SUPERFAMILY 1.75 HMM library and genome assignments server


KA1-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   TBP-like [ 55944] (11)
Superfamily:   KA1-like [ 103243] (2)
Families:   Kinase associated domain 1, KA1 [ 103244]
  Ssp2 C-terminal domain-like [ 160723] (3)


Superfamily statistics
Genomes (418) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 1,758 1,544 5
Proteins 1,754 1,542 5


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details) Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 1.036e-10 Least Informative Direct
Biological Process (BP) developmental process 4.353e-07 Least Informative Direct
Biological Process (BP) multicellular organismal process 1.651e-05 Least Informative Direct
Biological Process (BP) localization 6.242e-05 Least Informative Direct
Biological Process (BP) response to stimulus 0.0001679 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0001798 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0003768 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.3511 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 2.02e-07 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 2.349e-05 Moderately Informative Direct
Biological Process (BP) nervous system development 3.855e-05 Moderately Informative Direct
Biological Process (BP) lipid biosynthetic process 0.0001642 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0001657 Moderately Informative Direct
Biological Process (BP) cellular localization 0.4309 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.09536 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.3168 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.1027 Moderately Informative Inherited
Biological Process (BP) organ development 0.6938 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.02777 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.03823 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.2769 Moderately Informative Inherited
Biological Process (BP) reproduction 0.272 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.1983 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.02296 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.006741 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.1228 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.1152 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.02347 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.3553 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.004037 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.2661 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.391 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.04256 Moderately Informative Inherited
Biological Process (BP) immune system process 0.00178 Moderately Informative Inherited
Biological Process (BP) protein phosphorylation 0 Informative Direct
Biological Process (BP) generation of neurons 5.777e-14 Informative Direct
Biological Process (BP) cell proliferation 7.499e-10 Informative Direct
Biological Process (BP) locomotion 6.059e-08 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 1.393e-07 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 2.316e-07 Informative Direct
Biological Process (BP) response to external stimulus 8.7e-06 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0001352 Informative Direct
Biological Process (BP) regulation of cell development 0.000145 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0001973 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0002223 Informative Direct
Biological Process (BP) localization of cell 0.0002749 Informative Direct
Biological Process (BP) growth 0.000486 Informative Direct
Biological Process (BP) muscle tissue development 0.0004906 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0009095 Informative Direct
Biological Process (BP) microtubule-based process 0.0009858 Informative Direct
Biological Process (BP) cytoskeleton organization 0.04641 Informative Inherited
Biological Process (BP) regulation of reproductive process 0.006339 Informative Inherited
Biological Process (BP) muscle structure development 0.1503 Informative Inherited
Biological Process (BP) cell projection organization 0.04486 Informative Inherited
Biological Process (BP) response to other organism 0.06016 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.05512 Informative Inherited
Biological Process (BP) chromosome organization 0.4395 Informative Inherited
Biological Process (BP) organ morphogenesis 0.5572 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.005226 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.4844 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.1409 Informative Inherited
Biological Process (BP) cellular component movement 0.001906 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.7512 Informative Inherited
Biological Process (BP) sexual reproduction 0.02477 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.03046 Informative Inherited
Biological Process (BP) single organism reproductive process 0.2211 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.4386 Informative Inherited
Biological Process (BP) immune response 0.209 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.1111 Informative Inherited
Biological Process (BP) epithelium development 0.04935 Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0 Highly Informative Direct
Biological Process (BP) peptidyl-serine modification 0 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 5.966e-15 Highly Informative Direct
Biological Process (BP) neural precursor cell proliferation 7.773e-13 Highly Informative Direct
Biological Process (BP) lipid homeostasis 2.286e-11 Highly Informative Direct
