SUPERFAMILY 1.75 HMM library and genome assignments server

KA1-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   TBP-like [ 55944] (11)
Superfamily:   KA1-like [ 103243] (2)
Families:   Kinase associated domain 1, KA1 [ 103244]
  Ssp2 C-terminal domain-like [ 160723] (3)


Superfamily statistics
Genomes (471) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,971 2,066 5
Proteins 1,968 2,062 5


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.0000000002467 Least Informative Direct
Biological Process (BP) response to stimulus 0.000000466 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.000004659 Least Informative Direct
Biological Process (BP) developmental process 0.0000582 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.0004756 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 0.4843 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.5171 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.728 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) localization 0.003179 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.001148 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.00002128 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.00007403 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.0002214 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.0002618 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0003759 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0.0008099 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.002737 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.1438 Moderately Informative Inherited
Biological Process (BP) reproductive process 0.127 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.02513 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.4844 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.3128 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.001129 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.3559 Moderately Informative Inherited
Biological Process (BP) single-organism organelle organization 0.002143 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.02054 Moderately Informative Inherited
Biological Process (BP) immune system process 0.001273 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.0468 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.2538 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.4402 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.2595 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.005994 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.218 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.7872 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.005163 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.5831 Moderately Informative Inherited
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) response to nutrient levels 0.000000000000001913 Informative Direct
Biological Process (BP) generation of neurons 0.000000005243 Informative Direct
Biological Process (BP) locomotion 0.00000001957 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.0000001429 Informative Direct
Biological Process (BP) positive regulation of catabolic process 0.000000523 Informative Direct
Biological Process (BP) apoptotic process 0.0000006002 Informative Direct
Biological Process (BP) cellular response to external stimulus 0.000001233 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.000003868 Informative Direct
Biological Process (BP) localization of cell 0.00001203 Informative Direct
Biological Process (BP) regulation of cell development 0.0000335 Informative Direct
Biological Process (BP) cell proliferation 0.00003868 Informative Direct
Biological Process (BP) cellular component movement 0.0002234 Informative Direct
Biological Process (BP) growth 0.0002638 Informative Direct
Biological Process (BP) negative regulation of signaling 0.000464 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0005451 Informative Direct
Biological Process (BP) microtubule-based process 0.0007124 Informative Direct
Biological Process (BP) cytoskeleton organization 0.02519 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.1196 Informative Inherited
Biological Process (BP) sexual reproduction 0.02685 Informative Inherited
Biological Process (BP) organelle localization 0.002595 Informative Inherited
Biological Process (BP) response to oxidative stress 0.009782 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.0267 Informative Inherited
Biological Process (BP) cell projection organization 0.03001 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.001642 Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.02824 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.00953 Informative Inherited
Biological Process (BP) single-organism cellular localization 0.04177 Informative Inherited
Biological Process (BP) chromosome organization 0.318 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.04091 Informative Inherited
Biological Process (BP) organ morphogenesis 0.571 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.01918 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.02786 Informative Inherited
Biological Process (BP) single organism reproductive process 0.5445 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.4954 Informative Inherited
Biological Process (BP) immune response 0.284 Informative Inherited
Biological Process (BP) epithelium development 0.0575 Informative Inherited
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.00000000000003082 Highly Informative Direct
Biological Process (BP) regulation of autophagy 0.0000000000001439 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.00000000001094 Highly Informative Direct
Biological Process (BP) regulation of circadian rhythm 0.0000000001119 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular signal transduction 0.000000004282 Highly Informative Direct
