SUPERFAMILY 1.75 HMM library and genome assignments server

MFS general substrate transporter superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   MFS general substrate transporter [ 103472]
Superfamily:   MFS general substrate transporter [ 103473] (2)
Families:   Glycerol-3-phosphate transporter [ 103474]
  LacY-like proton/sugar symporter [ 103477]


Superfamily statistics
Genomes (3,213) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 192,216 814,685 2
Proteins 185,799 798,757 2


Functional annotation
General category Processes_IC
Detailed category Ion metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)localization00Least InformativeDirect
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)protein metabolic process11Least InformativeInherited
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)organic substance transport0.0000000021840Moderately InformativeDirect
Biological Process (BP)response to external stimulus11Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process11Moderately InformativeInherited
Biological Process (BP)ion transport0.0060220Moderately InformativeInherited
Biological Process (BP)multi-organism process11Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.99371Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process0.59721Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process11Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process11Moderately InformativeInherited
Biological Process (BP)lipid metabolic process11Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process11Moderately InformativeInherited
Biological Process (BP)cellular response to stress11Moderately InformativeInherited
Biological Process (BP)cellular catabolic process11Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process11Moderately InformativeInherited
Biological Process (BP)single-organism organelle organization11Moderately InformativeInherited
Biological Process (BP)organic acid transport0.0000000058690InformativeDirect
Biological Process (BP)anion transport0.000000170InformativeDirect
Biological Process (BP)nitrogen compound transport0.00045050InformativeDirect
Biological Process (BP)single-organism membrane organization0.45751InformativeInherited
Biological Process (BP)cellular response to external stimulus0.011020.01365InformativeInherited
Biological Process (BP)response to nutrient levels0.025680.9822InformativeInherited
Biological Process (BP)synaptic transmission0.023410.4255InformativeInherited
Biological Process (BP)ion transmembrane transport11InformativeInherited
Biological Process (BP)organic hydroxy compound transport0.0037150.000000000001904InformativeInherited
Biological Process (BP)cellular chemical homeostasis0.0012590.1082InformativeInherited
Biological Process (BP)regulation of response to external stimulus0.57761InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.82161InformativeInherited
Biological Process (BP)negative regulation of cell communication0.32461InformativeInherited
Biological Process (BP)regulation of cellular catabolic process0.65611InformativeInherited
Biological Process (BP)cation homeostasis0.28071InformativeInherited
Biological Process (BP)monovalent inorganic cation transport0.24721InformativeInherited
Biological Process (BP)metal ion transport0.8181InformativeInherited
Biological Process (BP)alcohol metabolic process0.24661InformativeInherited
Biological Process (BP)cellular biogenic amine metabolic process0.26360.8672InformativeInherited
Biological Process (BP)phospholipid metabolic process0.29461InformativeInherited
Biological Process (BP)liposaccharide metabolic process0.12260.7388InformativeInherited
Biological Process (BP)membrane lipid metabolic process0.030230.5336InformativeInherited
Biological Process (BP)carbohydrate transport00Highly InformativeDirect
Biological Process (BP)response to drug0.000000000036240Highly InformativeDirect
Biological Process (BP)carbohydrate derivative transport0.000000005410Highly InformativeDirect
Biological Process (BP)sodium ion transport0.000000078850.0008091Highly InformativeDirect
Biological Process (BP)lysosome organization0.000035830.000001861Highly InformativeDirect
Biological Process (BP)membrane fusion0.015280.9984Highly InformativeInherited
Biological Process (BP)regulation of neurotransmitter levels0.00025870.001118Highly InformativeInherited
Biological Process (BP)anion transmembrane transport0.097210.05416Highly InformativeInherited
Biological Process (BP)negative regulation of response to external stimulus0.013751Highly InformativeInherited
Biological Process (BP)regulation of response to nutrient levels11Highly InformativeInherited
Biological Process (BP)negative regulation of cellular catabolic process0.0049370.7753Highly InformativeInherited
Biological Process (BP)regulation of autophagy0.00010390.4853Highly InformativeInherited
Biological Process (BP)regulation of cellular response to stress0.024621Highly InformativeInherited
Biological Process (BP)amino acid transport0.048940.933Highly InformativeInherited
