SUPERFAMILY 1.75 HMM library and genome assignments server

Mob1/phocein superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Bromodomain-like [ 47363] (15)
Superfamily:   Mob1/phocein [ 101152]
Families:   Mob1/phocein [ 101153]


Superfamily statistics
Genomes (478) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,927 2,140 2
Proteins 1,912 2,131 2


Functional annotation
General category Regulation
Detailed category Other regulatory function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.16170.4667Least InformativeInherited
Biological Process (BP)regulation of cellular process0.097150.3301Least InformativeInherited
Biological Process (BP)positive regulation of biological process0.2240.2496Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.28570.2844Least InformativeInherited
Biological Process (BP)regulation of phosphorus metabolic process0.0016710.0001218Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.010790.02955Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.02310.005074Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.1410.1624Moderately InformativeInherited
Biological Process (BP)cell division0.00095130.00004291InformativeDirect
Biological Process (BP)positive regulation of cellular protein metabolic process0.009910.0001486InformativeInherited
Molecular Function (MF)binding0.015130.2554Least InformativeInherited
Molecular Function (MF)enzyme binding0.00095630.001932InformativeInherited
Molecular Function (MF)kinase binding0.000000099170.000001033Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0.4667 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.3301 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 0.2496 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.2844 Least Informative Inherited
Biological Process (BP) regulation of phosphorus metabolic process 0.0001218 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.02955 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.005074 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.1624 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.0001486 Informative Direct
Biological Process (BP) cell division 0.00004291 Informative Direct
Molecular Function (MF) binding 0.2554 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.000008631 Moderately Informative Direct
Molecular Function (MF) enzyme binding 0.001932 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.01984 Informative Inherited
Molecular Function (MF) kinase binding 0.000001033 Highly Informative Direct

Document: GO annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)neuroanatomy defective0Moderately InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0.0001136Moderately InformativeDirect
Cellular componentNucleus0.0001015Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionMetal-binding0.00000000000001135Least InformativeDirect
Post-translational modificationPhosphoprotein0.00001973Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR005301 SSF101152 Protein matches
Abstract

Mob1 is an essential Saccharomyces cerevisiae protein, identified from a two-hybrid screen, that binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Mob1 contains no known structural motifs; however MOB1 is a member of a conserved gene family and shares sequence similarity with a nonessential yeast gene, MOB2. Mob1 is a phosphoprotein in vivo and a substrate for the Mps1p kinase in vitro. Conditional alleles of MOB1 cause a late nuclear division arrest at restrictive temperature [PubMed9436989]. This family also includes phocein , a rat protein that by yeast two hybrid interacts with striatin [PubMed11251078].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Mob1/phocein domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Mob1/phocein superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]