Biological Process (BP) neural precursor cell proliferation 0.00000005131 Highly Informative Direct
Biological Process (BP) maintenance of location 0.0000009502 Highly Informative Direct
Biological Process (BP) humoral immune response 0.000002388 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0.000003542 Highly Informative Direct
Biological Process (BP) peptidyl-serine modification 0.000005494 Highly Informative Direct
Biological Process (BP) columnar/cuboidal epithelial cell differentiation 0.000008073 Highly Informative Direct
Biological Process (BP) epidermis development 0.00007765 Highly Informative Direct
Biological Process (BP) female gamete generation 0.0002086 Highly Informative Direct
Biological Process (BP) cell fate commitment 0.0003325 Highly Informative Direct
Biological Process (BP) epithelial cell development 0.0006345 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 0.0006717 Highly Informative Direct
Biological Process (BP) regulation of reproductive process 0.002177 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.006147 Highly Informative Inherited
Biological Process (BP) developmental growth 0.01569 Highly Informative Inherited
Biological Process (BP) germ cell development 0.002476 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.02709 Highly Informative Inherited
Biological Process (BP) histone modification 0.004009 Highly Informative Inherited
Biological Process (BP) response to ionizing radiation 0.006467 Highly Informative Inherited
Biological Process (BP) intrinsic apoptotic signaling pathway 0.001395 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.003611 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.02768 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.001067 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.0002303 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.000638 Moderately Informative Direct
Molecular Function (MF) cation binding 0.01554 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.3568 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.00000005376 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 0.0000000876 Informative Direct
Molecular Function (MF) chromatin binding 0.000001848 Informative Direct
Molecular Function (MF) nucleotide binding 0.000002242 Informative Direct
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Molecular Function (MF) ATP binding 0.000000001477 Highly Informative Direct
Cellular Component (CC) membrane 0.08125 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.1508 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.002152 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.7417 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) transferase complex 0.00000001926 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.0000001163 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.05267 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.09808 Moderately Informative Inherited
Cellular Component (CC) membrane region 0.006268 Moderately Informative Inherited
Cellular Component (CC) plasma membrane part 0.04235 Moderately Informative Inherited
Cellular Component (CC) cell cortex 0 Informative Direct
Cellular Component (CC) neuron projection 0.00005255 Informative Direct
Cellular Component (CC) plasma membrane region 0.00006463 Informative Direct
Cellular Component (CC) synapse 0.006768 Informative Inherited
Cellular Component (CC) basolateral plasma membrane 0.00003371 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body phenotype0Least InformativeDirect
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal hormone level0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal lipid homeostasis0.08097Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adipose tissue amount0.00006571InformativeDirect
Mammalian Phenotype (MP)abnormal triglyceride level0.0005515InformativeDirect
Mammalian Phenotype (MP)abnormal energy expenditure0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal susceptibility to weight gain0Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)gametogenesis variant0.2309Moderately InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical entity in vitro0InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0.0000000006984Moderately InformativeDirect
Biological processApoptosis0.0000004217Moderately InformativeDirect
Biological processCarbohydrate metabolism0.000002108Moderately InformativeDirect
Biological processTranscription regulation0.00003984Moderately InformativeDirect
Biological processBiological rhythms0InformativeDirect
Biological processWnt signaling pathway0InformativeDirect
Biological processFatty acid metabolism0.000000000000004146InformativeDirect
Biological processSteroid metabolism0.0000000000004422InformativeDirect
Biological processLipid biosynthesis0.00000000001449InformativeDirect
Biological processAutophagy0Highly InformativeDirect
Biological processCholesterol metabolism0Highly InformativeDirect
Biological processSterol biosynthesis0Highly InformativeDirect
Biological processSteroid biosynthesis0.00000000000007897Highly InformativeDirect
Cellular componentNucleus0.0000009984Least InformativeDirect
Cellular componentMembrane0.00001632Least InformativeDirect
Cellular componentCytoplasm0.1065Least InformativeInherited
Cellular componentCytoskeleton0.000001744Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionMagnesium0.00001041Moderately InformativeDirect
Molecular functionLipid-binding0.000000000000002061InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.0003482Moderately InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationChromatin regulator0.00000000000002499InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0.0000001146Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a KA1-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the KA1-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]