SUPERFAMILY 1.75 HMM library and genome assignments server


Apyrase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   5-bladed beta-propeller [ 50933] (3)
Superfamily:   Apyrase [ 101887]
Families:   Apyrase [ 101888]


Superfamily statistics
Genomes (143) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 214 298 2
Proteins 209 293 2


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)nitrogen compound metabolic process00.02437Least InformativeInherited
Biological Process (BP)heterocycle metabolic process00.004791Least InformativeInherited
Biological Process (BP)single-organism metabolic process00.0169Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process00.008053Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process00.005563Least InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process06.366e-14Moderately InformativeDirect
Biological Process (BP)organic cyclic compound catabolic process01.27e-11Moderately InformativeDirect
Biological Process (BP)nucleobase-containing small molecule metabolic process02.942e-11Moderately InformativeDirect
Biological Process (BP)phosphate-containing compound metabolic process05.471e-08Moderately InformativeDirect
Biological Process (BP)organophosphate metabolic process06.382e-07Moderately InformativeDirect
Biological Process (BP)cellular catabolic process01.814e-05Moderately InformativeDirect
Biological Process (BP)organonitrogen compound catabolic process05.09e-05Moderately InformativeDirect
Biological Process (BP)organophosphate catabolic process09.708e-14InformativeDirect
Biological Process (BP)nucleobase-containing compound catabolic process02.099e-12InformativeDirect
Biological Process (BP)purine ribonucleoside metabolic process01.418e-11InformativeDirect
Biological Process (BP)purine ribonucleotide metabolic process02.379e-11InformativeDirect
Biological Process (BP)glycosyl compound catabolic process01.372e-05InformativeDirect
Biological Process (BP)carbohydrate derivative catabolic process00.0002993InformativeDirect
Biological Process (BP)nucleoside triphosphate metabolic process0.018250.1016InformativeInherited
Biological Process (BP)nucleoside monophosphate metabolic process0.00012220.02251InformativeInherited
Biological Process (BP)purine ribonucleoside catabolic process03.394e-12Highly InformativeDirect
Biological Process (BP)purine ribonucleotide catabolic process03.821e-12Highly InformativeDirect
Biological Process (BP)purine ribonucleoside triphosphate catabolic process6.097e-142.286e-10Highly InformativeDirect
Biological Process (BP)nucleoside monophosphate catabolic process0.00012530.1221Highly InformativeInherited
Molecular Function (MF)hydrolase activity01.148e-07Least InformativeDirect
Molecular Function (MF)nucleoside-triphosphatase activity0.42290.7012InformativeInherited
Molecular Function (MF)nucleoside-diphosphatase activity00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) nitrogen compound metabolic process 0.02437 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.004791 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.0169 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.008053 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.005563 Least Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 6.366e-14 Moderately Informative Direct
Biological Process (BP) organic cyclic compound catabolic process 1.27e-11 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 2.942e-11 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 5.471e-08 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 6.382e-07 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 1.814e-05 Moderately Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 5.09e-05 Moderately Informative Direct
Biological Process (BP) organophosphate catabolic process 9.708e-14 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 2.099e-12 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 1.418e-11 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 2.379e-11 Informative Direct
Biological Process (BP) glycosyl compound catabolic process 1.372e-05 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.0002993 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 0.1016 Informative Inherited
Biological Process (BP) nucleoside monophosphate metabolic process 0.02251 Informative Inherited
Biological Process (BP) purine ribonucleoside catabolic process 3.394e-12 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 3.821e-12 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate catabolic process 2.286e-10 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 0.1221 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 1.148e-07 Least Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 0.7012 Informative Inherited
Molecular Function (MF) nucleoside-diphosphatase activity 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR009283 SSF101887 Protein matches
Abstract

This family consists of several eukaryotic apyrase (or adenosine diphosphatase) proteins , and related nucleoside diphosphatases . The salivary apyrases of blood-feeding arthropods are nucleotide hydrolysing enzymes implicated in the inhibition of host platelet aggregation through the hydrolysis of extracellular adenosine diphosphate [PubMed12234496].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Apyrase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Apyrase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Enzyme Commission (EC) · Internal database links ]