SUPERFAMILY 1.75 HMM library and genome assignments server

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Apyrase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   5-bladed beta-propeller [ 50933] (3)
Superfamily:   Apyrase [ 101887]
Families:   Apyrase [ 101888]


Superfamily statistics
Genomes (163) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 243 463 2
Proteins 238 454 2


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)nitrogen compound metabolic process00.02383Least InformativeInherited
Biological Process (BP)heterocycle metabolic process00.004665Least InformativeInherited
Biological Process (BP)single-organism metabolic process00.01692Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process00.0078Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process00.005386Least InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process00.00000005195Moderately InformativeDirect
Biological Process (BP)organophosphate metabolic process00.0000006526Moderately InformativeDirect
Biological Process (BP)cellular catabolic process00.00001772Moderately InformativeDirect
Biological Process (BP)nucleobase-containing small molecule metabolic process00.00000000003202Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process00.00000000000006562Moderately InformativeDirect
Biological Process (BP)organic substance catabolic process00.00004133Moderately InformativeDirect
Biological Process (BP)purine ribonucleotide metabolic process00.00000000002514InformativeDirect
Biological Process (BP)nucleobase-containing compound catabolic process00.000000000001874InformativeDirect
Biological Process (BP)purine ribonucleoside metabolic process00.00000000001555InformativeDirect
Biological Process (BP)organophosphate catabolic process00.00000000000009892InformativeDirect
Biological Process (BP)carbohydrate derivative catabolic process00.0002969InformativeDirect
Biological Process (BP)organonitrogen compound catabolic process00.0000473InformativeDirect
Biological Process (BP)nucleoside triphosphate metabolic process0.018480.1019InformativeInherited
Biological Process (BP)nucleoside monophosphate metabolic process0.000095560.01982InformativeInherited
Biological Process (BP)purine nucleoside triphosphate catabolic process0.00000000000009340.0000000002455Highly InformativeDirect
Biological Process (BP)purine ribonucleotide catabolic process00.000000000003827Highly InformativeDirect
Biological Process (BP)purine ribonucleoside monophosphate metabolic process00.00000000005649Highly InformativeDirect
Biological Process (BP)ribonucleoside triphosphate catabolic process0.000000000000078130.0000000002292Highly InformativeDirect
Biological Process (BP)purine ribonucleoside triphosphate metabolic process0.00000000000011940.0000000003623Highly InformativeDirect
Biological Process (BP)purine ribonucleoside catabolic process00.000000000003398Highly InformativeDirect
Biological Process (BP)nucleoside monophosphate catabolic process0.00010070.1157Highly InformativeInherited
Molecular Function (MF)hydrolase activity00.0000001137Least InformativeDirect
Molecular Function (MF)nucleoside-triphosphatase activity0.42290.7079InformativeInherited
Molecular Function (MF)nucleoside-diphosphatase activity00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) nitrogen compound metabolic process 0.02383 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.004665 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.01692 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.0078 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.005386 Least Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.00000005195 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.0000006526 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.00001772 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.00000000003202 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.00000000000006562 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.00004133 Moderately Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 0.00000000002514 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0.000000000001874 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0.00000000001555 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.00000000000009892 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.0002969 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0.0000473 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 0.1019 Informative Inherited
Biological Process (BP) nucleoside monophosphate metabolic process 0.01982 Informative Inherited
Biological Process (BP) purine nucleoside triphosphate catabolic process 0.0000000002455 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 0.000000000003827 Highly Informative Direct
Biological Process (BP) purine ribonucleoside monophosphate metabolic process 0.00000000005649 Highly Informative Direct
Biological Process (BP) ribonucleoside triphosphate catabolic process 0.0000000002292 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate metabolic process 0.0000000003623 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 0.000000000003398 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 0.1157 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.0000001137 Least Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 0.7079 Informative Inherited
Molecular Function (MF) nucleoside-diphosphatase activity 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR009283 SSF101887 Protein matches
Abstract

This family consists of several eukaryotic apyrase (or adenosine diphosphatase) proteins , and related nucleoside diphosphatases . The salivary apyrases of blood-feeding arthropods are nucleotide hydrolysing enzymes implicated in the inhibition of host platelet aggregation through the hydrolysis of extracellular adenosine diphosphate [PubMed12234496].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Apyrase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Apyrase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Enzyme Commission (EC) · Internal database links ]