Biological Process (BP)dicarboxylic acid transport0.69480.2475Highly InformativeInherited
Biological Process (BP)monocarboxylic acid transport0.039670.0284Highly InformativeInherited
Biological Process (BP)monovalent inorganic cation homeostasis0.00061170.01919Highly InformativeInherited
Biological Process (BP)inorganic anion transport11Highly InformativeInherited
Biological Process (BP)ethanolamine-containing compound metabolic process0.000084210.09735Highly InformativeInherited
Biological Process (BP)ceramide metabolic process0.001040.0168Highly InformativeInherited
Biological Process (BP)glycosphingolipid metabolic process0.00013950.02171Highly InformativeInherited
Biological Process (BP)macroautophagy0.000053720.01982Highly InformativeInherited
Biological Process (BP)organelle fusion0.0012660.3607Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)transporter activity00Moderately InformativeDirect
Molecular Function (MF)metal ion transmembrane transporter activity0.000028880.03655InformativeInherited
Molecular Function (MF)anion transmembrane transporter activity0.0067810InformativeInherited
Molecular Function (MF)active transmembrane transporter activity10.8741InformativeInherited
Molecular Function (MF)monovalent inorganic cation transmembrane transporter activity0.011380.8296InformativeInherited
Molecular Function (MF)secondary active transmembrane transporter activity0.00000000000030850Highly InformativeDirect
Molecular Function (MF)carbohydrate transmembrane transporter activity0.000000000003710Highly InformativeDirect
Molecular Function (MF)sodium ion transmembrane transporter activity0.00000026650.000006793Highly InformativeDirect
Molecular Function (MF)gated channel activity0.018361Highly InformativeInherited
Molecular Function (MF)monosaccharide binding0.045680.03018Highly InformativeInherited
Molecular Function (MF)inorganic anion transmembrane transporter activity0.34181Highly InformativeInherited
Cellular Component (CC)membrane0.0000013490Least InformativeDirect
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)plasma membrane part00Moderately InformativeDirect
Cellular Component (CC)intrinsic component of membrane0.000000000000002780Moderately InformativeDirect
Cellular Component (CC)bounding membrane of organelle0.00026850.00000004854Moderately InformativeDirect
Cellular Component (CC)membrane region0.00033510.02578Moderately InformativeInherited
Cellular Component (CC)cell projection0.99621Moderately InformativeInherited
Cellular Component (CC)vesicle0.03120.1212Moderately InformativeInherited
Cellular Component (CC)integral component of membrane00InformativeDirect
Cellular Component (CC)intrinsic component of plasma membrane0.00000014180InformativeDirect
Cellular Component (CC)plasma membrane region0.0000010480.000000000009827InformativeDirect
Cellular Component (CC)vacuolar part0.0000035650InformativeDirect
Cellular Component (CC)secretory granule0.035340.09693InformativeInherited
Cellular Component (CC)synapse0.0063460.02352InformativeInherited
Cellular Component (CC)integral component of plasma membrane0.000000028050Highly InformativeDirect
Cellular Component (CC)integral component of organelle membrane0.0000013110.0001752Highly InformativeDirect
Cellular Component (CC)brush border0.0001090.00000001662Highly InformativeDirect
Cellular Component (CC)cell projection membrane0.7390.6776Highly InformativeInherited
Cellular Component (CC)cytoplasmic vesicle membrane0.010830.7643Highly InformativeInherited
Cellular Component (CC)acrosomal vesicle0.02570.2461Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) organic substance transport 0 Moderately Informative Direct
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism organelle organization 1 Moderately Informative Inherited
Biological Process (BP) organic acid transport 0 Informative Direct
Biological Process (BP) anion transport 0 Informative Direct
Biological Process (BP) nitrogen compound transport 0 Informative Direct
Biological Process (BP) organic hydroxy compound transport 0.000000000001904 Informative Direct
Biological Process (BP) lipid localization 0.07693 Informative Inherited
Biological Process (BP) ion transmembrane transport 1 Informative Inherited
Biological Process (BP) single-organism membrane organization 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) cellular response to external stimulus 0.01365 Informative Inherited
Biological Process (BP) response to nutrient levels 0.9822 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.1082 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) response to acid chemical 0.7947 Informative Inherited
Biological Process (BP) response to organonitrogen compound 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 1 Informative Inherited
Biological Process (BP) synaptic transmission 0.4255 Informative Inherited
Biological Process (BP) organelle localization 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) response to inorganic substance 1 Informative Inherited
Biological Process (BP) cation homeostasis 1 Informative Inherited
