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N-terminal domain of adenylylcyclase associated protein, CAP superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   N-terminal domain of adenylylcyclase associated protein, CAP [ 101277]
Superfamily:   N-terminal domain of adenylylcyclase associated protein, CAP [ 101278]
Families:   N-terminal domain of adenylylcyclase associated protein, CAP [ 101279]


Superfamily statistics
Genomes (450) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 698 769 2
Proteins 685 760 2


Functional annotation
General category Regulation
Detailed category Other regulatory function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) developmental process 0.00001215 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0004205 Least Informative Direct
Biological Process (BP) localization 0.0007469 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.00000008378 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.1212 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.522 Least Informative Inherited
Biological Process (BP) response to stimulus 0.01235 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.03276 Least Informative Inherited
Biological Process (BP) organelle organization 0.00001667 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0000000004948 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0.0001888 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.0003353 Moderately Informative Direct
Biological Process (BP) nervous system development 0.02118 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.018 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.02287 Moderately Informative Inherited
Biological Process (BP) cellular component movement 0.000000003095 Informative Direct
Biological Process (BP) cytoskeleton organization 0.00000000000001086 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.00000013 Informative Direct
Biological Process (BP) actin filament-based process 0.0000000000002613 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.00000001554 Informative Direct
Biological Process (BP) locomotion 0.0000000000003584 Informative Direct
Biological Process (BP) generation of neurons 0.0003937 Informative Direct
Biological Process (BP) localization of cell 0.00001166 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0.0000008492 Informative Direct
Biological Process (BP) cell projection organization 0.005498 Informative Inherited
Biological Process (BP) chemotaxis 0.0002626 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.000005517 Highly Informative Direct
Biological Process (BP) regulation of cyclic nucleotide metabolic process 0.0000000001503 Highly Informative Direct
Biological Process (BP) neuron projection development 0.00001227 Highly Informative Direct
Biological Process (BP) cell part morphogenesis 1 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.3875 Highly Informative Inherited
Molecular Function (MF) binding 0.2017 Least Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.000008627 Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.0009417 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.05264 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.05919 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.000002227 Moderately Informative Direct
Cellular Component (CC) cell cortex 0.000000000002552 Informative Direct
Cellular Component (CC) actin cytoskeleton 0.0000000004047 Informative Direct
Cellular Component (CC) cortical cytoskeleton 0.00000000000002039 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentMembrane0.0000004055Least InformativeDirect
Cellular componentCell membrane0.000000000001201Moderately InformativeDirect
Molecular functionActin-binding0InformativeDirect
Post-translational modificationAcetylation0.0000004872Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR013992 SSF101278 Protein matches
Abstract

Cyclase-associated protein (CAP) is a conserved two-domain protein that helps to activate the catalytic activity of adenylyl cyclase in the cyclase-bound state through interaction with Ras, which binds to the cyclase in a different region. With its other domain, CAP can bind monomeric actin and therefore also carries a cytoskeletal function. The protein is thus involved in Ras/cAMP-dependent signal transduction and most likely serves as an adapter protein translocating the adenylyl cyclase complex to the actin cytoskeleton [PubMed1550959, PubMed7962207].

Structurally, CAP is a protein of 474 to 551 residues. The N- and C-terminal domains of CAP are connected by an intermediate section which contains a proline-rich region. In the yeast protein, this domain has been further divided into the P1 and P2 regions. While the P1 region is constituted by a 14 amino-acid sequence of unknown function, the P2 region exhibits a consensus SH3-binding motif (PXXP) and is necessary to target CAP to cortical actin patches. Dictyostelium CAP is a phosphatidylinositol 4,5-biphosphate (PIP2) regulated G-actin sequestering protein, which is present in the cytosol and shows enrichment at plasma-membrane regions. The cortical translocation is mediated by the N-terminal domain [PubMed12351838].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a N-terminal domain of adenylylcyclase associated protein, CAP domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the N-terminal domain of adenylylcyclase associated protein, CAP superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]