SUPERFAMILY 1.75 HMM library and genome assignments server


Mob1/phocein superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Bromodomain-like [ 47363] (15)
Superfamily:   Mob1/phocein [ 101152]
Families:   Mob1/phocein [ 101153]


Superfamily statistics
Genomes (477) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,925 2,140 2
Proteins 1,910 2,131 2


Functional annotation
General category Regulation
Detailed category Other regulatory function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process0.55510.5788Least InformativeInherited
Biological Process (BP)regulation of cellular process0.080640.4319Least InformativeInherited
Biological Process (BP)positive regulation of cellular process0.110.1982Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.010040.009729Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.016280.0759Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10.001385Moderately InformativeInherited
Biological Process (BP)positive regulation of protein modification process0.00041350.0001106InformativeDirect
Biological Process (BP)regulation of protein phosphorylation0.00092050.2524InformativeInherited
Biological Process (BP)positive regulation of phosphate metabolic process0.00040920.01522InformativeInherited
Molecular Function (MF)binding0.012110.2191Least InformativeInherited
Molecular Function (MF)enzyme binding0.00094390.001771InformativeInherited
Molecular Function (MF)kinase binding9.707e-088.613e-07Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of metabolic process 0.5788 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.4319 Least Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.001385 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.1982 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.009729 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.0759 Moderately Informative Inherited
Biological Process (BP) positive regulation of protein modification process 0.0001106 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 0.2524 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.01522 Informative Inherited
Molecular Function (MF) binding 0.2191 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.0002656 Moderately Informative Direct
Molecular Function (MF) enzyme binding 0.001771 Informative Inherited
Molecular Function (MF) kinase binding 8.613e-07 Highly Informative Direct

Document: GO annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)neuroanatomy defective0Moderately InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0.0001207Moderately InformativeDirect
Cellular componentNucleus0.0001001Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionMetal-binding8.649e-15Least InformativeDirect
Post-translational modificationPhosphoprotein1.934e-05Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR005301 SSF101152 Protein matches
Abstract

Mob1 is an essential Saccharomyces cerevisiae protein, identified from a two-hybrid screen, that binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Mob1 contains no known structural motifs; however MOB1 is a member of a conserved gene family and shares sequence similarity with a nonessential yeast gene, MOB2. Mob1 is a phosphoprotein in vivo and a substrate for the Mps1p kinase in vitro. Conditional alleles of MOB1 cause a late nuclear division arrest at restrictive temperature [PubMed9436989]. This family also includes phocein , a rat protein that by yeast two hybrid interacts with striatin [PubMed11251078].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Mob1/phocein domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Mob1/phocein superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]