SUPERFAMILY 1.75 HMM library and genome assignments server


Stathmin superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Non-globular all-alpha subunits of globular proteins [ 48661] (14)
Superfamily:   Stathmin [ 101494]
Families:   Stathmin [ 101495]


Superfamily statistics
Genomes (109) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 453 463 2
Proteins 447 454 2


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process7.694e-153.532e-11Least InformativeDirect
Biological Process (BP)developmental process03.146e-12Least InformativeDirect
Biological Process (BP)single-organism cellular process4.452e-050.0002153Least InformativeDirect
Biological Process (BP)regulation of cellular process1.921e-100.0001993Least InformativeDirect
Biological Process (BP)response to stimulus0.081080.7052Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis2.056e-070.001188Least InformativeInherited
Biological Process (BP)nervous system development00Moderately InformativeDirect
Biological Process (BP)cell differentiation05.586e-15Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process2.742e-065.842e-06Moderately InformativeDirect
Biological Process (BP)regulation of cellular component organization1.272e-113.224e-11Moderately InformativeDirect
Biological Process (BP)response to endogenous stimulus0.00019530.001413Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.011490.01409Moderately InformativeInherited
Biological Process (BP)response to organic substance0.0013160.02257Moderately InformativeInherited
Biological Process (BP)regulation of localization0.0023720.0007162Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.00044160.001404Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.17520.3182Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.00095580.001212Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.070270.1708Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.39031Moderately InformativeInherited
Biological Process (BP)microtubule-based process0.00012229.457e-09InformativeDirect
Biological Process (BP)cell projection organization7.681e-104.12e-06InformativeDirect
Biological Process (BP)regulation of organelle organization00InformativeDirect
Biological Process (BP)regulation of cellular component biogenesis3.152e-151.931e-15InformativeDirect
Biological Process (BP)generation of neurons08.915e-14InformativeDirect
Biological Process (BP)negative regulation of cellular component organization1.075e-124.355e-13InformativeDirect
Biological Process (BP)regulation of cellular component movement4.579e-072.847e-07InformativeDirect
Biological Process (BP)regulation of nervous system development4.121e-083.963e-05InformativeDirect
Biological Process (BP)regulation of cell development1.187e-078.329e-05InformativeDirect
Biological Process (BP)cellular response to endogenous stimulus2.492e-060.0001202InformativeDirect
Biological Process (BP)positive regulation of cellular component organization0.0076580.01404InformativeInherited
Biological Process (BP)cellular component morphogenesis0.00011090.01184InformativeInherited
Biological Process (BP)regulation of neuron projection development9.557e-105.251e-07Highly InformativeDirect
Biological Process (BP)regulation of microtubule polymerization or depolymerization00Highly InformativeDirect
Biological Process (BP)neuron projection development01.188e-10Highly InformativeDirect
Biological Process (BP)cell part morphogenesis4.719e-136.36e-08Highly InformativeDirect
Biological Process (BP)regulation of protein complex assembly1.986e-091.979e-11Highly InformativeDirect
Biological Process (BP)negative regulation of cytoskeleton organization2.674e-071.409e-07Highly InformativeDirect
Biological Process (BP)cellular response to growth factor stimulus3.179e-098.682e-07Highly InformativeDirect
Biological Process (BP)cell morphogenesis involved in differentiation0.00080460.1688Highly InformativeInherited
Molecular Function (MF)binding0.028720.03499Least InformativeInherited
Molecular Function (MF)cytoskeletal protein binding0.0031461.796e-07InformativeInherited
Molecular Function (MF)tubulin binding1.456e-063.103e-13Highly InformativeDirect
Cellular Component (CC)cell projection1.676e-050.0007132Moderately InformativeDirect
Cellular Component (CC)cell leading edge1.974e-073.506e-06InformativeDirect
Cellular Component (CC)neuron projection1.864e-103.654e-07InformativeDirect
Cellular Component (CC)growth cone1.061e-078.21e-08Highly InformativeDirect
Cellular Component (CC)cell body1.299e-062.058e-05Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 3.532e-11 Least Informative Direct
Biological Process (BP) developmental process 3.146e-12 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0002153 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.0001993 Least Informative Direct
Biological Process (BP) response to stimulus 0.7052 Least Informative Inherited
Biological Process (BP) localization 0.236 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.001188 Least Informative Inherited
Biological Process (BP) nervous system development 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 5.586e-15 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0007162 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 5.842e-06 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 3.224e-11 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.001413 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.01409 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.02257 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.001404 Moderately Informative Inherited
