SUPERFAMILY 1.75 HMM library and genome assignments server


ADP-ribosylglycohydrolase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   ADP-ribosylglycohydrolase [ 101477]
Superfamily:   ADP-ribosylglycohydrolase [ 101478]
Families:   ADP-ribosylglycohydrolase [ 101479]


Superfamily statistics
Genomes (1,123) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,143 8,648 1
Proteins 2,102 8,601 1


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process0.00010620.0009213Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process0.00067310.01014Least InformativeInherited
Biological Process (BP)cellular protein modification process1.074e-063.901e-05Moderately InformativeDirect
Molecular Function (MF)hydrolase activity0.0013120.001016Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on glycosyl bonds3.808e-102.563e-10InformativeDirect
Molecular Function (MF)hydrolase activity, hydrolyzing N-glycosyl compounds7.07e-150Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0.0009213 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.01014 Least Informative Inherited
Biological Process (BP) cellular protein modification process 3.901e-05 Moderately Informative Direct
Molecular Function (MF) hydrolase activity 0.001016 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 2.563e-10 Informative Direct
Molecular Function (MF) hydrolase activity, hydrolyzing N-glycosyl compounds 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl1Moderately InformativeInherited
Enzyme Commission (EC)Hydrolyzing N-glycosyl compounds0.0276InformativeInherited

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Hydrolyzing N-glycosyl compounds0.02097Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Molecular functionMagnesium9.972e-07Moderately InformativeDirect
Post-translational modificationHydrolase2.237e-16Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR005502 SSF101478 Protein matches
Abstract This family includes enzymes that perform ADP-ribosylations, such as ADP-ribosylarginine hydrolase which cleaves ADP-ribose-L-arginine [PubMed8349667]. The family also includes dinitrogenase reductase activating glycohydrolase [PubMed2506427], and most surprisingly jellyfish crystallins [PubMed2506427], although these proteins appear to have lost the presumed active site residues.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ADP-ribosylglycohydrolase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the ADP-ribosylglycohydrolase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]