SUPERFAMILY 1.75 HMM library and genome assignments server


Formin homology 2 domain (FH2 domain) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Formin homology 2 domain (FH2 domain) [ 101446]
Superfamily:   Formin homology 2 domain (FH2 domain) [ 101447]
Families:   Formin homology 2 domain (FH2 domain) [ 101448] (2)


Superfamily statistics
Genomes (556) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 6,592 6,395 5
Proteins 6,514 6,317 5


Functional annotation
General category Processes_IC
Detailed category Cell motility

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 1.295e-11 Least Informative Direct
Biological Process (BP) developmental process 5.029e-06 Least Informative Direct
Biological Process (BP) multicellular organismal process 1.826e-05 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.00106 Least Informative Inherited
Biological Process (BP) localization 0.005208 Least Informative Inherited
Biological Process (BP) response to stimulus 0.4178 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 9.491e-14 Moderately Informative Direct
Biological Process (BP) organelle organization 5.081e-13 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 5.539e-07 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 1.38e-06 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 6.587e-05 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0001224 Moderately Informative Direct
Biological Process (BP) tissue development 0.000737 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.8197 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.1172 Moderately Informative Inherited
Biological Process (BP) organ development 0.8469 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.1032 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.4791 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.02036 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.5422 Moderately Informative Inherited
Biological Process (BP) reproduction 0.001452 Moderately Informative Inherited
Biological Process (BP) system process 0.165 Moderately Informative Inherited
Biological Process (BP) regulation of organelle organization 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) regulation of anatomical structure size 2.099e-14 Informative Direct
Biological Process (BP) programmed cell death 3.049e-11 Informative Direct
Biological Process (BP) localization of cell 1.911e-08 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 4.162e-08 Informative Direct
Biological Process (BP) muscle system process 7.923e-08 Informative Direct
Biological Process (BP) locomotion 1.862e-07 Informative Direct
Biological Process (BP) tissue morphogenesis 2.809e-06 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.0001291 Informative Direct
Biological Process (BP) regulation of locomotion 0.0001594 Informative Direct
Biological Process (BP) cellular component movement 0.0001923 Informative Direct
Biological Process (BP) growth 0.0001982 Informative Direct
Biological Process (BP) cellular macromolecular complex assembly 0.0003277 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.0005057 Informative Direct
Biological Process (BP) epithelium development 0.005814 Informative Inherited
Biological Process (BP) response to wounding 0.002378 Informative Inherited
Biological Process (BP) tube development 0.002967 Informative Inherited
Biological Process (BP) organ morphogenesis 0.02966 Informative Inherited
Biological Process (BP) regulation of cell development 0.005914 Informative Inherited
Biological Process (BP) protein complex assembly 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.3967 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.03947 Informative Inherited
Biological Process (BP) gland development 0.001799 Informative Inherited
Biological Process (BP) muscle structure development 0.03113 Informative Inherited
Biological Process (BP) organelle assembly 0.0638 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.07046 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.09959 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.01414 Informative Inherited
Biological Process (BP) cell cycle process 0.00642 Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0 Highly Informative Direct
Biological Process (BP) actin filament organization 0 Highly Informative Direct
Biological Process (BP) respiratory system development 0 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 1.167e-13 Highly Informative Direct
Biological Process (BP) protein polymerization 3.091e-12 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 3.287e-11 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 1.547e-09 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 5.789e-09 Highly Informative Direct
Biological Process (BP) regulation of protein depolymerization 2.702e-07 Highly Informative Direct
Biological Process (BP) response to drug 8.838e-07 Highly Informative Direct
Biological Process (BP) wound healing 1.294e-06 Highly Informative Direct
Biological Process (BP) cell division 2.414e-05 Highly Informative Direct
Biological Process (BP) negative regulation of protein complex disassembly 2.57e-05 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 0.0002066 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.0004219 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 0.0007443 Highly Informative Direct
Biological Process (BP) developmental growth 0.04847 Highly Informative Inherited
Biological Process (BP) renal system development 0.006449 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.9582 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.006857 Highly Informative Inherited
Biological Process (BP) limb morphogenesis 0.7954 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.001022 Highly Informative Inherited
Biological Process (BP) positive regulation of cell differentiation 0.01185 Highly Informative Inherited
Biological Process (BP) meiosis 0.01155 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.495 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) cation binding 0.002319 Moderately Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) enzyme binding 7.14e-06 Informative Direct
Molecular Function (MF) protein phosphatase binding 2.327e-15 Highly Informative Direct
Molecular Function (MF) Ras GTPase binding 3.071e-15 Highly Informative Direct
Molecular Function (MF) actin binding 1.684e-12 Highly Informative Direct
Molecular Function (MF) drug binding 1.569e-09 Highly Informative Direct
Molecular Function (MF) calcium ion binding 2.219e-07 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.08755 Highly Informative Inherited
Molecular Function (MF) tubulin binding 1 Highly Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 5.136e-06 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.7594 Least Informative Inherited
Cellular Component (CC) membrane 0.5415 Least Informative Inherited
Cellular Component (CC) protein complex 0.01345 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoskeleton 1.193e-11 Moderately Informative Direct
Cellular Component (CC) cell projection 5.035e-06 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.3559 Moderately Informative Inherited
Cellular Component (CC) cell leading edge 9.144e-08 Informative Direct
Cellular Component (CC) cell cortex 1.487e-06 Informative Direct
Cellular Component (CC) contractile fiber part 6.441e-06 Informative Direct
Cellular Component (CC) actin cytoskeleton 7.568e-06 Informative Direct
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) protein serine/threonine phosphatase complex 3.344e-14 Highly Informative Direct
Cellular Component (CC) leading edge membrane 3.534e-09 Highly Informative Direct
Cellular Component (CC) contractile ring 4.803e-09 Highly Informative Direct
Cellular Component (CC) cell division site part 2.927e-07 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 5.876e-06 Highly Informative Direct
Cellular Component (CC) myofilament 9.713e-06 Highly Informative Direct
Cellular Component (CC) cell projection membrane 1.463e-05 Highly Informative Direct
Cellular Component (CC) ruffle 0.0002293 Highly Informative Direct
Cellular Component (CC) growth cone 0.002028 Highly Informative Inherited
Cellular Component (CC) sarcomere 0.188 Highly Informative Inherited

