SUPERFAMILY 1.75 HMM library and genome assignments server

Coproporphyrinogen III oxidase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Coproporphyrinogen III oxidase [ 102885]
Superfamily:   Coproporphyrinogen III oxidase [ 102886]
Families:   Coproporphyrinogen III oxidase [ 102887] (2)


Superfamily statistics
Genomes (1,463) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,633 6,772 4
Proteins 1,629 6,770 4


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.45260.02144Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.55470.02135Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.69180.003379Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.5350.02093Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.6990.0601Moderately InformativeInherited
Biological Process (BP)cofactor metabolic process0.14340.000004819Moderately InformativeInherited
Biological Process (BP)tetrapyrrole metabolic process0.0001280.0000000000002404InformativeDirect
Biological Process (BP)pigment metabolic process0.0050150.000000001462InformativeInherited
Biological Process (BP)porphyrin-containing compound biosynthetic process0.000014530.000000000000003707Highly InformativeDirect
Biological Process (BP)heme metabolic process0.000065160.00000000000002591Highly InformativeDirect
Molecular Function (MF)binding00Least InformativeDirect
Molecular Function (MF)oxidoreductase activity0.83870.04652Moderately InformativeInherited
Molecular Function (MF)protein dimerization activity00InformativeDirect
Molecular Function (MF)protein homodimerization activity00Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on the CH-CH group of donors0.000060670.000000000001077Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cofactor metabolic process 0.000004819 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.02144 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.02135 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.003379 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.0601 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.02093 Moderately Informative Inherited
Biological Process (BP) tetrapyrrole metabolic process 0.0000000000002404 Informative Direct
Biological Process (BP) pigment metabolic process 0.000000001462 Informative Direct
Biological Process (BP) porphyrin-containing compound biosynthetic process 0.000000000000003707 Highly Informative Direct
Biological Process (BP) heme metabolic process 0.00000000000002591 Highly Informative Direct
Biological Process (BP) pigment biosynthetic process 0.00000000004954 Highly Informative Direct
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) oxidoreductase activity 0.04652 Moderately Informative Inherited
Molecular Function (MF) protein dimerization activity 0 Informative Direct
Molecular Function (MF) protein homodimerization activity 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-CH group of donors 0.000000000001077 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on the CH-CH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0Highly InformativeDirect

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processHeme biosynthesis0Highly InformativeDirect
Biological processPorphyrin biosynthesis0Highly InformativeDirect
Biological processChlorophyll biosynthesis0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cofactor metabolism0Least InformativeDirect
UniPathway (UP)macrocycle metabolism0Moderately InformativeDirect
UniPathway (UP)porphyrin-containing compound metabolism0Moderately InformativeDirect
UniPathway (UP)protoporphyrin-IX biosynthesis0InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR001260 SSF102886 Protein matches
Abstract Coprogen oxidase (i.e. coproporphyrin III oxidase or coproporphyrinogenase) catalyses the oxidative decarboxylation of coproporphyrinogen III to proto-porhyrinogen IX in the haem and chlorophyll biosynthetic pathways [PubMed8407975, PubMed8219054]. The protein is a homodimer containing two internally bound iron atoms per molecule of native protein [PubMed3516695]. The enzyme is active in the presence of molecular oxygen that acts as an electron acceptor). The enzyme is widely distributed having been found in a variety of eukaryotic and prokaryotic sources.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Coproporphyrinogen III oxidase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Coproporphyrinogen III oxidase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]