SUPERFAMILY 1.75 HMM library and genome assignments server

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NHL repeat superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   6-bladed beta-propeller [ 50938] (11)
Superfamily:   NHL repeat [ 101898]
Families:   NHL repeat [ 101899] (2)


Superfamily statistics
Genomes (1,380) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 7,686 13,740 2
Proteins 7,452 13,378 2


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.00003032 Least Informative Direct
Biological Process (BP) developmental process 0.0000006492 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.09404 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.04596 Least Informative Inherited
Biological Process (BP) response to stimulus 0.9095 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.1577 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.04719 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.4952 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.5574 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.4642 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.6333 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.6765 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.0236 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0.000391 Moderately Informative Direct
Biological Process (BP) nervous system development 0.00002022 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.000554 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.0006736 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.00002419 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.2728 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.7686 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.3782 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.476 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.6321 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.03193 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.1108 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.00321 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1798 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.005715 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.06232 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.5864 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.2322 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.0007269 Informative Direct
Biological Process (BP) negative regulation of biosynthetic process 0.0001282 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0.0005203 Informative Direct
Biological Process (BP) cell cycle process 0.0006531 Informative Direct
Biological Process (BP) biological adhesion 0.000001314 Informative Direct
Biological Process (BP) cell projection organization 0.00005892 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.0006789 Informative Direct
Biological Process (BP) ncRNA metabolic process 0.0004226 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.00005084 Informative Direct
Biological Process (BP) generation of neurons 0.0000002667 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.000002704 Informative Direct
Biological Process (BP) protein modification by small protein conjugation or removal 0.0000000000008991 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.002609 Informative Inherited
Biological Process (BP) cellular component movement 0.001471 Informative Inherited
Biological Process (BP) locomotion 0.01275 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.01304 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.004687 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.007232 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.005198 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.02371 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.1698 Informative Inherited
Biological Process (BP) protein catabolic process 0.005721 Informative Inherited
Biological Process (BP) proteolysis 0.06704 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.07497 Informative Inherited
Biological Process (BP) regulation of translation 0.000003078 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 0.0003277 Highly Informative Direct
Biological Process (BP) cell adhesion 0.000002668 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.00004595 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0.0000215 Highly Informative Direct
Biological Process (BP) gene silencing 0.000007935 Highly Informative Direct
Biological Process (BP) protein ubiquitination 0.000000000000001938 Highly Informative Direct
Biological Process (BP) neural tube development 0.00000722 Highly Informative Direct
Biological Process (BP) cell cycle phase 0.000004861 Highly Informative Direct
Biological Process (BP) regulation of gene expression, epigenetic 0.0002712 Highly Informative Direct
Biological Process (BP) regulation of neuron apoptotic process 0.0001426 Highly Informative Direct
Biological Process (BP) mitotic cell cycle phase transition 0.00009998 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0.00001555 Highly Informative Direct
Biological Process (BP) stem cell proliferation 0.000000144 Highly Informative Direct
Biological Process (BP) regulation of neural precursor cell proliferation 0.00000001623 Highly Informative Direct
Biological Process (BP) neuron projection development 0.659 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.00166 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.2919 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.5191 Highly Informative Inherited
Molecular Function (MF) binding 0.02228 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0.08286 Moderately Informative Inherited
Molecular Function (MF) RNA binding 0.00003848 Informative Direct
Molecular Function (MF) ligase activity 0 Informative Direct
Molecular Function (MF) protein dimerization activity 0.000007303 Informative Direct
Molecular Function (MF) small conjugating protein ligase activity 0 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 0.0000000002436 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 0.00002243 Highly Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.02329 Least Informative Inherited
Cellular Component (CC) membrane 0.01115 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.7405 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 0.0008677 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0.00008843 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.204 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.3844 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.01747 Moderately Informative Inherited
Cellular Component (CC) integral to membrane 0.00003914 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 0.000004891 Informative Direct
Cellular Component (CC) contractile fiber part 0.0003516 Informative Direct
Cellular Component (CC) synapse part 0.001207 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.003769 Informative Inherited
Cellular Component (CC) cytoplasmic mRNA processing body 0.000000000005763 Highly Informative Direct
Cellular Component (CC) integral to plasma membrane 0.000561 Highly Informative Direct
Cellular Component (CC) nuclear body 0.0000001196 Highly Informative Direct
Cellular Component (CC) sarcomere 0.0001272 Highly Informative Direct
Cellular Component (CC) postsynaptic membrane 0.0000007389 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0.0000001589Least InformativeDirect
Enzyme Commission (EC)Carbon-nitrogen lyases7.054e-16InformativeDirect
Enzyme Commission (EC)Lyases acting on amides, amidines, etc0Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)abnormal neuron morphology0.4788Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neurite morphology0.06904Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)cell0Least InformativeDirect
Fly Anatomy (FA)late embryo0Moderately InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence meristem0Moderately InformativeDirect
Plant ANatomical entity (PAN)cotyledon0Moderately InformativeDirect
Plant ANatomical entity (PAN)gamete0.001904InformativeInherited
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0.0000001948Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.001316Least InformativeInherited
Enzyme Commission (EC)Carbon-nitrogen lyases0.000000000000008504InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen0.000000002447InformativeDirect
Enzyme Commission (EC)Lyases acting on amides, amidines, etc0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0.00000000003477Moderately InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processCell adhesion0.0000000003285InformativeDirect
Biological processRNA-mediated gene silencing0.0000000000001083Highly InformativeDirect
Cellular componentNucleus0.00000118Least InformativeDirect
Cellular componentCell projection0.00000000001297Moderately InformativeDirect
Cellular componentCell junction0.00006751Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.0001561Moderately InformativeDirect
Cellular componentGolgi apparatus0.0006245Moderately InformativeDirect
Cellular componentSynapse0.0000006629InformativeDirect
Cellular componentSynaptosome0.00000000001881Highly InformativeDirect
Cellular componentPostsynaptic cell membrane0.00000001521Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane0.854Least InformativeInherited
DomainZinc-finger0.0000000003024Moderately InformativeDirect
DomainCoiled coil0.0003399Moderately InformativeDirect
DomainEGF-like domain0InformativeDirect
Molecular functionZinc2.32e-16Least InformativeDirect
Molecular functionMetal-binding0.000006355Least InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationRepressor0.0000006034Moderately InformativeDirect
Post-translational modificationLigase0.000001831Moderately InformativeDirect
Post-translational modificationGlycoprotein0.00001159Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0.000006318Moderately InformativeDirect
Post-translational modificationUbl conjugation0.00001065Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a NHL repeat domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the NHL repeat superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]