Document: GO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect
Fly Phenotype (FP)stress response defective0.0007245InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)late embryo0Moderately InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation1.211e-06Moderately InformativeDirect
Biological processApoptosis0.0001407Moderately InformativeDirect
Biological processUbl conjugation pathway0.0001599InformativeDirect
Cellular componentMembrane9.293e-10Least InformativeDirect
Cellular componentNucleus1.015e-05Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton4.427e-15Moderately InformativeDirect
Cellular componentCytoplasmic vesicle2.72e-07Moderately InformativeDirect
Cellular componentCell projection2.396e-06Moderately InformativeDirect
Cellular componentCell junction0.0005775Moderately InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
Molecular functionActin-binding0InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationDevelopmental protein2.178e-09Moderately InformativeDirect
Post-translational modificationProtein phosphatase3.391e-14InformativeDirect
Post-translational modificationPhosphoprotein1.91e-07Least InformativeDirect
Post-translational modificationUbl conjugation7.084e-06Moderately InformativeDirect
Post-translational modificationMyristate3.139e-05InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism4.123e-05Least InformativeDirect
UniPathway (UP)protein ubiquitination6.4e-10Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR015425 SSF101447 Protein matches
Abstract

Formin homology (FH) proteins play a crucial role in the reorganization of the actin cytoskeleton, which mediates various functions of the cell cortex including motility, adhesion, and cytokinesis [PubMed10631086]. Formins are multidomain proteins that interact with diverse signalling molecules and cytoskeletal proteins, although some formins have been assigned functions within the nucleus. Formins are characterised by the presence of three FH domains (FH1, FH2 and FH3), although members of the formin family do not necessarily contain all three domains [PubMed12538772]. The proline-rich FH1 domain mediates interactions with a variety of proteins, including the actin-binding protein profilin, SH3 (Src homology 3) domain proteins, and WW domain proteins. The FH2 domain is required for the self-association of formin proteins through the ability of FH2 domains to directly bind each other [PubMed14576350], and may also act to inhibit actin polymerisation [PubMed14992721]. The FH3 domain is less well conserved and may be important for determining intracellular localisation of formin family proteins. In addition, some formins can contain a GTPase-binding domain (GBD) required for binding to Rho small GTPases, and a C-terminal conserved Dia-autoregulatory domain (DAD).

This entry represents the FH2 domain, which was shown by X-ray crystallography to have an elongated, crescent shape containing three helical subdomains [PubMed15006353].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Human Phenotype (HP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Formin homology 2 domain (FH2 domain) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Formin homology 2 domain (FH2 domain) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Human Phenotype (HP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]