Biological Process (BP) reproduction 0.006657 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.3182 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.001212 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.08026 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.1708 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) microtubule-based process 9.457e-09 Informative Direct
Biological Process (BP) sexual reproduction 2.935e-05 Informative Direct
Biological Process (BP) cell projection organization 4.12e-06 Informative Direct
Biological Process (BP) regulation of organelle organization 0 Informative Direct
Biological Process (BP) locomotion 0.0003631 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 1.931e-15 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 3.499e-05 Informative Direct
Biological Process (BP) cellular process involved in reproduction 0.0004084 Informative Direct
Biological Process (BP) generation of neurons 8.915e-14 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 4.355e-13 Informative Direct
Biological Process (BP) regulation of cellular component movement 2.847e-07 Informative Direct
Biological Process (BP) localization of cell 8.105e-06 Informative Direct
Biological Process (BP) regulation of nervous system development 3.963e-05 Informative Direct
Biological Process (BP) regulation of cell development 8.329e-05 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0.0001202 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.01404 Informative Inherited
Biological Process (BP) single organism reproductive process 0.003049 Informative Inherited
Biological Process (BP) cellular component movement 0.01822 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.01184 Informative Inherited
Biological Process (BP) microtubule-based movement 2.363e-05 Highly Informative Direct
Biological Process (BP) female gamete generation 5.286e-08 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 5.251e-07 Highly Informative Direct
Biological Process (BP) cellular process involved in reproduction in multicellular organism 3.037e-07 Highly Informative Direct
Biological Process (BP) regulation of microtubule polymerization or depolymerization 0 Highly Informative Direct
Biological Process (BP) neuron projection development 1.188e-10 Highly Informative Direct
Biological Process (BP) cell part morphogenesis 6.36e-08 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 1.979e-11 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 1.409e-07 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 8.682e-07 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.1688 Highly Informative Inherited
Molecular Function (MF) binding 0.03499 Least Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 1.796e-07 Informative Direct
Molecular Function (MF) tubulin binding 3.103e-13 Highly Informative Direct
Cellular Component (CC) intracellular organelle part 0.9571 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.018 Least Informative Inherited
Cellular Component (CC) protein complex 0.05393 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.0002358 Moderately Informative Direct
Cellular Component (CC) cell projection 0.0007132 Moderately Informative Direct
Cellular Component (CC) microtubule cytoskeleton 6.841e-06 Informative Direct
Cellular Component (CC) cell leading edge 3.506e-06 Informative Direct
Cellular Component (CC) neuron projection 3.654e-07 Informative Direct
Cellular Component (CC) microtubule associated complex 1.434e-09 Highly Informative Direct
Cellular Component (CC) growth cone 8.21e-08 Highly Informative Direct
Cellular Component (CC) cell body 2.058e-05 Highly Informative Direct

Document: GO annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)visual system0Moderately InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentCytoplasm0.2782Least InformativeInherited
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentGolgi apparatus2.4e-14Moderately InformativeDirect
Cellular componentCytoskeleton6.948e-08Moderately InformativeDirect
Cellular componentMicrotubule3.015e-11InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
Post-translational modificationPhosphoprotein2.721e-05Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000956 SSF101494 Protein matches
Abstract Stathmin is a ubiquitous phosphorylated protein thought to act as an intracellular relay for diverse regulatory pathways [PubMed2358074], functioning through a variety of second messengers. Its phosphorylation and gene expression are regulated throughout development [PubMed8344928] and in response to extracellular signals regulating cell proliferation, differentiation and function [PubMed2745432]. Stathmin, and the related proteins SCG10 and XB3, contain a N-terminal domain (XB3 contains an additional N-terminal hydrophobic region), a 78 amino acid coiled-coil region, and a short C-terminal domain.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Stathmin domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Stathmin superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]