SUPERFAMILY 1.75 HMM library and genome assignments server


Formin homology 2 domain (FH2 domain) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Formin homology 2 domain (FH2 domain) [ 101446]
Superfamily:   Formin homology 2 domain (FH2 domain) [ 101447]
Families:   Formin homology 2 domain (FH2 domain) [ 101448] (2)


Superfamily statistics
Genomes (516) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 5,990 4,595 5
Proteins 5,918 4,557 5


Functional annotation
General category Processes_IC
Detailed category Cell motility

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.000899 Least Informative Direct
Biological Process (BP) developmental process 0.0002194 Least Informative Direct
Biological Process (BP) single-organism cellular process 2.318e-11 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) localization 0.2657 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.003228 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) organelle organization 1.249e-12 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0007579 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 5.865e-13 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 9.109e-05 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0003301 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 2.112e-14 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0.625 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.9747 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.7273 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.4484 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.0181 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.07993 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.4778 Moderately Informative Inherited
Biological Process (BP) tissue development 0.1103 Moderately Informative Inherited
Biological Process (BP) organ development 0.9153 Moderately Informative Inherited
Biological Process (BP) reproduction 0.00165 Moderately Informative Inherited
Biological Process (BP) system process 0.653 Moderately Informative Inherited
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 2.468e-05 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) regulation of organelle organization 1.416e-11 Informative Direct
Biological Process (BP) cellular macromolecular complex assembly 0.0003164 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 3.239e-12 Informative Direct
Biological Process (BP) localization of cell 0.0009278 Informative Direct
Biological Process (BP) regulation of anatomical structure size 7.697e-11 Informative Direct
Biological Process (BP) protein complex assembly 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.1993 Informative Inherited
Biological Process (BP) generation of neurons 0.2927 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.1214 Informative Inherited
Biological Process (BP) regulation of cell development 0.1973 Informative Inherited
Biological Process (BP) organ morphogenesis 0.6912 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.03311 Informative Inherited
Biological Process (BP) gland development 0.1105 Informative Inherited
Biological Process (BP) cell death 0.00143 Informative Inherited
Biological Process (BP) sexual reproduction 0.01828 Informative Inherited
Biological Process (BP) single organism reproductive process 0.07166 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.323 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.01849 Informative Inherited
Biological Process (BP) cell cycle process 0.007774 Informative Inherited
Biological Process (BP) actin filament organization 0 Highly Informative Direct
Biological Process (BP) spermatogenesis 0.000912 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 1.263e-14 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 1.178e-05 Highly Informative Direct
Biological Process (BP) limb morphogenesis 4.083e-05 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 0.0001346 Highly Informative Direct
Biological Process (BP) response to drug 7.376e-07 Highly Informative Direct
Biological Process (BP) negative regulation of protein complex disassembly 2.26e-05 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 1.929e-11 Highly Informative Direct
Biological Process (BP) protein polymerization 2.463e-12 Highly Informative Direct
Biological Process (BP) cell division 1.381e-05 Highly Informative Direct
Biological Process (BP) regulation of protein depolymerization 2.708e-07 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 0.2603 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.3822 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.0747 Highly Informative Inherited
Biological Process (BP) skeletal system development 0.05802 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.1086 Highly Informative Inherited
Biological Process (BP) meiosis 0.03216 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 1 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) cation binding 0.0006387 Moderately Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) enzyme binding 4.137e-06 Informative Direct
Molecular Function (MF) calcium ion binding 2.475e-07 Highly Informative Direct
Molecular Function (MF) drug binding 1.093e-09 Highly Informative Direct
Molecular Function (MF) Ras GTPase binding 4.531e-14 Highly Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.0001052 Least Informative Direct
Cellular Component (CC) membrane 0.6975 Least Informative Inherited
Cellular Component (CC) protein complex 0.02535 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.9909 Least Informative Inherited
Cellular Component (CC) cytoskeleton 2.397e-07 Moderately Informative Direct
Cellular Component (CC) cell projection 7.442e-05 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 0.55 Moderately Informative Inherited
Cellular Component (CC) cell cortex 1.706e-07 Informative Direct
Cellular Component (CC) actin cytoskeleton 7.333e-06 Informative Direct
Cellular Component (CC) cell leading edge 3.438e-08 Informative Direct
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) ruffle 7.414e-05 Highly Informative Direct
Cellular Component (CC) adherens junction 2.479e-05 Highly Informative Direct
Cellular Component (CC) protein serine/threonine phosphatase complex 1.143e-14 Highly Informative Direct
Cellular Component (CC) cell projection membrane 3.686e-06 Highly Informative Direct
Cellular Component (CC) leading edge membrane 1.664e-09 Highly Informative Direct
Cellular Component (CC) cell division site part 1.154e-07 Highly Informative Direct
Cellular Component (CC) contractile ring 2.708e-09 Highly Informative Direct
Cellular Component (CC) growth cone 0.007063 Highly Informative Inherited
Cellular Component (CC) axon part 0.04733 Highly Informative Inherited

Document: GO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)fertile0Least InformativeDirect
Fly Phenotype (FP)increased mortality0Least InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation1.061e-06Moderately InformativeDirect
Biological processApoptosis0.0001332Moderately InformativeDirect
Biological processUbl conjugation pathway0.0008744InformativeDirect
Cellular componentMembrane6.917e-10Least InformativeDirect
Cellular componentNucleus2.235e-05Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton3.144e-15Moderately InformativeDirect
Cellular componentCytoplasmic vesicle2.246e-07Moderately InformativeDirect
Cellular componentCell projection1.903e-06Moderately InformativeDirect
Cellular componentCell junction0.0005166Moderately InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
Molecular functionActin-binding0InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationDevelopmental protein1.979e-09Moderately InformativeDirect
Post-translational modificationProtein phosphatase3.305e-14InformativeDirect
Post-translational modificationPhosphoprotein1.901e-07Least InformativeDirect
Post-translational modificationUbl conjugation6.762e-06Moderately InformativeDirect
Post-translational modificationMyristate3.298e-05InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details) Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR015425 SSF101447 Protein matches
Abstract

Formin homology (FH) proteins play a crucial role in the reorganization of the actin cytoskeleton, which mediates various functions of the cell cortex including motility, adhesion, and cytokinesis [PubMed10631086]. Formins are multidomain proteins that interact with diverse signalling molecules and cytoskeletal proteins, although some formins have been assigned functions within the nucleus. Formins are characterised by the presence of three FH domains (FH1, FH2 and FH3), although members of the formin family do not necessarily contain all three domains [PubMed12538772]. The proline-rich FH1 domain mediates interactions with a variety of proteins, including the actin-binding protein profilin, SH3 (Src homology 3) domain proteins, and WW domain proteins. The FH2 domain is required for the self-association of formin proteins through the ability of FH2 domains to directly bind each other [PubMed14576350], and may also act to inhibit actin polymerisation [PubMed14992721]. The FH3 domain is less well conserved and may be important for determining intracellular localisation of formin family proteins. In addition, some formins can contain a GTPase-binding domain (GBD) required for binding to Rho small GTPases, and a C-terminal conserved Dia-autoregulatory domain (DAD).

This entry represents the FH2 domain, which was shown by X-ray crystallography to have an elongated, crescent shape containing three helical subdomains [PubMed15006353].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Human Phenotype (HP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Formin homology 2 domain (FH2 domain) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Formin homology 2 domain (FH2 domain) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Human Phenotype (HP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]