SUPERFAMILY 1.75 HMM library and genome assignments server


Stathmin superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Non-globular all-alpha subunits of globular proteins [ 48661] (14)
Superfamily:   Stathmin [ 101494]
Families:   Stathmin [ 101495]


Superfamily statistics
Genomes (121) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 507 575 2
Proteins 498 560 2


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process6.509e-151.119e-11Least InformativeDirect
Biological Process (BP)developmental process08.776e-13Least InformativeDirect
Biological Process (BP)single-organism cellular process5.04e-050.0001566Least InformativeDirect
Biological Process (BP)regulation of cellular process1.852e-100.000274Least InformativeDirect
Biological Process (BP)response to stimulus0.081170.7491Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis2.246e-070.001794Least InformativeInherited
Biological Process (BP)nervous system development00Moderately InformativeDirect
Biological Process (BP)cell differentiation00Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process2.365e-066.169e-06Moderately InformativeDirect
Biological Process (BP)regulation of cellular component organization8.48e-123.663e-11Moderately InformativeDirect
Biological Process (BP)response to endogenous stimulus0.00020320.001676Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.011330.01493Moderately InformativeInherited
Biological Process (BP)response to organic substance0.0012450.0246Moderately InformativeInherited
Biological Process (BP)regulation of localization0.0026730.000839Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.00046160.001585Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.18230.3267Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.068380.1767Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.39841Moderately InformativeInherited
Biological Process (BP)microtubule-based process0.00013771.363e-09InformativeDirect
Biological Process (BP)cell projection organization8.915e-107.872e-06InformativeDirect
Biological Process (BP)regulation of organelle organization00InformativeDirect
Biological Process (BP)regulation of cellular component biogenesis1.72e-153.77e-15InformativeDirect
Biological Process (BP)generation of neurons01.614e-13InformativeDirect
Biological Process (BP)negative regulation of cellular component organization5.472e-134.251e-13InformativeDirect
Biological Process (BP)regulation of cellular component movement3.75e-072.928e-07InformativeDirect
Biological Process (BP)regulation of nervous system development4.778e-084.888e-05InformativeDirect
Biological Process (BP)regulation of cell development1.249e-070.0001028InformativeDirect
Biological Process (BP)cellular response to endogenous stimulus2.24e-060.0001325InformativeDirect
Biological Process (BP)positive regulation of cellular component organization0.0067180.01408InformativeInherited
Biological Process (BP)cellular component morphogenesis0.00011320.01643InformativeInherited
Biological Process (BP)regulation of neuron projection development1.081e-096.44e-07Highly InformativeDirect
Biological Process (BP)regulation of microtubule polymerization or depolymerization00Highly InformativeDirect
Biological Process (BP)regulation of protein complex assembly1.698e-092.612e-11Highly InformativeDirect
Biological Process (BP)negative regulation of cytoskeleton organization2.364e-071.537e-07Highly InformativeDirect
Biological Process (BP)cellular response to growth factor stimulus2.592e-091.001e-06Highly InformativeDirect
Biological Process (BP)cell morphogenesis involved in neuron differentiation0.0040080.03169Highly InformativeInherited
Biological Process (BP)cell projection morphogenesis0.0029240.05172Highly InformativeInherited
Biological Process (BP)axon development0.18760.2668Highly InformativeInherited
Molecular Function (MF)binding0.026820.01855Least InformativeInherited
Molecular Function (MF)cytoskeletal protein binding0.0029492.618e-08InformativeInherited
Molecular Function (MF)tubulin binding1.4e-065.337e-15Highly InformativeDirect
Cellular Component (CC)cell projection1.383e-050.0008466Moderately InformativeDirect
Cellular Component (CC)cell leading edge1.519e-073.672e-06InformativeDirect
Cellular Component (CC)neuron projection2.144e-104.833e-07InformativeDirect
Cellular Component (CC)growth cone7.139e-086.745e-08Highly InformativeDirect
Cellular Component (CC)cell body1.183e-062.3e-05Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 1.119e-11 Least Informative Direct
Biological Process (BP) developmental process 8.776e-13 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0001566 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.000274 Least Informative Direct
Biological Process (BP) response to stimulus 0.7491 Least Informative Inherited
Biological Process (BP) localization 0.1335 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.001794 Least Informative Inherited
Biological Process (BP) nervous system development 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.000839 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 6.169e-06 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 3.663e-11 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.001676 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.01493 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.0246 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.001585 Moderately Informative Inherited
