SUPERFAMILY 1.75 HMM library and genome assignments server


JAB1/MPN domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Cytidine deaminase-like [ 53926] (2)
Superfamily:   JAB1/MPN domain [ 102712]
Families:   JAB1/MPN domain [ 102713]


Superfamily statistics
Genomes (2,080) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 4,860 20,757 2
Proteins 4,858 20,756 2


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 8.549e-14 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 9.052e-10 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.02232 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.009207 Least Informative Inherited
Biological Process (BP) response to stimulus 0.4909 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.7054 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.004225 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) positive regulation of metabolic process 4.033e-06 Moderately Informative Direct
Biological Process (BP) organelle organization 4.52e-06 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 8.93e-06 Moderately Informative Direct
Biological Process (BP) cellular response to stress 3.195e-05 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 5.843e-05 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.004013 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.04366 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.05927 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.5413 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.7789 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.09107 Moderately Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 0 Informative Direct
Biological Process (BP) response to DNA damage stimulus 1.972e-09 Informative Direct
Biological Process (BP) chromosome organization 6.746e-07 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 8.111e-06 Informative Direct
Biological Process (BP) regulation of response to stress 5.485e-05 Informative Direct
Biological Process (BP) regulation of cell cycle process 0.04702 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.02939 Informative Inherited
Biological Process (BP) protein catabolic process 0.05036 Informative Inherited
Biological Process (BP) proteolysis 0.1082 Informative Inherited
Biological Process (BP) DNA metabolic process 0.03732 Informative Inherited
Biological Process (BP) regulation of cellular response to stress 1.463e-08 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 3.491e-08 Highly Informative Direct
Biological Process (BP) DNA damage checkpoint 8.517e-08 Highly Informative Direct
Biological Process (BP) response to ionizing radiation 3.16e-06 Highly Informative Direct
Biological Process (BP) histone modification 2.394e-05 Highly Informative Direct
Molecular Function (MF) hydrolase activity 2.911e-11 Least Informative Direct
Molecular Function (MF) binding 0.2693 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.0006707 Moderately Informative Direct
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) thiolester hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) metallopeptidase activity 5.287e-10 Highly Informative Direct
Molecular Function (MF) protein binding transcription factor activity 2.856e-07 Highly Informative Direct
Cellular Component (CC) protein complex 4.092e-11 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.0008202 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.05031 Least Informative Inherited
Cellular Component (CC) nuclear part 1.191e-06 Moderately Informative Direct
Cellular Component (CC) proteasome complex 2.47e-11 Highly Informative Direct

Document: GO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0Moderately InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0Moderately InformativeDirect
Worm Phenotype (WP)protein aggregation variant0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDNA damage4.428e-05Moderately InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentProteasome1.277e-15Highly InformativeDirect
Coding sequence diversityAlternative splicing0.0008525Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationActivator0.0002952Moderately InformativeDirect
Post-translational modificationChromatin regulator0InformativeDirect
Post-translational modificationMetalloprotease0InformativeDirect
Post-translational modificationAcetylation1.811e-06Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a JAB1/MPN domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the JAB1/MPN domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]