SUPERFAMILY 1.75 HMM library and genome assignments server

AXH domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   AXH domain [ 102030]
Superfamily:   AXH domain [ 102031]
Families:   AXH domain [ 102032]


Superfamily statistics
Genomes (119) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 309 326 1
Proteins 309 325 1


Functional annotation
General category Regulation
Detailed category RNA binding, metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0.01029 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.03707 Least Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.0001157 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0.0001607 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.0002319 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0.0003289 Moderately Informative Direct
Molecular Function (MF) binding 0.007373 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.0000939 Least Informative Direct

Document: GO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited

Document: MP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Biological processWnt signaling pathway0.00000000000006848InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationPhosphoprotein0.00006334Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR013723 SSF102031 Protein matches
Abstract

AXH is a protein-protein and RNA binding motif found in Ataxin-1 (ATX1)[PubMed14583607]. ATX1 is responsible for the autosomal-dominant neurodegenerative disorder Spinocerebellar ataxia type-1 (SCA1) in humans. The AXH module has also been identified in the apparently unrelated transcription factor HBP1 which is thought to be involved in the architectural regulation of chromatin and in specific gene expression [PubMed12965213].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a AXH domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the AXH domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · UniProtKB KeyWords (KW) · Internal database links ]