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Sema domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   7-bladed beta-propeller [ 50964] (14)
Superfamily:   Sema domain [ 101912]
Families:   Sema domain [ 101913] (3)

Superfamily statistics
Genomes (126) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 3,246 3,138 3
Proteins 3,107 3,107 3

 Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document: Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)developmental process1.331e-060Least InformativeDirect
Biological Process (BP)multicellular organismal process4.252e-060Least InformativeDirect
Biological Process (BP)single-organism cellular process1.008e-057.758e-13Least InformativeDirect
Biological Process (BP)regulation of cellular process0.00032411.026e-11Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis0.0095350Least InformativeInherited
Biological Process (BP)localization0.0018630.003505Least InformativeInherited
Biological Process (BP)response to stimulus0.001240Least InformativeInherited
Biological Process (BP)cell differentiation7.056e-090Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.00025480Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process0.00083646.458e-14Moderately InformativeDirect
Biological Process (BP)anatomical structure morphogenesis0.064644.964e-13Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.0038020Moderately InformativeInherited
Biological Process (BP)tissue development0.0010240.297Moderately InformativeInherited
Biological Process (BP)nervous system development0.0096820Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.0074328.226e-13Moderately InformativeInherited
Biological Process (BP)locomotion1.202e-090InformativeDirect
Biological Process (BP)regulation of anatomical structure morphogenesis4.888e-080InformativeDirect
Biological Process (BP)generation of neurons1.846e-070InformativeDirect
Biological Process (BP)regulation of cell development2.033e-060InformativeDirect
Biological Process (BP)localization of cell0.00014910InformativeDirect
Biological Process (BP)cell projection organization0.00052990InformativeDirect
Biological Process (BP)epithelium development0.34290.1124InformativeInherited
Biological Process (BP)cellular component morphogenesis0.0040160InformativeInherited
Biological Process (BP)cellular component movement0.0012471.009e-09InformativeInherited
Biological Process (BP)regulation of nervous system development0.019199.771e-07InformativeInherited
Biological Process (BP)response to external stimulus0.0030870InformativeInherited
Biological Process (BP)tissue morphogenesis0.00090040.001483InformativeInherited
Biological Process (BP)morphogenesis of a branching epithelium2.295e-080.0004253Highly InformativeDirect
Biological Process (BP)regulation of cell projection organization5.362e-080Highly InformativeDirect
Biological Process (BP)axonogenesis1.627e-070.000122Highly InformativeDirect
Biological Process (BP)chemotaxis7.467e-070Highly InformativeDirect
Biological Process (BP)regulation of neuron differentiation1.126e-070.0145Highly InformativeInherited
Biological Process (BP)regulation of cell morphogenesis0.0047050Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 7.758e-13 Least Informative Direct
Biological Process (BP) regulation of cellular process 1.026e-11 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 0.003505 Least Informative Inherited
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 6.458e-14 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 2.191e-08 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 8.226e-13 Moderately Informative Direct
Biological Process (BP) nervous system development 0 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 2.883e-07 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 4.964e-13 Moderately Informative Direct
Biological Process (BP) signal transduction 2.218e-11 Moderately Informative Direct
Biological Process (BP) tissue development 0.297 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.1991 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.09227 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.7014 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.001396 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.7097 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.7618 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.1416 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.2116 Moderately Informative Inherited
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0 Informative Direct
Biological Process (BP) generation of neurons 0 Informative Direct
Biological Process (BP) regulation of cell development 0 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) cellular component movement 1.009e-09 Informative Direct
Biological Process (BP) response to external stimulus 0 Informative Direct
Biological Process (BP) cellular component morphogenesis 0 Informative Direct
Biological Process (BP) regulation of nervous system development 9.771e-07 Informative Direct
Biological Process (BP) regulation of locomotion 0 Informative Direct
Biological Process (BP) regulation of cellular component movement 1.164e-12 Informative Direct
Biological Process (BP) regulation of anatomical structure size 1.471e-09 Informative Direct
Biological Process (BP) regulation of response to external stimulus 9.171e-07 Informative Direct
Biological Process (BP) single-organism behavior 1.401e-06 Informative Direct
Biological Process (BP) positive regulation of signal transduction 1.514e-06 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 1.709e-06 Informative Direct
Biological Process (BP) regulation of growth 3.592e-06 Informative Direct
Biological Process (BP) positive regulation of phosphorus metabolic process 5.613e-05 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 9.484e-05 Informative Direct
Biological Process (BP) epithelium development 0.1124 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.001483 Informative Inherited
Biological Process (BP) gland development 0.1356 Informative Inherited
Biological Process (BP) cell proliferation 0.005553 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.007056 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.3964 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.6724 Informative Inherited
Biological Process (BP) muscle structure development 0.7556 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.001723 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.006648 Informative Inherited
Biological Process (BP) muscle tissue development 0.517 Informative Inherited
Biological Process (BP) positive regulation of transport 0.01886 Informative Inherited
Biological Process (BP) central nervous system development 0.02356 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.1477 Informative Inherited
Biological Process (BP) tube development 0.0107 Informative Inherited
Biological Process (BP) cardiovascular system development 0.2448 Informative Inherited
Biological Process (BP) protein phosphorylation 0.02184 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.04126 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.9074 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.01343 Informative Inherited
Biological Process (BP) morphogenesis of a branching epithelium 0.0004253 Highly Informative Direct
Biological Process (BP) regulation of cell projection organization 0 Highly Informative Direct
