SUPERFAMILY 1.75 HMM library and genome assignments server

N-terminal domain of adenylylcyclase associated protein, CAP superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   N-terminal domain of adenylylcyclase associated protein, CAP [ 101277]
Superfamily:   N-terminal domain of adenylylcyclase associated protein, CAP [ 101278]
Families:   N-terminal domain of adenylylcyclase associated protein, CAP [ 101279]


Superfamily statistics
Genomes (451) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 699 769 2
Proteins 686 760 2


Functional annotation
General category Regulation
Detailed category Other regulatory function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) developmental process 0.00001988 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0001658 Least Informative Direct
Biological Process (BP) localization 0.0008914 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0000002644 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.5629 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.06061 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.1004 Least Informative Inherited
Biological Process (BP) response to stimulus 0.01235 Least Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.000000002167 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.0005458 Moderately Informative Direct
Biological Process (BP) regulation of phosphorus metabolic process 0.0005966 Moderately Informative Direct
Biological Process (BP) single-organism organelle organization 0.000000111 Moderately Informative Direct
Biological Process (BP) nervous system development 0.02249 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.02696 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.03486 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.003048 Moderately Informative Inherited
Biological Process (BP) cellular component movement 0.0000000007096 Informative Direct
Biological Process (BP) cytoskeleton organization 0.00000000000004707 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.0000002973 Informative Direct
Biological Process (BP) actin filament-based process 0.00000000000005513 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.00000006674 Informative Direct
Biological Process (BP) locomotion 0.0000000000006548 Informative Direct
Biological Process (BP) generation of neurons 0.000635 Informative Direct
Biological Process (BP) localization of cell 0.00001017 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0.000001627 Informative Direct
Biological Process (BP) cell projection organization 0.002863 Informative Inherited
Biological Process (BP) chemotaxis 0.0002616 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.000002817 Highly Informative Direct
Biological Process (BP) neuron projection development 0.00002052 Highly Informative Direct
Biological Process (BP) cell projection morphogenesis 0.9634 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.3689 Highly Informative Inherited
Molecular Function (MF) binding 0.2999 Least Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.00000859 Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.0001492 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.01494 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.2307 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.00000002833 Moderately Informative Direct
Cellular Component (CC) cell cortex 0.000000000002484 Informative Direct
Cellular Component (CC) actin cytoskeleton 0.001276 Informative Inherited
Cellular Component (CC) cortical cytoskeleton 0.00000007913 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentMembrane0.0000004055Least InformativeDirect
Cellular componentCell membrane0.000000000001201Moderately InformativeDirect
Molecular functionActin-binding0InformativeDirect
Post-translational modificationAcetylation0.0000004872Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR013992 SSF101278 Protein matches
Abstract

Cyclase-associated protein (CAP) is a conserved two-domain protein that helps to activate the catalytic activity of adenylyl cyclase in the cyclase-bound state through interaction with Ras, which binds to the cyclase in a different region. With its other domain, CAP can bind monomeric actin and therefore also carries a cytoskeletal function. The protein is thus involved in Ras/cAMP-dependent signal transduction and most likely serves as an adapter protein translocating the adenylyl cyclase complex to the actin cytoskeleton [PubMed1550959, PubMed7962207].

Structurally, CAP is a protein of 474 to 551 residues. The N- and C-terminal domains of CAP are connected by an intermediate section which contains a proline-rich region. In the yeast protein, this domain has been further divided into the P1 and P2 regions. While the P1 region is constituted by a 14 amino-acid sequence of unknown function, the P2 region exhibits a consensus SH3-binding motif (PXXP) and is necessary to target CAP to cortical actin patches. Dictyostelium CAP is a phosphatidylinositol 4,5-biphosphate (PIP2) regulated G-actin sequestering protein, which is present in the cytosol and shows enrichment at plasma-membrane regions. The cortical translocation is mediated by the N-terminal domain [PubMed12351838].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a N-terminal domain of adenylylcyclase associated protein, CAP domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the N-terminal domain of adenylylcyclase associated protein, CAP superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]