SUPERFAMILY 1.75 HMM library and genome assignments server

ASF1-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   ASF1-like [ 101546]
Families:   ASF1-like [ 101547]


Superfamily statistics
Genomes (486) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 713 813 7
Proteins 704 806 7


Functional annotation
General category Regulation
Detailed category Other regulatory function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) heterocycle metabolic process 0.000000001433 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0.000000001765 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.00000000424 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.00000001408 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.00000008276 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.000001 Least Informative Direct
Biological Process (BP) response to stimulus 0.05768 Least Informative Inherited
Biological Process (BP) cellular response to stress 0.00006574 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.00159 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.001526 Moderately Informative Inherited
Biological Process (BP) chromosome organization 0.00000000003668 Informative Direct
Biological Process (BP) cellular macromolecular complex assembly 0.1069 Informative Inherited
Molecular Function (MF) binding 0.0004639 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.04217 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.2672 Least Informative Inherited
Cellular Component (CC) chromosome 0.0002494 Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Cellular componentNucleus0Least InformativeDirect
DomainCoiled coil0.0000000009954Moderately InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationChromatin regulator0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR006818 SSF101546 Protein matches
Abstract This family includes the yeast ASF1 protein, which derepresses transcriptionally silenced genes. The human ASF1 homologue has been found to possess histone chaperone activity, which may explain the derepressing function of this family [PubMed10759893].

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ASF1-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the ASF1-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]