeDirect
Biological processLipid transport3.928e-08InformativeDirect
Biological processAutophagy0Highly InformativeDirect
Biological processNeurotransmitter transport0Highly InformativeDirect
Biological processNitrate assimilation0Highly InformativeDirect
Biological processSodium transport0Highly InformativeDirect
Biological processSugar transport0Highly InformativeDirect
Biological processAmino-acid transport8.902e-08Highly InformativeDirect
Biological processDetoxification0.000357Highly InformativeDirect
Biological processAntiport0.0008572Highly InformativeDirect
Biological processSpermatogenesis0.0009215Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasmic vesicle1.154e-12Moderately InformativeDirect
Cellular componentCell membrane4.129e-08Moderately InformativeDirect
Cellular componentCell junction2.006e-07Moderately InformativeDirect
Cellular componentVacuole0InformativeDirect
Cellular componentCell inner membrane2.879e-14InformativeDirect
Cellular componentSynapse8.59e-08InformativeDirect
Cellular componentLysosome1.857e-07InformativeDirect
Cellular componentSynaptosome2.361e-05Highly InformativeDirect
DiseaseDisease mutation2.604e-07Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionIron1Moderately InformativeInherited
Molecular functionSodium0InformativeDirect
Molecular functionIron transport0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)glycan metabolism0Moderately InformativeDirect
UniPathway (UP)amine and polyamine metabolism0.000484Moderately InformativeDirect
UniPathway (UP)putrescine metabolism1.561e-07InformativeDirect
UniPathway (UP)amine and polyamine biosynthesis1.815e-05InformativeDirect
UniPathway (UP)sucrose metabolism0Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a MFS general substrate transporter domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the MFS general substrate transporter superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]
Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

Please send feedback, comments or questions to superfamily@cs.bris.ac.uk or use the feedback form.

© Copyright 2013 The SUPERFAMILY authors and Julian Gough.