SUPERFAMILY 1.75 HMM library and genome assignments server


ASF1-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   ASF1-like [ 101546]
Families:   ASF1-like [ 101547]


Superfamily statistics
Genomes (473) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 681 0 7
Proteins 673 0 7


Functional annotation
General category Regulation
Detailed category Other regulatory function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 2.598e-08 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 1.916e-07 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 1.262e-06 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 2.115e-08 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1.406e-05 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 6.096e-08 Least Informative Direct
Biological Process (BP) response to stimulus 0.1368 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.03081 Least Informative Inherited
Biological Process (BP) organelle organization 0.0001904 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.0001549 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.009838 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.001642 Moderately Informative Inherited
Biological Process (BP) DNA metabolic process 7.281e-15 Informative Direct
Biological Process (BP) cellular macromolecular complex assembly 4.366e-09 Informative Direct
Biological Process (BP) chromosome organization 2.204e-10 Informative Direct
Biological Process (BP) chromatin assembly 0 Highly Informative Direct
Biological Process (BP) protein-DNA complex assembly 2.099e-14 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.3395 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.1564 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.04093 Least Informative Inherited
Cellular Component (CC) nuclear part 0.1681 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.01657 Moderately Informative Inherited
Cellular Component (CC) chromosome 0.0002859 Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Cellular componentNucleus0Least InformativeDirect
DomainCoiled coil9.769e-10Moderately InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationChromatin regulator0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR006818 SSF101546 Protein matches
Abstract This family includes the yeast ASF1 protein, which derepresses transcriptionally silenced genes. The human ASF1 homologue has been found to possess histone chaperone activity, which may explain the derepressing function of this family [PubMed10759893].

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ASF1-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the ASF1-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]