Biological Process (BP) axonogenesis 0.000122 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis 0 Highly Informative Direct
Biological Process (BP) regulation of cellular component size 1.049e-12 Highly Informative Direct
Biological Process (BP) regulation of behavior 5.849e-10 Highly Informative Direct
Biological Process (BP) positive regulation of MAPK cascade 4.264e-09 Highly Informative Direct
Biological Process (BP) negative regulation of cell growth 2.591e-07 Highly Informative Direct
Biological Process (BP) positive regulation of protein serine/threonine kinase activity 1.078e-06 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 4.205e-06 Highly Informative Direct
Biological Process (BP) regulation of Ras protein signal transduction 5.418e-06 Highly Informative Direct
Biological Process (BP) angiogenesis 1.092e-05 Highly Informative Direct
Biological Process (BP) regulation of purine nucleotide catabolic process 8.634e-05 Highly Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0.0001112 Highly Informative Direct
Biological Process (BP) organelle localization 0.0001252 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.0001875 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0.000657 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 0.3608 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.008029 Highly Informative Inherited
Biological Process (BP) regulation of neuron differentiation 0.0145 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 0.0315 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.1895 Highly Informative Inherited
Biological Process (BP) stem cell development 0.5396 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.1433 Highly Informative Inherited
Biological Process (BP) epithelial tube morphogenesis 0.2162 Highly Informative Inherited
Biological Process (BP) regulation of MAP kinase activity 0.05266 Highly Informative Inherited
Biological Process (BP) activation of protein kinase activity 0.05602 Highly Informative Inherited
Molecular Function (MF) binding 2.822e-06 Least Informative Direct
Molecular Function (MF) transferase activity 0.5127 Least Informative Inherited
Molecular Function (MF) protein binding 6.115e-12 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.04157 Moderately Informative Inherited
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) receptor binding 1.822e-12 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.007589 Informative Inherited
Molecular Function (MF) kinase activity 0.01502 Informative Inherited
Molecular Function (MF) protein kinase activity 0.002205 Highly Informative Inherited
Cellular Component (CC) membrane 2.143e-12 Least Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 7.549e-08 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 6.969e-06 Moderately Informative Direct
Cellular Component (CC) integral to membrane 1.765e-11 Informative Direct
Cellular Component (CC) receptor complex 9.173e-06 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the genital system0.234Moderately InformativeInherited
Phenotypic Abnormality (PA)Genital hypoplasia0.000736InformativeDirect
Phenotypic Abnormality (PA)Abnormality of male external genitalia0.006112InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.0004919Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.08818Least InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.006715Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.01774Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.1697Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.5141Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.9669Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell migration0.0001186InformativeDirect
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.0001972InformativeDirect
Mammalian Phenotype (MP)abnormal neuron physiology0.002769InformativeInherited
Mammalian Phenotype (MP)abnormal hindbrain morphology0.2255InformativeInherited
Mammalian Phenotype (MP)abnormal cerebrum morphology0.3881InformativeInherited
Mammalian Phenotype (MP)ectopic cerebellar granule cells4.294e-08Highly InformativeDirect
Mammalian Phenotype (MP)abnormal amacrine cell morphology6.831e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal hippocampal mossy fiber morphology7.079e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal neuronal migration0.0001395Highly InformativeDirect
Mammalian Phenotype (MP)abnormal retinal inner plexiform layer morphology0.0002213Highly InformativeDirect
Mammalian Phenotype (MP)abnormal retinal ganglion cell morphology0.0004172Highly InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system tract morphology0.1604Highly InformativeInherited
Mammalian Phenotype (MP)abnormal brain white matter morphology0.1817Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cranial nerve morphology0.2001Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system development variant0.0003446Moderately InformativeDirect
Worm Phenotype (WP)male morphology variant1.081e-11InformativeDirect
Worm Phenotype (WP)anchor cell invasion variant2.861e-09InformativeDirect
Worm Phenotype (WP)sensillum morphology variant3.069e-09InformativeDirect
Worm Phenotype (WP)male nervous system morphology variant4.286e-13Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)neuroanatomy defective0Moderately InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)larva0.2175Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0Moderately InformativeDirect
Fly Anatomy (FA)anatomical group0.01519Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.02209Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.09469Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.1001Moderately InformativeInherited
Fly Anatomy (FA)embryonic/larval peripheral nervous system1.278e-06InformativeDirect
Fly Anatomy (FA)nerve1.153e-05InformativeDirect
Fly Anatomy (FA)neuromere0.0001125InformativeDirect
Fly Anatomy (FA)larval abdominal segment0.001771InformativeInherited
Fly Anatomy (FA)ganglion0.01586InformativeInherited
Fly Anatomy (FA)tract0.25InformativeInherited
Fly Anatomy (FA)embryonic/larval central nervous system0.4223InformativeInherited
Fly Anatomy (FA)intersegmental nerve2.808e-07Highly InformativeDirect
Fly Anatomy (FA)abdominal segmental nerve4.559e-06Highly InformativeDirect
Fly Anatomy (FA)longitudinal connective0.0003119Highly InformativeDirect
Fly Anatomy (FA)presumptive embryonic/larval central nervous system0.0003974Highly InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.4254Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.1589Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.2707Moderately InformativeInherited
Xenopus ANatomical entity (XAN)cranial placode0.000118Highly InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0Moderately InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processAngiogenesis7.084e-14InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentSecreted4.535e-10Moderately InformativeDirect
DiseaseProto-oncogene0Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainRepeat5.329e-05Least InformativeDirect
DomainImmunoglobulin domain0InformativeDirect
Post-translational modificationTransferase0.1461Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationUbl conjugation2.621e-15Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001627 SSF101912 Protein matches
Abstract

