SUPERFAMILY 1.75 HMM library and genome assignments server

Stathmin superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Non-globular all-alpha subunits of globular proteins [ 48661] (14)
Superfamily:   Stathmin [ 101494]
Families:   Stathmin [ 101495]


Superfamily statistics
Genomes (121) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 507 575 2
Proteins 498 560 2


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process0.0000000000000048440.000000000005219Least InformativeDirect
Biological Process (BP)developmental process00.000000000001038Least InformativeDirect
Biological Process (BP)regulation of cellular process0.00000000035730.0003816Least InformativeDirect
Biological Process (BP)response to stimulus0.085830.7733Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.00000028910.002539Least InformativeInherited
Biological Process (BP)positive regulation of biological process0.0042250.007318Least InformativeInherited
Biological Process (BP)single-organism cellular process0.0048770.002188Least InformativeInherited
Biological Process (BP)nervous system development00Moderately InformativeDirect
Biological Process (BP)cell differentiation00.000000000000001913Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process0.0000052350.00001003Moderately InformativeDirect
Biological Process (BP)regulation of cellular component organization0.000000000018850.0000000000738Moderately InformativeDirect
Biological Process (BP)response to endogenous stimulus0.00021070.001918Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.011560.01672Moderately InformativeInherited
Biological Process (BP)response to organic substance0.00140.02731Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.070320.1812Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.14690.2758Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.00098860.003428Moderately InformativeInherited
Biological Process (BP)regulation of localization0.003190.0009904Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.40011Moderately InformativeInherited
Biological Process (BP)microtubule-based process0.000029670.0000000003248InformativeDirect
Biological Process (BP)cell projection organization0.000000000065780.000002081InformativeDirect
Biological Process (BP)regulation of organelle organization00InformativeDirect
Biological Process (BP)regulation of cellular component biogenesis0.0000000000000032510.000000000000007248InformativeDirect
Biological Process (BP)generation of neurons00.0000000000001924InformativeDirect
Biological Process (BP)negative regulation of cellular component organization0.00000000000074110.0000000000007329InformativeDirect
Biological Process (BP)regulation of cellular component movement0.00000032580.000000272InformativeDirect
Biological Process (BP)regulation of nervous system development0.000000056460.00005418InformativeDirect
Biological Process (BP)regulation of cell development0.00000013360.00007301InformativeDirect
Biological Process (BP)positive regulation of multicellular organismal process0.032610.04474InformativeInherited
Biological Process (BP)positive regulation of developmental process0.010780.01726InformativeInherited
Biological Process (BP)cellular component morphogenesis0.00031620.03284InformativeInherited
Biological Process (BP)positive regulation of cellular component organization0.0081560.01469InformativeInherited
Biological Process (BP)regulation of neuron projection development0.0000000012510.0000007072Highly InformativeDirect
Biological Process (BP)regulation of microtubule polymerization or depolymerization00Highly InformativeDirect
Biological Process (BP)neuron projection development00.0000000001921Highly InformativeDirect
Biological Process (BP)regulation of protein complex assembly0.00000000086670.00000000001884Highly InformativeDirect
Biological Process (BP)positive regulation of neurogenesis0.00000000052930.0000002905Highly InformativeDirect
Biological Process (BP)negative regulation of cytoskeleton organization0.00000020310.00000009585Highly InformativeDirect
Biological Process (BP)cellular response to growth factor stimulus0.0000000040910.000001312Highly InformativeDirect
Biological Process (BP)response to nerve growth factor0.0000000000000094410.00000000000002753Highly InformativeDirect
Biological Process (BP)cell morphogenesis involved in differentiation0.00053480.1998Highly InformativeInherited
Biological Process (BP)cell projection morphogenesis0.0031280.05134Highly InformativeInherited
Molecular Function (MF)binding0.031970.02372Least InformativeInherited
Molecular Function (MF)cytoskeletal protein binding0.0030340.00000002444InformativeInherited
Molecular Function (MF)tubulin binding0.0000013760.000000000000006187Highly InformativeDirect
Cellular Component (CC)cell projection0.000018730.00114Moderately InformativeInherited
Cellular Component (CC)cell leading edge0.00000015070.000003726InformativeDirect
Cellular Component (CC)neuron projection0.00000000032850.000000624InformativeDirect
Cellular Component (CC)growth cone0.000000052550.00000006439Highly InformativeDirect
Cellular Component (CC)cell body0.0000012040.00002382Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.000000000005219 Least Informative Direct
Biological Process (BP) developmental process 0.000000000001038 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.0003816 Least Informative Direct
Biological Process (BP) response to stimulus 0.7733 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.002539 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 0.007318 Least Informative Inherited
Biological Process (BP) localization 0.1549 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.002188 Least Informative Inherited
Biological Process (BP) nervous system development 0 Moderately Informative Direct
Biological Process (BP) reproductive process 0.0008375 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.000000000000001913 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0009904 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.00001003 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.0000000000738 Moderately Informative Direct
