SUPERFAMILY 1.75 HMM library and genome assignments server

JAB1/MPN domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Cytidine deaminase-like [ 53926] (2)
Superfamily:   JAB1/MPN domain [ 102712]
Families:   JAB1/MPN domain [ 102713]


Superfamily statistics
Genomes (2,089) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 4,936 20,757 2
Proteins 4,934 20,756 2


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0.0000000000006548 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.000000004006 Least Informative Direct
Biological Process (BP) positive regulation of biological process 0.0001612 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.01356 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.02481 Least Informative Inherited
Biological Process (BP) response to stimulus 0.393 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.005931 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.04927 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.000000463 Moderately Informative Direct
Biological Process (BP) single-organism organelle organization 0.000002854 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.00002333 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.00003377 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.00003735 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.00006647 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0.05759 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.003684 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.5708 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.8091 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.02809 Moderately Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 0 Informative Direct
Biological Process (BP) DNA repair 0.00000000002619 Informative Direct
Biological Process (BP) chromosome organization 0.0000003375 Informative Direct
Biological Process (BP) cell cycle process 0.000003336 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.03081 Informative Inherited
Biological Process (BP) protein catabolic process 0.05522 Informative Inherited
Biological Process (BP) proteolysis 0.1159 Informative Inherited
Biological Process (BP) DNA integrity checkpoint 0.000000000000005526 Highly Informative Direct
Biological Process (BP) histone modification 0.0000000000006265 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.00000002282 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.00000004586 Highly Informative Direct
Biological Process (BP) response to ionizing radiation 0.000003717 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0.000000000004085 Least Informative Direct
Molecular Function (MF) binding 0.2155 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.00478 Moderately Informative Inherited
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) thiolester hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) metallopeptidase activity 0.0000000006057 Highly Informative Direct
Molecular Function (MF) transcription factor binding transcription factor activity 0.00000003183 Highly Informative Direct
Cellular Component (CC) protein complex 0.000000000004471 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.0009988 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.02359 Least Informative Inherited
Cellular Component (CC) nuclear part 0.0000001677 Moderately Informative Direct

Document: GO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0Moderately InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0Moderately InformativeDirect
Worm Phenotype (WP)protein aggregation variant0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDNA damage0.00004389Moderately InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentProteasome0.00000000000000128Highly InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationActivator0.0002957Moderately InformativeDirect
Post-translational modificationChromatin regulator0InformativeDirect
Post-translational modificationMetalloprotease0InformativeDirect
Post-translational modificationAcetylation0.000001936Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a JAB1/MPN domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the JAB1/MPN domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]