SUPERFAMILY 1.75 HMM library and genome assignments server

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Stathmin superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Non-globular all-alpha subunits of globular proteins [ 48661] (14)
Superfamily:   Stathmin [ 101494]
Families:   Stathmin [ 101495]


Superfamily statistics
Genomes (121) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 507 575 2
Proteins 498 560 2


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process0.0000000000000079780.00000000001383Least InformativeDirect
Biological Process (BP)developmental process00.000000000001066Least InformativeDirect
Biological Process (BP)single-organism cellular process0.000047170.0001525Least InformativeDirect
Biological Process (BP)regulation of cellular process0.0000000002490.0003402Least InformativeDirect
Biological Process (BP)response to stimulus0.087420.7726Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.00000026540.002072Least InformativeInherited
Biological Process (BP)nervous system development00Moderately InformativeDirect
Biological Process (BP)cell differentiation00Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process0.0000025660.000007279Moderately InformativeDirect
Biological Process (BP)regulation of cellular component organization0.0000000000084140.00000000003937Moderately InformativeDirect
Biological Process (BP)response to endogenous stimulus0.00020270.001872Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.011320.01657Moderately InformativeInherited
Biological Process (BP)response to organic substance0.0013760.02699Moderately InformativeInherited
Biological Process (BP)regulation of localization0.0029120.0008828Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.00053690.001777Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.18850.3307Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.070320.1813Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.4021Moderately InformativeInherited
Biological Process (BP)microtubule-based process0.00012940.000000001184InformativeDirect
Biological Process (BP)cell projection organization0.0000000009380.000007522InformativeDirect
Biological Process (BP)regulation of organelle organization00InformativeDirect
Biological Process (BP)regulation of cellular component biogenesis0.0000000000000032610.000000000000003755InformativeDirect
Biological Process (BP)generation of neurons00.0000000000001857InformativeDirect
Biological Process (BP)negative regulation of cellular component organization0.00000000000068960.0000000000004482InformativeDirect
Biological Process (BP)regulation of cellular component movement0.00000038330.0000002774InformativeDirect
Biological Process (BP)regulation of nervous system development0.000000054470.0000532InformativeDirect
Biological Process (BP)regulation of cell development0.00000016770.0001169InformativeDirect
Biological Process (BP)cellular response to endogenous stimulus0.0000024960.0001534InformativeDirect
Biological Process (BP)positive regulation of cellular component organization0.0071440.01433InformativeInherited
Biological Process (BP)cellular component morphogenesis0.00011510.01596InformativeInherited
Biological Process (BP)regulation of neuron projection development0.0000000011510.0000006744Highly InformativeDirect
Biological Process (BP)regulation of microtubule polymerization or depolymerization00Highly InformativeDirect
Biological Process (BP)neuron projection development00.0000000001857Highly InformativeDirect
Biological Process (BP)cell part morphogenesis0.00000000000069970.00000009457Highly InformativeDirect
Biological Process (BP)regulation of protein complex assembly0.0000000016550.00000000002801Highly InformativeDirect
Biological Process (BP)negative regulation of cytoskeleton organization0.00000024750.0000001203Highly InformativeDirect
Biological Process (BP)cellular response to growth factor stimulus0.0000000033060.000001236Highly InformativeDirect
Biological Process (BP)cell morphogenesis involved in differentiation0.00064270.2158Highly InformativeInherited
Molecular Function (MF)binding0.03080.02204Least InformativeInherited
Molecular Function (MF)cytoskeletal protein binding0.0030270.00000002473InformativeInherited
Molecular Function (MF)tubulin binding0.0000013190.000000000000006053Highly InformativeDirect
Cellular Component (CC)cell projection0.00001670.0009798Moderately InformativeDirect
Cellular Component (CC)cell leading edge0.00000015340.000003782InformativeDirect
Cellular Component (CC)neuron projection0.00000000032770.0000006353InformativeDirect
Cellular Component (CC)growth cone0.000000057990.00000007788Highly InformativeDirect
Cellular Component (CC)cell body0.0000012540.0000238Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.00000000001383 Least Informative Direct
Biological Process (BP) developmental process 0.000000000001066 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0001525 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.0003402 Least Informative Direct
Biological Process (BP) response to stimulus 0.7726 Least Informative Inherited
Biological Process (BP) localization 0.1419 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.002072 Least Informative Inherited
Biological Process (BP) nervous system development 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0008828 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.000007279 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.00000000003937 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.001872 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.01657 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.02699 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.001777 Moderately Informative Inherited