Biological Process (BP) monovalent inorganic cation transport 1 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) alcohol metabolic process 1 Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 0.8672 Informative Inherited
Biological Process (BP) phospholipid metabolic process 1 Informative Inherited
Biological Process (BP) liposaccharide metabolic process 0.7388 Informative Inherited
Biological Process (BP) membrane lipid metabolic process 0.5336 Informative Inherited
Biological Process (BP) cellular metabolic compound salvage 0.6206 Informative Inherited
Biological Process (BP) glycosyl compound biosynthetic process 0.8991 Informative Inherited
Biological Process (BP) purine-containing compound biosynthetic process 1 Informative Inherited
Biological Process (BP) purine ribonucleoside metabolic process 1 Informative Inherited
Biological Process (BP) carbohydrate transport 0 Highly Informative Direct
Biological Process (BP) response to drug 0 Highly Informative Direct
Biological Process (BP) carbohydrate derivative transport 0 Highly Informative Direct
Biological Process (BP) sodium ion transport 0.0008091 Highly Informative Direct
Biological Process (BP) lysosome organization 0.000001861 Highly Informative Direct
Biological Process (BP) amide transport 0.00000000008911 Highly Informative Direct
Biological Process (BP) dopamine transport 0.0004544 Highly Informative Direct
Biological Process (BP) membrane fusion 0.9984 Highly Informative Inherited
Biological Process (BP) response to carbohydrate 0.04952 Highly Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.001118 Highly Informative Inherited
Biological Process (BP) anion transmembrane transport 0.05416 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 1 Highly Informative Inherited
Biological Process (BP) regulation of response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular catabolic process 0.7753 Highly Informative Inherited
Biological Process (BP) regulation of autophagy 0.4853 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 1 Highly Informative Inherited
Biological Process (BP) nucleobase-containing compound transport 1 Highly Informative Inherited
Biological Process (BP) establishment of synaptic vesicle localization 0.7949 Highly Informative Inherited
Biological Process (BP) amino acid transport 0.933 Highly Informative Inherited
Biological Process (BP) dicarboxylic acid transport 0.2475 Highly Informative Inherited
Biological Process (BP) monocarboxylic acid transport 0.0284 Highly Informative Inherited
Biological Process (BP) monovalent inorganic cation homeostasis 0.01919 Highly Informative Inherited
Biological Process (BP) inorganic anion transport 1 Highly Informative Inherited
Biological Process (BP) ethanolamine-containing compound metabolic process 0.09735 Highly Informative Inherited
Biological Process (BP) ceramide metabolic process 0.0168 Highly Informative Inherited
Biological Process (BP) glycosphingolipid metabolic process 0.02171 Highly Informative Inherited
Biological Process (BP) macroautophagy 0.01982 Highly Informative Inherited
Biological Process (BP) organelle fusion 0.3607 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) anion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0.03655 Informative Inherited
Molecular Function (MF) active transmembrane transporter activity 0.8741 Informative Inherited
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 0.8296 Informative Inherited
Molecular Function (MF) secondary active transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) carbohydrate transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) sodium ion transmembrane transporter activity 0.000006793 Highly Informative Direct
Molecular Function (MF) carbohydrate derivative transporter activity 0.00000000000000467 Highly Informative Direct
Molecular Function (MF) organic hydroxy compound transmembrane transporter activity 0.00000000000723 Highly Informative Direct
Molecular Function (MF) organic cation transmembrane transporter activity 0.00000000003044 Highly Informative Direct
Molecular Function (MF) transition metal ion transmembrane transporter activity 0.000001032 Highly Informative Direct
Molecular Function (MF) amino acid transmembrane transporter activity 1 Highly Informative Inherited
Molecular Function (MF) inorganic anion transmembrane transporter activity 1 Highly Informative Inherited
Molecular Function (MF) gated channel activity 1 Highly Informative Inherited
Molecular Function (MF) monosaccharide binding 0.03018 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) plasma membrane part 0 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0.00000004854 Moderately Informative Direct
Cellular Component (CC) vesicle 0.1212 Moderately Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) membrane region 0.02578 Moderately Informative Inherited
Cellular Component (CC) integral component of membrane 0 Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0 Informative Direct
Cellular Component (CC) plasma membrane region 0.000000000009827 Informative Direct