The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in a hepatocyte growth factor receptor, in SEX protein [PubMed9875845] and in viral proteins.

CD100 (also called SEMA4D) is associated with PTPase and serine kinase activity. CD100 increases PMA, CD3 and CD2 induced T cell proliferation, increases CD45 induced T cell adhesion, induces B cell homotypic adhesion and down-regulates B cell expression of CD23.

The Sema domain is characterised by a conserved set of cysteine residues, which form four disulphide bonds to stabilise the structure. The Sema domain fold is a variation of the beta propeller topology, with seven blades radially arranged around a central axis. Each blade contains a four- stranded (strands A to D) antiparallel beta sheet. The inner strand of each blade (A) lines the channel at the centre of the propeller, with strands B and C of the same repeat radiating outward, and strand D of the next repeat forming the outer edge of the blade. The large size of the Sema domain is not due to a single inserted domain but results from the presence of additionnal secondary structure elements inserted in most of the blades. The Sema domain uses a 'loop and hook' system to close the circle between the first and the last blades. The blades are constructed sequentially with an N-terminal beta- strand closing the circle by providing the outermost strand (D) of the seventh (C-terminal) blade. The beta-propeller is further stabilized by an extension of the N-terminus, providing an additional, fifth beta-strand on the outer edge of blade 6 [PubMed12925274, PubMed12958590, PubMed15167892].

CD molecules are leucocyte antigens on cell surfaces. CD antigens nomenclature is updated at Protein Reviews On The Web (http://mpr.nci.nih.gov/prow/).


InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Sema domain domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Sema domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]
Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

Please send feedback, comments or questions to superfamily@cs.bris.ac.uk or use the feedback form.

© Copyright 2013 The SUPERFAMILY authors and Julian Gough.