Biological Process (BP) reproduction 0.001941 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.3307 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.03897 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.1813 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) microtubule-based process 0.000000001184 Informative Direct
Biological Process (BP) sexual reproduction 0.000003414 Informative Direct
Biological Process (BP) cell projection organization 0.000007522 Informative Direct
Biological Process (BP) regulation of organelle organization 0 Informative Direct
Biological Process (BP) locomotion 0.00006926 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.000000000000003755 Informative Direct
Biological Process (BP) single organism reproductive process 0.0008331 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 0.000004294 Informative Direct
Biological Process (BP) cellular process involved in reproduction 0.0000692 Informative Direct
Biological Process (BP) generation of neurons 0.0000000000001857 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.0000000000004482 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.0000002774 Informative Direct
Biological Process (BP) localization of cell 0.0000008083 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0000532 Informative Direct
Biological Process (BP) regulation of cell development 0.0001169 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0.0001534 Informative Direct
Biological Process (BP) developmental process involved in reproduction 0.09772 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.01433 Informative Inherited
Biological Process (BP) cellular component movement 0.006529 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.01596 Informative Inherited
Biological Process (BP) microtubule-based movement 0.000004584 Highly Informative Direct
Biological Process (BP) female gamete generation 0.000000002769 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.0000006744 Highly Informative Direct
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.00000001964 Highly Informative Direct
Biological Process (BP) cytoskeleton-dependent intracellular transport 0.0000000000003211 Highly Informative Direct
Biological Process (BP) regulation of microtubule polymerization or depolymerization 0 Highly Informative Direct
Biological Process (BP) neuron projection development 0.0000000001857 Highly Informative Direct
Biological Process (BP) cell part morphogenesis 0.00000009457 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 0.00000000002801 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 0.0000001203 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0.000001236 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.2158 Highly Informative Inherited
Molecular Function (MF) binding 0.02204 Least Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.00000002473 Informative Direct
Molecular Function (MF) tubulin binding 0.000000000000006053 Highly Informative Direct
Cellular Component (CC) intracellular organelle part 0.8955 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.01441 Least Informative Inherited
Cellular Component (CC) protein complex 0.02222 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.00005904 Moderately Informative Direct
Cellular Component (CC) cell projection 0.0009798 Moderately Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.0000009376 Informative Direct
Cellular Component (CC) cell leading edge 0.000003782 Informative Direct
Cellular Component (CC) neuron projection 0.0000006353 Informative Direct
Cellular Component (CC) microtubule associated complex 0.00000000004071 Highly Informative Direct
Cellular Component (CC) growth cone 0.00000007788 Highly Informative Direct
Cellular Component (CC) cell body 0.0000238 Highly Informative Direct

Document: GO annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)visual system0Moderately InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentCytoplasm0.2813Least InformativeInherited
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentGolgi apparatus0.00000000000002517Moderately InformativeDirect
Cellular componentCytoskeleton0.0000000716Moderately InformativeDirect
Cellular componentMicrotubule0.00000000002918InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
Post-translational modificationPhosphoprotein0.00002735Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000956 SSF101494 Protein matches
Abstract Stathmin is a ubiquitous phosphorylated protein thought to act as an intracellular relay for diverse regulatory pathways [PubMed2358074], functioning through a variety of second messengers. Its phosphorylation and gene expression are regulated throughout development [PubMed8344928] and in response to extracellular signals regulating cell proliferation, differentiation and function [PubMed2745432]. Stathmin, and the related proteins SCG10 and XB3, contain a N-terminal domain (XB3 contains an additional N-terminal hydrophobic region), a 78 amino acid coiled-coil region, and a short C-terminal domain.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Stathmin domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Stathmin superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]