Biological Process (BP) reproduction 0.001829 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.3267 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.03834 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.1767 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) microtubule-based process 1.363e-09 Informative Direct
Biological Process (BP) sexual reproduction 3.128e-06 Informative Direct
Biological Process (BP) cell projection organization 7.872e-06 Informative Direct
Biological Process (BP) regulation of organelle organization 0 Informative Direct
Biological Process (BP) locomotion 6.548e-05 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 3.77e-15 Informative Direct
Biological Process (BP) single organism reproductive process 0.0008299 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 3.954e-06 Informative Direct
Biological Process (BP) cellular process involved in reproduction 7.234e-05 Informative Direct
Biological Process (BP) generation of neurons 1.614e-13 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 4.251e-13 Informative Direct
Biological Process (BP) regulation of cellular component movement 2.928e-07 Informative Direct
Biological Process (BP) localization of cell 7.362e-07 Informative Direct
Biological Process (BP) regulation of nervous system development 4.888e-05 Informative Direct
Biological Process (BP) regulation of cell development 0.0001028 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0.0001325 Informative Direct
Biological Process (BP) developmental process involved in reproduction 0.09674 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.01408 Informative Inherited
Biological Process (BP) cellular component movement 0.006741 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.01643 Informative Inherited
Biological Process (BP) microtubule-based movement 4.747e-06 Highly Informative Direct
Biological Process (BP) female gamete generation 2.432e-09 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 6.44e-07 Highly Informative Direct
Biological Process (BP) cellular process involved in reproduction in multicellular organism 1.689e-08 Highly Informative Direct
Biological Process (BP) regulation of microtubule polymerization or depolymerization 0 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 2.612e-11 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 1.537e-07 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 1.001e-06 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in neuron differentiation 0.03169 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 0.05172 Highly Informative Inherited
Biological Process (BP) axon development 0.2668 Highly Informative Inherited
Molecular Function (MF) binding 0.01855 Least Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 2.618e-08 Informative Direct
Molecular Function (MF) tubulin binding 5.337e-15 Highly Informative Direct
Cellular Component (CC) intracellular organelle part 0.9004 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.01405 Least Informative Inherited
Cellular Component (CC) protein complex 0.02114 Least Informative Inherited
Cellular Component (CC) cytoskeleton 5.45e-05 Moderately Informative Direct
Cellular Component (CC) cell projection 0.0008466 Moderately Informative Direct
Cellular Component (CC) microtubule cytoskeleton 9.01e-07 Informative Direct
Cellular Component (CC) cell leading edge 3.672e-06 Informative Direct
Cellular Component (CC) neuron projection 4.833e-07 Informative Direct
Cellular Component (CC) microtubule associated complex 4.075e-11 Highly Informative Direct
Cellular Component (CC) growth cone 6.745e-08 Highly Informative Direct
Cellular Component (CC) cell body 2.3e-05 Highly Informative Direct

Document: GO annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)visual system0Moderately InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentCytoplasm0.2816Least InformativeInherited
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentGolgi apparatus2.418e-14Moderately InformativeDirect
Cellular componentCytoskeleton7.071e-08Moderately InformativeDirect
Cellular componentMicrotubule2.935e-11InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
Post-translational modificationPhosphoprotein2.686e-05Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000956 SSF101494 Protein matches
Abstract Stathmin is a ubiquitous phosphorylated protein thought to act as an intracellular relay for diverse regulatory pathways [PubMed2358074], functioning through a variety of second messengers. Its phosphorylation and gene expression are regulated throughout development [PubMed8344928] and in response to extracellular signals regulating cell proliferation, differentiation and function [PubMed2745432]. Stathmin, and the related proteins SCG10 and XB3, contain a N-terminal domain (XB3 contains an additional N-terminal hydrophobic region), a 78 amino acid coiled-coil region, and a short C-terminal domain.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Stathmin domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Stathmin superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]