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Stathmin superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Non-globular all-alpha subunits of globular proteins [ 48661] (14)
Superfamily:   Stathmin [ 101494]
Families:   Stathmin [ 101495]

 Superfamily statistics
Genomes (107) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 445 463 2
Proteins 439 454 2

 Functional annotation
General category Regulation
Detailed category Signal transduction

Document: Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)developmental process1.441e-114.822e-09Least InformativeDirect
Biological Process (BP)multicellular organismal process2.007e-103.528e-08Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis5.824e-080.0005287Least InformativeDirect
Biological Process (BP)regulation of cellular process5.437e-070.01266Least InformativeInherited
Biological Process (BP)single-organism cellular process0.00047140.001375Least InformativeInherited
Biological Process (BP)nervous system development00Moderately InformativeDirect
Biological Process (BP)cell differentiation3.777e-128.296e-11Moderately InformativeDirect
Biological Process (BP)regulation of cellular component organization3.339e-084.496e-08Moderately InformativeDirect
Biological Process (BP)single-organism developmental process2.155e-052.145e-05Moderately InformativeDirect
Biological Process (BP)regulation of localization0.00011552.268e-05Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process0.00011770.0001789Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process0.0075350.01603Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.13380.8601Moderately InformativeInherited
Biological Process (BP)regulation of organelle organization04.085e-13InformativeDirect
Biological Process (BP)generation of neurons1.598e-155.055e-09InformativeDirect
Biological Process (BP)negative regulation of cellular component organization4.418e-124.642e-10InformativeDirect
Biological Process (BP)cell projection organization1.394e-113.555e-07InformativeDirect
Biological Process (BP)regulation of cellular component biogenesis4.862e-101.72e-10InformativeDirect
Biological Process (BP)regulation of cellular component movement1.7e-085.184e-09InformativeDirect
Biological Process (BP)microtubule-based process2.304e-056.819e-10InformativeDirect
Biological Process (BP)cellular component morphogenesis1.003e-050.002836InformativeInherited
Biological Process (BP)regulation of microtubule polymerization or depolymerization00Highly InformativeDirect
Biological Process (BP)axonogenesis9.05e-153.177e-09Highly InformativeDirect
Biological Process (BP)regulation of protein complex assembly1.372e-066.375e-08Highly InformativeDirect
Biological Process (BP)negative regulation of cytoskeleton organization3.107e-052.382e-05Highly InformativeDirect
Molecular Function (MF)binding0.019740.02734Least InformativeInherited
Molecular Function (MF)protein binding0.00078390.00116Moderately InformativeInherited
Molecular Function (MF)cytoskeletal protein binding0.0036432.549e-07InformativeInherited
Molecular Function (MF)tubulin binding1.42e-062.671e-13Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) developmental process 4.822e-09 Least Informative Direct
Biological Process (BP) multicellular organismal process 3.528e-08 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0005287 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.01266 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.001375 Least Informative Inherited
Biological Process (BP) localization 0.1717 Least Informative Inherited
Biological Process (BP) nervous system development 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 8.296e-11 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 4.496e-08 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 2.145e-05 Moderately Informative Direct
Biological Process (BP) regulation of localization 2.268e-05 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0001789 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.01603 Moderately Informative Inherited
Biological Process (BP) reproduction 0.004064 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.8601 Moderately Informative Inherited
Biological Process (BP) regulation of organelle organization 4.085e-13 Informative Direct
Biological Process (BP) generation of neurons 5.055e-09 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 4.642e-10 Informative Direct
Biological Process (BP) cell projection organization 3.555e-07 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 1.72e-10 Informative Direct
Biological Process (BP) regulation of cellular component movement 5.184e-09 Informative Direct
Biological Process (BP) microtubule-based process 6.819e-10 Informative Direct
Biological Process (BP) localization of cell 7.903e-06 Informative Direct
Biological Process (BP) sexual reproduction 2.13e-05 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 2.897e-05 Informative Direct
Biological Process (BP) cellular process involved in reproduction 0.000112 Informative Direct
Biological Process (BP) locomotion 0.0002152 Informative Direct
Biological Process (BP) single organism reproductive process 0.0008437 Informative Direct
Biological Process (BP) developmental process involved in reproduction 0.06959 Informative Inherited
Biological Process (BP) cellular component movement 0.001656 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.002836 Informative Inherited
Biological Process (BP) regulation of microtubule polymerization or depolymerization 0 Highly Informative Direct
Biological Process (BP) axonogenesis 3.177e-09 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 6.375e-08 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 2.382e-05 Highly Informative Direct
Biological Process (BP) germ cell migration 7.835e-15 Highly Informative Direct
Biological Process (BP) female gamete generation 5.316e-08 Highly Informative Direct
Molecular Function (MF) binding 0.02734 Least Informative Inherited
Molecular Function (MF) protein binding 0.00116 Moderately Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 2.549e-07 Informative Direct
Molecular Function (MF) tubulin binding 2.671e-13 Highly Informative Direct
Cellular Component (CC) intracellular organelle part 0.7738 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.03944 Least Informative Inherited
Cellular Component (CC) protein complex 0.04414 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.0003294 Moderately Informative Direct
Cellular Component (CC) microtubule cytoskeleton 9.504e-06 Informative Direct
Cellular Component (CC) microtubule associated complex 1.809e-09 Highly Informative Direct

Document: GO annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0Moderately InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentCytoplasm0.301Least InformativeInherited
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentGolgi apparatus1.968e-14Moderately InformativeDirect
Cellular componentCytoskeleton4.971e-08Moderately InformativeDirect
Cellular componentMicrotubule3.302e-11InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
Post-translational modificationPhosphoprotein6.549e-05Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000956 SSF101494 Protein matches
Abstract Stathmin is a ubiquitous phosphorylated protein thought to act as an intracellular relay for diverse regulatory pathways [PubMed2358074], functioning through a variety of second messengers. Its phosphorylation and gene expression are regulated throughout development [PubMed8344928] and in response to extracellular signals regulating cell proliferation, differentiation and function [PubMed2745432]. Stathmin, and the related proteins SCG10 and XB3, contain a N-terminal domain (XB3 contains an additional N-terminal hydrophobic region), a 78 amino acid coiled-coil region, and a short C-terminal domain.

InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Stathmin domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Stathmin superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]
Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

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© Copyright 2013 The SUPERFAMILY authors and Julian Gough.