Cellular Component (CC) vacuolar part 0 Informative Direct
Cellular Component (CC) secretory granule 0.09693 Informative Inherited
Cellular Component (CC) synapse 0.02352 Informative Inherited
Cellular Component (CC) lytic vacuole 0.8667 Informative Inherited
Cellular Component (CC) integral component of plasma membrane 0 Highly Informative Direct
Cellular Component (CC) integral component of organelle membrane 0.0001752 Highly Informative Direct
Cellular Component (CC) brush border 0.00000001662 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 0.0006821 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 0.0000000002989 Highly Informative Direct
Cellular Component (CC) coated vesicle 1 Highly Informative Inherited
Cellular Component (CC) cell projection membrane 0.6776 Highly Informative Inherited
Cellular Component (CC) cytoplasmic vesicle membrane 0.7643 Highly Informative Inherited
Cellular Component (CC) acrosomal vesicle 0.2461 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of metabolism0.002813Moderately InformativeInherited
Disease Ontology (DO)endocrine system disease0.3879Moderately InformativeInherited
Disease Ontology (DO)pancreas disease0.05873InformativeInherited
Disease Ontology (DO)glucose metabolism disease1InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.05703Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.4678Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.1896InformativeInherited
Phenotypic Abnormality (PA)Hypouricemia0.000003164Highly InformativeDirect
Phenotypic Abnormality (PA)Conjugated hyperbilirubinemia0.00007207Highly InformativeDirect
Phenotypic Abnormality (PA)Gait disturbance0.3619Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.000731Least InformativeDirect
Mammalian Phenotype (MP)renal/urinary system phenotype0.006491Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.3962Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal urine homeostasis0.01327InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system physiology0.09379InformativeInherited
Mammalian Phenotype (MP)abnormal digestion0.007025Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant1Least InformativeInherited
Worm Phenotype (WP)organism stress response variant0.256InformativeInherited
Worm Phenotype (WP)organism osmotic stress response variant0.04267Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0.6722Least InformativeInherited
Yeast Phenotype (YP)nutrient utilization1Moderately InformativeInherited

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0.0002734Least InformativeDirect
Fly Phenotype (FP)fertile0.0001861Moderately InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.8908Least InformativeInherited
Plant ANatomical entity (PAN)portion of ground tissue0.004879InformativeInherited
Plant ANatomical entity (PAN)cortex0.1867Highly InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)musculo-skeletal system0.03048Moderately InformativeInherited
Drugbank ATC_code (DB)probenecid0.00000009224Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport1Moderately InformativeInherited
Biological processProtein transport1Moderately InformativeInherited
Biological processAntibiotic resistance0InformativeDirect
Biological processLipid transport0.00000003244InformativeDirect
Biological processAutophagy0Highly InformativeDirect
Biological processNeurotransmitter transport0Highly InformativeDirect
Biological processNitrate assimilation0Highly InformativeDirect
Biological processSodium transport0Highly InformativeDirect
Biological processSugar transport0Highly InformativeDirect
Biological processAmino-acid transport0.00000008094Highly InformativeDirect
Biological processDetoxification0.0003534Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell membrane6.436e-16Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.000000000002421Moderately InformativeDirect
Cellular componentCell junction0.0000005714Moderately InformativeDirect
Cellular componentVacuole0InformativeDirect
Cellular componentCell inner membrane0.000000004556InformativeDirect
Cellular componentSynapse0.00000003216InformativeDirect
Cellular componentLysosome0.0000002704InformativeDirect
Cellular componentSynaptosome0.00007761Highly InformativeDirect
DiseaseDisease mutation0.000001837Least InformativeDirect
DiseaseDiabetes mellitus0.00001821Highly InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionIron1Moderately InformativeInherited
Molecular functionSodium0InformativeDirect
Molecular functionIron transport0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)glycan metabolism0Moderately InformativeDirect
UniPathway (UP)amine and polyamine metabolism0.0004733Moderately InformativeDirect
UniPathway (UP)putrescine metabolism0.0000001591InformativeDirect
UniPathway (UP)amine and polyamine biosynthesis0.00001802InformativeDirect
UniPathway (UP)sucrose metabolism0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a MFS general substrate transporter domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the MFS general substrate transporter superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]