Biological Process (BP) cellular localization 0.0005096 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.001918 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.01672 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.02731 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.1812 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.2758 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.003428 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.001453 Moderately Informative Inherited
Biological Process (BP) tissue development 0.7881 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) microtubule-based process 0.0000000003248 Informative Direct
Biological Process (BP) sexual reproduction 0.000005155 Informative Direct
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.000008059 Informative Direct
Biological Process (BP) cell projection organization 0.000002081 Informative Direct
Biological Process (BP) regulation of organelle organization 0 Informative Direct
Biological Process (BP) locomotion 0.00006903 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.000000000000007248 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 0.00000352 Informative Direct
Biological Process (BP) generation of neurons 0.0000000000001924 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.0000000000007329 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.000000272 Informative Direct
Biological Process (BP) localization of cell 0.0000008358 Informative Direct
Biological Process (BP) regulation of nervous system development 0.00005418 Informative Direct
Biological Process (BP) regulation of cell development 0.00007301 Informative Direct
Biological Process (BP) epithelium development 0.00001956 Informative Direct
Biological Process (BP) single-organism intracellular transport 0.000004745 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.04474 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.01726 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.03284 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.01469 Informative Inherited
Biological Process (BP) cellular component movement 0.00317 Informative Inherited
Biological Process (BP) single organism reproductive process 0.004519 Informative Inherited
Biological Process (BP) columnar/cuboidal epithelial cell differentiation 0.00000000002562 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0.000004565 Highly Informative Direct
Biological Process (BP) female gamete generation 0.00000000272 Highly Informative Direct
Biological Process (BP) germ cell migration 0 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.0000007072 Highly Informative Direct
Biological Process (BP) regulation of microtubule polymerization or depolymerization 0 Highly Informative Direct
Biological Process (BP) neuron projection development 0.0000000001921 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 0.00000000001884 Highly Informative Direct
Biological Process (BP) positive regulation of neurogenesis 0.0000002905 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 0.00000009585 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0.000001312 Highly Informative Direct
Biological Process (BP) response to nerve growth factor 0.00000000000002753 Highly Informative Direct
Biological Process (BP) epithelial cell development 0.001273 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.1998 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 0.05134 Highly Informative Inherited
Biological Process (BP) germ cell development 0.002769 Highly Informative Inherited
Molecular Function (MF) binding 0.02372 Least Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.00000002444 Informative Direct
Molecular Function (MF) protein complex binding 0.000004928 Informative Direct
Molecular Function (MF) tubulin binding 0.000000000000006187 Highly Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.01766 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.8753 Least Informative Inherited
Cellular Component (CC) protein complex 0.02149 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.00007301 Moderately Informative Direct
Cellular Component (CC) cell projection 0.00114 Moderately Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.000001005 Informative Direct
Cellular Component (CC) cell leading edge 0.000003726 Informative Direct
Cellular Component (CC) neuron projection 0.000000624 Informative Direct
Cellular Component (CC) microtubule associated complex 0.00000000003955 Highly Informative Direct
Cellular Component (CC) growth cone 0.00000006439 Highly Informative Direct
Cellular Component (CC) cell body 0.00002382 Highly Informative Direct

Document: GO annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)visual system0Moderately InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentCytoplasm0.2813Least InformativeInherited
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentGolgi apparatus0.00000000000002517Moderately InformativeDirect
Cellular componentCytoskeleton0.0000000716Moderately InformativeDirect
Cellular componentMicrotubule0.00000000002918InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
Post-translational modificationPhosphoprotein0.00002735Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000956 SSF101494 Protein matches
Abstract Stathmin is a ubiquitous phosphorylated protein thought to act as an intracellular relay for diverse regulatory pathways [PubMed2358074], functioning through a variety of second messengers. Its phosphorylation and gene expression are regulated throughout development [PubMed8344928] and in response to extracellular signals regulating cell proliferation, differentiation and function [PubMed2745432]. Stathmin, and the related proteins SCG10 and XB3, contain a N-terminal domain (XB3 contains an additional N-terminal hydrophobic region), a 78 amino acid coiled-coil region, and a short C-terminal domain.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Stathmin domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Stathmin superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]