SUPERFAMILY 1.75 HMM library and genome assignments server

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KA1-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   TBP-like [ 55944] (11)
Superfamily:   KA1-like [ 103243] (2)
Families:   Kinase associated domain 1, KA1 [ 103244]
  Ssp2 C-terminal domain-like [ 160723] (3)


Superfamily statistics
Genomes (470) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,968 2,066 5
Proteins 1,965 2,062 5


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.0000000004186 Least Informative Direct
Biological Process (BP) response to stimulus 0.0000003016 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.000002228 Least Informative Direct
Biological Process (BP) developmental process 0.00004385 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.000146 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.0007083 Least Informative Direct
Biological Process (BP) localization 0.002091 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.4534 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.00006641 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.0001652 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.000459 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.0006393 Moderately Informative Direct
Biological Process (BP) nervous system development 0.0009502 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.3645 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.1931 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.006887 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.2184 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.3262 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.002413 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.01052 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.528 Moderately Informative Inherited
Biological Process (BP) reproduction 0.1962 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.01435 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.001642 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.1528 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.162 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.2573 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.3559 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.006031 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.001006 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.7665 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.3418 Moderately Informative Inherited
Biological Process (BP) immune system process 0.001143 Moderately Informative Inherited
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) response to nutrient levels 0 Informative Direct
Biological Process (BP) generation of neurons 0.000000004087 Informative Direct
Biological Process (BP) locomotion 0.00000001607 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.000000195 Informative Direct
Biological Process (BP) apoptotic process 0.0000005406 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.000001676 Informative Direct
Biological Process (BP) localization of cell 0.00001453 Informative Direct
Biological Process (BP) regulation of cell development 0.00005946 Informative Direct
Biological Process (BP) growth 0.0002437 Informative Direct
Biological Process (BP) muscle tissue development 0.000293 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0003378 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0003928 Informative Direct
Biological Process (BP) cellular component movement 0.0005122 Informative Direct
Biological Process (BP) cytoskeleton organization 0.03427 Informative Inherited
Biological Process (BP) microtubule-based process 0.001191 Informative Inherited
Biological Process (BP) organelle localization 0.002398 Informative Inherited
Biological Process (BP) muscle structure development 0.07012 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.02511 Informative Inherited
Biological Process (BP) cell projection organization 0.05023 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.001122 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.01063 Informative Inherited
Biological Process (BP) chromosome organization 0.3675 Informative Inherited
Biological Process (BP) response to oxidative stress 0.008995 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.02609 Informative Inherited
Biological Process (BP) organ morphogenesis 0.2184 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.01656 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.1469 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.3095 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.4909 Informative Inherited
Biological Process (BP) sexual reproduction 0.01999 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.0379 Informative Inherited
Biological Process (BP) single organism reproductive process 0.2457 Informative Inherited
Biological Process (BP) immune response 0.2857 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.02733 Informative Inherited
Biological Process (BP) epithelium development 0.03795 Informative Inherited
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.00000000000002793 Highly Informative Direct
Biological Process (BP) regulation of autophagy 0.00000000000009575 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.00000000003037 Highly Informative Direct
Biological Process (BP) positive regulation of catabolic process 0.0000000000455 Highly Informative Direct
Biological Process (BP) regulation of circadian rhythm 0.0000000001172 Highly Informative Direct
Biological Process (BP) neural precursor cell proliferation 0.0000000495 Highly Informative Direct
Biological Process (BP) cellular response to starvation 0.00000008979 Highly Informative Direct
Biological Process (BP) maintenance of location 0.0000001096 Highly Informative Direct
Biological Process (BP) muscle fiber development 0.00000168 Highly Informative Direct
Biological Process (BP) humoral immune response 0.000002253 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0.000003284 Highly Informative Direct
Biological Process (BP) peptidyl-serine modification 0.000005426 Highly Informative Direct
Biological Process (BP) epidermal cell differentiation 0.0000195 Highly Informative Direct
Biological Process (BP) female gamete generation 0.0001973 Highly Informative Direct
Biological Process (BP) cell fate commitment 0.0003597 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 0.0003702 Highly Informative Direct
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.0007422 Highly Informative Direct
Biological Process (BP) regulation of reproductive process 0.004058 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.006081 Highly Informative Inherited
Biological Process (BP) developmental growth 0.003547 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.02181 Highly Informative Inherited
Biological Process (BP) histone modification 0.6654 Highly Informative Inherited
Biological Process (BP) response to ionizing radiation 0.006195 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.02237 Highly Informative Inherited
Biological Process (BP) intrinsic apoptotic signaling pathway 0.001914 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.001721 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.00095 Least Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0.01534 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.3572 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.0000000476 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 0.00000007796 Informative Direct
Molecular Function (MF) chromatin binding 0.000001773 Informative Direct
Molecular Function (MF) nucleotide binding 0.000002013 Informative Direct
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Molecular Function (MF) ATP binding 0.000000001309 Highly Informative Direct
Cellular Component (CC) protein complex 0.0002561 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.7107 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.09641 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 0.07128 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.00000006456 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.2347 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.08794 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.02385 Moderately Informative Inherited
Cellular Component (CC) cell cortex 0 Informative Direct
Cellular Component (CC) neuron projection 0.00004877 Informative Direct
Cellular Component (CC) synapse part 0.0004765 Informative Direct
Cellular Component (CC) basolateral plasma membrane 0.0005307 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body phenotype0Least InformativeDirect
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal hormone level0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal lipid homeostasis0.08097Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adipose tissue amount0.00006571InformativeDirect
Mammalian Phenotype (MP)abnormal triglyceride level0.0005515InformativeDirect
Mammalian Phenotype (MP)abnormal energy expenditure0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal susceptibility to weight gain0Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)gametogenesis variant0.2309Moderately InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical entity in vitro0InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0.0000000006984Moderately InformativeDirect
Biological processApoptosis0.0000004217Moderately InformativeDirect
Biological processCarbohydrate metabolism0.000002108Moderately InformativeDirect
Biological processTranscription regulation0.00003984Moderately InformativeDirect
Biological processBiological rhythms0InformativeDirect
Biological processWnt signaling pathway0InformativeDirect
Biological processFatty acid metabolism0.000000000000004146InformativeDirect
Biological processSteroid metabolism0.0000000000004422InformativeDirect
Biological processLipid biosynthesis0.00000000001449InformativeDirect
Biological processAutophagy0Highly InformativeDirect
Biological processCholesterol metabolism0Highly InformativeDirect
Biological processSterol biosynthesis0Highly InformativeDirect
Biological processSteroid biosynthesis0.00000000000007897Highly InformativeDirect
Cellular componentNucleus0.0000009984Least InformativeDirect
Cellular componentMembrane0.00001632Least InformativeDirect
Cellular componentCytoplasm0.1065Least InformativeInherited
Cellular componentCytoskeleton0.000001744Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionMagnesium0.00001041Moderately InformativeDirect
Molecular functionLipid-binding0.000000000000002061InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.0003482Moderately InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationChromatin regulator0.00000000000002499InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0.0000001146Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a KA1-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the KA1-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]