Biological Process (BP) cellular response to starvation 1.93e-09 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 7.813e-09 Highly Informative Direct
Biological Process (BP) cell fate commitment 1.946e-07 Highly Informative Direct
Biological Process (BP) maintenance of location 2.347e-07 Highly Informative Direct
Biological Process (BP) cell division 2.221e-06 Highly Informative Direct
Biological Process (BP) humoral immune response 2.803e-06 Highly Informative Direct
Biological Process (BP) muscle fiber development 2.9e-06 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis 1.701e-05 Highly Informative Direct
Biological Process (BP) pattern specification process 2.742e-05 Highly Informative Direct
Biological Process (BP) stem cell proliferation 3.661e-05 Highly Informative Direct
Biological Process (BP) post-embryonic development 3.826e-05 Highly Informative Direct
Biological Process (BP) germ cell development 0.0001851 Highly Informative Direct
Biological Process (BP) female gamete generation 0.0002958 Highly Informative Direct
Biological Process (BP) organelle localization 0.000624 Highly Informative Direct
Biological Process (BP) microtubule cytoskeleton organization 0.001078 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.003019 Highly Informative Inherited
Biological Process (BP) developmental growth 0.0136 Highly Informative Inherited
Biological Process (BP) histone modification 0.8887 Highly Informative Inherited
Biological Process (BP) negative regulation of signal transduction 0.00593 Highly Informative Inherited
Biological Process (BP) epidermis development 0.01073 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.01691 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.02626 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0.01322 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.3873 Moderately Informative Inherited
Molecular Function (MF) heterocyclic compound binding 0.6072 Moderately Informative Inherited
Molecular Function (MF) organic cyclic compound binding 0.6366 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) nucleotide binding 7.745e-06 Informative Direct
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Molecular Function (MF) ATP binding 9.802e-09 Highly Informative Direct
Molecular Function (MF) chromatin binding 4.317e-07 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.3986 Least Informative Inherited
Cellular Component (CC) protein complex 0.02013 Least Informative Inherited
Cellular Component (CC) membrane 0.004109 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.394 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.0006287 Moderately Informative Direct
Cellular Component (CC) extracellular region 0.3742 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.07718 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.2151 Moderately Informative Inherited
Cellular Component (CC) cell cortex 0 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 3.902e-06 Informative Direct
Cellular Component (CC) cell projection part 0.03514 Informative Inherited
Cellular Component (CC) synapse 0.004928 Informative Inherited
Cellular Component (CC) neuron part 0.00579 Informative Inherited
Cellular Component (CC) neuromuscular junction 3.095e-07 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 4.529e-05 Highly Informative Direct
Cellular Component (CC) axon part 0.0002869 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal hormone level0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal lipid level0.00408Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal circulating hormone level0InformativeDirect
Mammalian Phenotype (MP)abnormal adipose tissue amount4.265e-05InformativeDirect
Mammalian Phenotype (MP)abnormal triglyceride level0.0004546InformativeDirect
Mammalian Phenotype (MP)decreased susceptibility to diet-induced obesity6.789e-06Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)gametogenesis variant0.2309Moderately InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)lethal0Least InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)male genitalia0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical entity in vitro0InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism6.205e-10Moderately InformativeDirect
Biological processApoptosis3.534e-07Moderately InformativeDirect
Biological processCarbohydrate metabolism1.336e-06Moderately InformativeDirect
Biological processTranscription regulation3.023e-05Moderately InformativeDirect
Biological processWnt signaling pathway0InformativeDirect
Biological processFatty acid metabolism4.304e-15InformativeDirect
Biological processSteroid metabolism4.233e-13InformativeDirect
Biological processLipid biosynthesis1.423e-11InformativeDirect
Biological processAutophagy0Highly InformativeDirect
Biological processBiological rhythms0Highly InformativeDirect
Biological processCholesterol biosynthesis0Highly InformativeDirect
Biological processSterol biosynthesis0Highly InformativeDirect
Biological processSteroid biosynthesis8.547e-14Highly InformativeDirect
Cellular componentNucleus9.432e-07Least InformativeDirect
Cellular componentMembrane1.828e-05Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionMagnesium2.498e-06Moderately InformativeDirect
Molecular functionLipid-binding9.196e-16InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.0003669Moderately InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationChromatin regulator2.53e-14InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation6.554e-08Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a KA1-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the KA1-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]